Evaluation of the antibacterial activity of Punica granatum Linn. (Pomegranate) against oral bacteria: An integrative review
DOI:
https://doi.org/10.33448/rsd-v10i7.16238Keywords:
Pomegranate; Dentistry; Phytotherapy; Antibacterial.Abstract
Sabe-se que há um grande potencial de plantas medicinais com atividade antibacteriana, tornando-se alternativa para o combate às infecções. Dentre as plantas medicinais destaca-se a Punica granatum Linn. (Romã), que possui compostos bioativos utilizados para o tratamento de doenças e é utilizada como antisséptico oral para tratar a dor de garganta. Assim, o estudo apresentou como objetivo avaliar a atividade antibacteriana de Punica granatum L. frente a bactérias orais. Para isso, foi realizada uma revisão integrativa, com busca de artigos nas bases de dados PubMed, LILACS e SciELO, utilizando os termos “punica granatum”, “pomegranate”’, “dentistry”, “mouth” e “oral”. Foram selecionados artigos de acordo com os seguintes critérios para inclusão: artigos originais disponíveis na íntegra, publicados nos idiomas inglês, espanhol ou português e publicados nos últimos 10 anos (2010 a 2020). A busca resultou em 126 artigos e após leitura de título e resumo, 16 artigos atenderam aos objetivos da pesquisa e foram incluídos na revisão. Os resultados demonstram que há efeitos antibacterianos principalmente a partir de estudos in vitro (n=13; 81,25%), com ação, na maioria dos estudos da revisão, sobre Streptococcus mutans e outras espécies de Streptococcus orais. Através das análises, constata-se que diferentes formas de utilização do material da planta possuem atividade antibacteriana in vivo e in vitro, em especial o extrato da casca. Portanto, a utilização da romã tem potencial antibacteriano podendo ser uma alternativa para prevenção e terapêutica de infecções orais.
References
Abdel Moneim A. E. (2012). Evaluating the potential role of pomegranate peel in aluminum-induced oxidative stress and histopathological alterations in brain of female rats. Biological trace element research, 150(1-3), 328–336. https://doi.org/10.1007/s12011-012-9498-2
Abdollahzadeh, S. h., Mashouf, R., Mortazavi, H., Moghaddam, M., Roozbahani, N., & Vahedi, M. (2011). Antibacterial and antifungal activities of punica granatum peel extracts against oral pathogens. Journal of dentistry (Tehran, Iran), 8(1), 1–6. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3184731/
American Dental Association. (2008). Acceptance program guidelines. Chemotherapeutic products for control of gingivitis. Chicago: American Dental Association Council on Scientific Affairs. https://www.yumpu.com/en/document/read/19431269/chemotherapeutic-products-for-the-control-of-gingivitis-american-
Antonio, Gisele Damian, Tesser, Charles Dalcanale, & Moretti-Pires, Rodrigo Otávio. (2013). Contributions of medicinal plants to care and health promotion in primary healthcare. Interface - Comunicação, Saúde, Educação, 17(46), 615-633. Epub August 23, 2013. https://doi.org/10.1590/S1414-32832013005000014
Aparecida Procópio Gomes, L., Alves Figueiredo, L. M., Luiza do Rosário Palma, A., Corrêa Geraldo, B. M., Isler Castro, K. C., Ruano de Oliveira Fugisaki, L., Jorge, A., de Oliveira, L. D., & Junqueira, J. C. (2016). Punica granatum L. (Pomegranate) Extract: In Vivo Study of Antimicrobial Activity against Porphyromonas gingivalis in Galleria mellonella Model. TheScientificWorldJournal, 2016, 8626987. https://doi.org/10.1155/2016/8626987
Assaf, A. M., Amro, B. I., Mashallah, S., & Haddadin, R. N. (2016). Antimicrobial and anti-inflammatory potential therapy for opportunistic microorganisms. Journal of infection in developing countries, 10(5), 494–505. https://doi.org/10.3855/jidc.7610
