Management of melasma in adult women

Authors

DOI:

https://doi.org/10.33448/rsd-v10i5.14874

Keywords:

Melanosis; Therapeutics; Dermatology.

Abstract

Objective: To describe the treatments available for melasma in adult women. Methodology: This is an integrative review about the treatments available for adult women with melasma, through searches in the following databases: Medical Literature Analysis and Retrieval System (MEDLINE/PubMed), Scientific Electronic Library Online (SciELO) and Literature Latin American and Caribbean Health Sciences (LILACS). Altogether, 23 articles were included in this review. Results: After analyzing the treatments used in the selected works, five categories of treatments were identified, namely: use of tranexamic acid, microneedling treatments, laser treatments, treatments with plant extracts and other treatments. Conclusion: This article considered that when comparing topical treatment with tranexamic acid and hydroquinone the results are similar, however the second option has more adverse effects. In patients with frequent relapses, the association of microneedling contributes to an increase in the effectiveness of tranexamic acid, with laser therapy being another management option in these cases. In addition, formulations containing plant extracts show improvement in hyperchromic spots, as well as other treatments.

References

Abadchi, S. N., Naeini, F. F., & Beheshtian, E. (2019). Combination of hydroquinone and fractional CO2 laser versus hydroquinone monotherapy in melasma treatment: A randomized, single-blinded, split-face clinical trial. Indian journal of dermatology, 64(2), 129.

Adalatkhah, H., & Sadeghi-Bazargani, H. (2015). The first clinical experience on efficacy of topical flutamide on melasma compared with topical hydroquinone: a randomized clinical trial. Drug design, development and therapy, 9, 4219.

Akabane, A. L., Almeida, I. P., & Simão, J. C. L. (2017). Avaliação dos índices de qualidade de vida (MELASQoL e DLQI) e do MASI em pacientes com melasma tratadas com Polypodium Leucotomos. Surgical & Cosmetic Dermatology, 9(3), 214-217.

Alavi, S., Abolhasani, E., Asadi, S., & Nilforoushzadeh, M. (2017). Combination of Q-switched Nd: YAG and fractional Erbium: YAG lasers in treatment of melasma: a randomized controlled clinical trial. Journal of lasers in medical sciences, 8(1), 1.

Arrowitz, C., Schoelermann, A. M., Mann, T., Jiang, L. I., Weber, T., & Kolbe, L. (2019). Effective tyrosinase inhibition by thiamidol results in significant improvement of mild to moderate melasma. Journal of Investigative Dermatology, 139(8), 1691-1698.

Atefi, N., Dalvand, B., Ghassemi, M., Mehran, G., & Heydarian, A. (2017). Therapeutic effects of topical tranexamic acid in comparison with hydroquinone in treatment of women with melasma. Dermatology and therapy, 7(3), 417-424.

Ayuthaya, P. K. N., Niumphradit, N., Manosroi, A., & Nakakes, A. (2012). Topical 5% tranexamic acid for the treatment of melasma in Asians: a double-blind randomized controlled clinical trial. Journal of Cosmetic and Laser Therapy, 14(3), 150-154.

Chen, Y. T., Chang, C. C., Hsu, C. R., Shen, J. H., Shih, C. J., & Lin, B. S. (2016). Combined vitamin C sonophoresis and neodymium-doped yttrium aluminum garnet (NdYAG) laser for facial hyperpigmentation: An outcome observation study in Asian patients. Indian Journal of Dermatology, Venereology, and Leprology, 82(5), 587.

Costa, A., Moisés, T. A., Cordero, T., Alves, C. R. T., & Marmirori, J. (2010). Associação de emblica, licorice e belides como alternativa à hidroquinona no tratamento clínico do melasma. Anais Brasileiros de Dermatologia, 85(5), 613-620.

Costa, F. V., Souza, L. S. de, Conradesque, P. R., & Carniel, P. (2020). Therapeutic response of cysteamine in the treatment of melasma. Research, Society and Development, 9(6), e75963468.

Diosti, G. M., Mulinari-Brenner, F., Filus Neto, J., Werner, B., Nascimento, A., & Piva, F. M. (2012). Avaliação clínica e histológica de pacientes com melasma refratário tratadas com laser de érbio: Yag fracionado. Surgical & cosmetic dermatology, 4(2), 114-120.

Ebrahimi, B., & Naeini, F. F. (2014). Topical tranexamic acid as a promising treatment for melasma. Journal of research in medical sciences: the official journal of Isfahan University of Medical Sciences, 19(8), 753.

Eshghi, G., Khezrian, L., & Esna Ashari, F. (2016). Comparison between Intralesional Triamcinolone and Kligman's Formula in Treatment of Melasma. Acta medica Iranica, 54(1), 67–71.

Faghihi, G., Taheri, A., Shahmoradi, Z., & Nilforoushzadeh, M. A. (2017). Solution of azelaic acid (20%), resorcinol (10%) and phytic acid (6%) versus glycolic acid (50%) peeling agent in the treatment of female patients with facial melasma. Advanced Biomedical Research, 6.

