Epidemiological characterization of immediate transfusion reactions in a public teaching hospital

Authors

DOI:

https://doi.org/10.33448/rsd-v10i9.16635

Keywords:

Transfusion reaction; Blood transfusion; Protocols; Blood safety; Epidemiologic studies.

Abstract

Objectives: To characterize immediate Transfusion Reactions (RT) and analyze the means for diagnosing these reactions. Methodology: This is a research with a retrospective, exploratory and descriptive longitudinal design, carried out at a Public University Hospital in Aracaju – SE, Brazil. All ethical aspects were respected approved by the Research Ethics Committee of the Federal University of Sergipe, data collection took place between 2019 and 2020. Data on transfusion reactions were extracted from the hospital's notification system and were characterized according to national and international protocols, as to the imputability of a Transfusional Reaction with clinical and laboratory criteria and with the temporal bond. The statistical analysis performed on the data was descriptive and inferential according to the researchers' variables and objectives. Results: The date of the transfusion incident and the notification in the system provided an average time of 3.91 days for professionals to notify the TRs. The transfusion history was not completed in 85% (67) of the notifications. The possibility of RT recurrences in these patients occurred between 1 to 18 days after the initial event and only 27% (n=3) were in different units. Final considerations: Transfusion reactions when notified demonstrate a rich source for more adequate care for patients undergoing transfusion treatment with blood components.

Author Biographies

Aline Bezerra Silva, Federal University of Sergipe

Graduated in Nursing from the Catholic University of Salvador(1999), specialization in Specialization Course in Patient Safety for Network professionals from Oswaldo Cruz Foundation(2017), specialization in SPECIALIZATION IN OCCUPATIONAL NURSING from Castelo Branco University(2008), and specialization in SPECIALIZATION COURSE IN SURGICAL MEDICAL NURSING IN THE FORM OF RESID at Universidade Federal da Bahia (2004). She is currently an Intensive Care Nurse at Hospital Universitário de Sergipe and a Member of the Advisory Committee at HOSPITAL UNIVERSITÁRIO DE SERGIPE. She has experience in the field of Nursing.

Adicinéia Aparecida de Oliveira, Federal University of Sergipe

Graduated in Business Administration from Universidade Cruzeiro do Sul (1987), Master's in Administration from Pontifical Catholic University of São Paulo (1995), and Ph.D. in Electrical Engineering from Universidade de São Paulo (2005). She is currently Associate Professor II at the Department of Computing at the Federal University of Sergipe and Head of the Process Management and Information Technology Sector at the University Hospital of UFS / EBSERH. She has experience in the field of Computer Science, with an emphasis on Information Systems, Software Engineering, ICT Management, Health Informatics, and Digital Health. She is the leader of the Study and Research Group on Health Informatics (GEPIS) at UFS. She works in the Postgraduate Program of Professional Masters in Management and Technological Innovation in Health (PPGITS) at UFS.

Juliana de Oliveira Musse Silva , Tiradentes University

Graduated in Nursing from the Catholic University of Salvador (2010), Postgraduate in Intensive Care from Faculdade São Francisco da Paraíba (2014); Master in Public Health from the State University of Paraíba (2013); Doctor of the Postgraduate Program in Health and Environment - Unit. Lines of action: Public Health and Forensic Nursing. Adjunct Professor I at Tiradentes University - SE. Coordinator of Professional Practices of the Brazilian Nursing Association - SE. First Secretary of the Brazilian Society of Forensic Nursing - SOBEF

Gleyce Kelly de Brito Brasileiro Santos , Federal University of Sergipe

Master's Student in Nursing from the Post-Graduate Program in Nursing at the Federal University of Sergipe, Post-Graduate Student at the MBA in Hospital Management and Infection Control at INESP, Specialist in Adult and Elderly Health by the Multiprofessional Residency Program at UFS, Company Nurse Brazilian of Hospital services with a position in the Skin Care Committee of the University Hospital of Sergipe and a Nurse at the Federal University of the Nursing Department at the Campus de Lagarto. She has experience in the Nursing Care area (surgical center, Materials, and Sterilization Center, Medical and surgical clinic) and in the Hospital Infection Control Commission. Technique in Informatics - systems analysis and object-oriented programming by the Federal Institute of Sergipe (2002).

