Effect of caffeine gel and caffeine gel associated with iontophoresis in women gynoidlipodystrophy: A pilot randomized trial





Iontophoresis; Caffeine; Cellulite; Gynoid lipodystrophy; Thermography; Treatment.


Caffeine has been widely used to treat gynoid lipodystrophy (GLD). Despite caffeine has been considered as a promise treatment, there is a lack of scientific evidences regarding its effect on GLD when associated with iontophoresis or others equipment. We aimed to evaluate the effects of a caffeine gel alone and associated with iontophoresis in GLD treatment. In a single-blind randomized clinical trial, women with mild/moderate GLD in the buttocks were randomized to topical caffeine gel group (CG; n=10); caffeine gel plus iontophoresis group (CIG; n=11) or iontophoresis group (IG; n=10). The groups were treated with 10 sessions, two times/week, 20 min/session. The subjects were evaluated pre and post treatment by photonumeric GLD severity scale, ultrasound image, thermography and quality of life questionnaire with a blind evaluator. There were statistical reduction in subcutaneous tissue thickness (P≤0.046) as well as in subcutaneous tissue plus dermis thickness (P≤0.044) in buttocks both in CG and CIG. GLD reduction was similar between CG and CIG, and these reductions were more pronounced than in IG (P<0.0001). Furthermore, quality of life improved in all groups (P<0.017). We concluded that caffeine alone and associated with iontophoresis were effective for decreasing the subcutaneous fat layer in women with GLD.


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How to Cite

QUESSADA , A. R. F. .; FURLANETTO, K. C.; ALVES, T. B. .; PIRES , O. I. .; PINTO, A. L. .; LONNI, A. A. S. G. .; ANDRAUS, R. A. C. . Effect of caffeine gel and caffeine gel associated with iontophoresis in women gynoidlipodystrophy: A pilot randomized trial . Research, Society and Development, [S. l.], v. 10, n. 4, p. e25710413813, 2021. DOI: 10.33448/rsd-v10i4.13813. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/13813. Acesso em: 8 may. 2021.



Health Sciences