Association of clinical and laboratory data of rural area residents to chronic exposure to glyphosate

Authors

DOI:

https://doi.org/10.33448/rsd-v10i1.12214

Keywords:

Glyphosate; Chronic exposure; Environmental exposure; Clinical evaluation.

Abstract

Commonly used by farmers, glyphosate has become the subject of many studies in recent years. However, these studies investigate and correlate glyphosate exposure to the most diverse physiological, motor, sensory, respiratory and hepatic functions, and possibly be related to causes of carcinogenicity and genotoxicity. Thus, the objective of the present study was to evaluate whether the population living in rural area of Paraguaçu, Brazil, presents evidence of chronic intoxication by glyphosate-based formulations through the evaluation of clinical signs and symptoms and laboratory data. A total of 162 samples were collected and analyzed using 53 samples from individuals who reported no contact with glyphosate for the control sample. Biochemical analyzes were performed on automated equipment, while cholinesterase was performed by Ellman's kinetic method. Data were submitted to statistical analysis, where changes in the nervous, respiratory, auditory, cutaneous and urinary systems were observed. Through the analysis of the data, associated with the literature information on the symptoms and damage generated by glyphosate, it can be concluded that the population living in the rural area, practicing family farming, has strong indications of having chronic poisoning by formulations based on glyphosate.

Author Biographies

Luiz Filipe Costa, Universidade José do Rosário Velano

Bioquimico graduado pela Unifenas - Alfenas. Trabalhos são voltados para a área de toxicologia ocupacional. Monitor das disciplinas de Bioquímica, Processos Físicos e Químicos e Metodologia Cientifica. Estagiário no laboratório de Análises Clínicas do Hospital Universitário Alzira Vellano. Participante da liga de Toxicologia Clínica da Unifenas.

Maurício Daniel dos Santos, Universidade José do Rosário Velano

 Médico graduado pela Universidade José do Rosário Velano. Carreira desenvolvida na área de Medicina, com experiência na identificação de doenças e sintomas, orientação sobre o tratamento mais apropriado, realização e solicitação de exames complementares e encaminhamento ao especialista. Vivência na prescrição de tratamento clínico, ambulatorial e hospitalar, avaliando e acompanhando o desenvolvimento do quadro clínico de cada paciente. Atuação em diversos setores hospitalares, tais como: pronto socorro, clínica médica, pediatria, centro cirúrgico e UTI.  Participação ativa na avaliação da qualidade da assistência prestada aos pacientes pelas instituições, propondo melhorias do programa de assistência global.

Malu Labecca Selicani, Universidade José do Rosário Velano

Graduanda do sexto período em Medicina na Faculdade de Ciências Médicas da Universidade José do Rosário Vellano (Unifenas) com início em 2018. Membro do Grupo de Pesquisa em Saúde Pública - UNIFENAS. Atual Presidente do Projeto de Extensão Plantando e Colhendo Saúde e fundadora do Projeto de Extensão (G)Estação Luz. Membro do Núcleo de Estudos e Desenvolvimento de Tecnologia e Saúde Unifenas. Foi monitora voluntária das disciplinas Bioquímica Médica I e Bioquímica Médica II no ano de 2019. Durante a gestão de 2019, atuou como Coordenadora Científica da Liga de Cuidados Paliativos da Unifenas e atualmente exerce o cargo de Tesoureira. É membro da Liga de Toxicologia da Unifenas (2018-atual), da Liga de Saúde da Família e Comunidade da Unifenas (2019-atual) e da Liga de Farmacologia e Terapêutica da Unifenas (2020). Bolsista do Programa Institucional de Bolsas de Extensão (PIBEX) Unifenas (02/2020-03/2021).