Bagri, P., Ali, M., Aeri, V., Bhowmik, M., & Sultana, S. (2009). Antidiabetic effect of Punica granatum flowers: effect on hyperlipidemia, pancreatic cells lipid peroxidation and antioxidant enzymes in experimental diabetes. Food and chemical toxicology: an international journal published for the
British Industrial Biological Research Association, 47(1), 50–54. https://doi.org/10.1016/j.fct.2008.09.058
Behera, S., Khetrapal, P., Punia, S. K., Agrawal, D., Khandelwal, M., & Lohar, J. (2017). Evaluation of Antibacterial Activity of Three Selected Fruit Juices on Clinical Endodontic Bacterial Strains. Journal of pharmacy & bioallied sciences, 9(Suppl 1), S217–S221. https://doi.org/10.4103/jpbs.JPBS_164_17
Botelho, L. L. R., de Almeida Cunha, C. C., & Macedo, M. (2011). O método da revisão integrativa nos estudos organizacionais. Gestão e sociedade, 5(11), 121-136. https://www.gestaoesociedade.org/gestaoesociedade/article/view/1220
Brasil. Ministério da saúde. Secretaria de ciência, tecnologia e insumos estratégicos. Departamento de assistência farmacêutica. (2006). Política nacional de plantas medicinais e fitoterápicos. http://bvsms.saude.gov.br/bvs/publicacoes/politica_nacional_fitoterapicos.pdf
Chinsembu K. C. (2016). Plants and other natural products used in the management of oral infections and improvement of oral health. Acta tropica, 154, 6–18. https://doi.org/10.1016/j.actatropica.2015.10.019
da Silva, G. G., de Souza, J. H. A., de Moura Lima, A. E. C., da Rocha Santos, L. M., Pinheiro, J. C., Leite, R. B., ... & Macedo, M. R. C. (2020). Atividade antimicrobiana de substâncias fitoterápicas utilizadas no tratamento de afecções bucais: estudo in vitro. Revista Ciência Plural, 6(2), 113-124. https://pesquisa.bvsalud.org/portal/resource/pt/biblio-1100316
Dahham, S. S., Ali, M. N., Tabassum, H., & Khan, M. (2010). Studies on antibacterial and antifungal activity of pomegranate (Punica granatum L.). Am. Eurasian J. Agric. Environ. Sci, 9(3), 273-281. https://portal.arid.my/Publications/148b7c19-cf2e-4e8.pdf
de Medeiros Nóbrega, D. R., Santos, R. L., Soares, R. D. S. C., Alves, P. M., Medeiros, A. C. D., & Pereira, J. V. (2015). A randomized, controlled clinical trial on the clinical and microbiological efficacy of Punica granatum Linn mouthwash. Pesquisa Brasileira em Odontopediatria e Clínica Integrada, 15(1). https://pesquisa.bvsalud.org/portal/resource/pt/lil-796375
de Oliveira, J. R., de Castro, V. C., das Graças Figueiredo Vilela, P., Camargo, S. E., Carvalho, C. A., Jorge, A. O., & de Oliveira, L. D. (2013). Cytotoxicity of Brazilian plant extracts against oral microorganisms of interest to dentistry. BMC complementary and alternative medicine, 13, 208. https://doi.org/10.1186/1472-6882-13-208
Derks, A., Frencken, J., Bronkhorst, E., Kuijpers-Jagtman, A. M., & Katsaros, C. (2008). Effect of chlorhexidine varnish application on mutans streptococci counts in orthodontic patients. American journal of orthodontics and dentofacial orthopedics: official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics, 133(3), 435–439. https://doi.org/10.1016/j.ajodo.2007.10.024
Duman, A. D., Ozgen, M., Dayisoylu, K. S., Erbil, N., & Durgac, C. (2009). Antimicrobial activity of six pomegranate (Punica granatum L.) varieties and their relation to some of their pomological and phytonutrient characteristics. Molecules (Basel, Switzerland), 14(5), 1808–1817. https://doi.org/10.3390/molecules14051808