Rafael Braga Esteves, University of São Paulo

Ph.D. in Sciences (Direct Doctorate) by the Graduate Program in Psychiatric Nursing at Ribeirão Preto College of Nursing, University of São Paulo (2020). During this period, he was a CAPES doctoral fellow in Brazil and a fellow of the Sandwich Doctorate Program Abroad, PDSE / CAPES, for an international internship at the University of Alberta, Canada (2019). Specialist in Forensic Nursing, the title conferred by the Brazilian Society in Forensic Nursing (2019). Specialist in Health Services Evaluation, the title conferred by the Federal University of Health Sciences of Porto Alegre and Open University of the Unified Health System (2015). Bachelor and Licentiate in Nursing from the School of Nursing of Ribeirão Preto, USP (2013), during his undergraduate studies he did an exchange at the University of Alberta, Canada through the Academic Merit Scholarship - USP (2013). He completed the Sexual Assault Nurse Examine - SANE (2019) course. The researcher has already developed and participated in research and university extension projects and collaborated in scientific events related to Forensic Nursing. Founding member of the Brazilian Society of Forensic Nursing. E, Member of the Academy of Forensic Nursing. He is currently a collaborating member of the Academic League of Forensic Nursing at the Ribeirão Preto College of Nursing, USP. He is Technical Support for Research at the same Educational Institution through the Level 3 Technical Training Training Program, sponsored by the São Paulo State Research Support Foundation-FAPESP.

Ângela Maria da Silva, Federal University of Sergipe

Graduated in Medicine from the Federal University of Sergipe (1985), Master in Tropical Medicine from the University of Brasília (1990), and Ph.D. in Infectious Diseases from the Federal University of São Paulo (2001). She is currently on the editorial board of Gazeta Médica da Bahia, Revista Pan-Americana de Infectologia, and associate professor of DIP at the Department of Medicine at the Federal University of Sergipe. She has experience in Medicine, with an emphasis on Infectious and Parasitic Diseases, acting on the following topics: Clinical Immunology Schistosomiasis, Leptospirosis, Visceral Leishmaniasis, Tuberculosis, Chagas Disease, and HIV / AIDS and cardiovascular repercussion in patients with the disease under treatment

References

Adkins, B. D., Lawicki, S., Johnson, M., & Eichbaum, Q. (2019). Mild Allergic Transfusion Reactions. American Journal of Clinical Pathology, 151(3), 344–348. https://doi.org/10.1093/ajcp/aqy150

Agência Nacional de Vigilância Sanitária - ANVISA. (2015). Marco Conceitual e Operacional de Hemovigilância: Guia para a Hemovigilância no Brasil. Brasília, Brasil.

Agência Nacional de Vigilância Sanitária - ANVISA. (2016). Hemovigilância no Brasil - Relatório consolidado 2007 - 2015. Brasilia. Retrieved from https://www.gov.br/anvisa/pt-br/assuntos/fiscalizacao-e-monitoramento/hemovigilancia/publicacoes/hemovigilancia-no-brasil-relatorio-consolidado-2007-2015.pdf/view

Agence nationale de sécurité du medicament - ANSM. (2018). Sécurité du Médicament et des produits de Santé. ANSM. L’ANSM publie le rapport d’activité hémovigilance 2018. Retrieved from https://ansm.sante.fr/qui-sommes-nous/publications-institutionnelles/publications-2019

Aubron, C., Aries, P., Le Niger, C., Sparrow, R. L., & Ozier, Y. (2018). How clinicians can minimize transfusion-related adverse events? Transfusion Clinique et Biologique, 25(4), 257–261. https://doi.org/10.1016/j.tracli.2018.08.158

Borges, K. V., Souza, M. A., Masiero, A. V., & Souza, P. A. (2020). Análise da Eficácia Transfusional através dos Exames Pré e Pós Transfusionais Em Idosos no Hospital Tereza Ramos em Lages, Santa Catarina. Hematology, Transfusion and Cell Therapy, 42(S2), 371. https://doi.org/10.1016/j.htct.2020.10.624

Bosboom, J. J., Klanderman, R. B., Peters, A. L., van de Weerdt, E. K., Goudswaard, E. J., Binnekade, J. M., … Vlaar, A. P. (2018). The practice of diagnosing and reporting transfusion-associated circulatory overload: a national survey among physicians and haemovigilance officers. Transfusion Medicine, 28(5), 363–370. https://doi.org/10.1111/tme.12480

Brasil. Resolução no 466, de 12 de dezembro de 2012. Dispõe sobre diretrizes e normas regulamentadoras de pesquisas envolvendo seres humanos. , Diário Oficial da União § (2012). BRASIL.

