Dental care needs in cancer patients during COVID-19 pandemic - a review
DOI:
https://doi.org/10.33448/rsd-v9i12.11120Keywords:
Cancer; Coronavirus; COVID-19; Dental care; Oncology.Abstract
The risk of contamination by SARS-Cov-2 from cancer patients is high due to immunosuppression. The aim of this study is to investigate evidence that demonstrates the treatment needs related to the main diseases that manifest in the oral cavity and also, the fundamentals that support dental care protocols in cancer patients during the COVID-19 pandemic. The study is characterized as a literature review. Search for articles which have been published in Lilacs, PubMed, Scopus and Web of Science databases. The included articles were presented in the English language and addressed the risk and association among COVID-19, cancer and their oral complications, with recommendations for management and treatment of these patients during outbreak times. In addition to the review, studies about oral complications from antineoplastic therapy were also included. 386 studies about cancer, COVID-19 and dental care were considered in the data base. After applying the inclusion and exclusion criteria, 45 articles were considered. Besides articles involving COVID-19, 31 articles involving oral complications from antineoplastic therapy and possible associations between cancer and oral cavity were included. The results revealed that the main oral diseases in cancer patients were mucositis, xerostomia and periodontal disease. Oral complications may be related to a worse evolution of COVID-19. For the management of oral complications, the dentist must be included in the interdisciplinary team to develop strategies for prevention and promotion of oral health. Dental care is crucial to prevent and treat oral lesions resulting from cancer treatment that can affect the prognosis of COVID-19.
References
Achard, V., Tsoutsou, P., & Zilli, T. (2020). Radiotherapy in the time of the Coronavirus pandemic: when less is better. International Journal of Radiation Oncology, Biology, Physics.
Ahadian, H., Yassaei, S., Bouzarjomehri, F., Ghaffari Targhi, M., & Kheirollahi, K. h. (2017). Oral Complications of The Oromaxillofacial Area Radiotherapy. Asian Pacific Journal of Cancer Prevention: APJCP, 18(3), 721–725.
Alharbi, A., Alharbi, S., & Alqaidi, S. (2020). Guidelines for dental care provision during the COVID-19 pandemic. The Saudi Dental Journal.
Ather, A., Patel, B., Ruparel, N. B., Diogenes, A., & Hargreaves, K. M. (2020). Coronavirus Disease 19 (COVID-19): Implications for Clinical Dental Care. Journal of Endodontics.
Berlin-Broner, Y., & Levin, L. (2020). 'Dental Hierarchy of Needs' in the COVID-19 Era - or Why Treat When It Doesn't Hurt?. Oral health & preventive dentistry, 18(1), 95.
Boev, C., & Kiss, E. (2017). Hospital-Acquired Infections: Current Trends and Prevention. Critical Care Nursing Clinics of North America, 29(1), 51–65.
Bouffet, E., Challinor, J., Sullivan, M., Biondi, A., Rodriguez-Galindo, C., & Pritchard-Jones, K. (2020). Early advice on managing children with cancer during the COVID-19 pandemic and a call for sharing experiences. Pediatric Blood & Cancer, 2, e28327.
Burki T. K. (2020a). Cancer guidelines during the COVID-19 pandemic. The Lancet. Oncology, 21(5), 629-630.
Burki T. K. (2020b). Cancer care in the time of COVID-19. The Lancet. Oncology, 21(5), 628.
Cardoso, E. M., Reis, C. & Manzanares-Céspedes M. C. (2018) Chronic periodontitis, inflammatory cytokines, and interrelationship with other chronic diseases. Postgraduate Medicine, 130:1, 98-104.
Carneiro-Neto, J. N., de-Menezes, J. D., Moura, L. B., Massucato, E. M., & de-Andrade, C. R. (2017). Protocols for management of oral complications of chemotherapy and/or radiotherapy for oral cancer: Systematic review and meta-analysis current. Medicina Oral, Patologia Oral y Cirugia Bucal, 22(1), e15–e23.
Carvalho, C. G., Medeiros-Filho, J. B., & Ferreira, M. C. (2018). Guide for health professionals addressing oral care for individuals in oncological treatment based on scientific evidence. Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer, 26(8), 2651–2661.
Cestari, J. A., Fabri, G. M., Kalil, J., Nitrini, R., Jacob-Filho, W., de Siqueira, J. T., & Siqueira, S. R. (2016). Oral Infections and Cytokine Levels in Patients with Alzheimer's Disease and Mild Cognitive Impairment Compared with Controls. Journal of Alzheimer's Disease : JAD, 52(4), 1479–1485.