Simone Caetani Machado, Universidade Federal de Alfenas

Possui graduação em Farmácia pela Universidade José do Rosário Vellano (2008), mestrado em Ciências Farmacêuticas pela Universidade Federal de Alfenas (2011) e doutorado em Ciências Farmacêuticas pela Universidade Federal de Alfenas (2018). Tem experiência na área de Farmácia, com ênfase em Avaliação e Análises toxicológicas, atuando principalmente nos seguintes temas: preparo de amostras biológicas, avaliação da exposição ocupacional e avaliação da exposição aos praguicidas. (Texto informado pelo autor)

Alessandra Cristina Pupin Silvério, Universidade José do Rosário Velano

Possui graduação em farmácia-bioquímica pela Universidade Federal de Alfenas (1995), mestrado em Ciências Biológicas pela Universidade Federal de Alfenas (1999) e doutorado em Ciências farmacêuticas pela Universidade Federal de Alfenas (2016). Atualmente é professor titular da UNIVERSIDADE JOSÉ DO ROSÁRIO VELANO com tempo integral. Tem experiência na área de Farmácia como docente e pesquisadora, com ênfase em Avaliação e analises toxicológicas atuando principalmente nos seguintes temas: trabalhador rural, intoxicação, carboxiemoglobina, anticolinesterásicos e bolsa de sangue. Experiência como docente e pesquisadora em Medicina com ênfase em Bioquímica médica, diabetes e saúde coletiva, Professora nos cursos de Medicina, Farmácia , Biomedicina, nutrição e educação física. Coordenadora do Projeto Plantando e Colhendo Saúde responsável por saúde de trabalhadores rurais na regional de Saúde de Alfenas e Guaxupé - sul de Minas Gerais. Coordenadora do grupo de Pesquisa em Saúde Coletiva da UNIFENAS. MEMBRO DO COLEGIADO E NÚCLEO DOCENTE ESTRUTURANTE DO CURSO DE FARMÁCIA - MEMBRO DO NÚCLEO DOCENTE ESTRUTURANTE DO CURSO DE BIOMEDICINA- MEMBRO DO COMITÊ DE ÉTICA EM PESQUISA HUMANA - CONEP DA UNIVERSIDADE JOSÉ DO ROSÁRIO VELANO e MEMBRO DO CONSUNI - CONSELHO UNIVERSITÁRIO - UNIVERSIDADE JOSÉ DO ROSÁRIO VELLANO.

References

Aparicio, V. C., De Gerónimo, E., Marino, D., Primost, J., Carriquiriborde, P., & Costa, J. L. (2013). Environmental fate of glyphosate and aminomethylphosphonic acid in surface waters and soil of agricultural basins. Chemosphere, 93(9), 1866–1873. https://doi.org/10.1016/j.chemosphere.2013.06.041

Battaglin, W. A., Meyer, M. T., Kuivila, K. M., & Dietze, J. E. (2014). Glyphosate and its degradation product AMPA occur frequently and widely in U.S. soils, surface water, groundwater, and precipitation. Journal of the American Water Resources Association, 50(2), 275–290. https://doi.org/10.1111/jawr.12159

Bento, C. P. M., Goossens, D., Rezaei, M., Riksen, M., Mol, H. G. J., Ritsema, C. J., & Geissen, V. (2017). Glyphosate and AMPA distribution in wind-eroded sediment derived from loess soil. Environmental Pollution, 220, 1079–1089. https://doi.org/10.1016/j.envpol.2016.11.033

Bolognesi, C., Carrasquilla, G., Volpi, S., Solomon, K. R., & Marshall, E. J. P. (2009). Biomonitoring of genotoxic risk in agricultural workers from five Colombian regions: Association to occupational exposure to glyphosate. Journal of Toxicology and Environmental Health - Part A: Current Issues, 72(15–16), 986–997. https://doi.org/10.1080/15287390902929741

Botero-Coy, A. M., Ibáñez, M., Sancho, J. V., & Hernández, F. (2013). Direct liquid chromatography-tandem mass spectrometry determination of underivatized glyphosate in rice, maize and soybean. Journal of Chromatography A, 1313, 157–165. https://doi.org/10.1016/j.chroma.2013.07.037

