Effect of caffeine gel and caffeine gel associated with iontophoresis in women gynoidlipodystrophy: A pilot randomized trial

Authors

DOI:

https://doi.org/10.33448/rsd-v10i4.13813

Keywords:

Iontophoresis; Caffeine; Cellulite; Gynoid lipodystrophy; Thermography; Treatment.

Abstract

Caffeine has been widely used to treat gynoid lipodystrophy (GLD). Despite caffeine has been considered as a promise treatment, there is a lack of scientific evidences regarding its effect on GLD when associated with iontophoresis or others equipment. We aimed to evaluate the effects of a caffeine gel alone and associated with iontophoresis in GLD treatment. In a single-blind randomized clinical trial, women with mild/moderate GLD in the buttocks were randomized to topical caffeine gel group (CG; n=10); caffeine gel plus iontophoresis group (CIG; n=11) or iontophoresis group (IG; n=10). The groups were treated with 10 sessions, two times/week, 20 min/session. The subjects were evaluated pre and post treatment by photonumeric GLD severity scale, ultrasound image, thermography and quality of life questionnaire with a blind evaluator. There were statistical reduction in subcutaneous tissue thickness (P≤0.046) as well as in subcutaneous tissue plus dermis thickness (P≤0.044) in buttocks both in CG and CIG. GLD reduction was similar between CG and CIG, and these reductions were more pronounced than in IG (P<0.0001). Furthermore, quality of life improved in all groups (P<0.017). We concluded that caffeine alone and associated with iontophoresis were effective for decreasing the subcutaneous fat layer in women with GLD.

References

Akomeah, F. K., Martin, G. P., & Brown, M. B. (2009). Short-term iontophoretic and post iontophoretic transport of model penetrants across excised human epidermis. International Journal of Pharmaceutics, 367, 162–168.

Atamoros, F. M. P., Pérez, D. A., Sigall, D. A., Romay, A. A. Á., Gastelum, J. A. B., Salcedo, José A de la Peña Salgado, Pablo E Escalante Palacios, G. J. G., Guerrero-Gonzalez, G. A., la Cerda, R. M. De, Olivera, R. M. P., Soriano, F. R., Tinoco, E. S., & Hernández, E. C. W. (2018). Evidence-based treatment for gynoid lipodystrophy: A review of the recent literature. J Cosmet Dermatol, 17(6), 977–983.

Bertin, C., Zunino, H., Pittet, J. C., Beau, P., Pineau, P., Massonneau, M., Robert, C., & Hopkins, J. (2001). No A double-blind evaluation of the activity of an anti-cellulite product containing retinol, caffeine, and ruscogenine by a combination of several non-invasive methodsTitle. J Cosmet Sci, 52(4), 199–210.

da Silva, C., Pinto, M., Barbosa, L., Filho, S., Rocha, L., & Gonçalves, R. (2013). Effect of ultrasound and hyaluronidase on gynoid lipodystrophy type II–An ultrasonography study. Journal of Cosmetic and Laser Therapy, 15(4), 231–236.

Emanuele, E. (2013). Cellulite: Advances in treatment: Facts and controversies. Clinics in Dermatology, 31(725), 730.

Hamishehkar, H., Shokri, J., Fallahi, S., Jahangiri, A., Ghanbarzadeh, S., & Kouhsoltani, M. (2015). Histopathological evaluation of caffeine-loaded solid lipid nanoparticles in efficient treatment of cellulite. Drug Development and Industrial Pharmacy, 41(10), 1640–1646.

Hexsel, D., do Prado, D. Z., Rao, J., & Goldman, M. P. (2006). Topical Management of Cellulite.

Hexsel, D. M., Dal’Forno, T., & Hexsel, C. L. (2009). A validated photonumeric cellulite severity scale. Journal of the European Academy of Dermatology and Venereology, 23(5), 523–528.

Hexsel, D., & Soirefmann, M. (2011). Cosmeceuticals for Cellulite. Seminars in Cutaneous Medicine and Surgery, 30(3), 167–170.

Hexsel, D., Weber, M. B., Taborda, M. L., Dal’Forno, T., & Zechmeister-Prado, D. (2011). Celluqol® - instrumento de avaliação de qualidade de vida em pacientes com celulite. Surgical and Cosmetic Dermatology, 3(2), 96–101.

Iqbal, B., Ali, J., & Baboota, S. (2018). Recent advances and development in epidermal and dermal drug deposition enhancement technology. Journal of Dermatology, 57(6), 646–660.

Janda, K., & Tomikowska, A. (2014). Cellulite - causes, prevention, treatment. Ann Acad Med Stetin, 60(1), 29–38.

Kanikkannan, N. (2002). Iontophoresis-based transdermal delivery systems. BioDrugs, 16(5), 339–347.

Luo, L., & Lane, M. E. (2015). Topical and transdermal delivery of caffeine. International Journal of Pharmaceutics, 490(1–2), 155–164. https://doi.org/10.1016/j.ijpharm.2015.05.050

Mlosek, R. K., Debowska, R. M., Lewandowski, M., Malinowska, S., Nowicki, A., & Eris, I. (2011). Imaging of the skin and subcutaneous tissue using classical and high frequency ultrasonographies in anti cellulite therapy. Skin Research and Technology, 17, 461–468.

Nkengne, A., Papillon, A., & Bertin, C. (2013). Evaluation of the cellulite using a thermal infra-red camera. Skin Research and Technology, 19(1), 1–7.

Semalty, A., Semalty, M., Singh, R., Saraf, S., & Saraf, S. (2007). Iontophoretic drug delivery system: A review. Technology and Health Care, 15, 237–245.

Velasco, M. V. R., Tano, C. T. N., Machado-Santelli, G. M., Consiglieri, V. O., Kaneko, T. M., & Baby, A. R. (2008). Effects of caffeine and siloxanetriol alginate caffeine, as anticellulite agents, on fatty tissue: Histological evaluation. Journal of Cosmetic Dermatology, 7(1), 23–29.

Wagner, D. R. (2013). Ultrasound as a tool to assess body fat. Journal of Obesity, 2013. https://doi.org/10.1155/2013/280713

Wilczyński, S., Koprowski, R., Deda, A., Janiczek, M., Kuleczka, N., & Błońska‐Fajfrowska, B. (2017). Thermographic mapping of the skin surface in biometric evaluation of cellulite treatment effectiveness. Skin Research and Technology, 23(1), 61–69.

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Published

10/04/2021

How to Cite

QUESSADA , A. R. F. .; FURLANETTO, K. C.; ALVES, T. B. .; PIRES , O. I. .; PINTO, A. L. .; LONNI, A. A. S. G. .; ANDRAUS, R. A. C. . Effect of caffeine gel and caffeine gel associated with iontophoresis in women gynoidlipodystrophy: A pilot randomized trial . Research, Society and Development, [S. l.], v. 10, n. 4, p. e25710413813, 2021. DOI: 10.33448/rsd-v10i4.13813. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/13813. Acesso em: 8 may. 2021.

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Section

Health Sciences