Garcia, A. K. A., Fonseca, L. F., Aroni, P., & Galvão, C. M. (2016). Estratégias para o alívio da sede: revisão integrativa da literatura. Revista Brasileira de Enfermagem, 69(6), 1148-55.

Guo, X., Cai, X., Jin, Y., Zhang, T., Wang, B., & Li, Q. (2019). Q-PTP is an optimized technology of 1064-nm Q-switched neodymium-doped yttrium aluminum garnet laser in the laser therapy of melasma: A prospective split-face study. Oncology letters, 18(4), 4136-4143.

Hammerschmidt, M., Mattos, S. M. L., Suzuki, H. S., Freitas, C. F. N. P., & Mukai, M. M. (2012). Avaliação dos métodos de classificação do melasma de acordo com a resposta ao tratamento. Surgical & Cosmetic Dermatology, 4(2), 155-158.

Iraji, F., Tagmirriahi, N., & Gavidnia, K. (2012). Comparison between the efficacy of 10% zinc sulfate solution with 4% hydroquinone cream on improvement of melasma. Advanced Biomedical Research, 1.

Jiang, J., Akinseye, O., Tovar-Garza, A., & Pandya, A. G. (2018). The effect of melasma on self-esteem: A pilot study. International journal of women's dermatology, 4(1), 38-42.

Kim, J. Y., Choi, M., Nam, C. H., Kim, J. S., Kim, M. H., Park, B. C., & Hong, S. P. (2016). Treatment of melasma with the photoacoustic twin pulse mode of low-fluence 1,064 nm Q-switched Nd: YAG laser. Annals of dermatology, 28(3), 290-296.

Lima, E. D. A. (2015). Microneedling in facial recalcitrant melasma: report of a series of 22 cases. Anais brasileiros de dermatologia, 90(6), 919-921.

Lima, E. V., Lima, M. M. D., Paixão, M. P., & Miot, H. A. (2017). Assessment of the effects of skin microneedling as adjuvant therapy for facial melasma: a pilot study. BMC dermatology, 17(1), 1-6.

Magalhães, G. M., Borges, M. D. F. M., Vieira, P. J., & Neves, D. R. (2010). Peeling de ácido láctico no tratamento do melasma: avaliação clínica e impacto na qualidade de vida. Surgical & Cosmetic Dermatology, 2(3), 173-179.

Mann, T., Gerwat, W., Batzer, J., Eggers, K., Scherner, C., Wenck, H., Stäb, F., Hearing, V. J., Röhm, K. H., & Kolbe, L. (2018). Inhibition of human tyrosinase requires molecular motifs distinctively different from mushroom tyrosinase. Journal of Investigative Dermatology, 138(7), 1601-1608.

Medeiros, J. K. G., Neves, W. W., Moura, N. M. D., & Medina, W. S. G. (2016). Combinação terapêutica no tratamento do melasma. CuidArte, Enferm, 180-187.

Moreira, A. M., Bravo, B. S. F., Amorim, A. G. F., Luiz, R. R., & Issa, M. C. A. (2010). Estudo duplo cego comparativo entre hidroquinona e extrato de uva-ursina no tratamento do melasma. Surgical & Cosmetic Dermatology, 2(2), 99-104.

Muramatsu, T., Funahashi, Y., Yamamoto, A., Sassa, N., Matsukawa, Y., & Gotoh, M. (2019). A case of advanced prostate cancer controlled for the long term by flutamide after bicalutamide failure. Nagoya journal of medical science, 81(4), 707–710.

Oliveira, A. A., Gonçalves, P. F., Santos, K. S., Duarte, S. F. P., David, I. R., & Santos, J. A. B. (2019). Impacto do Melasma na Autoestima de Mulheres/Impact of Melasma on Women's Self-Estems. ID on line REVISTA DE PSICOLOGIA, 13(48), 435-443.

Souza, M. T., Silva, M. D., & Carvalho, R. (2010). Revisão integrativa: o que é e como fazer. Einstein (São Paulo), 8(1), 102-106.

Xu, Y., Ma, R., Juliandri, J., Wang, X., Xu, B., Wang, D., Lu, Y., Zhou, B., & Luo, D. (2017). Efficacy of functional microarray of microneedles combined with topical tranexamic acid for melasma: A randomized, self-controlled, split-face study. Medicine, 96(19).

Zhong, S. M., Sun, N., Liu, H. X., Niu, Y. Q., & Wu, Y. (2015). Reduction of facial pigmentation of melasma by topical lignin peroxidase: a novel fast-acting skin-lightening agent. Experimental and therapeutic medicine, 9(2), 341-344.

Published

09/05/2021

How to Cite

BARBOSA, G. S. L.; COSTA, C. P. M.; BORGES, M. V. R.; COUTINHO, M. Ângela de O. C.; LOPES, M. S.; CACAU , B. L.; ATTEM, M. S.; MASS, D. W.; PEREIRA, B. S.; LUZ, F. A.; FONTENELLE, L. F. V. Management of melasma in adult women. Research, Society and Development, [S. l.], v. 10, n. 5, p. e35310514874, 2021. DOI: 10.33448/rsd-v10i5.14874. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/14874. Acesso em: 20 apr. 2024.

Issue

Section

Review Article