Laboratory findings in imaging diagnostic tests in patients infected with COVID-19 – A study review
DOI:
https://doi.org/10.33448/rsd-v10i6.15936Keywords:
COVID-19; Medical imaging; Computed tomography; X-ray; Thorax radiography.Abstract
Purpose: This study disseminates the diagnosis of COVID-19 emphasizing the importance of imaging tests in medical interpretation and identification of its complications, besides demonstrating the contribution to patient care. Methodology: The study was conducted based on a literature review, in addition to the acquired results of imaging tests from clinical patients at a Public Hospital of the State of Sergipe, Brazil, to point the scoring system in thorax radiography and compare to computed tomography (CT). Results: The imaging tests are not indicated for patients with mild symptoms and suspected COVID-19 infection, except for risk of disease progression, being indicated in the complementary diagnosis of COVID-19 positive patients. Studies show that thorax radiography is more used because it has low cost and easy access. However, its use has limitations due to the low sharpness of the images and impossibility of visualization of some lesions. Computed tomography, on the other hand, can be used as a pulmonary monitoring and evolution test in patients with COVID-19 worsening and/or persistent homeostatic changes. Nevertheless, this test is not indicated for acute cases without aggravating symptoms. Conclusion: The high degree of dissemination of SARS-CoV-2 and the collapse of health systems demonstrated the importance of the science in health. In addition, the importance of laboratory tests in the diagnosis of virus infection and imaging tests in the early diagnosis of SARS-CoV-2 pneumonia has been shown as efficient complementarity in the evolution and clinical interpretation of patients, highlighting the importance of radiography and CT exams.
References
Araujo-Filho, J. A. B., Sawamura, M. V. Y., Costa, A. N., Cerri, G. G. & Nomura, C. H. (2020). Pneumonia por COVID-19: qual o papel da imagem no diagnóstico? Jornal Brasileiro de Pneumologia, 46(2). https://doi.org/10.36416/1806-3756/e20200114
Barone, M. T. U., Harnik, S. B., de Luca, P. V, Lima, B. L. S., Wieselberg, R. J. P., Ngongo, B., Pedrosa, H. C., Pimazoni-Netto, A., Franco, D. R., Souza, M. F. M., Malta, D. C. & Giampaoli, V. (2020). The impact of COVID-19 on people with diabetes in Brazil. Diabetes Research and Clinical Practice, 166, 108304. doi: 10.1016/j.diabres.2020.108304.
Baroni, R. H. (2003). Radiografia de tórax ou tomografia? Einsten, 1, 43-44.
Bertolazzi, P. & Melo, H. J. F. (2020). A importância da Tomografia Computadorizada no diagnóstico da COVID-19/The importance of Computed Tomography in diagnosis of COVID-19. Arquivos Médicos dos Hospitais e da Faculdade de Ciências Médicas da Santa Casa de São Paulo, 65:e11,1-4. https://doi.org/10.26432/1809-3019.2020.65.011
Borghesi A. & Maroldi, R. (2020a). COVID-19 outbreak in Italy: experimental chest X-ray scoring system for quantifying and monitoring disease progression. Radiol Med, 125(5), 509-513. https://doi.org/10.1007/s11547-020-01200-3
Borghesi, A., Zigliani, A., Masciullo, R., Golemi, S., Maculotti, P., Farina, D. & Maroldi, R. (2020b). Radiographic severity index in COVID-19 pneumonia: relationship to age and sex in 783 Italian patients. Radiol Med, 125(5), 461-464. https://doi.org/10.1007/s11547-020-01202-1
Casanova, J. L. & Su, H. C. (2020). COVID Human Genetic Effort, A Global Effort to Define the Human Genetics of Protective Immunity to SARS-CoV-2 Infection. Cell, 181(6), 1194-1199. doi: 10.1016/j.cell.2020.05.016.
Cellina, M., Orsi, M., Toluian, T., Valenti Pittino, C. & Oliva, G. (2020). False negative chest X-Rays in patients affected by COVID-19 pneumonia and corresponding chest CT findings. Radiography (Lond), 26(3), e189-e194. doi: 10.1016/j.radi.2020.04.017.
Chate, R. C. (2003). Radiografia de tórax: ainda é útil? Einsten, 1, 42-43.
