Eye changes related to Zika Vírus infection: an integrative review

Authors

DOI:

https://doi.org/10.33448/rsd-v10i2.12840

Keywords:

Zika Virus Disease; Arbovirus Infections; Eye manifestations.

Abstract

Recently the Zika virus (ZV) has emerged as an important arbovirus due to its high prevalence. The global expansion of these arboviruses was preceded by the global spread of their vectors. The clinical manifestations of ZV infection include fever, skin rashes and joint pain, as well as ocular manifestations, which are the most recently known manifestations. Objective: to carry out a bibliographic survey and describe the main ocular changes in individuals infected with the Zika virus. Methodology: This is an integrative bibliographic review carried out in the databases PubMed / MEDLINE, SciELO, Science Direct. Results: 16 articles published between 2015 and 2018 were selected. Cataracts, congenital glaucoma, atrophic changes in the optic nerve, loss of the retinal pigment epithelium and presence of a choroid layer, uveitis, hyperpigmentation and collagen of the iris are found in individuals infected with ZV. Conclusion: Eye changes associated with ZV can affect from neonates to adults, and can be a limiting factor in activities of daily living and quality of life. Therefore, it is recommended that further association studies investigate ZK infection and the appearance of eye diseases.

References

Agrawal, R., Oo, H. H., Balne, P. K., Ng, L., Tong, L., & Leo, Y. S. (2017). Zika Virus and Eye. Ocular Immunology and Inflammation, 1–6. https://doi.org/10.1080/09273948.2017.1294184

Al-Qahtani, A. A., Nazir, N., Al-Anazi, M. R., Rubino, S., & Al-Ahdal, M. N. (2016). Zika virus: A new pandemic threat. Journal of Infection in Developing Countries, 10(3), 201–207. https://doi.org/10.3855/jidc.8350

Carabali, M., Austin, N., King, N. B., & Kaufman, J. S. (2018). The Zika epidemic and abortion in Latin America: a scoping review. Global Health Research and Policy, 3(1), 15. https://doi.org/10.1186/s41256-018-0069-8

de Andrade, G. C., Ventura, C. V., Mello Filho, P. A. de A., Maia, M., Vianello, S., & Rodrigues, E. B. (2017). Arboviruses and the eye. International Journal of Retina and Vitreous, 3(1), 4. https://doi.org/10.1186/s40942-016-0057-4

de Oliveira Dias, J. R., Ventura, C. V., de Paula Freitas, B., Prazeres, J., Ventura, L. O., Bravo-Filho, V., Aleman, T., Ko, A. I., Zin, A., Belfort, R., & Maia, M. (2018). Ocular abnormalities in congenital Zika syndrome: are the ophthalmoscopic findings “the top of the iceberg”? Progress in Retinal and Eye Research. https://doi.org/10.1016/j.preteyeres.2018.04.004

Donalisio, M. R., Freitas, A. R. R., & Zuben, A. P. B. Von. (2017). Arboviruses emerging in Brazil: challenges for clinic and implications for public health. Revista de Saúde Pública, 51. https://doi.org/10.1590/s1518-8787.2017051006889

Fitzgerald, B., Boyle, C., & Honein, M. A. (2018). Birth Defects Potentially Related to Zika Virus Infection During Pregnancy in the United States. Jama, 319(12), 1195. https://doi.org/10.1001/jama.2018.0126

Gloria-Soria, A., Ayala, D., Bheecarry, A., Calderon-Arguedas, O., Chadee, D. D., Chiappero, M., Coetzee, M., Elahee, K. Bin, Fernandez-Salas, I., Kamal, H. A., Kamgang, B., Khater, E. I. M., Kramer, L. D., Kramer, V., Lopez-Solis, A., Lutomiah, J., Martins, A., Micieli, M. V., Paupy, C., … Powell, J. R. (2016). Global genetic diversity of Aedes aegypti. Molecular Ecology, 25(21), 5377–5395. https://doi.org/10.1111/mec.13866