Bueno, C. S., Milani, C. L. de S., & Soares, S. C. de L. (2019). Epidemiologia das reações tranfusionais imediatas notificadas em um hospital de alta complexidade no interior de Rondônia. Revista Recien - Revista Científica de Enfermagem, 9(25), 77. https://doi.org/10.24276/rrecien2358-3088.2019.9.25.77-84

Canadian Blood Services - CBS. (2017). System Progress Reports. Retrieved from https://www.blood.ca/en/about-us/publications-and-reports/system-progress-reports.

Center for Disease Control/National Healthcare Safety Network - CDC/NHSN. (2018). NHSN Biovigilance Component, Hemovigilance Module Protocol. The United States of America. Retrieved from https://www.cdc.gov/nhsn/acute-care-hospital/bio-hemo/index.html.

Center for Disease Control/National Healthcare Safety Network - CDC/NHSN. (2021). National Healthcare Safety Network biovigilance component hemovigilance module surveillance Protocol v2.6. The United States of America. Retrieved from https://www.cdc.gov/nhsn/pdfs/biovigilance/bv-hv-protocol-current.pdf.

Coberly, E. A., & Booth, G. S. (2016, February 1). Ten-year retrospective review of transfusion practices in beating-heart organ donors. Transfusion, Vol. 56, pp. 339–343. Blackwell Publishing Inc. https://doi.org/10.1111/trf.13340.

Conselho Federal de Enfermagem - COFEN. Resolução Cofen no 511 de 29 de março de 2016 Conselho Federal de Enfermagem - Brasil. , Diário Oficial da União § (2016).

Empresa Brasileira de Serviços Hospitalares - Ebserh. (2021). Procedimento Operacional Padrão Código: POP ENF 15.1 Rotina de Instalação de Hemocomponentes para Transfusão. Rio de Janeiro.

Frantz, S. R. de S., Vargas, M. A. de O., Pires, D. E. P. de, Brito, M. J. M., Bitencourt, J. V. de O. V., & Ribeiro, G. (2020). Nursing work and competence in hemotherapy services: an ergological approach. Revista Brasileira de Enfermagem, 73(3), e20180775. https://doi.org/10.1590/0034-7167-2018-0775.

Gehrie, E. A., Hendrickson, J. E., & Tormey, C. A. (2015). Measuring the influence of blood component infusion rate on recipient vital signs. Vox Sanguinis, 109(4), 353–358. https://doi.org/10.1111/vox.12310.

Goel, R., Tobian, A. A. R., & Shaz, B. H. (2019). Noninfectious transfusion-associated adverse events and their mitigation strategies. Blood, 133(17), 1831–1839. https://doi.org/10.1182/blood-2018-10-833988.

Grandi, J. L., Grell, M. C., Areco, K. C. N., & Barbosa, D. A. (2018). Hemovigilância: a experiência da notificação de reações transfusionais em Hospital Universitário. Revista Da Escola de Enfermagem Da USP, 52, e03331. https://doi.org/10.1590/s1980-220x2017010603331.

Gurgel, A. P., Melo, V. S. de, Leitão, J. S., Studart, R. M. B., Bonfim, I. M., & Barbosa, I. V. (2019). Paciente crítico: segurança em terapia transfusional mediante lista de verificações. Revista Brasileira de Ciências Da Saúde, 23(4), 525–534. https://doi.org/10.22478/ufpb.2317-6032.2019v23n4.37205

Hinkle, D. E., Wiersma, W., & Jurs, S. G. (2003). Applied statistics for the behavioral sciences (Vol. 663). Houghton Mifflin College Division.