Çaǧlar, S., & Kolankaya, D. (2008). The effect of sub-acute and sub-chronic exposure of rats to the glyphosate-based herbicide Roundup. Environmental Toxicology and Pharmacology, 25(1), 57–62. https://doi.org/10.1016/j.etap.2007.08.011

Camacho, A., & Mejía, D. (2017). The health consequences of aerial spraying illicit crops: The case of Colombia. Journal of Health Economics, 54, 147–160. https://doi.org/10.1016/j.jhealeco.2017.04.005

Carles, L., Gardon, H., Joseph, L., Sanchís, J., Farré, M., & Artigas, J. (2019). Meta-analysis of glyphosate contamination in surface waters and dissipation by biofilms. Environment International, 124(January), 284–293. https://doi.org/10.1016/j.envint.2018.12.064

Cattani, D., Cesconetto, P. A., Tavares, M. K., Parisotto, E. B., De Oliveira, P. A., Rieg, C. E. H., Leite, M. C., Prediger, R. D. S., Wendt, N. C., Razzera, G., Filho, D. W., & Zamoner, A. (2017). Developmental exposure to glyphosate-based herbicide and depressive-like behavior in adult offspring: Implication of glutamate excitotoxicity and oxidative stress. Toxicology, 387(February), 67–80. https://doi.org/10.1016/j.tox.2017.06.001

Cattani, D., de Liz Oliveira Cavalli, V. L., Heinz Rieg, C. E., Domingues, J. T., Dal-Cim, T., Tasca, C. I., Mena Barreto Silva, F. R., & Zamoner, A. (2014). Mechanisms underlying the neurotoxicity induced by glyphosate-based herbicide in immature rat hippocampus: Involvement of glutamate excitotoxicity. Toxicology, 320(1), 34–45. https://doi.org/10.1016/j.tox.2014.03.001

Cattelan, M. D. P., Maurer, P., Garcia, F., Berro, L. F., Machado, M. M., Manfredini, V., & Piccoli, J. da C. E. (2018). Occupational exposure to pesticides in family agriculture and the oxidative, biochemical and hematological profile in this agricultural model. Life Sciences, 203(January), 177–183. https://doi.org/10.1016/j.lfs.2018.04.038

Chen, M. X., Cao, Z. Y., Jiang, Y., & Zhu, Z. W. (2013). Direct determination of glyphosate and its major metabolite, aminomethylphosphonic acid, In fruits and vegetables by mixed-mode hydrophilic interaction/weak anion-exchange liquid chromatography coupled with electrospray tandem mass spectrometry. Journal of Chromatography A, 1272, 90–99. https://doi.org/10.1016/j.chroma.2012.11.069

Cho, Y., Jeong, W., Kim, S., Choi, H., You, Y., Cho, S., Oh, S., Ahn, H., Park, J., & Min, J. (2019). Serial measurement of glyphosate blood concentration in a glyphosate potassium herbicide-intoxicated patient: A case report. The American Journal of Emergency Medicine. https://doi.org/10.1016/j.ajem.2019.04.042

Cockcroft, D. W., & Gault, M. H. (1976). Prediction of creatinine clearance from serum creatinine. Nephron, 16(1), 31–41.

Connolly, A., Jones, K., Basinas, I., Galea, K. S., Kenny, L., McGowan, P., & Coggins, M. A. (2019). Exploring the half-life of glyphosate in human urine samples. International Journal of Hygiene and Environmental Health, 222(2), 205–210. https://doi.org/10.1016/j.ijheh.2018.09.004

Connolly, A., Jones, K., Galea, K. S., Basinas, I., Kenny, L., McGowan, P., & Coggins, M. (2017). Exposure assessment using human biomonitoring for glyphosate and fluroxypyr users in amenity horticulture. International Journal of Hygiene and Environmental Health, 220(6), 1064–1073. https://doi.org/10.1016/j.ijheh.2017.06.008

Connolly, A., Leahy, M., Jones, K., Kenny, L., & Coggins, M. A. (2018). Glyphosate in Irish adults - A pilot study in 2017. Environmental Research, 165(January), 235–236. https://doi.org/10.1016/j.envres.2018.04.025