Heukelbach, J., Alencar, C. H., Kelvin, A. A., de Oliveira, W. K., & de Góes Cavalcanti, L. P. (2016). Zika virus outbreak in Brazil. Journal of Infection in Developing Countries, 10(2), 116–120. https://doi.org/10.3855/jidc.8217

Marcondes, C. B., & Ximenes, M. de F. F. de M. (2015). Zika virus in Brazil and the danger of infestation by Aedes (Stegomyia) mosquitoes. Revista Da Sociedade Brasileira de Medicina Tropical, 49(1), 4–10. https://doi.org/10.1590/0037-8682-0220-2015

Miranda, H. A. de, Costa, M. C., Frazão, M. A. M., Simão, N., Franchischini, S., & Moshfeghi, D. M. (2016). Expanded Spectrum of Congenital Ocular Findings in Microcephaly with Presumed Zika Infection. Ophthalmology, 123(8), 1788–1794. https://doi.org/10.1016/j.ophtha.2016.05.001

Miura, H., Silva, O. J. da, & Almeida, V. R. de. (2020). Diagnóstico de alterações refracionais em crianças com microcefalia, presumidamente por síndrome congênita do Zika vírus. Research, Society and Development, 9(10), e4429108674. https://doi.org/10.33448/rsd-v9i10.8674

Prakalapakorn, S. G., Meaney-Delman, D., Honein, M. A., & Rasmussen, S. A. (2017). The eyes as a window to improved understanding of the prenatal effects of Zika virus infection. Journal of AAPOS, 21(4), 259–261. https://doi.org/10.1016/j.jaapos.2017.07.001

Singh, M. S., Marquezan, M. C., Omiadze, R., Reddy, A. K., Belfort, R., & May, W. N. (2018). Inner retinal vasculopathy in Zika virus disease. American Journal of Ophthalmology Case Reports, 10, 6–7. https://doi.org/10.1016/j.ajoc.2018.01.023

Stassen, L., Armitage, C. W., van der Heide, D. J., Beagley, K. W., & Frentiu, F. D. (2018). Zika Virus in the Male Reproductive Tract. Viruses, 10(4). https://doi.org/10.3390/v10040198

Ventura, C. V., & Ventura, L. O. (2018). Ophthalmologic Manifestations Associated With Zika Virus Infection. Pediatrics, 141(Supplement 2), S161–S166. https://doi.org/10.1542/peds.2017-2038E

White, M. K., Wollebo, H. S., David Beckham, J., Tyler, K. L., & Khalili, K. (2016). Zika virus: An emergent neuropathological agent. Annals of Neurology, 80(4), 479–489. https://doi.org/10.1002/ana.24748

Zin, A. A., Tsui, I., Rossetto, J., Vasconcelos, Z., Adachi, K., Valderramos, S., Halai, U. A., Da Silva Pone, M. V., Pone, S. M., Silveira Filho, J. C. B., Aibe, M. S., Da Costa, A. C. C., Zin, O. A., Belfort, R., Brasil, P., Nielsen-Saines, K., & Moreira, M. E. L. (2017). Screening criteria for ophthalmic manifestations of congenital zika virus infection. JAMA Pediatrics, 171(9), 847–854. https://doi.org/10.1001/jamapediatrics.2017.1474

Published

22/02/2021

How to Cite

SOUZA, R. A.; DANTAS, M. I. L.; VIEIRA, I. V. T.; FRANÇA, H. K. S.; CARVALHO, B. G. F. de S. T. de .; OLIVEIRA, A. J. A. da S. .; OLIVEIRA, L. C. L. de; SILVEIRA, N. G. M. .; CRUZ, M. E. T.; DANTAS JUNIOR, K. da M. .; OLIVEIRA, J. M.; ALEXANDRINO JÚNIOR, J. da S. .; BARBOSA, G. de M. L. .; CASTELO, L. S. Eye changes related to Zika Vírus infection: an integrative review. Research, Society and Development, [S. l.], v. 10, n. 2, p. e43710212840, 2021. DOI: 10.33448/rsd-v10i2.12840. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/12840. Acesso em: 25 apr. 2024.

Issue

Section

Review Article