Vitamin D linked to high blood pressure




Hypovitaminosis D; Blood pressure levels; Public health.


The aim of the review was to verify the link between vitamin D and hypertension. The study is an integrative review based on the search for articles in the PubMed, Lilacs and Scielo databases, using as descriptors: “Vitamin D” associated with “hypertension”, “metabolic syndrome” and “cardiovascular diseases”. All researched in Portuguese and English. Original and review articles published from 2007 to 2018 were included. It was found that the majority of studies already conducted found interaction between hypovitaminosis D and the onset of hypertension, recommending the association of solar and dietary sources. supplementation to achieve significant levels of prevention. However, many authors highlight the absence of association, and when present, it is not significant, which suggests the development of new studies.




Barral, D.; Barros, A. C & Araújo, R. P. C. (2007). Vitamina D: Uma Abordagem Molecular. Pesq Bras OdontopedClinIntegr, 7(3), 309-315.

Beveridge, L. al. (2015). Effect of Vitamin D supplementation on blood pressure: A systematic review and meta-analysis incorporating individual. Patient data. JAMA Intern Med, 175(1), 745–754.

Carregueta O. M. (2016). A vitamina D e as doenças cardiovasculares. Revista Factores de Risco, 42(1), 42-46.

Forman, J. P. et al. (2005). Vitamin D intake and risk of incident hypertension: results from three large prospective cohort studies. Hypertension, 46(1), 676–682.

Forman, J. P.; Williams, J. S ¨& Fisher, N. D. (2010). Plasma 25-hydroxyvitamin D and regulation of the renin-angiotensin system in humans. Hypertension, 55(1), 1283–1288.

Freundlich, M.; Queiroz, Y & Zhang, Z. (2008). Suppression of renin-angiotensin gene expression in the kidney by paricalcitol. Kidney International, 74(1), 1394–1402.

Hilger, J. et al. (2014). A systematic review of vitamin D status in populations worldwide. Br J Nutr. 111(1), 23-45.

Holick, M. F. (2007). Vitamin D: deficiency. New England Journal of Medicine, 357(1), 266–281.

Jorde, R. et al. (2010). Serum 25-hydroxyvitamin D levels are strongly related to systolic blood pressure but do not predict future hypertension. Hypertension, 55(1), 792-798.

Jolfaie, R. N. et al. (2016). The association between Vitamin D and health outcomes in women: A review on the related evidence. J Res Med Sci, 21(1).

Krause, R. et al. (1998). Ultraviolet B and blood pressure. Lancet, 352(1), 709-710.

Kota, S. K. et al. (2011) Renin-angiotensin system activity in vitamin D deficient, obese individuals with hypertension: An urban Indian study. Endocrinol Metab, 15(1), 390–401.

Li, Y. C. et al. (2002). 1,25-Dihydroxyvitamin D(3) is a negative endocrine regulator of the renin-angiotensin system. J Clin Invest, 110(1), 229–238.

MirdamadI, A & Moshikdar, P. (2016). Benefício da correção da deficiêcia de vitamina D em pacientes com hipertensão pulomar. Capsain Journal of Internal Medicine, 7(4), 253-259.

Oliveira, R. M. et al. (2014). Association of vitamin D insufficiency with adiposity and metabolic disorders in Brazilian adolescents. Public Health Nutr, 17(4), 787-794.

Rafaelli, A. R. et al. (2015). Influencia da vitamina D nas doenças endocrinometabólicas. Semina: Ciências Biológicas e da saúde, 36(1), 333-348.

Santoro, D. et al. (2015). Interplay of vitamin D, erythropoiesis, and the renin-angiotensin system. Biomed Res Int, 145-148.

Schuch, N. J.; Garcia, V. C & Martini, L. A. (2009). Vitamina D e doenças endocrinometabólicas. Arquivos Brasileiros de Endocrinologia e Metabologia, 53(1), 625-633.

Scragg, R.; Sowers, M & Bell, C. (2007). Serum 25-hydroxyvitamin D, ethnicity, and blood pressure in the Third National Health and Nutrition Examination Survey. Am J Hypertens, 20(1), 713-719.

Shab-Bidar, S. et al. (2011). Regular consumption of vitamin D-fortified yogurt drink (Doogh) improved endothelial biomarkers in subjects with type 2 diabetes: a randomized double-blind clinical trial. BMC Med, 129-135.

Tamez, H. (2012). Vitamin D and hypertension: an update and review. Curr Opin Nephrol Hypertens, 21(1), 492-499.

Vimaleswaran, K. S. et al. (2014). Association of vitamin D status with arterial blood pressure and hypertension risk: a mendelian randomisation study. Lancet Diabetes Endocrinol, 2(1), 719-729.



How to Cite

BORGES, A. C. do N.; BEZERRA, J. B.; ALENCAR, V. Y. C.; SILVA, K. de A.; COSTA, A. A. A.; OLIVEIRA, B. G. S.; COSTA, A. L.; PORTELA, J. V. F.; BEZERRA, F. das C. L. Vitamin D linked to high blood pressure. Research, Society and Development, [S. l.], v. 9, n. 1, p. e110911691, 2020. DOI: 10.33448/rsd-v9i1.1691. Disponível em: Acesso em: 24 jan. 2022.



Review Article