Hepatitis B vaccination in people living with HIV in the State of Piauí, Brazil

Authors

DOI:

https://doi.org/10.33448/rsd-v10i6.11459

Keywords:

Immunization; Hepatitis B; HIV; AIDS.

Abstract

Hepatitis B (HB) is responsible for several conditions such as cirrhosis and hepatocellular carcinoma. Prevention through vaccination is essential for people living with HIV, since this group has a higher rate of progression to the chronicity of the disease. The objective of the study was to analyze vaccination coverage against HB virus in the state of Piauí, through an epidemiological serum study of seropositive patients registered in the Laboratory Examination Control System (SISCEL) of the Central Laboratory of Public Health of Piauí in the year 2010. Data from 569 HIV-positive people were analyzed, with epidemiological variables such as age, color, education and serological markers for hepatitis B. The viral marker for hepatitis B, anti-HBs, was also determined. The findings were filtered and organized to compare the frequencies of anti-HBs titers among HIV-positive individuals. Seroconversion values ​​for anti-HBs were observed in only 39.7% of the participants, which confirms that lower rates of production of these antibodies occur in patients immunocompromised by HIV. According to the anti-HBs titles, key vulnerability behaviors were observed that make patients susceptible to infection, with emphasis on: family income and education, which point to the need to implement public policies that serve the population less favored.

Author Biography

Evaldo Hipólito de Oliveira, Universidade Federal do Piauí

Possui graduação em Farmácia pela Universidade Federal da Paraíba (1990), graduação em Farmácia e Bioquímica pela Universidade Federal da Paraíba (1991), graduação em Direito pela Universidade Federal do Piauí (1999), Doutorado em Biologia de Agentes Infecciosos e Parasitários (2010), mestrado em Administração pela Universidade Federal da Paraíba (2002), especialização em Vigilância Sanitária e Epidemiológica (1997) e Citologia Clínica (2005). Foi Diretor do Laboratório Central de Saúde Pública do Estado do Piauí-LACEN-PI (2003 a 2007). Atualmente é professor Associado da Universidade Federal do Piauí de microbiologia clínica e imunologia clínica (1994). Tem experiência na área de Farmácia (Interdisciplinaridade), atuando principalmente nos seguintes temas: análises clínicas ( bacteriologia, virologia, imunologia, citologia e hematologia ) e Vírus Linfotrópico de Células T Humanas-1/2-HTLV-1/2, HIV, HBV e HCV (Epidemiologa, Imunologia e Análise Molecular).

References

Brasil. Ministério da Saúde. Secretaria de Vigilância em Saúde. Departamento de DST, Aids e Hepatites Virais. Protocolo Clínico e Diretrizes Terapêuticas para Hepatite B e Coinfecções/Ministério da Saúde, Secretaria de Vigilância em Saúde, Departamento de DST, Aids e Hepatites Virais. – Brasília : Ministério da Saúde, 2017.

Caballero, A., Tabernero, D., Buti, M., & Rodriguez-Frias, F. (2018). Hepatitis B virus: The challenge of an ancient virus with multiple faces and a remarkable replication strategy. Antiviral research, 158, 34-44.

Carne, C. A., Weller, I. V., Waite, J., Briggs, M., Pearce, F., Adler, M. W., & Tedder, R. S. (1987). Impaired responsiveness of homosexual men with HIV antibodies to plasma derived hepatitis B vaccine. Br Med J (Clin Res Ed), 294(6576), 866-868.

Collier, A. C., Corey, L., Murphy, V. L., & Handsfield, H. H. (1988). Antibody to human immunodeficiency virus (HIV) and suboptimal response to hepatitis B vaccination. Annals of internal medicine, 109(2), 101-105.

Silva, A. L., Vitorino, R. R., Esperidião-Antonio, V., Santos, E. T., Santana, L. A., Henriques, B. D., & Gomes, A. P. (2012). Hepatites virais: B, C e D: atualização. Rev Bras Clin Med, 10(3), 206-18.

Davitkov, P., & Falck-Ytter, Y. (2019). Reactivation of Hepatitis B. In Liver Disease (pp. 279-289).

Souza, F. O., Freitas, P. S. P., Araújo, T. M., & Gomes, M. R. (2015). Vacinação contra hepatite B e Anti-HBS entre trabalhadores da saúde. Cadernos Saúde Coletiva, 23 (2): 172-179.

Fonseca, M. O., Pang, L. W., Paula Cavalheiro, N., Barone, A. A., & Lopes, M. H. (2005). Randomized trial of recombinant hepatitis B vaccine in HIV-infected adult patients comparing a standard dose to a double dose. Vaccine, 23(22), 2902-2908.

Goel, A., Aggarwal, A., & Aggarwal, R. (2016). Hepatitis B vaccine: Using skin when muscle does not work.

Hadziyannis, S. J., Tassopoulos, N. C., Heathcote, E. J., Chang, T. T., Kitis, G., Rizzetto, M., & Xiong, S. (2003). Adefovir dipivoxil for the treatment of hepatitis B e antigen–negative chronic hepatitis B. New England Journal of Medicine, 348(9), 800-807.

