Scientific evidence of guaco biological activity: literature review




Medicinal Plants; Guaco; Popular culture.


Plants with potential biological activity in the organism have important applicability in the present day as soon as the use is present in the culture of which it was adhered by the ancestors. The mikania, better known as guaco is used for several pathological conditions, both for cases related to the respiratory system and anti-inflammatory functions in various organs. This work aims to review the literature on the pharmacological effects of Mikania and to know the most used species. In studies done, it was verified that Mikania have several pharmacological effects, with antibacterial in dental infections, anti-hemorrhagic in cases of snakebite, anti-nociceptive with opioid-like actions, anti-inflammatory and antipyretic, useful in cases such as dengue. And this is due to its chemical constitution, since it holds a concentration of important active substances, especially coumarins. It is evident that secondary metabolites have biological activities in the body, with desired effects. M. glomerata was the most searched with positive results against tests. More effort is needed in the evaluation of compounds that can be used by society in the form of drugs with minimal side effects.


Gasparetto, J. C., Peccinini, R. G., De Francisco, T. M. G., Cerqueira, L. B., Campos, F. R., & Pontarolo, R. (2015). A kinetic study of the main guaco metabolites using syrup formulation and the identification of an alternative route of coumarin metabolism in humans. PLoS ONE, 10(3), 1–22. DOI:

Laurella, L. C., Cerny, N., Bivona, A. E., Alberti, A. S., Giberti, G., Malchiodi, E. L., ... & Sülsen, V. P. (2017). Assessment of sesquiterpene lactones isolated from Mikania plants species for their potential efficacy against Trypanosoma cruzi and Leishmania sp. PLoS neglected tropical diseases, 11(9), e0005929.

Moreti, D. L. C., Leandro, L. F., da Silva Moraes, T., Moreira, M. R., Sola Veneziani, R. C., Ambrosio, S. R., … Martins, C. H. G. (2017). Mikania glomerata Sprengel extract and its major compound ent-kaurenoic acid display activity against bacteria present in endodontic infections. Anaerobe, 47, 201–208.

Mourão, V. B., Giraldi, G. M., Neves, L. M. G., Gaspi, F. O. D. G. D., Rodrigues, R. A. F., Alves, A. A., ... & Santos, G. M. T. D. (2014). Anti-hemorrhagic effect of hydro-alcoholic extract of the leaves of Mikania glomerata in lesions induced by Bothrops jararaca venom in rats. Acta cirurgica brasileira, 29(1), 30-37.

Santos, R. R. D. (2019). Comparação de sistemas de cultivo convencional e orgânico na produção de cumarina em mikania glomerata spreng.(asteraceae) e avaliação de genotoxicidade.

Silva, Oliveira S., Gomes, T. K., Machado, L. M., Pieszak, G. M., & Rodrigues, S. O. (2017). Saberes e práticas de homens adultos acerca do uso de plantas medicinais: implicações para o cuidado. Saúde (Santa Maria), 43(2), 45-54.

Simões, C. M. O., Schenkel, E. P., Mello, J. C. P., Mentz, L. A., & Petrovick, P. R. (2016). Farmacognosia: do produto natural ao medicamento. Artmed Editora.

Silva, A. S. B., Owiti, A. O., & Barbosa, W. L. R. (2018). Pharmacology of Mikania genus: A systematic review. Pharmacognosy Reviews, 12(24), 230.

Souza, J. S. S., Gomes, E. C., Rocha, T. C., & Böger, B. (2018). USO DE PLANTAS MEDICINAIS POR COMUNIDADES DO MUNICÍPIO DE CURITIBA. Divers@!, 10(2), 91-97.

Siddiqui, S. A., Rahman, A., Rahman, M. O., Akbar, M. A., Rouf, A. S., Ali, M. A., ... & Farah, M. A. (2018). Evaluation of anti-nociceptive, anti-inflammatory and antipyretic potential of Mikania cordata (Burm. f.) Robinson in experimental animal model. Saudi journal of biological sciences, 25(6), 1049-1055.

Souza, M. T., Silva, M. D., & Carvalho, R. (2010). Revisão integrativa: o que é e como fazer. Einstein (São Paulo), 8(1), 102-106. DOI:

Vanderlinde, F. A., Rocha, F. F., Malvar, D. C., Ferreira, R. T., Costa, E. A., Florentino, I. F., ... & Lima, T. (2012). Anti-inflammatory and opioid-like activities in methanol extract of Mikania lindleyana, sucuriju. Revista Brasileira de Farmacognosia, 22(1), 150-156.



How to Cite

SANTOS, T. das V.; MARTINS, V. H. da S.; NASCIMENTO, F. R.; SANTOS, R. de C. M. Scientific evidence of guaco biological activity: literature review. Research, Society and Development, [S. l.], v. 8, n. 7, p. e22871125, 2019. DOI: 10.33448/rsd-v8i7.1125. Disponível em: Acesso em: 26 sep. 2021.



Agrarian and Biological Sciences