Consumption of Brugmansia suaveolens (Angel´s Trumpet) and psychic perturbation

Authors

DOI:

https://doi.org/10.33448/rsd-v10i1.11366

Keywords:

Toxins; Hallucinations; Delirium; Anticholinergic syndrome; Scopolamine; Atropine.

Abstract

The Brugmansia suaveolens (Humb. & Bonpl. ex Willd.) Sweet plant, popularly known as "Angel´s Trumpet ", is typical of tropical and South American regions, including Brazil, and is famous for its hallucinogenic, disturbing, sedative, among others. In this context, it is used in ritualistic, curative and recreational practices. Thus, the present study aims to analyze and discuss the consumption of B. suaveolens and its potential for psychic disturbance. An integrative bibliographic review was made, using articles from the last 10 years (2010-2020), with the descriptors "Brugmansia suaveolens", "Toxins", "Hallucinations", "Delirium", "Acute Anticholinergic Syndrome", "Scopolamine", "Atropine", "Trumpet Tea", "Angel´s Trumpet", "Mududu". B. suaveolens has antinociceptive, nematicide and muscle relaxant properties and the toxicity of its consumption is dose dependent. In this sense, higher concentrations of flowers in water infusion reflect higher concentrations of atropine and scopolamine, which instill muscarinic receptors. This inhibition is responsible for anticholinergic toxicity, causing fever, hallucinations, confusion, delirium, among other symptoms. It is concluded that the use of B. suaveolens presents risks, due to its high hallucinogenic potential, and should be seen, therefore, with clinical importance.

Author Biography

Eduardo de Sousa Martins e Silva, Universidade Federal do Triângulo Mineiro

Acadêmico de medicina - UFTM

References

Barreto, S. A. (2016). Intoxicación por uso recreativo de ‘floripondio’, reporte de caso. Revista Médica de Risaralda, 22(1), 71-72.

Bussmann, R. W., Malca G., Glenn, A., Sharon, D., Nilsen, B., Parris, B., & Townesmith, A. (2011). Toxicity of medicinal plants used in traditional medicine in Northern Peru. Journal of Ethnopharmacology, 137(1), 121-140.

Dawson, A. H., & Buckley, N. A. (2016). Pharmacological management of anticholinergic delirium - theory, evidence and practice. British journal of clinical pharmacology, 81(3), 516–524. https://doi.org/10.1111/bcp.12839.

de Souza, G. L. S., Portela, C. R., & Marques, D. D. (2019). O uso da espécie Brugmansia suaveolens (Solanaceae) como ornamental e na medicina popular. Scientia Naturalis, 1(1).

Doan, U. V., Wu, M. L., Phua, D. H., Mendez Rojas, B., & Yang, C. C. (2019). Datura and Brugmansia plants related antimuscarinic toxicity: an analysis of poisoning cases reported to the Taiwan poison control center. Clinical toxicology (Philadelphia, Pa.), 57(4), 246–253. https://doi.org/10.1080/15563650.2018.1513527.

Encarnación-Dimayuaga, R., Altamirano, L., & Maki, K. A. (1998). Screening of Medical Plants from Baja California Sur (Mexico) by Their Effects on Smooth Muscle Contractility. Pharmaceutical Biology, 36(2), 124-130.

Gaebel, W., Stricker, J., & Kerst, A. (2020). Changes from ICD-10 to ICD-11 and future directions in psychiatric classification . Dialogues in clinical neuroscience, 22(1), 7–15. https://doi.org/10.31887/DCNS.2020.22.1/wgaebel.

Jayawickreme, K. P., Janaka, K., & Subasinghe, S. (2019). Unknowing ingestion of Brugmansia suaveolens leaves presenting with signs of anticholinergic toxicity: a case report. Journal of medical case reports, 13(1), 322. https://doi.org/10.1186/s13256-019-2250-1.

Lusweti, A., Wabuyele, E., Ssegawa, P., & Mauremootoo, J. (2011). Brugmansia suaveolens (Angel's trumpet). Brugmansia suaveolens (Angel's trumpet). <https://keys.lucidcentral.org/keys/v3/eafrinet/weeds/key/weeds/Media/Html/Brugmansia_suaveolens_(Angels_Trumpet).htm>.

Lakstygal, A. M., Kolesnikova, T. O., Khatsko, S. L., Zabegalov, K. N., Volgin, A. D., Demin, K. A., Shevyrin,V.A., Wappler-Guzzetta, E.A., & Kalueff, A. V. (2018). DARK Classics in Chemical Neuroscience: Atropine, Scopolamine, and Other Anticholinergic Deliriant Hallucinogens. ACS chemical neuroscience, 10(5), 2144-2159.

