Evaluation of diabetic retinopathy in adults with type 1 diabetes at Ceará state

Authors

DOI:

https://doi.org/10.33448/rsd-v9i11.10360

Keywords:

Diabetic retinopathy; Diabetes Mellitus Type 1; Public health.

Abstract

It is estimated that there are more than 30 thousand people with type 1 diabetes mellitus (DM1) in Brazil. Among the complications, diabetic retinopathy (DR) is one of the most prevalent, affecting up to 50% of DM1 patients in some populations. This study aims to estimate the prevalence of DR in DM1 or Latent autoimmune diabetes in adults (LADA), in addition to assessing risk factors involved. A cross-sectional study was carried out evaluating 81 patients over 18 years of age and diagnosed with long-term type 1 DM. Demographic, clinical and laboratory aspects were assessed using a structured questionnaire. Ophthalmological examination data were collected from medical records. We observed a 33% prevalence of DR in patients with DM1 in the state of Ceará. This complication was more associated with older patients (p = 0.004), longer DM1 time (p <0.001), inadequate metabolic control and, mainly, increased creatinine levels (p = 0.011). It was observed that patients with episodes of severe hypoglycemia had a higher prevalence of DR. In addition, an important association was observed between DR and diabetic nephropathy, as described in the literature. This study demonstrates the high prevalence of DR in patients with DM1 and confirms the need for tracking the disease, especially in patients with longer disease duration and inadequate metabolic control and other complications such as nephropathy.

Author Biography

Alexis Galeno Matos , Hospital de Olhos Leiria de Andrade

 

 

 

References

Sociedade Brasileira de Diabetes (2018). Diretrizes SBD 2017-2018. Diretrizes da Sociedade Brasileira de Diabetes.

Alberti, K. G. M. M., & Zimmet, P. Z. (1998). Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus. Provisional report of a WHO consultation. Diabetic Medicine, 15(7), 539-553.

Atlas, D. (2015). International diabetes federation. IDF diabetes atlas. Brussels: International Diabetes Federation.

King, P., Peacock, I., & Donnelly, R. (1999). The UK prospective diabetes study (UKPDS): clinical and therapeutic implications for type 2 diabetes. British Journal of Clinical Pharmacology, 48(5), 643-648.

Klein, R. (2000). Epidemiology of eye disease in diabetes. Diabetes and Ocular Disease. Recuperado de https://ci.nii.ac.jp/naid/10018944710

Klein, R., Klein, B. E., & Moss, S. E. (1984). Visual impairment in diabetes. Ophthalmology, 91(1), 1-9.

Sociedade Brasileira de Diabetes (2015). Diretriz Brasileira de Retinopatia Diabética. Diretrizes SBD. Recuperado de http://www.diabetes.org.br/profissionais/images/pdf/diabetes-tipo-1/012-Diretrizes-SBD-Retinopatia-Diabetica-pg149.pdf

Bosco, A., Lerário, A. C., Soriano, D., Santos, R. F. D., Massote, P., Galvão, D., & Ferreira, A. R. (2005). Retinopatia diabética. Arquivos Brasileiros de Endocrinologia & Metabologia, 49(2), 217-227.

Diabetes Control and Complications Trial Research Group (DCCTRG). (1993). The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. New England Journal of Medicine, 329(14), 977-986.

Silveira, V. M. F. D., Menezes, A. M. B., Post, C. L. A., & Machado, E. C. (2001). Uma amostra de pacientes com diabetes tipo 1 no sul do Brasil. Arquivos Brasileiros de Endocrinologia & Metabologia, 45(5), 433-440.

Hainsworth, D. P., Bebu, I., Aiello, L. P., Sivitz, W., Gubitosi-Klug, R., Malone, J., & Barkmeier, A. J. (2019). Risk factors for retinopathy in type 1 diabetes: the DCCT/EDIC study. Diabetes Care, 42(5), 875-882.

Li, Y., Xia, X., & Paulus, Y. M. (2018). Advances in Retinal Optical Imaging. In Photonics 5(2): 9).

Sabrosa, N. A., Sabrosa, A. S., Gouvea, K. C., & Gonçalves Filho, P. (2013). Tratamento cirúrgico da retinopatia diabética. Revista Brasileira de Oftalmologia, 72(3), 204-209.

Nathan, D. M., & DCCT/Edic Research Group. (2014). The diabetes control and complications trial/epidemiology of diabetes interventions and complications study at 30 years: overview. Diabetes Care, 37(1), 9-16.

Li, T., Jia, Y., Wang, S., Wang, A., Gao, L., Yang, C., & Zou, H. (2019). Retinal microvascular abnormalities in children with type 1 diabetes mellitus without visual impairment or diabetic retinopathy. Investigative ophthalmology & visual science, 60(4), 990-998.

Goto, K., & Kitazono, T. (2019). Endothelium-Dependent Hyperpolarization (EDH) in Diabetes: Mechanistic Insights and Therapeutic Implications. International Journal of Molecular Sciences, 20(15), 3737.

Nery, M. (2008). Hipoglicemia como fator complicador no tratamento do diabetes melito tipo 1. Arquivos Brasileiros de Endocrinologia & Metabologia, 52(2), 288-298.

Granado-Casas, M., Castelblanco, E., Ramírez-Morros, A., Martín, M., Alcubierre, N., Martínez-Alonso, M., & Hernández, M. (2019). Poorer quality of life and treatment satisfaction is associated with diabetic retinopathy in patients with type 1 diabetes without other advanced late complications. Journal of clinical medicine, 8(3), 377.

Sakamoto, M., Hashimoto, R., Yoshida, I., Ubuka, M., & Maeno, T. (2018). Risk factors for neovascular glaucoma after vitrectomy in eyes with proliferative diabetic retinopathy. Clinical Ophthalmology, 12(1), 2323.

Published

03/12/2020

How to Cite

TRAVASSOS, M. P. P. .; LIMA BISNETO, J. A. .; DIAS, I. T. .; TORQUATO, G. C. P. .; LOPES, F. M. .; FAÇANHA , C. F. S. .; MATOS , A. G. .; KUPFER, R. Evaluation of diabetic retinopathy in adults with type 1 diabetes at Ceará state. Research, Society and Development, [S. l.], v. 9, n. 11, p. e75391110360, 2020. DOI: 10.33448/rsd-v9i11.10360. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/10360. Acesso em: 20 nov. 2024.

Issue

Section

Health Sciences