Dziedzic, A., Kubina, R., Wojtyczka, R. D., Kabała-Dzik, A., Tanasiewicz, M., & Morawiec, T. (2013). The antibacterial effect of ethanol extract of polish propolis on mutans streptococci and lactobacilli isolated from saliva. Evidence-based complementary and alternative medicine: eCAM, 2013, 681891. https://doi.org/10.1155/2013/681891
Ferrazzano, G. F., Scioscia, E., Sateriale, D., Pastore, G., Colicchio, R., Pagliuca, C., Cantile, T., Alcidi, B., Coda, M., Ingenito, A., Scaglione, E., Cicatiello, A. G., Volpe, M. G., Di Stasio, M., Salvatore, P., & Pagliarulo, C. (2017). In Vitro Antibacterial Activity of Pomegranate Juice and Peel Extracts on Cariogenic Bacteria. BioMed research international, 2017, 2152749. https://doi.org/10.1155/2017/2152749
Gunsolley J. C. (2010). Clinical efficacy of antimicrobial mouthrinses. Journal of dentistry, 38 Suppl 1, S6–S10. https://doi.org/10.1016/S0300-5712(10)70004-X
Hajifattahi, F., Moravej-Salehi, E., Taheri, M., Mahboubi, A., & Kamalinejad, M. (2016). Antibacterial Effect of Hydroalcoholic Extract of Punica granatum Linn. Petal on Common Oral Microorganisms. International journal of biomaterials, 2016, 8098943. https://doi.org/10.1155/2016/809894
Hofer, D., Meier, A., Sener, B., Guggenheim, B., Attin, T., & Schmidlin, P. R. (2011). Biofilm reduction and staining potential of a 0.05% chlorhexidine rinse containing essential oils. International journal of dental hygiene, 9(1), 60–67. https://doi.org/10.1111/j.1601-5037.2009.00437.x
How, K. Y., Song, K. P., & Chan, K. G. (2016). Porphyromonas gingivalis: An Overview of Periodontopathic Pathogen below the Gum Line. Frontiers in microbiology, 7, 53. https://doi.org/10.3389/fmicb.2016.00053
Jardini, F. A., De Lima, A., Mendonca, R. M. Z., Pinto, R. J., Mancini, D. A. P., & Mancini-Filho, J. (2010). Phenolic compounds from pulp and seeds of pomegranate (Punica granatum, L.): antioxidant activity and protection of MDCK cells/Compostos fenolicos da polpa e sementes de roma (Punica granatum, l.): atividade antioxidante e protetora em celulas MDCK. Alimentos e Nutricao [Brazilian Journal of Food and Nutrition], 21(4), 509+. https://link.gale.com/apps/doc/A340423408/HRCA?u=anon~603fdefd&sid=HRCA&xid=0730516a
Jurenka J. S. (2008). Therapeutic applications of pomegranate (Punica granatum L.): a review. Alternative medicine review: a journal of clinical therapeutic, 13(2), 128–144. https://pubmed.ncbi.nlm.nih.gov/18590349/
Koo, H., Rosalen, P. L., Cury, J. A., Park, Y. K., & Bowen, W. H. (2002). Effects of compounds found in propolis on Streptococcus mutans growth and on glucosyltransferase activity. Antimicrobial agents and chemotherapy, 46(5), 1302–1309. https://doi.org/10.1128/aac.46.5.1302-1309.2002
Kote, S., Kote, S., & Nagesh, L. (2011). Effect of pomegranate juice on dental plaque microorganisms (streptococci and lactobacilli). Ancient science of life, 31(2), 49–51. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3530267/
Leite, S. J. O., de Oliveira, F. M., Almeida, L. M. S., Gusmão, M. A. N., Chedier, L. M., Vasconcelos, E. G., ... & Pinto, P. F. (2014). In vitro assessment of the antimicrobial effects of pomegranate (Punica granatum L.) peel decoction on saliva samples. Revista de Ciências Farmacêuticas Básica e Aplicada, 35(1). https://pesquisa.bvsalud.org/portal/resource/pt/lil-718823
Lorenzi, H., & Matos, F. J. (2002). Plantas medicinais no Brasil: nativas e exóticas. http://www.sidalc.net/cgi-bin/wxis.exe/?IsisScript=LIBROS.xis&method=post&formato=2&cantidad=1&expresion=mfn=008440
Mahboubi, A., Asgarpanah, J., Sadaghiyani, P. N., & Faizi, M. (2015). Total phenolic and flavonoid content and antibacterial activity of Punica granatum L. var. pleniflora flowers (Golnar) against bacterial strains causing foodborne diseases. BMC complementary and alternative medicine, 15, 366. https://doi.org/10.1186/s12906-015-0887-x
