Complications presented by patients with acute kidney disease that used furosemide associated or not albumin replacement
DOI:
https://doi.org/10.33448/rsd-v9i12.11143Keywords:
Acute Kidney Injury; Diurects; Furosemide; Albumin; Dialysis.Abstract
Acute kidney injury or acute kidney injury (AKI) is a syndrome characterized by a sudden decline in kidney function. Furosemide is the most widely used diuretic in these conditions and studies have shown that both this drug and albumin are involved in inducing diuresis and natriuresis, thus decreasing complications in the short and long term. The aim of the present study is to evaluate the complications presented by patients with AKI who used furosemide associated or not with albumin replacement in an ICU. The medical records of patients admitted to the Hospital Menandro de Farias between the years 2012 to 2017 were analyzed. Patients admitted to the ICU, regardless of the diagnosis of entry, who had taken AKI and used furosemide associated or not with albumin, were included in the study. , and who needed dialysis or not. Patients known to have chronic kidney injury were excluded from the study. Patients who used only furosemide were less submitted to hemodialysis and had higher values of urea and serum creatinine at the end of hospitalization. There was no change in the hospital outcome among patients who used furosemide alone or associated with albumin. However, individuals who used only furosemide had a lower need to undergo hemodialysis therapy.
References
Abosaif, N. Y., Tolba, Y. A., Heap, M., Russell, J., & Nahas, A. M. (2005). The outcome of acute renal failure in the intensive care unit according to RIFLE: Model application, sensitivity, and predictability. Am J Kidney Dis. 46(6):1038–1048.
Chertow, G. M., Burdick, E., Honour, M., Bonventre, J. V., & Bates, D. W. (2005). Acute kidney injury, mortality, length of stay, and costs in hospitalized patients. J Am Soc Nephrol. 16(11):3365–3370.
Chalasani, N., Gorski, J. C., Horlander, S., Craven, R., Hoen, H., & Maya, J. (2001). Effects of albumin/furosemide mixtures on responses to furosemide in hypoalbuminemic patients. J Am Soc Nephrol. 12(5):1010–1016.
Cheung, M., Ponnusamy, A., & Anderton, J. G. (2008). Management of acute renal filure in the elderly patitent. Drugs Aging. 25:455- 476.
Clark, E. G., McIntyre, L., Ramsay, T., Tinmouth, A., Knoll, G., & Brown P. A. (2019). Saline versus albumin fluid for extracorporeal removal with slow low-efficiency dialysis (SAFER-SLED): study protocol for a pilot trial. Pilot Feasibility Stud. 5(1):1–6.
Cantarovich, F., Rangoonwala, B., Lorenz, H., Verho, M., & Esnault, V. L. M. (2004). High-dose furosemide for established ARF: A prospective, randomized, double-blind, placebo-controlled, multicenter trial. Am J Kidney Dis. 44(3):402–409.
Carmo, P. A. V., Amaral, C. F., Paiva, A. R. B., Ribeiro, C. C. O. S., Ramalho, G. T., & Bastos, M. G. (2006). Insuficiência renal aguda dialítica: experiência em hospital universitário. J Bras Nefrol. 28:7-14.
Dharmaraj, R., Hari, P., & Bagga, A. (2009). Randomized cross-over trial comparing albumin and frusemide infusions in nephrotic syndrome. Pediatr Nephrol. 24(4):775–782.
Dalla-Bernardina, L., Diccini, S., Belasco, A. G. S., Bittencourt, A. R. D. C., & Barbosa, D. A. (2008). The clinical outcome of patients with acute renal failure in intensive care unit. ACTA Paul Enferm. 1(1):174–178.
Dasta, J. F., & Kane-Gill, S. (2019). Review of the Literature on the Costs Associated With Acute Kidney Injury. J Pharm Pract. 32(3):292–302.
Doungngern, T., Huckleberry, Y., Bloom, J. W., & Erstad, B. (2012). Effect of albumin on diuretic response to furosemide in patients with hypoalbuminemia. Am J Crit Care. 21: 280-286.