Chaveli-López, B., & Bagán-Sebastián, J. V. (2016). Treatment of oral mucositis due to chemotherapy. Journal of Clinical and Experimental Dentistry, 8(2), e201–e209.
Cortiula, F., Pettke, A., Bartoletti, M., Puglisi, F., & Helleday, T. (2020). Managing COVID-19 in the oncology clinic and avoiding the distraction effect. Annals of oncology : official journal of the European Society for Medical Oncology, 31(5), 553–555.
Coulthard P. (2020). Dentistry and coronavirus (COVID-19) - moral decision-making. British Dental Journal, 228(7), 503–505.
Dave, M., Seoudi, N., & Coulthard, P. (2020). Urgent dental care for patients during the COVID-19 pandemic. The Lancet. 395(10232), 1257.
Daugėlaitė, G., Užkuraitytė, K., Jagelavičienė, E., & Filipauskas, A. (2019). Prevention and Treatment of Chemotherapy and Radiotherapy Induced Oral Mucositis. Medicina (Kaunas, Lithuania), 55(2), 25.
Desai, A., Sachdeva, S., Parekh, T., & Desai, R. (2020). COVID-19 and Cancer: Lessons From a Pooled Meta-Analysis. JCO Global Oncology, 6, 557–559.
Devi, S. & Singh, N. (2014). Dental care during and after radiotherapy in head and neck cancer. National Journal of Maxillofacial Surgery. v. 5, n. 2, p. 117–125.
Dewhirst, F.E., Chen, T., Izard, J., Paster, B.J, Tanner, A.C., Yu, W.H., Lakshmanan, A., & Wade, W.G. (2010). The Human Oral Microbiome. J Bacteriol, 192(19), 5002-17.
Edwards, S. P., Kasten, S., Nelson, C., Elner, V., & McKean, E. (2020). Maxillofacial Trauma Management During COVID-19: Multidisciplinary Recommendations. Facial Plastic Surgery & Aesthetic Medicine, 22(3), 157-159.
Elad, S., Ranna, V., Ariyawardana, A., Correa, M. E., Tilly, V., Nair, R. G., Rouleau, T., Logan, R. M., Pinto, A., Charette, V., Saunders, D. P., Jensen, S. B., & Viral Infections Section, Oral Care Study Group, Multinational Association of Supportive Care in Cancer (MASCC)/International Society of Oral Oncology (ISOO) (2017). A systematic review of oral herpetic viral infections in cancer patients: commonly used outcome measures and interventions. Supportive Care in Cancer : Official Journal of The Multinational Association of Supportive Care in Cancer, 25(2), 687–700.
Fabri, G. M. C. (2020). Potential Link between COVID-19 and Periodontitis: Cytokine Storm, Immunosuppression, and Dysbiosis. Oral Health and Dental Management, 20(1), 1-5.
Fabri, G. M. C., Pereira, R. M., Savioli, C., Saad, C. G., de Moraes, J. C., Siqueira, J. T., & Bonfa, E. (2015). Periodontitis Response to Anti-TNF Therapy in Ankylosing Spondylitis. Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases, 21(7), 341–345.
Fabri, G. M. C., Savioli, C., Siqueira, J. T., Campos, L. M., Bonfá, E., & Silva, C. A. (2014). [Periodontal disease in pediatric rheumatic diseases]. Revista Brasileira de Reumatologia, 54(4), 311–317.5.
Falandry, C., Filteau, C., Ravot, C., & Le Saux, O. (2020). Challenges with the management of older patients with cancer during the COVID-19 pandemic. Journal of Geriatric Oncology.
Farquhar, D. R., Divaris, K., Mazul, A. L., Weissler, M. C., Zevallos, J. P., & Olshan, A. F. (2017). Poor oral health affects survival in head and neck cancer. Oral Oncology, 73, 111–117.
Ferreira, M. C., Dias-Pereira, A. C., Branco-de-Almeida, L. S., Martins, C. C., & Paiva, S. M. (2017). Impact of periodontal disease on quality of life: a systematic review. Journal of Periodontal Research, 52(4), 651–665.
Filippi, A. R., Russi, E., Magrini, S. M., & Corvò, R. (2020). Letter from Italy: First practical indications for radiation therapy departments during COVID-19 outbreak. International Journal of Radiation Oncology, Biology, Physics.
Franco, J., Arancibia, M., Simancas-Racines, D., & Madrid, E. (2018). Syntheses of biomedical information: narrative reviews, systematic reviews and emerging formats. Síntesis de información biomédica: revisiones narrativas, revisiones sistemáticas y estructuras emergentes. Medwave, 18(7), e7354.
