Feline mammary hyperplasia: why is it so common in Brazil?
DOI:
https://doi.org/10.33448/rsd-v10i5.15002Keywords:
Cats; Endocrinology; Tumor.Abstract
Feline breast hyperplasia (FBH) is a non-neoplastic disorder, characterized by cellular proliferation of the duct stroma of the mammary glands, commonly diagnosed in Brazil. Such change is often caused by the inappropriate use of exogenous progestogens in cats, which can be stored in the organism of the animal, and sensitize the glands to the proliferation exacerbated by hormonal stimulus. One of the factors associated with recurrent cases of FBH is the sale of these drugs in stores that provide service for the sale of veterinary products, applied without restrictions and without knowledge of feline physiology, in an attempt to control pregnancy. The awareness of owners about the harms of uncontrolled application of progestins and the stimulation of them to opt for surgical sterilization of their animals should be done by veterinarians, in order to avoid further complications such as breast cancer, thus ensuring greater welfare of the feline population. The purpose of this review is to address epidemiological, physiological and clinical aspects, and to promote an allusion to the indiscriminate use of contraceptives in this species.
References
Aguiar, R. A. C., Moreira, V. S. & Porto, M. R. (2017). Patologias Reprodutivas diagnosticadas durante a ovariosalpingoesterectomia (OSH) em gatas e cadelas. Simpósio de TCC e seminário de IC. 2016. Disponível em 28 Congresso Nacional de Medicina Veterinária FAG.
Amorim, F. V., Souza, H. J. M., Ferreira, A. M. R. & Fonseca, A. B. M. (2006). Clinical, cytological and histopathological evaluation of mammary masses in cats from Rio de Janeiro, Brazil. Journal of Feline Medicine and Surgery, 8, 379-388.
Araújo, E. K. D., Moura, V. M., Honório, T. G. A. F., Alves, R. A., Fonseca, A. P. B., Rodrigues, M. C. & Klein, R. P. (2017). Principais patologias relacionadas aos efeitos adversos do uso de fármacos contraceptivos em gatas em Teresina – PI. Pubvet, 11 (3), 256-261.
Aspinall, V. (2011). Reproductive system of the dog and cat part 1 - the female system. Veterinary Nursing Journal, 26, 43-55.
Burstyn, U. (2010). Management of mastitis and abscessation of mammary glands secondary to fibroadenomatous hyperplasia in a primiparturient cat. Journal of the American Veterinary Medical Association, 236 (3), 326-329.
Estévez, J. O., De La Sota, R. L. & Gobello, M. C. (1999). Fibroadenomatous mammary hyperplasia in a neutered cat. Revista Brasileira de Reprodução animal, 26 (3), 470-496.
Feldman, E. C. & Nelson, R. W. (1996). Breeding Pregnancy and Parturition. In: Feldman, E. C. & Nelson, R. W. Canine and Feline endocrinology and Reproduction. Philadelphia: Saunders, 547-571.
Filgueira, K. D., Reis, P. C. C. R. & Paula, V. V. (2008). Relato de caso: hiperplasia mamária felina: sucesso terapêutico com o uso do aglepristone. Ciência Animal Brasileira, 9 (4), 1010-1016.
Filgueira, K. D., Reis, P. C. C. R., Macêdo, L. B., Oliveira, I. V. P. M., Pimentel, M. M. L., & Júnior. A. R. (2015). Caracterização clínica e terapêutica de lesões mamárias não neoplásicas em fêmeas da espécie felina. Acta Veterinaria Brasilica, 9 (1), 98-107.
Foss, M. A., County, S., Stwart, N., County, K. & County, J. S. S. (2013). Cat Anatomy and Physiology. Washington State University.
Gaviria, E. F. B., Bonilla, D. F. E. & Gómez, A. F. L. (2010). Hiperplasia fibroepitelial mamaria felina: reporte de un caso. Revista CES Medicina Veterinaria y Zootecnia, 5 (1), 70-76.
Giménez, F., Hecht, S., Craig, L. E. & Legendre, A. M. (2010). Early detection, agressive therapy: Optimizing the management of feline mammary masses. Journal of Feline Medicine and Surgery, 12, 214-224.