Ejaz, A. A., & Mohandas, R. (2014). Are diuretics harmful in the management of acute kidney injury? Curr Opin Nephrol Hypertens. 23(2):155–160.
Hoste, E. A. J., & Shurgers, M. (2008). Epidemiology of acute kidney injury: How big is this problem? Crit Care. 36:146-151.
Joannidis, M., Klein, S. J., & Ostermann, M. (2019). 10 Myths About Frusemide. Intensive Care Med. 45(4):545–548.
Karajala, V., Mansour, W., & Kellum, J. A. (2009). Diuretics in acute kidney injury. Minerva Anestesiol. 75(5):251–257.
Kellum, J. A., Sileanu, F. E., Murugan, R., Lucko, N., Shaw, A. D., & Clermont, G. (2015). Classifying AKI by urine output versus serum creatinine level. J Am Soc Nephrol. 26(9):2231–2238.
Kitsios, G. D., Mascari, P., Ettunsi, R., & Gray, A. W. (2014). Co-administration of furosemide with albumin for overcoming diuretic resistance in patients with hypoalbuminemia: A meta-analysis. J Crit Care. 29(2):253–9.
Mariano, F., Mella, A., Vincenti, M., & Biancone, L. (2019). Furosemide as a functional marker of acute kidney injury in ICU patients: a new role for an old drug. J Nephrol. 32(6):883–893.
Martin, G. S., Mangialardi, R. J., Wheeler, A. P., Dupont, W. D., Morris, J. A., & Bernard, G. R. (2002). Albumin och furo vid ali. Crit Care Med. 30(10):2175–2182.
Mehta, R. L., Pascual, M. T., Soroko, S., Savage, B. R., Himmelfarb, J., & Ikizler, T. A. (2004). Spectrum of acute renal failure in the intensive care unit: The PICARD experience. Kidney Int. 66(4):1613–1621.
Phakdeekitcharoen, B., & Boonyawat, K. (2012). The added-up albumin enhances the diuretic effect of furosemide in patients with hypoalbuminemic chronic kidney disease: A randomized controlled study. BMC Nephrol. 13(1):1.
Saner, F. H., Bienholz, A., Tyczynski, B., Kribben, A., & Feldkamp, T. (2015). Überwässerung und Dialyse beim akuten Nierenversagen. Dtsch Medizinische Wochenschrift. 140(10):744–749.
Shah, K. K., Murtagh, F. E. M., McGeechan, K., Crail, S., Burns, A., & Tran, A. D. (2019). Health-related quality of life and well-being in people over 75 years of age with end-stage kidney disease managed with dialysis or comprehensive conservative care: A cross-sectional study in the UK and Australia. BMJ Open. 9(5):1–8.
Shilliday, I. R., Quinn, K. J., & Allison, M. E. M. (1997). Loop diuretics in the management of acute renal failure: A prospective, double-blind, placebo-controlled, randomized study. Nephrol Dial Transplant. 12(12):2592–2596.
Teixeira, C., Garzotto, F., Piccinni, P., Brienza, N., Iannuzzi, M., & Gramaticopolo, S. (2013). Fluid balance and urine volume are independent predictors of mortality in acute kidney injury. Crit Care. 17(1):1–11.
Van-Der-Voort, P. H. J., Boerma, E. C., Koopmans, M., Zandberg, M., De-Ruiter, J., & Gerritsen, R. T. (2009). Furosemide does not improve renal recovery after hemofiltration for acute renal failure in critically ill patients: A double blind randomized controlled trial. Crit Care Med. 37(2):533–538.
Vincent, J. L., Navickis, R. J., & Wilkes, M. M. (2004). Morbidity in hospitalized patients receiving human albumin: A meta-analysis of randomized, controlled trials. Crit Care Med. 32(10):2029–2038.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2020 Antônio Monteiro Borges Júnior; João Paulo Moraes Pereira Figueiredo; Albert Bacelar de Sousa
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
