Clinical and symptomatological characterization regarding Chagas disease caused by the Trypanosoma cruzi parasite
DOI:
https://doi.org/10.33448/rsd-v10i5.14873Keywords:
Trypanosoma cruzi; Epidemiological profile; Chagas disease; Clinical aspects.Abstract
Neglected diseases are a group of communicable diseases that mainly affect tropical regions of developing countries. Among this group of diseases is Chagas disease, which has been classified among the six most important parasitic diseases in the world, and it is estimated that more than one billion people are at risk in endemic countries. The objective of this study is to review the literature on the symptomatological and clinical characterization of Chagas disease caused by Trypanosoma cruzi. This is an integrative literature review study. For this, we used the following descriptors in the search: Trypanosoma cruzi, epidemiological profile, Chagas disease and clinical aspects (together and separately). In the selection criteria we opted for full articles, in the period 2013 - 2021 (last 9 years), in Portuguese and English. The searches were conducted in the following databases: Scientific Electronic Library Online (Scielo), Pubmed, Latin American and Caribbean Literature on Health Sciences (Lilacs), Google Scholar. The articles were selected first by title, then by abstract, and finally by complete reading. The literature shows that Chagas disease is caused by the protozoan Trypanosoma cruzi, characterized by the presence of a flagellum and kinetoplast. Some of its clinical manifestations include: fever, asthenia, adynamia, myalgia, arthralgia, headache, myocarditis, and hepatosplenomegaly. Therefore, it is important to know all the characteristics of this disease, since it can be considered a public health problem. It is suggested that new studies be carried out with different approaches, in order to elucidate even more specifically the dynamics surrounding this disease.
References
Alves, D. F., Muniz, A. S. C., Abrel, C. D. R., Freitas, N. R., Teixeira, A. B., & Ferreira, E. S. (2018). Métodos de diagnóstico para a doença de Chagas: uma atualização. Revista Brasileira de Análises Clínicas, 50(4), 330-333.
Benck, L., Kransdorf, E., & Patel, J. (2018). Diagnosis and management of Chagas cardiomyopathy in the United States. Current cardiology reports, 20(12), 1-8.
Bernstein, A. J., Falk, N., Moscatelli, G., Moroni, S., Gonzalez, N., Garcia-Bournissen, F., ... & Altcheh, J. (2021). Adverse events associated with nifurtimox treatment for Chagas disease in children and adults. Antimicrobial Agents and Chemotherapy, 65(2).
Brasil. Ministério da Saúde. Situação epidemiológica.
Boletim epidemiológico. Brasília: Secretaria de Vigilância em Saúde, v. 46, n. 21, mar. 2015.
Caldas, I. S., Santos, E. G., & Novaes, R. D. (2019). An evaluation of benznidazole as a Chagas disease therapeutic. Expert opinion on pharmacotherapy, 20(15), 1797-1807.
Cardoso, C. S., Ribeiro, A. L. P., Oliveira, C. D. L., Oliveira, L. C., Ferreira, A. M., Bierrenbach, A. L., ... & Sabino, E. C. (2018). Beneficial effects of benznidazole in Chagas disease: NIH SaMi-Trop cohort study. PLoS neglected tropical diseases, 12(11), e0006814.
Castro, R. S. D. S. (2018). Construção e validação de um manual para diagnóstico de doença de Chagas (Doctoral dissertation).
Correia, J. R., Ribeiro, S. C. S., de Araújo, L. V. F., Santos, M. C., Rocha, T. R., Viana, E. A. S., ... & de Carvalho, L. C. (2021). Doença de Chagas: aspectos clínicos, epidemiológicos e fisiopatológicos. Revista Eletrônica Acervo Saúde, 13(3), e6502-e6502.
Costa, A. C. D., Silva Filho, J. D. D., Rocha, E. A., Andrade, M. C., Fidalgo, A. S. O. D. B. V., Almeida, E. R. B., ... & Oliveira, M. D. F. (2018). Trypanosoma cruzi seroprevalence among solid organ donors in Ceará State, Brazil. Revista da Sociedade Brasileira de Medicina Tropical, 51(5), 616-621.
Cordeiro, T. A. R. (2020). Detecção simultânea das doenças de chagas e leishmaniose visceral: uma plataforma específica para o diagnóstico point-of-care.
da Silva Macedo, G. P., da Silva Ribeiro, Á., Adati, M. C., Borges, H. C. B. G., Passo, R. M., de Mendonça, V. F., ... & de Castro, J. R. N. (2020). Revalidação do painel sorológico empregado na avaliação dos kits de diagnóstico da doença de Chagas. Vigilância Sanitária em Debate: Sociedade, Ciência & Tecnologia (Health Surveillance under Debate: Society, Science & Technology)–Visa em Debate, 8(4), 124-128.
de Souza, H. P., de Oliveira, W. T. G. H., dos Santos, J. P. C., Toledo, J. P., Ferreira, I. P. S., de Sousa Esashika, S. N. G., ... & de Sousa Delácio, A. (2020). Doenças infecciosas e parasitárias no Brasil de 2010 a 2017: aspectos para vigilância em saúde. Revista Panamericana de Salud Publica, 44, e10.
