Evaluation of the biocompatibility of the dialyzer membrane in dogs with acute kidney injury induced by gentamicin treated by hemodialysis

Authors

DOI:

https://doi.org/10.33448/rsd-v10i3.12361

Keywords:

Experimental hemodialyses; Dogs; Acute kidney injury; Biocompatibility; Hemodialyser.

Abstract

The dialysis procedures as hemodialysis (HD) try to keep the patient with acute kidney injury (AKI) alive until kidney regeneration. This paper evaluates the biocompatibility of cellulose acetate and polysulfone membranes in healthy dogs and in AIK ones submited to hemodialyses, analyzing biological parameters and clinical signs presented in this procedure. The hemodialysis animals were divided in four groups (each one with 8 dogs): group 1 composed by healthy animals that used cellulose acetate membrane; group 2 constituted by dogs with AKI that used cellulose acetate membrane; group 3 formed by healthy animals that used polysulfone membrane; group 4 composed by dogs with AKI that used polysulfone membrane. AKI induction was made by applying gentamicin (45mg/kg/EV/day). The main change was related to weight loss of the animals in the groups with AKI. There was also a significant reduction in urea and creatinine levels, mainly in hemodialysis animals with polysulfone membrane, while sodium, potassium and glucose levels did not show significant differences between the groups. The C3´s and microglobulin b2 levels didn´t present significant changes in the groups, while the TNFa was in high levels in AKI´s groups hemodialysed with polysulfone and cellulose acetate membranes, with higher level found in the last one. It didn´t have significant changes related to arterial blood pressure and others hematologial parameters. It is possible conclude that there was an increase in TNFa level from AKI´s dogs submitted to hemodialyses, and polysulfone membrane was slightly more biocompatible than cellulose acetate membrane, however more markers should be tested.

Author Biographies

Andre Marcelo Conceição Meneses, Universidade Federal Rural da Amazônia; Escola Universitária Vasco da Gama

  1. Professor Associado do Programa de Pós Graduação de Saúde e Produção Animal na Amazônia (PPGSPAA), Universidade Federa Rural da Amazônia – UFRA, Belém, Brasil. Professor Associado da Escola Universitária Vasco da Gama, Coimbra, Portugal.

Alessandra Melchert, Universidade Estadual Paulista “Júlio de Mesquita Filho”

  1. Professor Associada do Departamento de Clínica Médica da Faculdade de Medicina de Botucatu - FMB, UNESP, Botucatu, Brasil.

João Roberto de Araujo Caldeira Brant, Médico Veterinário Autônomo

Médico Veterinário Autônomo, Distrito Federal, Brasília, Brasil.

Pasqual Barretti, Universidade Estadual Paulista “Júlio de Mesquita Filho”

Professor Associado da Faculdade de Medicina Veterinária e Zootecnia - FMVZ, UNESP, Botucatu, Brasil.

Regina Kiomi Takahira, Universidade Estadual Paulista “Júlio de Mesquita Filho”

Professor Associado da Faculdade de Medicina Veterinária e Zootecnia - FMVZ, UNESP, Botucatu, Brasil.

Ednaldo da Silva Filho, Universidade Federal Rural da Amazônia

Professor Associado do Programa de Pós Graduação de Saúde e Produção Animal na Amazônia (PPGSPAA), Universidade Federa Rural da Amazônia – UFRA, Belém, Brasil.

Jacqueline Costa Teixeira Caramori, Universidade Estadual Paulista “Júlio de Mesquita Filho”

Professor Associado da Faculdade de Medicina Veterinária e Zootecnia - FMVZ, UNESP, Botucatu, Brasil.

References

Amore, A., & Coppo, R. (2002). Immunological basis of inflammation in dialysis. Nephrol. Dial. Transplant. 17 (8), 16-24. https://doi.org/10.1007/s11255-013-0460-9

Basile, C., & Drueke, T. (1989). Dialysis membrane biocompatibility. Nephron. 52, 113-118. https://doi.org/10.1159/000185612

Brant, J. R. A. C. Estudo comparativo entre os anticoagulantes heparina sódica e heparina de baixo peso molecular em cães (Canis familiaris) submetidos à hemodiálise. 2003. 112p. Dissertação (Mestrado). Faculdade de Medicina Veterinária e Zootecnia, Universidade Estadual Paulista, Botucatu. Retrived from 01-CAPA-FINAL.doc (unesp.br)

Cowgill, L. D., & Elliot, D. A. (2004). Tratado de Medicina Interna Veterinária: Insuficiência renal aguda. uanabara koogan.