Chen, T., Wu, D., Chen, H., Yan, W., Yang, D., Chen, G., Ma, K., Xu, D., Yu, h., Wang, H., Wang, T., Guo, W., Chen, J., Ding, C., Zhang, X., Huanf, J., Han, M., Li, S., Lu, X., Zhao, J. & Li, S. (2020). Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study. BMJ, 368. doi: https://doi.org/10.1136/bmj.m1091
Elicker, B., Pereira, C. A. C., Webb, R. & Leslie, K. O. (2008). Padrões tomográficos das doenças intersticiais pulmonares difusas com correlação clínica e patológica. J Bras pneumol., 34(9), 715-744. http://dx.doi.org/10.1590/S1806-37132008000900013
Estevão, A. (2020). COVID -19. Acta Radiológica Portuguesa, 32(1), 5-6.
Foust, A. M., Phillips, G. S., Chu, W. C., Daltro, P., Das, K. M., Garcia-Peña, P., Kilbonr, T., Winant, A. J., & Lee, E. Y. (2020). International Expert Consensus Statement on Chest Imaging in Pediatric COVID-19 Patient Management: Imaging Findings, Imaging Study Reporting and Imaging Study Recommendations. Radiology: Cardiothoracic Imaging, 2(2), e200214. https://doi.org/10.1148/ryct.2020200214
Gordon, L., Nowik, P., Kesheh, S. M., Lidegran, M. & Diaz, S. (2020). Diagnosis of foreign body aspiration with ultralow-dose CT using a tin filter: a comparison study. Emerg Radio.l, 27(4), 399-404. https://doi.org/10.1007/s10140-020-01764-7
Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Zhang, L., Fan, G., Xu, J., Gu, X., Cheng, Z., Yu, T., Xia, J., Wei, Y., Wu, W., Xie, X., Yin, W., Li, H., Liu, M., Xiao, Y., Gao, H., Guo, L., Xie, J., Wang, G., Jiang, R., gAO, z., jIN, q., Wang, J. & Cao, B. (2020). Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet, 395(10223), 497-506. doi: 10.1016/S0140-6736(20)30183-5.
Huang, P., Liu, T., Huang, L., Liu, H., Lei, M., Xu, W., Chen, J. & Liu, Bo. (2020). Use of Chest CT in Combination with Negative RT-PCR Assay for the 2019 Novel Coronavirus but High Clinical Suspicion. Radiology. 295(1), 22-23. doi: 10.1148/radiol.2020200330.
Long, C., Xu, H., Shen, Q., Zhang, X., Fan, B., Wang, C., Zeng, B., Li, Z., Li, X. & Li, H. (2020). Diagnosis of the Coronavirus disease (COVID-19): RT-PCR or CT? Eur J Radiol, 126:108961. doi: 10.1016/j.ejrad.2020.108961
Neto, A. G. S., Santos, A. F., Santos, J. R., Alves, L. L., Ramos, A. C. S., Santana, A. A. F., Santos, I. D. D., Gaspar, L. M. A. C. (2021). COVID-19: Metodologias de diagnóstico. Research, Society and Development, 10(5). http://dx.doi.org/10.33448/rsd-v10i5.15114
Organização Pan-Americana de Saúde (Brasil) (OPAS/OMS) (2020). Folha informativa – COVID-19: (doença causada pelo novo coronavírus). https://www.paho.org/bra/index.php?option=com_content&view=article&id=6101:covid 19&Itemid=875
Peck, K. R. (2020). Early diagnosis and rapid isolation: response to COVID-19 outbreak in Korea. Clinical Microbiology and Infection, 26(7), 805-807. doi: 10.1016/j.cmi.2020.04.025.