Dumonteil, E., Ramirez-Sierra, M. J., Pérez-Carrillo, S., Teh-Poot, C., Herrera, C., Gourbière, S., & Waleckx, E. (2018). Detailed ecological associations of triatomines revealed by metabarcoding and next-generation sequencing: implications for triatomine behavior and Trypanosoma cruzi transmission cycles. Scientific reports, 8(1), 1-13.
Espinosa-Álvarez, O., Ortiz, P. A., Lima, L., Costa-Martins, A. G., Serrano, M. G., Herder, S., ... & Teixeira, M. M. (2018). Trypanosoma rangeli is phylogenetically closer to Old World trypanosomes than to Trypanosoma cruzi. International journal for parasitology, 48(7), 569-584.
Fidalgo, A. S. O. D. B. V., Costa, A. C. D., Silva Filho, J. D. D., Cândido, D. D. S., Freitas, E. C., Pereira, L. D. S., ... & Oliveira, M. D. F. (2018). Insect vectors of Chagas disease (Trypanosoma cruzi) in Northeastern Brazil. Revista da Sociedade Brasileira de Medicina Tropical, 51(2), 174-182.
Jackson, Y., Wyssa, B., & Chappuis, F. (2020). Tolerance to nifurtimox and benznidazole in adult patients with chronic Chagas’ disease. Journal of Antimicrobial Chemotherapy, 75(3), 690-696.
Jansen, A. M., das Chagas Xavier, S. C., & Roque, A. L. R. (2018). Trypanosoma cruzi transmission in the wild and its most important reservoir hosts in Brazil. Parasites & vectors, 11(1), 1-25.
OMS - Organização Mundial de Saúde, a leishmaniose. Disponível em: <http://www.who.int/topics/ leishmaniose / en / (2017) > , acessado em janeiro 2020.
Pearse, S. G., & Cowie, M. R. (2014). Heart failure: classification and pathophysiology. Medicine, 42(10), 556-561.
Sánchez-Valdéz, F. J., Padilla, A., Wang, W., Orr, D., & Tarleton, R. L. (2018). Spontaneous dormancy protects Trypanosoma cruzi during extended drug exposure. Elife, 7, e34039.
Santana, R. A. G., Guerra, M. G. V., Sousa, D. R., Couceiro, K., Ortiz, J. V., Oliveira, M., ... & Guerra, J. A. O. (2019). Oral transmission of trypanosoma cruzi, Brazilian Amazon. Emerging infectious diseases, 25(1), 132.
Silva, C., Carbajal-De-La-Fuente, A. L., Almeida, C. E., Gonçalves, T. C. M., & Santos-Mallet, J. (2019). Morphobiological, morphometric and ultrastructural characterization of sylvatic Trypanosoma cruzi isolates from Rio de Janeiro state, Brazil. Brazilian Journal of Biology, 79(2), 294-303.
Souza, D. D. S. M. D., & Povoa, R. M. D. S. (2016). Aspectos epidemiológicos e clínicos da doença de chagas aguda no Brasil e na América Latina. Rev. Soc. Cardiol. Estado de Säo Paulo, 222-9.
Vargas, A., Malta, J. M. A. S., Costa, V. M. D., Cláudio, L. D. G., Alves, R. V., Cordeiro, G. D. S., ... & Percio, J. (2018). Investigação de surto de doença de Chagas aguda na região extra-amazônica, Rio Grande do Norte, Brasil, 2016. Cadernos de saude publica, 34, e00006517.
Zingales, B. (2018). Trypanosoma cruzi genetic diversity: Something new for something known about Chagas disease manifestations, serodiagnosis and drug sensitivity. Acta Tropica, 184, 38-52.
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Copyright (c) 2021 Daniel Lopes Araújo; Mariana Silva Souza; Bruno Abilio da Silva Machado; José Marcos Fernandes Mascarenhas; Suzana Pereira Alves; Maria Leopoldina Mota do Nascimento; Éryca Maria Teixeira da Silva; Millena Raimunda Martins de Almeida Carvalho ; Larissa de Lima Machado Bandeira; Natália Rodrigues da Silva; Sarah Maria Osório de Carvalho; Lucas dos Santos Moreno ; Maria Gabriela Moreira Alves; Raimundo Nonato Araujo Vieira Neto ; Nágila Iane Pacheco; Luiza Aragão Paiva Pires Ferreira Mendes; Lívia Maria da Silva Gomes; Josemária Chaves Sipaúba Silva; Kaio Germano Sousa da Silva; João Eduardo Gomes de Oliveira
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