Guo, Y., Yuan, C., & Wei, C. (2020). Emergency measures for acute oral mucosa diseases during the outbreak of COVID-19. Oral Diseases.
Gupta, N., Pal, M., Rawat, S., Grewal, M. S., Garg, H., Chauhan, D., Ahlawat, P., Tandon, S., Khurana, R., Pahuja, A. K., Mayank, M., & Devnani, B. (2015). Radiation-induced dental caries, prevention and treatment - A systematic review. National Journal of Maxillofacial Surgery, 6(2), 160–166.
Hanna, T. P., Evans, G. A., & Booth, C. M. (2020). Cancer, COVID-19 and the precautionary principle: prioritizing treatment during a global pandemic. Nature reviews. Clinical oncology, 17(5), 268–270.
Hong, C., Hu, S., Haverman, T., Stokman, M., Napeñas, J. J., Braber, J. B., Gerber, E., Geuke, M., Vardas, E., Waltimo, T., Jensen, S. B., & Saunders, D. P. (2018). A systematic review of dental disease management in cancer patients. Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer, 26(1), 155–174.
Hong, C. H. L., Napeñas, J. J., Hodgson, B. D., Stokman, M. A., Mathers-Stauffer, V., Elting, L. S., Spijkervet, F. K. L. & Brennan, M. T. (2010). A systematic review of dental disease in patients undergoing cancer therapy. Supportive Care in Cancer, v. 18, n. 8, p. 1007–1021.
Jazieh, A. R., Al Hadab, A., Al Olayan, A., AlHejazi, A., Al Safi, F., Al Qarni, A., Farooqui, F., Al Mutairi, N., & Alenazi, T. H. (2020). Managing Oncology Services During a Major Coronavirus Outbreak: Lessons From the Saudi Arabia Experience. JCO Global oncology, 6, 518–524.
Joebges, S., & Biller-Andorno, N. (2020). Ethics guidelines on COVID-19 triage-an emerging international consensus. Critical care (London, England), 24(1), 201.
Kawashita, Y., Soutome, S., Umeda, M., & Saito, T. (2020). Oral management strategies for radiotherapy of head and neck cancer. The Japanese Dental Science Review, 56(1), 62–67.
Kolokythas, A., Rasmussen, J. T., Reardon, J., & Feng, C. (2019). Management of osteoradionecrosis of the jaws with pentoxifylline-tocopherol: a systematic review of the literature and meta-analysis. International journal of Oral and Maxillofacial Surgery, 48(2), 173–180.
Kotecha R. S. (2020). Challenges posed by COVID-19 to children with cancer. The Lancet. Oncology, 21(5), e235.
Kutikov, A., Weinberg, D. S., Edelman, M. J., Horwitz, E. M., Uzzo, R. G., & Fisher, R. I. (2020). A War on Two Fronts: Cancer Care in the Time of COVID-19. Annals of Internal Medicine, M20-1133.
La Rosa, G., Gattuso, G., Pedullà, E., Rapisarda, E., Nicolosi, D., & Salmeri, M. (2020). Association of oral dysbiosis with oral cancer development. Oncology Letters, 19(4), 3045–3058.
Lambertini, M., Toss, A., Passaro, A., Criscitiello, C., Cremolini, C., Cardone, C., Loupakis, F., Viscardi, G., Meattini, I., Dieci, M. V., Ferrara, R., Giusti, R., & Maio, M. D. (2020). Cancer care during the spread of coronavirus disease 2019 (COVID-19) in Italy: young oncologists' perspective. ESMO Open, 5(2), e000759.
Levi, L. E. & Lalla, R. V. (2018). Dental Treatment Planning for the Patient with Oral Cancer. Dental Clinics of North America, v. 62, n. 1, p. 121–130.
Liang, W., Guan, W., Chen, R., Wang, W., Li, J., Xu, K., Li, C., Ai, Q., Lu, W., Liang, H., Li, S., & He, J. (2020). Cancer patients in SARS-CoV-2 infection: a nationwide analysis in China. The Lancet. Oncology, 21(3), 335–337.
Loftus, R. W., Dexter, F., Parra, M. C., & Brown, J. R. (2020). Importance of oral and nasal decontamination for patients undergoing anesthetics during the COVID-19 era. Anesthesia and Analgesia.
Machado, R. A., de Souza, N. L., Oliveira, R. M., Martelli Júnior, H., & Bonan, P. (2020). Social media and telemedicine for oral diagnosis and counselling in the COVID-19 era. Oral oncology, 105, 104685.
Mann, J., Bernstein, Y., & Findler, M. (2020). Periodontal disease and its prevention, by traditional and new avenues. Experimental and Therapeutic Medicine, 19(2), 1504–1506.