Gogny, A. & Fieni, F. (2016). Aglepristone: A review on its clinical use in animals. Theriogenology, 85 (4), 555-566.
Gomide P. R. (2009). Estudo retrospectivo de cadelas portadoras de neoplasia mamáriasubmetidas à mastectomia. Faculdade de Medicina Veterinária e Zootecnia (FMVZ), Universidade Estadual Paulista (Unesp), Botucatu.
Gorlinger, S., Kooistra H. S., Van Den Broek, A. & Okkens, A. C. (2002). Treatment of fibroadenomatous hyperplasia in cats with aglépristone. Journal of Veterinary Internal Medicine, 16, 710-713.
Gracanin, A., De Gier, J., Zegers, K., Bominaar, M., Rutteman, G. R., Schaefers-Okkens, A. C., Kooistra, H. S. & Mol. J. A. (2012). Progesterone Receptor Isoforms in the Mammary Gland of Cats and Dogs. Reproduction in Domestic Animals, 47 (6), 313-317.
Hayden, D. W., Johnson, K. H. & Ghobrial, H. K. (1983). Ultrastructure of Feline Mammary Hypertrophy. Veterinary Pathology, 20, 254-264.
Hayden, D. W., Barnes, D. M. & Johnson, K. H. (1989). Morphologic changes in the mammary gland of megestrol acetate-treated and untreated cats: A retrospective study. Veterinary Pathology, 26, 104-103.
Honório, T. G. A. F., Fonseca, A. P. B., Araújo, E. K. D., Moura, V. M., Chaves, R. A. A., Rodrigues, M. C. & KLEIN, R. P. (2017). Implicações patológicas após o uso de anticoncepcional, em cadelas situadas em Teresina – PI. Pubvet, 11 (2), 103-206.
Hovey, R. C., Trott, J. F. & Vonderhaar, B. K. (2002). Establishing a framework for the functional mammary gland: From endocrinology to morphology. Journal of Mammary Gland Biology and Neoplasia, 7 (1), 17-38.
Jacobs, T. M., Hoppe, B. R., Poehlmann, C. E., Ferracone, J. D. & Sorenmo, K. U. (2010). Case report: Mammary adenocarcinomas in three male cats exposed to medroxyprogesterone acetate (1990-2006). Journal of Feline Medicine and Surgery, 12 (2), 169-174.
Johnston, S. D., Kustritz, M. V. R. & Olson, P.N.S. (2001). Canine and Feline Theriogenology. Saunders.
Jurka, P. & Max, A. (2009). Treatment of fibroadenomatosis in 14 cats with aglepristone – changes in blood parameters and follow-up. The Veterinary Record, 165, 657-660.
Keskin, A., Yilmazbas, G., Yilmaz, R., Ozyigit, M. O. & Gumen, A. (2009). Pathological abnormalities after long-term administration of medroxyprogesterone acetate in a queen. Journal of Feline Medicine and Surgery, 11 (6), 518-521.
Krawczyk M., Łopuszyński, W., Szczubiał, M. & Millán, Y. (2017). Progesterone receptor expression and proliferative activity in relation to histological architecture of feline mammary fibroadenomatous change. Medycyna Weterynaryjna-Veterinary Medicine-Science and Practice, 73 (1), 33 - 38.
Kutzler, M. & Wood, A. (2006). Non-surgical methods of contraception and sterilization. Theriogenology, 66 (3), 514-525.
Leidinger, E., Hooijberg E., Sick, K., Reinelt, B. & Kirtz, G. (2011). Fibroepithelial hyperplasia in an entire male cat: Cytologic and histopathological features. Tierärztliche Praxis, 39 (3), 198-202.
Little, S. (2011). Feline Reproduction: Problems and clinical challenges. Journal of Feline Medicine and Surgery, 13, 508-515.
Lopes, M. D. & Ackermann, C. L. (2017). Contracepção em felinos domésticos: novas abordagens. Revista Brasileira de Reprodução Animal, 41 (1), 270-277.
Loretti, A.P., Ilha, M. R. S., Ordás, J. & Mulas, J M. (2005). Clinical, pathological and immunohistochemical study of feline mammary fibroepithelial hyperplasia following a single injection of depot medroxyprogesterone acetate. Journal of Feline Medicine and Surgery, 7 (1), 43-52.