Matias, I. J. S. E. F., & Coutinho, I. R. M. H. D. (2013). Modulation of the antibiotic activity by the essential oils of Origanum vulgare and Coriandrum sativum. Journal of Food and Nutrition Research, 52(3), 191-194. file:///C:/Users/USUARIO/Downloads/jfnr20133p_6%20(2).pdf
Mehta, V. V., Rajesh, G., Rao, A., Shenoy, R., & B H, M. P. (2014). Antimicrobial Efficacy of Punica granatum mesocarp, Nelumbo nucifera Leaf, Psidium guajava Leaf and Coffea Canephora Extract on Common Oral Pathogens: An In-vitro Study. Journal of clinical and diagnostic research: JCDR, 8(7), ZC65–ZC68. https://doi.org/10.7860/JCDR/2014/9122.4629
Menezes, S. M., Cordeiro, L. N., & Viana, G. S. (2006). Punica granatum (pomegranate) extract is active against dental plaque. Journal of herbal pharmacotherapy, 6(2), 79–92. https://pubmed.ncbi.nlm.nih.gov/17182487/
Millo, G., Juntavee, A., Ratanathongkam, A., Nualkaew, N., Peerapattana, J., & Chatchiwiwattana, S. (2017). Antibacterial Inhibitory Effects of Punica Granatum Gel on Cariogenic Bacteria: An in vitro Study. International journal of clinical pediatric dentistry, 10(2), 152–157. https://doi.org/10.5005/jp-journals-10005-1426
Palmer, E. A., Vo, A., Hiles, S. B., Peirano, P., Chaudhry, S., Trevor, A., Kasimi, I., Pollard, J., Kyles, C., Leo, M., Wilmot, B., Engle, J., Peterson, J., Maier, T., & Machida, C. A. (2012). Mutans streptococci genetic strains in children with severe early childhood caries: follow-up study at one-year post-dental rehabilitation therapy. Journal of oral microbiology, 4, 10.3402/jom. v4i0.19530. https://doi.org/10.3402/jom.v4i0.19530
Santos, Esther Bandeira, Dantas, Gesira Soares, Santos, Hosana Bandeira, Diniz, Margareth F. F. Melo, & Sampaio, Fabio Correia. (2009). Estudo etnobotânico de plantas medicinais para problemas bucais no município de João Pessoa, Brasil. Revista Brasileira de Farmacognosia, 19(1b), 321-324. https://doi.org/10.1590/S0102-695X2009000200024
Sateriale, D., Facchiano, S., Colicchio, R., Pagliuca, C., Varricchio, E., Paolucci, M., Volpe, M. G.,
Salvatore, P., & Pagliarulo, C. (2020). In vitro Synergy of Polyphenolic Extracts from Honey, Myrtle and Pomegranate Against Oral Pathogens, S. mutans and R. dentocariosa. Frontiers in microbiology, 11, 1465. https://doi.org/10.3389/fmicb.2020.01465
Vahabi, S., Najafi, E., & Alizadeh, S. (2011). In vitro antimicrobial effects of some herbal essences against oral pathogens. Journal of Medicinal Plants Research, 5(19), 4870-4878. https://academicjournals.org/article/article1380735018_Vahabi%20et%20al.pdf
Vahid Dastjerdi, E., Abdolazimi, Z., Ghazanfarian, M., Amdjadi, P., Kamalinejad, M., & Mahboubi, A. (2014). Effect of Punica granatum L. Flower Water Extract on Five Common Oral Bacteria and Bacterial Biofilm Formation on Orthodontic Wire. Iranian journal of public health, 43(12), 1688–1694. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4499091/
Vahid-Dastjerdi, E., Monadi, E., Khalighi, H. R., & Torshabi, M. (2016). Down-Regulation of Glycosyl Transferase Genes in Streptococcus Mutans by Punica Granatum L. Flower and Rhus Coriaria L. Fruit Water Extracts. Iranian journal of pharmaceutical research: IJPR, 15(2), 513–519. https://pubmed.ncbi.nlm.nih.gov/27642322/
Vasconcelos, L. C., Sampaio, M. C., Sampaio, F. C., & Higino, J. S. (2003). Use of Punica granatum as an antifungal agent against candidosis associated with denture stomatitis. Mycoses, 46(5-6), 192–196. https://doi.org/10.1046/j.1439-0507.2003.00884.x
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