Meng, L., Hua, F., & Bian, Z. (2020). Coronavirus Disease 2019 (COVID-19): Emerging and Future Challenges for Dental and Oral Medicine. Journal of Dental Research, 99(5), 481-487.
Mercadante, V., Al Hamad, A., Lodi, G., Porter, S., & Fedele, S. (2017). Interventions for the management of radiotherapy-induced xerostomia and hyposalivation: A systematic review and meta-analysis. Oral Oncology, 66, 64–74.
Mosel, D. D., Bauer, R. L., Lynch, D. P. & Hwang, S. T. (2011). Oral complications in the treatment of cancer patients. Oral Diseases. v. 17, p. 550-559.
Motlagh, A., Yamrali, M., Azghandi, S., Azadeh, P., Vaezi, M., Ashrafi, F., Zendehdel, K., Mirzaei, H., Basi, A., Rakhsha, A., Seifi, S., Tabatabaeefar, M., Elahi, A., Pirjani, P., Moadab Shoar, L., Nadarkhani, F., Khoshabi, M., Bahar, M., Esfahani, F., Fudazi, H., … Malekzadeh, R. (2020). COVID19 Prevention & Care; A Cancer Specific Guideline. Archives of Iranian Medicine, 23(4), 255–264.
Mussetti, A., Maluquer, C., Albasanz-Puig, A., Gudiol, C., Moreno-Gonzalez, G., Corradini, P., & Sureda, A. (2020). Handling the COVID-19 pandemic in the oncological setting. The Lancet. Haematology, 7(5), e365-e366.
Peng, X., Xu, X., Li, Y., Cheng, L., Zhou, X., & Ren, B. (2020). Transmission routes of 2019-nCoV and controls in dental practice. International Journal of Oral Science, 12(1), 9.
Pino, L., Perez, C., Cardona, A., & Triana, I. (2020). Cancer Center Recommendations to Mitigate COVID-19 Impact in Patients With Cancer: Low-Resource Settings Version. JCO Global Oncology, 6, 569–570.
Porzio, G., Cortellini, A., Bruera, E., Verna, L., Ravoni, G., Peris, F., & Spinelli, G. (2020). Home Care for Cancer Patients During COVID-19 Pandemic: The Double Triage Protocol. Journal of pain and symptom management, 60(1), e5–e7.
Rapidis, A. D., Dijkstra, P. U., Roodenburg, J. L., Rodrigo, J. P., Rinaldo, A., Strojan, P., Takes, R. P., & Ferlito, A. (2015). Trismus in patients with head and neck cancer: etiopathogenesis, diagnosis and management. Clinical otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery, 40(6), 516–526.
Ritwik P. (2018). Dental Care for Patients With Childhood Cancers. The Ochsner Journal, 18(4), 351–357.
Rolim, T., Fabri, G. M., Nitrini, R., Anghinah, R., Teixeira, M. J., Siqueira, J. T., Cesari, J. A., & Siqueira, S. R. (2014). Evaluation of patients with Alzheimer's disease before and after dental treatment. Arquivos de Neuro-Psiquiatria, 72(12), 919–924.
Salako, O., Okunade, K., Allsop, M., Habeebu, M., Toye, M., Oluyede, G., Fagbenro, G., & Salako, B. (2020). Upheaval in cancer care during the COVID-19 outbreak. Ecancermedicalscience, 14, ed97.
Savioli, C., Ribeiro, A. C., Fabri, G. M., Calich, A. L., Carvalho, J., Silva, C. A., Viana, V. S., Bonfá, E., & Siqueira, J. T. (2012). Persistent periodontal disease hampers anti-tumor necrosis factor treatment response in rheumatoid arthritis. Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases, 18(4), 180–184.
Shankar, A., Saini, D., Roy, S., Mosavi Jarrahi, A., Chakraborty, A., Bharti, S. J., & Taghizadeh-Hesary, F. (2020). Cancer Care Delivery Challenges Amidst Coronavirus Disease - 19 (COVID-19) Outbreak: Specific Precautions for Cancer Patients and Cancer Care Providers to Prevent Spread. Asian Pacific Journal of Cancer Prevention: APJCP, 21(3), 569–573.
Shuman, A. G., & Pentz, R. D. (2020). Cancer Research Ethics and COVID-19. The oncologist, 25(6), 458–459.
Spagnuolo, G., De Vito, D., Rengo, S., & Tatullo, M. (2020). COVID-19 Outbreak: An Overview on Dentistry. International Journal of Environmental Research and Public Health, 17(6), 2094.