MacDougall, L. D. (2003). Mammary fibroadenomatous hyperplasia in a young cat attributed to treatment with megestrol acetate. Canadian Veterinary Journal, 44, 227-229.
Mayayo, S. R., Bo, S. & Pisu, M. C. (2018). Mammary fibroadenomatous hyperplasia in a male cat. Journal of Feline Medicine and Surgery Open Reports, 4 (1), 1 -5.
Millanta, F., Calandrella, M., Vannozzi, I. & Polli, A. (2006). Steroid hormone receptors in normal, dysplastic and neoplastic feline mammary tissues and their prognostic significance. The Veterinary Record, 158, 821-824.
Mol, J. A., Garderen, E., Selman, P. J., Wolfswinkel, J., Rijnberk, A. & Rutteman, G. R. (1995). Growth Hormone mRNA in Mammary Gland Tumors of Dogs and Cats. Journal of Clinical Investigation, 95, 2028-2034.
Montanha, F. P., Corrêa, C. S. S. & Parra, T. C. (2012). Maceração fetal em gata em decorrência do uso de contraceptivos - relato de caso. Revista Científica Eletrônica de Medicina Veterinária, 10 (19), 1-6.
Mulas, J. M., Niel, M., Millán, Y., Blankenstein, M. A., Mil, F. & Misdorp, W. (2000a). Immunohistochemical analysis of estrogen receptors in feline mammary gland benign and malignant lesions: comparison with biochemical assay. Domestic Animal Endocrinology, 18 (1), 111-125.
Mulas, J. M., Millán, Y., Bautista, J. M., Pérez, J. & Carrasco, L. (2000b). Oestrogen and progesterone receptors in feline fibroadenomatous change: an immunohistochemical study. Research in Veterinary Science, 68 (1), 15-21.
Munson, L. (2006). Contraception in felids. Theriogenology, 66 (1), 126-134.
Oliveira, E. C. S. & Marques J. R. A. P. (2006). Endocrinologia reprodutiva e controle da fertilidade da cadela. Revista Brasileira de Reprodução Animal, 30 (1/2), 11-18.
Nelson, R. W. & Couto, C. G. (2015). Medicina Interna de Pequenos Animais. Elsevier: Amsterdan.
Pantoja, A. R., Bastos, M. M. S. & João, C. F. (2017). Hiperplasia mamária felina. Ciência Animal, 27 (3), 89-98.
Payan-Carreira, R. (2013). Feline Mammary Fibroepithelial Hyperplasia: A Clinical Approach. In: Insights from veterinary medicine. InTechOpen, 215–232.
Petersen, A. (2015). Reproductive Physiology of the Female Cat. Dissertação (Mestrado em Medicina Veterinária). Fakulteten för veterinärmedicinoch husdjursvetenskap, Swedish University of Agricultural Sciences, Upsala.
Rahal, S. C., Caporali, E. H. G., Lopes, M. D., Rocha, N. S. & Melero, F. H. (2003). Hiperplasia mamária felina - relato de três casos. Ars Veterinária, 19 (2), 188-190.
Romagnoli, S. (2015). Progestins to control feline reproduction: Historical abuse of high doses and potentially safe use of low doses. Journal of Feline Medicine and Surgery, 17 (9), 743-752.
Robinson, B. & Noakes, D. E. (2018). Reproductive physiology of the female. In: Noakes, D. E., Pearson, H., Parkinson, T. J. & England, G. Veterinary Reproduction & Obstetrics. Beijing: Elsevier, 2 - 35.
Rutteman, G. R. (1992). Contraceptive steroids and the mammary gland: Is there a hazard? - Insights from animal studies. Breast Cancer Research and Treatment, 23, 29-41.
Siberino, G. B., Ortiz, B. C., Matte, K. L., Secchi, P., Gomes, V. R., Pozzatti, D. & Figueiredo, K. G. (2021). Hiperplasia mamária felina: Relato de caso. PubVet, 15 (1), 1-4.
Silva, F. B., Lima, A. E. S., Ribeiro, L. G. R., Neto, J. M. C., Costa, A. C. F., Silveira, C. P. B., Mello, S. B., Larangeira, D. F. & Oriá, A. P. (2012). Utilização do aglepristone no tratamento da hiperplasia fibroepitelial mamária felina. Veterinária e Zootecnia, 19 (3), 399-406.