Cowgill, L. D., & Langston, C. E. (1996). Role of hemodialysis in the management of dogs and cats with renal failure. Veterinary Clinics of North America: Small Animal Practice. 26, 1347-78. https://doi.org/10.1016/S0195-5616(96)50132-4

Cowgill, L. D.; & Maretzki, C. H. CVT update: Veterinary applications of hemodialysis. In: Bonagura, J. D., & Kirk, R. W. (1995). Kirk's Current Veterinary Therapy XII: Small Animal Practice. Philadelphia: WB Saunders.

Daugirdas, J. T., Van Stone, J. C., & Boag, J. T. (2003). Manual de Diálise: Aparelho de hemodiálise. MEDSI Editora Médica e Científica.

Flamenbaum, W. (1973). Pathophysiology of acute renal failure. Arch. Intern. Med. 10.1001/archinte.1973.00320120151011

Goldstein, S. L., Currier, H., Watters, L., et al. (2003). Acute and chronic inflammation in pediatric patients receiving hemodialysis. The J. Ped. 653-657. 10.1067/S0022-3476(03)00534-1.

Haag-Weber, M., & Horl, W. H. (1996). Disfunction of polymorphonuclear leukocytes in uremia. Semin. Nephrol. 16, 192-201. Dysfunction of polymorphonuclear leukocytes in uremia - PubMed (nih.gov)

Hansen, S. K. (1991). Improving hemodialysis biocompatibility. Dial. Transpl. 20(10), 610-13.

Hoenich, N. A., & Stamp, S. (2000). Clinical investigation of the role of membrane structure on blood contact and solute transport characteristics of a cellulose membrane. Biomat. 21, 317-324. Integrated Biomaterials Science | SpringerLink

Mccurnin, D. M.; & Poffenbarger, E. M. (1991). Small animal phisical diagnosis and clinical procedures. Philadelphia: WB Saunders.

Meneses, A. M. C. (2003). Desenvolvimento de um modelo experimental de hemodiálise em cães (Canis familiaris). Dissertação (Mestrado). Faculdade de Medicina, Universidade Estadual Paulista, Botucatu. https://doi.org/10.1590/S0100-736X2010001000009

Meneses, A. M. C.; Caramori, J. C. T.; Brant, J. R. A. C.; Melchert, A.; Moutinho, F. Q.; Mamprim, M. J.; & Barretti, P. (2002). Acesso vascular para hemodiálise em cães utilizando cateter duplo lúmen. In: Congresso Brasileiro De Clínicos Veterinários De Pequenos Animais. Anais... Brasília. http://dx.doi.org/10.1590/S0103-84782008000400016

Nakajima, Y., Hoshi, F., Higuchi, S., et al. The complete amino acid sequence of dog 2 microglobulin. J. Vet. Med. Sci. 65 (5), 517-521. 10.1292/jvms.61.517

Nakajima, Y., Hoshi, F., Higuchi, S., et al. (2000). Determination of canine 2 microglobulin in plasma and urine by Enzyme-linked Immunosorbent Assay. J. Vet. Med. Sci. 63(3), 343-345. 10.1292/jvms.63.343

Norman, G. R.; & Streiner, D. L. (1994) Bioestatistics – The bare essentials. Mosby – year book, St. Louis.

Riella M. C. (1996) Princípios de Nefrologia e Distúrbios Hidroeletrolíticos. Guanabara Koogan.

Simmons, E. M., Himmelfarb, J., Sezer, M. T., et al. (2004). Plasma cytokine levels predict mortality in patients with acute renal failure. Kid. Int. 65, 1357-1365. https://doi.org/10.1111/j.1523-1755.2004.00512.x

Singh, N. P., Bansal, R., Thakur, A., et al. (2003). Effect of membrane composition on cytokine production and clinical symptoms during hemodialysis: a crossover study. Ren. Fail. 25(3), 419-430. https://doi.org/10.1081/JDI-120021154

Published

10/03/2021

How to Cite

MENESES, A. M. C. .; PEREIRA, E. C. .; MELCHERT, A. .; BRANT, J. R. de A. C. .; BARRETTI, P. .; TAKAHIRA, R. K. .; SILVA FILHO, E. da .; CARAMORI, J. C. T. . Evaluation of the biocompatibility of the dialyzer membrane in dogs with acute kidney injury induced by gentamicin treated by hemodialysis. Research, Society and Development, [S. l.], v. 10, n. 3, p. e15410312361, 2021. DOI: 10.33448/rsd-v10i3.12361. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/12361. Acesso em: 12 apr. 2021.

Issue

Section

Health Sciences