Ueda, M., Martins, R., Hendrie, P. C., McDonnell, T., Crews, J. R., Wong, T. L., McCreery, B., Jagels, B., Crane, A., Byrd, D. R., Pergam, S. A., Davidson, N. E., Liu, C., & Stewart, F. M. (2020). Managing Cancer Care During the COVID-19 Pandemic: Agility and Collaboration Toward a Common Goal. Journal of The National Comprehensive Cancer Network: JNCCN, 1–4.
Villa, A., & Akintoye, S. O. (2018). Dental Management of Patients Who Have Undergone Oral Cancer Therapy. Dental clinics of North America, 62(1), 131–142.
Wang, H., & Zhang, L. (2020). Risk of COVID-19 for patients with cancer. The Lancet. Oncology, 21(4), e181.
Wang, Z., Wang, J., & He, J. (2020). Active and Effective Measures for the Care of Patients With Cancer During the COVID-19 Spread in China. JAMA Oncology, 6(5), 631-632.
Wei, W., Jiang, H., Chen, W., Zhou, Y., Guo, S., Zhong, G., Zhou, H., Wang, S., Zhang, H., Jiang, W., & Liu, Z. G. (2020). How should we implement radiotherapy for cancer patients in China during the endemic period of COVID-19?. Radiotherapy and Oncology: Journal of The European Society for Therapeutic Radiology and Oncology, 147, 100–102.
Wirk, B., & Wingard, J. R. (2009). Current approaches in antifungal prophylaxis in high risk hematologic malignancy and hematopoietic stem cell transplant patients. Mycopathologia, 168(6), 299–311.
Whitmore, S. E., & Lamont, R. J. (2014). Oral bacteria and cancer. PLoS Pathogens, 10(3), e1003933.
Xia, Y., Jin, R., Zhao, J., Li, W., & Shen, H. (2020). Risk of COVID-19 for patients with cancer. The Lancet. Oncology, 21(4), e180.
Xu, H., Zhong, L., Deng, J., Peng, J., Dan, H., Zeng, X., Li, T., & Chen, Q. (2020). High expression of ACE2 receptor of 2019-nCoV on the epitheli al cells of oral mucosa. International Journal Of oral Science, 12(1), 8.
Yang, C., Li, C., Wang, S., & National Clinical Research Center for Child Health and Disorders and Children's Oncology Committee of Chinese Research Hospital Association (2020). Clinical strategies for treating pediatric cancer during the outbreak of 2019 novel coronavirus infection. Pediatric Blood & Cancer, 67(5), e28248.
Yang, G., Zhang, H., & Yang, Y. (2020). Challenges and Countermeasures of Integrative Cancer Therapy in the Epidemic of COVID-19. Integrative Cancer Therapies, 19, 1534735420912811.
Yang, Y., Soh, H. Y., Cai, Z. G., Peng, X., Zhang, Y., & Guo, C. B. (2020). Experience of Diagnosing and Managing Patients in Oral Maxillofacial Surgery during the Prevention and Control Period of the New Coronavirus Pneumonia. The Chinese Journal of Dental Research: The Official Journal of The Scientific Section of The Chinese Stomatological Association (CSA), 23(1), 57–62.
You, B., Ravaud, A., Canivet, A., Ganem, G., Giraud, P., Guimbaud, R., Kaluzinski, L., Krakowski, I., Mayeur, D., Grellety, T., & Lotz, J. P. (2020). The official French guidelines to protect patients with cancer against SARS-CoV-2 infection. The Lancet. Oncology, 21(5), 619-621.
Yu, J., Ouyang, W., Chua, M., & Xie, C. (2020). SARS-CoV-2 Transmission in Patients With Cancer at a Tertiary Care Hospital in Wuhan, China. JAMA Oncology, e200980.
Zhang, L., Zhu, F., Xie, L., Wang, C., Wang, J., Chen, R., Jia, P., Guan, H. Q., Peng, L., Chen, Y., Peng, P., Zhang, P., Chu, Q., Shen, Q., Wang, Y., Xu, S. Y., Zhao, J. P., & Zhou, M. (2020). Clinical characteristics of COVID-19-infected cancer patients: A retrospective case study in three hospitals within Wuhan, China. Annals of Oncology: Official Journal of The European Society for Medical Oncology, S0923-7534(20)36383-3.
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Copyright (c) 2020 Raissa Caputo de Azevedo; Ana Carolina Alves Pereira; Yuri de Lima Medeiros; Victória Boechat Feyo; Karla de Andrade Luiz ; Tereza Cristina Esteves; Maria das Graças Afonso Miranda Chaves; Gisele Maria Campos Fabri
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