Organização Mundial da Saúde. (2019). Hepatitis B. Acessado em 26 Novembro 2019, em https://www.who.int/news-room/fact-sheets/detail/hepatitis-b

Hsu, Y. C., Ho, H. J., Lee, T. Y., Huang, Y. T., Wu, M. S., Lin, J. T., ... & El‐Serag, H. B. (2018). Temporal trend and risk determinants of hepatocellular carcinoma in chronic hepatitis B patients on entecavir or tenofovir. Journal of viral hepatitis, 25(5), 543-551.

Keet, I. P., Van Doornum, G., Safary, A., & Coutinho, R. A. (1992). Insufficient response to hepatitis B vaccination in HIV-positive homosexual men. AIDS (London, England), 6(5), 509.

Koc, Ö. M., Menart, C., Theodore, J., Kremer, C., Hens, N., Koek, G. H., & Oude Lashof, A. M. (2019). Ethnicity and response to primary three‐dose hepatitis B vaccination in employees in the Netherlands, 1983 through 2017. Journal of Medical Virology.

Lavanchy, D. (2012). Viral hepatitis: global goals for vaccination. Journal of Clinical Virology, 55(4), 296-302.

Martins, S., Livramento, A. D., Andrigueti, M., Kretzer, I. F., Machado, M. J., Spada, C., & Treitinger, A. (2015). Vaccination coverage and immunity against hepatitis B among HIV-infected patients in South Brazil. Brazilian Journal of Infectious Diseases, 19(2), 181-186.

Mena, G., García-Basteiro, A. L., & Bayas, J. M. (2015). Hepatitis B and A vaccination in HIV-infected adults: A review. Human vaccines & immunotherapeutics, 11(11), 2582-2598.

Moghadami, M., Dadashpour, N., Mokhtari, A. M., Ebrahimi, M., & Mirahmadizadeh, A. (2019). The effectiveness of the national hepatitis B vaccination program 25 years after its introduction in Iran: a historical cohort study. The Brazilian Journal of Infectious Diseases.

Neukam, K., Gutiérrez-Valencia, A., Llaves-Flores, S., Espinosa, N., Viciana, P., & López-Cortés, L. F. (2019). Response to a reinforced hepatitis B vaccination scheme in HIV-infected patients under real-life conditions. Vaccine, 37(20), 2758-2763.

Rodrigues, I. C., Silva, R. D. C. M. A., Felício, H. C. C. D., & Silva, R. F. D. (2019). New immunization schedule effectiveness against hepatitis B in liver transplantation patients. Arquivos de gastroenterologia, 56(4), 440-446.

Soriano, V., Mocroft, A., Peters, L., Rockstroh, J., Antunes, F., Kirkby, N., ... & Lundgren, J. (2010). Predictors of hepatitis B virus genotype and viraemia in HIV-infected patients with chronic hepatitis B in Europe. Journal of antimicrobial chemotherapy, 65(3), 548-555.

Souto, F. J. D. (2016). Distribution of hepatitis B infection in Brazil: the epidemiological situation at the beginning of the 21 st century. Revista da Sociedade Brasileira de Medicina Tropical, 49(1), 11-23.

Tonial, G. C., Passos, A. M., Livramento, A. D., Scaraveli, N. G., Batschauer, A. P. D. B., Bueno, E. C., ... & Treitinger, A. (2011). Hepatitis B marker seroprevalence and vaccination coverage in adolescents in the City of Itajaí, State of Santa Catarina, Southern Brazil, in 2008. Revista da Sociedade Brasileira de Medicina Tropical, 44(4), 416-419.

Tsai, K. N., Kuo, C. F., & Ou, J. H. J. (2018). Mechanisms of hepatitis B virus persistence. Trends in microbiology, 26(1), 33-42.

Weissmann, L., de Melo Picone, C., Gouvêa, M. S. G., Ferreira, P. R. A., Viana, M. S. V. B., Pinho, J. R. R., & Segurado, A. C. (2019). Hepatitis B viremia in HIV-coinfected individuals under antiretroviral therapy. The Brazilian Journal of Infectious Diseases.

World Health Organization. (‎2017)‎. Global hepatitis report 2017. World Health Organization.

Yuen, M. F., Chen, D. S., Dusheiko, G. M., Janssen, H. L., Lau, D. T., Locarnini, S. A., ... & Lai, C. L. (2018). Hepatitis B virus infection. Nature Reviews Disease Primers, 4, 18035.

Published

21/05/2021

How to Cite

OLIVEIRA, E. H. de .; SILVA, A. C. dos S. .; RÊGO, I. V. .; LOPES, T. B. de C. .; ROCHA , K. G. L. .; GUIMARÃES, L. O. .; OLIVEIRA, A. C. .; OLIVEIRA, M. M. de .; MOURA, Y. de S. . Hepatitis B vaccination in people living with HIV in the State of Piauí, Brazil. Research, Society and Development, [S. l.], v. 10, n. 6, p. e7010611459, 2021. DOI: 10.33448/rsd-v10i6.11459. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/11459. Acesso em: 23 jun. 2021.

Issue

Section

Health Sciences