El-Shenawy, N. S. (2009). Oxidative stress responses of rats exposed to Roundup and its active ingredient glyphosate. Environmental Toxicology and Pharmacology, 28(3), 379–385. https://doi.org/10.1016/j.etap.2009.06.001

Ellman, G. L., Courtney, K. D., Andres, V., & Featherstone, R. M. (1961). A new and rapid colorimetric determination of acetylcholinesterase activity. Biochemical Pharmacology, 7(2), 88–95. https://doi.org/10.1016/0006-2952(61)90145-9

Feola, G., Gallati, J. A., & Binder, C. R. (2012). Exploring behavioural change through an agent- oriented system dynamics model: the use of personal protective equipment among pesticide applicators in Colombia. System Dynamics Review, 28(1), 69–93. https://doi.org/10.1002/sdr.469

Fernandes, G., Aparicio, V. C., Bastos, M. C., De Gerónimo, E., Labanowski, J., Prestes, O. D., Zanella, R., & dos Santos, D. R. (2019). Indiscriminate use of glyphosate impregnates river epilithic biofilms in southern Brazil. Science of the Total Environment, 651, 1377–1387. https://doi.org/10.1016/j.scitotenv.2018.09.292

Fluegge, K., & Fluegge, K. (2016). Glyphosate use predicts healthcare utilization for ADHD in the healthcare cost and utilization project net (HCUPnet): A two-way fixed-effects analysis. Polish Journal of Environmental Studies, 25(4), 1489–1503. https://doi.org/10.15244/pjoes/61742

Fortes, C., Mastroeni, S., Segatto, M., Hohmann, C., Miligi, L., Bakos, L., & Bonamigo, R. (2016). Occupational Exposure to Pesticides with Occupational Sun Exposure Increases the Risk for Cutaneous Melanoma. Journal of Occupational and Environmental Medicine, 58(4), 370–375. https://doi.org/10.1097/JOM.0000000000000665

Garlich, F. M., Goldman, M., Pepe, J., Nelson, L. S., Allan, M. J., Goldstein, D. A., Goldfarb, D. S., & Hoffman, R. S. (2014). Hemodialysis clearance of glyphosate following a life-threatening ingestion of glyphosate-surfactant herbicide. Clinical Toxicology, 52(1), 66–71. https://doi.org/10.3109/15563650.2013.870344

Giesy, J. P., Dobson, S., & Solomon, K. R. (2000). Ecotoxicological Risk Assessment for Roundup® Herbicide. Rev. Environ. Contam. Toxicol, 167, 35–120. https://doi.org/10.1007/978-1-4612-1156-3_2

Harlin, K., & Ross, P. F. (1990). Enzymatic-spectrophotometric method for determination of cholinesterases activity in whole blood: collaborative study. Jounal of Association of Official Analytical Chemists, 73(4), 616–619.

Harris, C. A., & Gaston, C. P. (2004). Effects of refining predicted chronic dietary intakes of pesticide residues: A case study using glyphosate. Food Additives and Contaminants, 21(9), 857–864. https://doi.org/10.1080/02652030412331282385

Huen, K., Bradman, A., Harley, K., Yousefi, P., Boyd Barr, D., Eskenazi, B., & Holland, N. (2012). Organophosphate pesticide levels in blood and urine of women and newborns living in an agricultural community. Environmental Research, 117, 8–16. https://doi.org/10.1016/j.envres.2012.05.005

IARC monographs on the evaluation of carcinogenic risks to humans. (2017). Some organophosphate insecticides and herbicides/IARC Working Group on the Evaluation of Carcinogenic Risks to Humans (Vol. 112). International Agency for Research on Cancer. https://monographs.iarc.fr/wp-content/uploads/2018/07/mono112.pdf

Jasper, R., Locatelli, G. O., Pilati, C., & Locatelli, C. (2012). Evaluation of biochemical, hematological and oxidative parameters in mice exposed to the herbicide glyphosate-roundup ®. Interdisciplinary Toxicology, 5(3), 133–140. https://doi.org/10.2478/v10102-012-0022-5

