Detection of antibiotic waste in raw milk, pasteurized and Ultra High Temperature (UHT) commercialized in Unaí, Minas Gerais
DOI:
https://doi.org/10.33448/rsd-v9i11.10688Keywords:
β-lactam; Enzymatic test; Tetraciclina.Abstract
Milk quality can be evaluated by physical-chemical, sensory, microbiological parameters and by the presence of chemical residues, such as antimicrobial. The main source of these substances in the milk is a consequence is the inadequate management of medications aimed at the control of illness in the herd, breach of the milk dispose during the grace period and flaws in utensils and equipment hygiene. The aim of this study is to evaluate raw-milk, pasteurizes and UHT milk quality commercialized in Unaí-MG under surveillance of inspection services or informally commercialized, in relation to the presence of antibiotic residues. 56 milk samples were analyzed, being 16 of raw-milk, 16 of pasteurized milk and 24 of UHT milk (8 sample of whole milk, 8 samples of semi-skimmed milk and 8 samples of skimmed milk) using the IDEXX SNAP® duo™ ST Plus kit. After the accomplishment of analytical tests, it was possible to verify that pasteurized and UHT samples did not contain antibiotic residues tested, while just one raw-milk sample presented positive for the presence of β-lactam residues. These results show the necessity of the compliance of grace period during the treatment of livestock as well as the necessity to control antimicrobial residues on the dairy industry reception platform beyond the surveillance by the Official Inspection Service aimed at the production of innocuous food.
References
Araújo, G. B., Santos, H. A., Farias, C. E., Viana, D. A. F., Vieira, E. S. & Ferreira Júnior, A. M. (2015). Detecção de resíduo de antibiótico em leite in natura em laticínio sob inspeção federal. Scientia Plena, 11(4), 1-6.
Brasil. Ministério da Agricultura, Pecuária e Abastecimento. Instrução Normativa Nº 76, de 2018a. Dispõe sobre os critérios e procedimentos para a produção, acondicionamento, conservação, transporte, seleção e recepção do leite cru em estabelecimentos registrados no serviço de inspeção oficial, na forma desta Instrução Normativa e do seu Anexo. Diário Oficial da União, Brasília, DF, 30.11.2018.
Brasil. Ministério da Agricultura, Pecuária e Abastecimento. Instrução Normativa Nº 77, de 2018b. Dispõe sobre os Regulamentos Técnicos que fixam a identidade e as características de qualidade que devem apresentar o leite cru refrigerado, o leite pasteurizado e o leite pasteurizado tipo A, na forma desta Instrução Normativa e do Anexo Único. Diário Oficial da União, Brasília, DF, 30.11.2018.
Brasil. Ministério da Agricultura, Pecuária e Abastecimento. Departamento de Inspeção de Produtos de Origem Animal. Instrução Normativa n° 5 de 2019. Dispõe sobre “Aprovação do plano de amostragem e limites de referência para o Plano Nacional de Controle de Resíduos e Contaminantes em Produtos de Origem Animal - PNCRC de 2019 para as cadeias de carnes bovina, suína, caprina, ovina, equina, coelho, aves, avestruz, de leite, pescado, mel e ovos”. Diário Oficial da União, Brasília, DF, 25.04.2019.
Estevão Neto, A., Garino Júnior, F., Santos, J. C. A., Silva, L. C. A. & Matos, R. A. T. Avaliação de resíduo de antibiótico em amostras de leite de vacas após a terapia de vacas secas. Arquivos do Instituto Biológico de São Paulo, 82(1), 1-4. DOI: https://doi.org/10.1590/1808-1657000322013
Fernandes, S. A. A., Magnavita, A. P. A., Ferrao, S. P. B., Gualberto, S. A., Faleiro, A. S., Figueiredo, A. J. & Matarazzo, S. V. (2014). Daily ingestion of tetracycline residue present in pasteurized milk: a public health problem. Environmental Science and Pollution Research, 21(5), 3427–34. DOI: https://doi.org/10.1007/s11356-013-2286-5
IDEXX, Laboratories. Test SNAPduo ST Plus. Manual de Instruções. 2011. Disponível em: https://www.idexx.com.br/pt-br/milk/resources-support/training/dairy-test-protocols/. 2p.
Kabrite, S., Bou-Mitri, C., Fares, J.E.H., Hassan, H.F. & Boumosleh, J.M. (2019). Identification and dietary exposure assessment of tetracycline and penicillin residues in fluid milk, yogurt, and labneh: A cross-sectional study in Lebanon. Veterinary World, 12(4), 527-34. DOI: https://doi.org/10.14202/vetworld.2019.527-534
Khanal, B. K. S., Sadig, M. B., Singh, M. & Anal, A. K. (2018). Screening of antibiotic residues in fresh milk of Kathmandu Valley, Nepal. Journal of Environmental Science and Health, 53(1), 57-86. DOI: https://doi.org/10.1080/03601234.2017.1375832
Kosgey, A., Shitandi, A. & Marion, J. W. (2018). Antibiotic residues in milk from three popular Kenyan milk vending machines. American Journal of Tropical Medicine and Hygiene, 98(5),1520-22. DOI: https://doi.org/10.4269/ajtmh.17-0409
Macedo, L. C. S. & Freitas, J. A. (2009). Ocorrência de resíduos de antimicrobianos em leite. Revista de Ciências Agrárias, 52(1), 147-57.