Prado, G. L. M. & Barjud, M.B. (2020). Radiologia em COVID 19: Fisiopatologia e aspectos da imagem nas diferentes fases clínicas da doença. Revista da FAESF, 4, 11-15. Retrieved from https://www.faesfpi.com.br/revista/index.php/faesf/article/view/109
Rubin, G. D., Ryerson, C. J., Haramati, L. B., Sverzellati, N., Kanne, J. P., Raoof, S., Schluger, N. W., Volpi, A., Yim, J-J., Martin, I. B. K., Anderson, D. J., Kong, C., Altes, T., Bush, A., Desai, S. R., Goldin, O., Goo, J. M., Humbert, M., Inouse, Y., Kauczor, H-U., Luo, F., Mazone, P. J., Prokop, M., Remy-Jardin, M., Richeldi, L., Schaefer-Prokop, C. M., Tomiyama, N., Wells, A. U. & Leung, A. N. (2020). The Role of Chest Imaging in Patient Management during the COVID-19 Pandemic: A Multinational Consensus Statement from the Fleischner Society. Radiology, 296(1), 172-180. doi: 10.1148/radiol.2020201365
Santos, M. L. O., Marchiori, E., Vianna, a. d., Souza Jr, A. S. & Moraes, H. P. (2003). Opacidades em vidro fosco nas doenças pulmonares difusas: correlação da tomografia computadorizada de alta resolução com a anatomopatologia. Radiol Bras., 36(6). https://doi.org/10.1590/S0100-39842003000600003
Shi, H., Han, X., Jiang, N, Cao, Y., Alwalid, O., Gu, J., Fan, Y. & Zheng, C. (2020). Radiological findings from 81 patients with COVID-19 pneumonia in Wuhan, China: a descriptive study. The Lancet Infectious Diseases, 20(4), 425-434. DOI:https://doi.org/10.1016/S1473-3099(20)30086-4
Souza Jr, A. S., Neto, C. A., Jasinovodolinsky, D., Marchiori, E., Kavakama, J., et al. (2002). Terminologia para a descrição de Tomografia Computadorizada do Tórax: Sugestões iniciais para um consenso brasileiro. Radiol Bras., 35(2), 125-128. https://doi.org/10.1590/S0100-39842002000200016
Toussie, A., Voutsinas, N., Finkelstein, M., Cedillo, M. A., Manna, S., Maron, S. Z., Jacobi., A., Chung, M., Bernheim, A., Eber, C., Concepcion, J., Fayad, Z. A. & Gupta, S. (2020). Clinical and Chest Radiography Features determine patient outcomes in young and middle-aged adults with COVID-19. Radiologia, 297(1), 201754. https://doi.org/10.1148/radiol.2020201754
Vardavas, C. I. & Nikitara, K. (2020). COVID-19 and smoking: A systematic review of the evidence. Tobacco Induced Diseases, 18:20. doi: 10.18332/tid/119324.
Wang, M., Cao, R., Zhang, L., Yang, X., Liu, J., Xu, M., Shi, Z., Hu, Z., Zhong, W. & Xiao, G. (2020). Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell research, 30, 269-271.
World Health Organization. (2020, January 9). WHO statement regarding cluster of pneumonia cases in Wuhan, China. Retrieved from https://www.who.int/china/news/detail/09-01-2020-who-statement-regarding-cluster-of-pneumonia-cases-in-wuhan-china
World Health Organization. (2020, May 8). Painel da Doença de Coronavírus da OMS (COVID-19). Retrieved from https://covid19.who.int/
Wu, D., Wu, T., Liu, Q. & Yang, Z. (2020). The SARS-CoV-2 outbreak: What we know. International Journal of Infectious Diseases, 94, 44-48. doi: 10.1016/j.ijid.2020.03.004.
Zhang, J-J., Dong, X., Cao, Y-Y., Yuan, Y-D., Yang, Y-B., Yan, Y-Q., Akdis, C. A. & Gao, Y-D. (2020). Clinical characteristics of 140 patients infected with SARS-CoV-2 in Wuhan, China. Allergy, 75(7), 1730-1741. doi: 10.1111/all.14238.
Zheng, Z., Yao, Z., Wu, K. & Zheng, J. (2020). The diagnosis of pandemic coronavirus pneumonia: A review of radiology examination and laboratory test. Journal of Clinical Virology, (128), 104396. doi: 10.1016/j.jcv.2020.104396.
Zhou, F., Yu, T., Du, R., Fan, G., Liu, Y., Liu, Z., Xiang, J., Wang, Y., Song, B., Gu, X., Guan, L., Wei, Y., Li, H., Wu, X., Xu, J., Tu, S., Zhang, Y., Chen, H. & Cao, B. (2020). Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet, 395(10229), 1054-1062. doi: 10.1016/S0140-6736(20)30566-3.
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Copyright (c) 2021 Caio Robert Rodrigues Martins de Souza; Danilo Lopes Santos; Larissa Maria Freire de Melo; Lumar Lucena Alves; Luiz André Santos Silva; Natália Jamille Alves de Santana; Míriam Clécia de Oliveira Santos; Thatyane Gama Carvalho; Jonas Prata Estevão dos Santos; Tereza Tizar Alves Oliveira; Ingridy Evangelista Viana Lucena; Raphaella Ingrid Santana Oliveira
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