Jayasumana, C., Gunatilake, S., & Senanayake, P. (2014). Glyphosate, hard water and nephrotoxic metals: Are they the culprits behind the epidemic of chronic kidney disease of unknown etiology in Sri Lanka? International Journal of Environmental Research and Public Health, 11(2), 2125–2147. https://doi.org/10.3390/ijerph110202125

Jayasumana, C., Gunatilake, S., & Siribaddana, S. (2015). Simultaneous exposure to multiple heavy metals and glyphosate may contribute to Sri Lankan agricultural nephropathy. BMC Nephrology, 16(1), 0–7. https://doi.org/10.1186/s12882-015-0109-2

Kahl, V. F. S., Dhillon, V. S., Simon, D., da Silva, F. R., Salvador, M., Branco, C. dos S., Cappetta, M., Martínez-López, W., V. Thiesen, F., Dias, J. F., Souza, C. T. de, Fenech, M., & da Silva, J. (2018). Chronic occupational exposure endured by tobacco farmers from Brazil and association with DNA damage. Mutagenesis, January. https://doi.org/10.1093/mutage/gex045

Kwiatkowska, M., Huras, B., & Bukowska, B. (2014). The effect of metabolites and impurities of glyphosate on human erythrocytes (in vitro). Pesticide Biochemistry and Physiology, 109(1), 34–43. https://doi.org/10.1016/j.pestbp.2014.01.003

Kwiatkowska, M., Nowacka-Krukowska, H., & Bukowska, B. (2014). The effect of glyphosate, its metabolites and impurities on erythrocyte acetylcholinesterase activity. Environmental Toxicology and Pharmacology, 37(3), 1101–1108. https://doi.org/10.1016/j.etap.2014.04.008

Lee, D. H., & Choi, Y. H. (2017). Severe glyphosate-surfactant intoxication: Successful treatment with continuous renal replacement therapy. Hong Kong Journal of Emergency Medicine, 24(1), 40–44. https://doi.org/10.1177/102490791702400107

Lee, H.-L., Chen, K.-W., Chi, C.-H., Huang, J.-J., & Tsai, L.-M. (2000). Clinical presentations and prognostic factors of a glyphosate-surfactant herbicide intoxication: A review of 131 cases. Academic Emergency Medicine, 7(8), 906–910. https://doi.org/10.1111/j.1553-2712.2000.tb02069.x

Lémery, E., Briançon, S., Chevalier, Y., Bordes, C., Oddos, T., Gohier, A., & Bolzinger, M. A. (2015). Skin toxicity of surfactants: Structure/toxicity relationships. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 469, 166–179. https://doi.org/10.1016/j.colsurfa.2015.01.019

Lima-Costa, M. F., & Barreto, S. M. (2003). Tipos de estudos epidemiológicos: conceitos básicos e aplicações na área do envelhecimento. Epidemiologia e Serviços de Saúde, 12(4), 189–201. https://doi.org/10.5123/s1679-49742003000400003

Lopes, F. M., Sandrini, J. Z., & Souza, M. M. (2018). Toxicity induced by glyphosate and glyphosate-based herbicides in the zebrafish hepatocyte cell line (ZF-L). Ecotoxicology and Environmental Safety, 162(July), 201–207. https://doi.org/10.1016/j.ecoenv.2018.07.005

Martinez, A., & Al-Ahmad, A. J. (2019). Effects of glyphosate and aminomethylphosphonic acid on an isogeneic model of the human blood-brain barrier. Toxicology Letters, 304, 39–49. https://doi.org/10.1016/j.toxlet.2018.12.013

Menéndez-Helman, R. J., Ferreyroa, G. V., Dos Santos Afonso, M., & Salibián, A. (2012). Glyphosate as an acetylcholinesterase inhibitor in cnesterodon decemmaculatus. Bulletin of Environmental Contamination and Toxicology, 88(1), 6–9. https://doi.org/10.1007/s00128-011-0423-8