Instituto Português do Sangue e da Transplantação - IPST. (2016). Instituto Português do Sangue e da Transplantação. Retrieved from https://www.ine.pt/xportal/xmain?xpid=INE&xpgid=ine_indicadores&indOcorrCod=0006132&contexto=bd&selTab=tab2.

Instituto Português do Sangue e da Transplantação - IPST. (2019). Algoritmos de notificação o de Reação es Adversas em Receptores Sistema Português de Hemovigilância. Retrieved from http://ipst.pt/index.php/pt/dados-estatisticos-transplantacao.

International Society of Blood Transfusion/International Haemovigilance Network, ISBT/IHN. (2019). Definição revisada de caso de vigilância internacional de sobrecarga circulatória associada à transfusão: uma classificação estudo de validação de contrato. Retrieved from https://www.isbtweb.org/

.

Kasim, J., Aldarweesh, F., & Connor, J. P. (2019). Blood product and laboratory resource wastage in non‐severe allergic transfusion reactions: an opportunity for improvement. Transfusion Medicine, 29(5), 338–343. https://doi.org/10.1111/tme.12630.

Kathryn E. Webert, & Nancy M. Heddle. (2017). Investigation of Acute Transfusion Reactions. In M. F. Murphy & D. H. Pamphilon (Eds.), Practical Transfusion Medicine (5th ed., pp. 69–80). Oxford, UK: Blackwell Publishing Ltd. Retrieved from http://doi.wiley.com/10.1002/9780470988411.

Kenar, G., Köksoy, E. B., Ürün, Y., & Utkan, G. (2020). Prevalence, etiology and risk factors of anemia in patients with newly diagnosed cancer. Supportive Care in Cancer, 28(11), 5235–5242. https://doi.org/10.1007/s00520-020-05336-w.

Kim, J., & Na, S. (2015). Transfusion-related acute lung injury; clinical perspectives. Korean Journal of Anesthesiology, 68(2), 101. https://doi.org/10.4097/kjae.2015.68.2.101

Lee, S. J., Wang, H., Ahn, S. H., Son, M. K., Hyun, G. H., Yoon, S. J., … Kwon, S. W. (2019). Metabolomics Approach Based on Multivariate Techniques for Blood Transfusion Reactions. Scientific Reports, 9(1), 1740. https://doi.org/10.1038/s41598-018-37468-9.

Marconi, M., & Lakatos, E. (2003). Fundamentos de metodologia científica. In Editora Atlas S. A. (6th ed.). https://doi.org/10.1590/S1517-97022003000100005

Nazário, S. da S., Barancelli, M. D. C., Gandolfi, M., Marcondes, C., & Lilian Moura de Lima Spagnolo. (2019). Educação permanente de equipe de enfermagem em reação transfusional. Rev. Enferm. UFPE on Line, 13(2), 307–314. https://doi.org/10.5205/1981-8963-v13i2a237361p307-314-2019.

National Healthcare Safety Network - NHSN. (2021). National Healthcare Safety Network biovigilance component hemovigilance module surveillance Protocol. Atlanta. Retrieved from https://www.cdc.gov/nhsn/pdfs/biovigilance/bv-hv-protocol-current.pdf.

Ozier, Y., Aubron, C., & Nguyen, B.-V. (2016). Anémies nosocomiales : réalité, conséquences et prévention. Transfusion Clinique et Biologique, 23(4), 185–191. https://doi.org/10.1016/j.tracli.2016.07.005.

Reese, F. B. (2017). Plasma e Concentrado de Complexo Protrombínico. In PROAMI Programa de Atualização em Medicina Intensiva (1st ed., Vol. 1, pp. 97-145.). Alegre: Artmed Panamericana.

Ribeiro, W. A., Faillace, G. B. D., Fassarella, B. P. A., Neves, K. do C., Fassarella, M. B., Silva, A. C. S. da, … Farias, B. S. (2020). Protagonização do médico na segurança do paciente nas reações transfusionais: uma revisão integrativa. Research, Society and Development, 9(7), e572974597. https://doi.org/10.33448/rsd-v9i7.4597.

Rodrigues, A. D., & Ribeiro, L. R. (2021). Sistemas sanguíneos, incompatibilidade e procedimentos alternativos à transfusão. Brazilian Journal of Development, 7(2), 13007–13027. https://doi.org/10.34117/bjdv7n2-085.