Madougou, A. M., Douny, C., Moula, N., Scippo,M. L., Delcenserie, V., Daube, G., Hamani, M. & Korsak, N. (2019). Survey on the presence of antibiotic residues in raw milk samples from six sites of the dairy pool of Niamey, Niger. Veterinary World, 12 (12), 1970-74. DOI: www.doi.org/10.14202/vetworld.2019.1970-1974
Martins, M. T., Melo, J., Barreto, F., Hoff, R. B., Jank, L., Bittencourt, M. S., Arsand, J. B. & Schapoval, E. E. S. (2014). A simple, fast and cheap non-SPE screening method for antibacterial residue analysis in milk and liver using liquid chromatography-tandem mass spectrometry. Talanta, 129(1), 374–83. DOI: https://doi.org/10.1016/j.talanta.2014.04.049
Medeiros, N. G. A., Carvalho, M. G. X., Santos, M. G. O. & Lima, S. C. P. (2004). Detecção de antibióticos em leite in natura consumido no município de Patos, Paraíba. Revista Higiene Alimentar, 18(124), 85-88.
Moghadam, M. M., Amiri, M., Riabi, H. R., Riabi, H. R. (2016). Evaluation of antibiotic residues in pasteurized and raw milk distrib¬uted in the South of Khorasan-e Razavi Province, Iran. Journal of Clinical and Diagnostic Research, 10(12), 31-35. DOI: https:// 10.7860/JCDR/2016/21034.9034
Nascimento, G. G. F., Maestro, V. & Campos, M. S. P. (2001). Ocorrência de resíduos de antibióticos no leite comercializado em Piracicaba, SP. Revista de Nutrição, 14(2), 119-124. doi: https://doi.org/10.1590/S1415-52732001000200005
Nero, L. A., Mattos, M. R., Beloti, V., Barros, M. A. F.& Franco, B. D. G. M. (2007). Resíduos de antibióticos em leite cru de quatro regiões leiteiras no Brasil. Ciência e Tecnologia de Alimentos, 27(2), 787-792. doi: https://doi.org/10.1590/S0101-20612007000200031
Oliveira, C. R., Bando, E. & Machinski Junior, M. (2007). Ocorrência de cloranfenicol em leite pasteurizado comercializado no Estado do Paraná, Brasil. Acta Scientiarum. Health Science, 29(1), 59-62. DOI: https://doi.org/10.4025/actascihealthsci.v29i1.107
Prado, C. K., Ferreira, F. D., Bando, E. & Machinski JR, M. (2015). Oxytetracycline, Tetracycline, Chlortetracycline and Doxycycline in pasteurised cow's milk commercialised in Brazil. Food Additives & Contaminants: Part B. Surveillance, 8(2), 81-4. DOI: https://doi.org/10.1080/19393210.2014.968881
Sachi, S., Ferdous, J., Sikder, M. H. & Azizul, S. M. K. H. Antibiotic residues in milk: Past, present, and future. Journal of Advanced Veterinary and Animal Research, 6(3), 315‐332. DOI: http://doi.org/10.5455/javar.2019.f350
Shahbandeh, M. (2020). Global consumption of fluid milk 2019, by country. https://www.statista.com/statistics/272003/global-annual-consumption-of-milk-by region/#statisticContainer.
Silva, M. V. & Nogueira, J. L. (2010). Mastite: Controle e Profilaxia no Rebanho Bovino. Revista Cientifica Eletrônica de Medicina Veterinária, 8(15), 1-13.
Silva, T. S., Nicolau, E. S., Rezende, C. S. M., Carvalho, D. A. & Costa, H. T. (2015). Resíduos de antimicrobianos no leite produzido em Goiás, Brasil, sob fiscalização do Serviço de Inspeção Federal (SIF). Veterinária em Foco, 13(1), 26-36.
Tetzner, T. A. D., Benetti, E., Guimarães, E. C. & Peres, R. F. G. (2005). Prevalência de resíduos de antibióticos em amostras de leite cru na região do Triângulo Mineiro, MG. Revista Higiene Alimentar, 19(130), 69-72.
Van Boeckel, T. P., Brower, C., Gilbert, M., Grenfell, B. T., Levin, S. A., Robinson, T. P., Teillant, A. & Laxminarayan, R. (2015). Global trends in antimicrobial use in food ani¬mals. Proceedings of the National Academy of Sciences of the United States of America, 112(18), 5649-54. DOI: http://doi.org/10.1073/pnas.1503141112
Zingone, F., Bucci, C., Iovino, P. & Ciacci, C. (2017). Consumption of milk and dairy products: Facts and figures. Nutrition, 33(1), 322–325. DOI: http://doi.org/10.1016/j.nut.2016.07.019
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