Mercurio, P., Flores, F., Mueller, J. F., Carter, S., & Negri, A. P. (2014). Glyphosate persistence in seawater. Marine Pollution Bulletin, 85(2), 385–390. https://doi.org/10.1016/j.marpolbul.2014.01.021

Mesnage, R., Defarge, N., Spiroux de Vendômois, J., & Séralini, G. E. (2015). Potential toxic effects of glyphosate and its commercial formulations below regulatory limits. Food and Chemical Toxicology, 84, 133–153. https://doi.org/10.1016/j.fct.2015.08.012

Mesnage, Robin, Arno, M., Costanzo, M., Malatesta, M., Séralini, G. E., & Antoniou, M. N. (2015). Transcriptome profile analysis reflects rat liver and kidney damage following chronic ultra-low dose Roundup exposure. Environmental Health: A Global Access Science Source, 14(1), 1–14. https://doi.org/10.1186/s12940-015-0056-1

Mesnage, Robin, Benbrook, C., & Antoniou, M. N. (2019). Insight into the confusion over surfactant co-formulants in glyphosate-based herbicides. Food and Chemical Toxicology, 128(January), 137–145. https://doi.org/10.1016/j.fct.2019.03.053

Nanayakkara, S., Komiya, T., Ratnatunga, N., Senevirathna, S. T. M. L. D., Harada, K. H., Hitomi, T., Gobe, G., Muso, E., Abeysekera, T., & Koizumi, A. (2012). Tubulointerstitial damage as the major pathological lesion in endemic chronic kidney disease among farmers in North Central Province of Sri Lanka. Environmental Health and Preventive Medicine, 17(3), 213–221. https://doi.org/10.1007/s12199-011-0243-9

Pereira, A. S., Shitsuka, D. M., Parreira, F. J., & Shitsuka, R. (2018). Método Qualitativo, Quantitativo ou Quali-Quanti. In Metodologia da Pesquisa Científica. https://repositorio.ufsm.br/bitstream/handle/1/15824/Lic_Computacao_Metodologia-Pesquisa-Cientifica.pdf?sequence=1. Acesso em: 28 março 2020.

Perry, E. D., Hennessy, D. A., & Moschini, G. C. (2019). Product concentration and usage: Behavioral effects in the glyphosate market. Journal of Economic Behavior and Organization, 158(20156702322954), 543–559. https://doi.org/10.1016/j.jebo.2018.12.027

Ravier, S., Désert, M., Gille, G., Armengaud, A., Wortham, H., & Quivet, E. (2019). Monitoring of Glyphosate, Glufosinate-ammonium, and (Aminomethyl)phosphonic acid in ambient air of Provence-Alpes-Côte-d’Azur Region, France. Atmospheric Environment, 204(February), 102–109. https://doi.org/10.1016/j.atmosenv.2019.02.023

Rezaei, R., Damalas, C. A., & Abdollahzadeh, G. (2018). Understanding farmers’ safety behaviour towards pesticide exposure and other occupational risks: The case of Zanjan, Iran. Science of the Total Environment, 616–617, 1190–1198. https://doi.org/10.1016/j.scitotenv.2017.10.201

Roberts, D. M., Buckley, N. A., Mohamed, F., Eddleston, M., Goldstein, D. A., Mehrsheikh, A., Bleeke, M. S., & Dawson, A. H. (2010). A prospective observational study of the clinical toxicology of glyphosate-containing herbicides in adults with acute self- poisoning. Clin Toxicol (Phila), 48(2), 129–136. https://doi.org/10.3109/15563650903476491.A

Rodrigues, N. R., & de Souza, A. P. F. (2018). Occurrence of glyphosate and AMPA residues in soy-based infant formula sold in Brazil. Food Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment, 35(4), 723–730. https://doi.org/10.1080/19440049.2017.1419286

Romão Junior, J. E. (2004). Doença Renal Crônica: Definição, Epidemiologia e Classificação. Jornal Brasileiro de Nefrologia, 26(1), 1–3.