Marinho, J. C. S., de Almeida Cunha, L., Lacerda, M. F. L. S., Lacerda, G. P., Coelho, R. G., & Girelli, C. F. M. (2017). Avaliação comparativa da citotoxicidade dos cimentos MTA Fillapex e AH Plus: revisão integrativa. Arquivos em Odontologia, 53.

Mesquita, M. O. M. D., Pinto, T. M. F., & Moreira, R. F. (2017). Potencial antimicrobiano de extratos e moléculas isolados de plantas da Caatinga: uma revisão. Revista Fitos, Vol. 11(2), 119-249. https://doi.org/10.5935/2446-4775.20170028.

Moreira, L. C. B. (2013). Ação nematicida do eugenol em tomateiro. Pesqui. Agropecu. Trop, 286-291. https://doi.org/10.1590/S1983-40632013000300011.

Mendes, K. D. S., Silveira, R. C. D. C. P., & Galvão, C. M. (2008). Revisão integrativa: método de pesquisa para a incorporação de evidências na saúde e na enfermagem. Texto & contexto enfermagem, 17(4), 758-764.

Muccillo-Baisch, A. L., Parker, A. G., Cardoso, G. P., Cezar-Vaz, M. R., & Flores Soares, M. C. (2010). Evaluation of the Analgesic Effect of Aqueous Extract of Brugmansia suaveolens Flower in Mice: Possible Mechanism Involved. Biological Research For Nursing, 11(4), 345-350.

O´Malley, G.F., & O´Malley, R. (2020). General Principles of Poisoning. Kenilworth: MSD Manuals. <https://www.msdmanuals.com/en-pt/professional/injuries-poisoning/poisoning/general-principles-of-poisoning>.

Petricevich, V. L., Salinas-Sánchez, D. O., Avilés-Montes, D., Sotelo-Leyva, C., & Abarca-Vargas, R. (2020). Chemical Compounds, Pharmacological and Toxicological Activity of Brugmansia suaveolens: A Review. Plants, 9(9), 1161.

Ramnarine, M., &Ahmad, D. A. (2020). Anticholinergic Toxicity Treatment & Management. New York: Vearrier D. <https://emedicine.medscape.com/article/812644-treatment#d10>.

Salazar-Anton, W., & Guzman-Hernandez, T., J. (2014). Efecto nematicida de extractos de Quassia amara y Brugmansia suaveolens sobre Meloidogyne sp. Asociado al tomate en Nicaragua. Agronomía Mesoamericana, 25(1).

Silva, J. C., Lima-Saraiva, S. R. G., Oliveira-Júnior, R. G., & Almeida, J. R. G. S. (2013). Modelos experimentais para avaliação da atividade antinociceptiva de produtos naturais: uma revisão. Brazilian Journal of Pharmacy, 94, 18-23.

Soulaidopoulos, S., Sinakos, E., Dimopoulou, D., Vettas, C., Cholongitas, E., & Garyfallos, A. (2017). Anticholinergic syndrome induced by toxic plants. World journal of emergency medicine, 8(4), 297–301. https://doi.org/10.5847/wjem.j.1920-8642.2017.04.009.

Stillwell, S. B., Fineout-Overholt, E., Melnyk, B. M., & Williamson, K. M. (2010). Evidence-based practice, step by step: asking the clinical question: a key step in evidence-based practice. The American journal of nursing, 110(3), 58–61. https://doi.org/10.1097/01.NAJ.0000368959.11129.79.

The Royal Children's Hospital Melbourne. Poisoning: Acute Guidelines For Initial Management. (2017). Melbourne: The Royal Children's Hospital. <https://www.rch.org.au/clinicalguide/guideline_index/Poisoning_-_Acute_Guidelines_For_Initial_Management/>

World Health Organization. (2010). Acute intoxication. Geneva: Department of Mental Health and Substance Abuse. <https://www.who.int/substance_abuse/terminology/acute_intox/en/>.

Downloads

Published

04/01/2021

How to Cite

SILVA, E. de S. M. e .; ONO, B. H. V. S. .; MONTEIRO, B. M. M. .; MENEZES NETO, J. B. de .; SOUZA, J. C. Consumption of Brugmansia suaveolens (Angel´s Trumpet) and psychic perturbation. Research, Society and Development, [S. l.], v. 10, n. 1, p. e11610111366, 2021. DOI: 10.33448/rsd-v10i1.11366. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/11366. Acesso em: 22 nov. 2024.

Issue

Vol. 10 No. 1

Section

Health Sciences

License

Copyright (c) 2021 Eduardo de Sousa Martins e Silva; Ben Hur Vitor Silva Ono; Bruno Massayuki Makimoto Monteiro; Joaquim Borges de Menezes Neto; José Carlos Souza

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors who publish with this journal agree to the following terms:

1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.