Sahu, A., & Bajpai, M. (2020). Determining the true incidence of acute transfusion reactions: Active surveillance at a specialized liver center. Hematology, Transfusion and Cell Therapy, 42(4), 326–332. https://doi.org/10.1016/j.htct.2019.09.006.

Santos, A. A. B. da S., Teixeira, J. D. C., Pereira, L. D. C. da S., & Silva, A. L. de A. (2020). Conhecimento de enfermeiros sobre reações transfusionais: revisão integrativa. Revista Recien - Revista Científica de Enfermagem, 10(31), 65–73. https://doi.org/10.24276/rerecien2020.10.31.65-73.

Serious Hazards of Transfusion - SHOT. (2019). New or Unclassifiable Complications of Transfusion (UCT). Retrieved from https://www.shotuk.org/wp-content/uploads/myimages/19.-New-or-Unclassifiable-Complications-of-Transfusion-UCT.pdf.

Simons, F. E. R., Ebisawa, M., Sanchez-Borges, M., Thong, B. Y., Worm, M., Tanno, L. K., … Sheikh, A. (2015). 2015 update of the evidence base: World Allergy Organization anaphylaxis guidelines. World Allergy Organization Journal, 8(1), 32. https://doi.org/10.1186/s40413-015-0080-1.

Soares, F. M. M., Cruz, R. C., Almeida, R. D., Da Silva Camilo, J. K., & Scopacasa, L. F. (2020). Avaliação dos registros de enfermagem acerca da reação transfusional. Revista Enfermagem Atual In Derme, 90(28). https://doi.org/10.31011/reaid-2019-v.90-n.28-art.511

Sobral, P. A. D. S., Göttems, L. B. D., & Santana, L. A. (2020). Hemovigilance and patient safety: analysis of immediate transfusion reactions in elderly. Revista Brasileira de Enfermagem, 73(suppl 3), e20190735. https://doi.org/10.1590/0034-7167-2019-0735.

Souza, V. R. de, Costa, A. J. da, Costa, M. A. F. da, Dantas, S. R., Vila, L. L., & Liparizi, S. de M. (2019). Atuação do enfermeiro frente uma reação transfusional: uma revisão bibliográfica. Arquivos Brasileiros de Medicina Naval, 80(1), 30–34. Retrieved from https://portaldeperiodicos.marinha.mil.br/index.php/abmn/article/download/179/211.

Suddock, J. T., & Crookston, K. P. (2019). Transfusion Reactions. In StatPearls. Cham: Springer International Publishing. https://doi.org/10.1007/978-3-319-74588-6_107.

Veiga, V. C., & Rojas, S. S. O. (2018). Como reduzir os riscos de eventos adversos em transfusão. In Associação de Medicina Intensiva Brasileira (1st ed., pp. 59–75). Porto Alegre: Artmed Panamericana.

Vlaar, A. P. J., Toy, P., Fung, M., Looney, M. R., Juffermans, N. P., Bux, J., … Kleinman, S. (2019). A consensus redefinition of transfusion‐related acute lung injury. Transfusion, 59(7), 2465–2476. https://doi.org/10.1111/trf.15311.

Downloads

Published

21/07/2021

How to Cite

SILVA, A. B. .; OLIVEIRA, A. A. de .; SILVA , J. de O. M.; SANTOS , G. K. de B. B. .; ESTEVES, R. B. .; SILVA, Ângela M. da. Epidemiological characterization of immediate transfusion reactions in a public teaching hospital. Research, Society and Development, [S. l.], v. 10, n. 9, p. e5110916635, 2021. DOI: 10.33448/rsd-v10i9.16635. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/16635. Acesso em: 23 nov. 2024.

Issue

Vol. 10 No. 9

Section

Health Sciences

License

Copyright (c) 2021 Aline Bezerra Silva; Adicinéia Aparecida de Oliveira; Juliana de Oliveira Musse Silva ; Gleyce Kelly de Brito Brasileiro Santos ; Rafael Braga Esteves; Ângela Maria da Silva

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors who publish with this journal agree to the following terms:

1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.