Silva, T. P. D. & Silva, F. L. (2012). Hiperplasia mamária felina: Um relato de caso. Enciclopédia Biosfera, Centro Científico Conhecer, 8 (14), 634-640.
Silva, F. L., Silva, C. R. A., Sousa, M. P., Castro, L. R. M. S., Rocha, A. O., Costa, T. M., Brito, T. K. P., Fernandes, E. R. L. & Rodrigues, K. E. R. (2020). Avaliação do uso de anticoncepcionais em cães e gatos. PubVet, 14 (10), 1-5.
Sorenmo, K. U., Worley, D. R. & Goldschmidt, M. H. (2013). Tumors of the Mammary Gland. In: Withrow, S. J., Vail, D. M., Page, R. L. (Ed.) Small Animal Clinical Oncology. Missouri: Saunders, 540-556.
Souza, T. M., Fighera, R. A., Langohr, I. M. &Barros, C. S. L. (2002). Hiperplasia fibroepitelial mamária em felinos: cinco casos. Ciência Rural, 32 (5), 891 -894.
Thompson, F. N. Reprodução em mamíferos do sexo feminino. In: Reece, W. O. & DUKES. (2004). Fisiologia dos animais domésticos, (12a ed.), Guanabara Koogan, 644-669.
Togni, M., Masuda, E. K., Kommers, Fighera, R. A. & Irigoyen, L. F. (2013). Estudo retrospectivo de 207 casos de tumores mamários em gatas. Pesquisa Brasileira Veterinária, 33 (3), 353-358.
Tsutsui, T. & Stabenfeldt, G. H. (1993). Biology of ovarian cycles, pregnancy and pseudopregnancy in the domestic cat. Journal of Reproduction and Fertility, 47, 29- 35.
Uçmak, M., Enginler, S.Ö., Gündüz, M. C., Kirşan, I. & Sönmez, K. (2011). Treatment of feline mammary fibroepithelial hyperplasia with the combination of aglepristone and cabergoline. Journal of The Faculty of Veterinary Medicine, 37 (1), 69-73.
Vasconcellos, C. H. C. Hiperplasia mamária In: Souza, H. J. M. (2003). Coletâneas em medicina e cirurgia felina. L. F. Livros, 23 - 237.
Verhage, H. G., Beamer, N. B. & Brenner, R. M. P. (1976). Plasma levels of estradiol and progesterone in the cat during polyestrus, pregnancy and pseudopregnancy. Biology of Reproduction, 14, 579-585.
Viana, D. C., Santos, A. C., Rui, L. A., Oliveira, D. M., Silva, A. B., Costa, F. C. F. C. & Neto, A. C. A. (2012). Hiperplasia mamária felina-relato de caso. Veterinária Notícias, 18 (2), 121-125.
Vigo, F., Lubianca, J. N. & Corleta, H. E. (2011). Progestógenos: farmacologia e uso clínico. Femina, 39 (3), 127-137.
Vitasek, R. & Dendisova, H. (2006). Treatment of feline mammary fibroepithelial hyperplasia following a single injection of proligestone. Acta Veterinaria, 75 (2), 295-297.
Voorwald, F. A., Lopes, C., Silveira, G. C., Lima, D. T., Silva, M. F. C., Andreão, N. B. & Toniollo, G. H. (2021). Severe mammary fibroepithelial hyperplasia due to single injection of medroxyprogesterone acetate in two male cats. Ciência Rural, 51 (4), 1-9.
Wherend, A., Hospes, R. & Gruber, A. D. (2001). Treatment of feline mammary fibroadenomatous hyperplasia with a progesterone antagonist. Veterinary Records, 148 (11), 346-347.
Wildt, D. E., Chan, S. Y. W., Seager, S. W. J. & Chakraborty, P. K. (1981). Ovarian activity, circulating hormones and sexual behaviot in the cat. Relationships during the coitus induced luteal phase and the estrous period without mating. Biology of Reproduction, 25, 15 -18.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2021 Jamille Bispo de Carvalho Teixeira; Camilla Freitas Oliveira; Paula Elisa Brandão Guedes; Renata Santiago Alberto Carlos
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
