Intraosseous neurofibroma versus schwannoma, importance of histological differential diagnosis in the definitive diagnosis: Case report
DOI:
https://doi.org/10.33448/rsd-v10i5.15025Keywords:
Schwannoma; Neurofibroma; Diagnosis.Abstract
Neoplasms of neural origin represent 8% and 12% of all malignant and benign soft tissue neoplasms, respectively. In this group, tumors of the peripheral nerve sheath (TBNP) are inserted, a relatively rare group of diseases that are classified according to the specific characteristics of differentiation, cellular components and extracellular matrix. Neurofibroma and schwannoma are examples of lesions belonging to this group. The objective of this study is to present a clinical case of a female patient, 60 years old, diagnosed with a central lesion in the region of the right mandibular body. The lesion was discovered after a routine examination for prosthetic rehabilitation and, after incisional biopsy, initial diagnosis of schwannoma was obtained. The proposed treatment was a marginal resection, through the installation of a 2.4mm reconstruction plate and enucleation of the lesion. An escisional biopsy was then requested where neurofibroma was obtained as the final diagnosis. The patient had a satisfactory response to treatment, with no signs of recurrence. Although the decisive diagnosis of neurofibroma is based on histological findings, lesions such as schwannoma should be included as a differential histological diagnosis, which can hinder the definitive diagnosis. In this sense, peculiar characteristics of schwannoma and neurofibroma, their immunohistochemical behaviors and their similarities are necessary to trace their repercussions in establishing the diagnosis. Although there is no difference in treatment, such injuries may be associated which makes their final differentiation necessary, specifically for cases in which there is doubt.
References
Aqbal, A., Tamgadge, S., Tamgadge, A., Chande, M. (2018). Intraosseous neurofibroma in a 13 year old male paciente: a case report with review of literatury. J Cancer Res Ther. 14(3), 712-715.
Behrad, S., Sohanian, S., Ghanbarzadegan, A. (2020). Solitary intraosseous neurofibroma of the mandible: reporto f na extremely rare histopathologic feature. Indian J Pathol Microbiol. 63(2), 276-278.
Broly, E., Lefevre, B., Zachar, D. et al. (2019). Solitary neurofibroma of the floor of the mouth: rare localization at lingual nerve with intraoral excision. BMC Oral Health. 19, 197.
Cantanhede, A. L. C., Oliveira, J. C. S., Junior, E. F. V., Camelo, J., Bastos, E. G., Neto, R. S. M. (2019). Neurofibroma solitário extenso de nervo alveolar inferior em paciente pediátrico. Relatos Casos Cir. 5(2), 21-27.
Catanhende, A. L. C., Araújo, C. G., Almeida, P. M. S., Lima, H. L. O. (2021). Extenso neurofibroma solitário em mucosa jugal: relato de caso. Research Society and Development. 10(2).
Deichler, J., Martínez, R., Niklander, S., Seguel, H., Marshall, M., Esguep, A. (2011). Sol-itary intraosseous neurofibroma of the mandible. Apropos of a case. Med Oral Patol Oral Cir Bucal. 16(6). 704-7.
Drumond, G. C. (2018). Schwannoma intraósseo: relato de caso e revisão da literatura. Rev Bras Ortop. 1-5.
Franco, T. (2012). Estudo clínico patológicos dos tumores bucais de origem perineural e análise imunoistoquímica dos antígenos S-100 3 CD-57 nos diferentes tipos de lesão. Fac. Odont. Uberlandia. 1-78.
Johann, A. C. B. R., Caldeira, P. C., Souto, G. R., Freitas, J. B., Mesquita, R. A. (2008). Neurofibroma extra-ósseo solitário do palato duro. Rev Bras Otorrinolaringol. 74(2), 317.
Júnior, F. A. P., Pereira, L. C. F.O. (2012). Diagnóstico diferencial de neoplasia em bainha de nervo periférico: relato de caso clínico na Fundação Cristiano Virella, Muriaé (MG). Revista científica da faminas. 8(1), 44-59.
Lacerda, S. A. (2006). Intraosseous Schwannoma of Mandibular Symphysis: Case Report. Braz Dent J. 17(3), 255-258.
Martorelli, S. B. F., Andrade, F. B. M., Martorelli, F. O., Marinho, E. V. S., Coelho, E. (2009). Neurofibroma isolado da cavidade oral: Relato de caso. Rev. Cir. Traumatol. Buco-Maxilo-fac. Camaragibe/PE. 10(1), 43 – 48.
Melo, C. A. (2015). Schwanoma de grandes dimensões em palato duro: relato de caso incomum e 40 anos de revisão de literatura. Fac. Odont.. Tiradente. 1-6.
Morocchio, L. S. (2011). Neurofibroma isolado na região de cabeça e pescoço: considerações clínicas e histopatológicas. Fac. Odont.. dr Bauru. 88.
Nascimento, G. J. F. (2010). A 38-year review of oral schwannomas and neurofibromas in a Brazilian population: clinical, histopathological and immunohistochemical study. Clin Oral Invest. 5, 329–335. Springer-Verlag.
Neville, B.W., Allen, C. M., Damm, D. D. (2009). Patologia: Oral & Maxilofacial. 3ª RJ: Guanabara Koog.
Rodrigues, H. (2006). Extraaxial Neurofibroma versus Neurolemmomas: discrimination with MRI. Won-Hee Jee et col. AJR.
Salla, J. T., Johann, A. C., Garcia, B. G., Aguiar, M. C., Mesquita, R. A. (2009). Retrospec-tive analysis of oral peripheral nerve sheath tumors in Brazilians. Braz Oral Res. 23(1), 43-8.
Sekhar, P., Nandhini, G., Kumar, K. R., Kumar, A. R. (2019). Solitary neurofibroma of the palate mimicking mucocele: a rare case report. J. Oral Maxillofac Pathology. 23(1), 23-26.
Viott, A. M., Ramos, A. T., Inkelmann, M. A., Kommers, G. D., Graça, D. L. (2007). Aspectos histoquímicos e imunoistoquímicos nos neoplasmas do sistema nervoso periférico. Arq. Bras. Med. 59(5), 1145-1153.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2021 André Gustavo Góes da Silva; Paloma Rodrigues Genú; Antônio Jorge Orestes Cardoso; Riedel Frota Sá Nogueira Neves; Cauê Fontan Soares; Miquéias Oliveira de Lima Júnior
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