Sanborn, M., Kerr, K., Sanin, L., Cole, D., Bassil, K., & Vakil, C. (2007). Non-cancer health effects of pesticides: Systematic review and implications for family doctors. Canadian Family Physician, 53(10), 1712–1720. http://www.cfp.ca/cgi/reprint/53/10/1712%5Cnhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=reference&D=emed8&NEWS=N&AN=2008061751

Santos, R., Piccoli, C., Cremonese, C., & Freire, C. (2019). Thyroid and reproductive hormones in relation to pesticide use in an agricultural population in Southern Brazil. Environmental Research, 173(January), 221–231. https://doi.org/10.1016/j.envres.2019.03.050

Silva, V., Montanarella, L., Jones, A., Fernández-Ugalde, O., Mol, H. G. J., Ritsema, C. J., & Geissen, V. (2018). Distribution of glyphosate and aminomethylphosphonic acid (AMPA) in agricultural topsoils of the European Union. Science of the Total Environment, 621, 1352–1359. https://doi.org/10.1016/j.scitotenv.2017.10.093

Silvério, A. C. P., Machado, S. C., Azevedo, L., Nogueira, D. A., de Castro Graciano, M. M., Simões, J. S., Viana, A. L. M., & Martins, I. (2017). Assessment of exposure to pesticides in rural workers in southern of Minas Gerais, Brazil. Environmental Toxicology and Pharmacology, 55(January), 99–106. https://doi.org/10.1016/j.etap.2017.08.013

Swanson, N. L., Andre, L., Jon, A., & Bradley, W. (2014). Genetically engineered crops, glyphosate and the deterioration of health in the United States of America. Journal of Organic Systems, 9(2).

Van Bruggen, A. H. C., He, M. M., Shin, K., Mai, V., Jeong, K. C., Finckh, M. R., & Morris, J. G. (2018). Environmental and health effects of the herbicide glyphosate. Science of the Total Environment, 616–617, 255–268. https://doi.org/10.1016/j.scitotenv.2017.10.309

Viero, C. M., Camponogara, S., Cezar-Vaz, M. R., Costa, V. Z. da, & Beck, C. L. C. (2016). Risk society: the use of pesticides and implications for the health of rural workers. Escola Anna Nery - Revista de Enfermagem, 20(1), 99–105. https://doi.org/10.5935/1414-8145.20160014

Wang, G., Fan, X. N., Tan, Y. Y., Cheng, Q., & Chen, S. Di. (2011). Parkinsonism after chronic occupational exposure to glyphosate. Parkinsonism and Related Disorders, 17(6), 486–487. https://doi.org/10.1016/j.parkreldis.2011.02.003

Zhang, L., Rana, I., Shaffer, R. M., Taioli, E., & Sheppard, L. (2019). Exposure to Glyphosate-Based Herbicides and Risk for Non-Hodgkin Lymphoma: A Meta-Analysis and Supporting Evidence. Mutation Research/Reviews in Mutation Research. https://doi.org/10.1016/j.mrrev.2019.02.001

Zouaoui, K., Dulaurent, S., Gaulier, J. M., Moesch, C., & Lachâtre, G. (2013). Determination of glyphosate and AMPA in blood and urine from humans: About 13 cases of acute intoxication. Forensic Science International, 226(1–3). https://doi.org/10.1016/j.forsciint.2012.12.010

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31/01/2021

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COSTA, L. F. .; BORBA, B. G.; SANTOS, M. D. dos; SELICANI, M. L.; SILVÉRIO , A. P.; MACHADO, S. C. .; SILVÉRIO, A. C. P. Association of clinical and laboratory data of rural area residents to chronic exposure to glyphosate. Research, Society and Development, [S. l.], v. 10, n. 1, p. e56610112214, 2021. DOI: 10.33448/rsd-v10i1.12214. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/12214. Acesso em: 28 feb. 2021.

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Health Sciences