The use of propranolol in child hemangioma therapy

Authors

DOI:

https://doi.org/10.33448/rsd-v10i8.16968

Keywords:

Therapeutics; Propranolol; Hemangioma; Child.

Abstract

Objective: To evaluate the use of propranolol as a therapeutic option for childhood hemangioma, describing the evidence found in the literature, about the advantages of this new therapy when compared to conventional therapies. Methods: This is a integrative literature review, with articles in the Virtual Health Library (VHL) and PubMed databases, in Portuguese and English, using the keywords "propranolol treatment", "propranolol", "infantile hemangioma" and “hemangioma of infancy”. Results: A total of 1876 articles were found in the literature search, in which, after applying the inclusion and exclusion criteria and the peer review, there were 18 articles to be read in full. Of the 18 articles, 1380 patients who met the inclusion criteria were included. A total of 56.5% were female and comprised the age range from 1 week of life to 9 years of age. Final considerations: Propranolol is considered an alternative therapy for the treatment of infantile hemangioma because of its high efficacy and less adverse effects.

References

Aly, M. M., Hamza, A. F., Kader, H. M. A., Saafan, H. A., Ghazy, M. S., & Ragab, I. A. (2015). Superioridade terapêutica do propranolol combinado com

curso curto de esteroides sobre a monoterapia com propranolol no hemangioma infantil. European journal of pediatrics, 174 (11), 1503-1509.

Abarzúa-Araya, Á., Navarrete-Dechent, C. P., Heusser, F., Retamal, J., & Zegpi-Trueba, M. S. (2014). Atenolol versus propranolol for the treatment of

infantile hemangiomas: a randomized controlled study. Journal of the American Academy of Dermatology, 70(6), 1045-1049.

Baselga, E., Dembowska-Baginska, B., Przewratil, P., González-Enseñat, M. A, Wyrzykowski, D., Torrelo, A., & Voisard, JJ (2018). Eficácia do propranolol

entre 6 e 12 meses de idade no hemangioma infantil de alto risco. Pediatrics, 142 (3).

Bauman, N. M., McCarter, R. J., Guzzetta, P. C., Shin, J. J., Oh, A. K., Preciado, D. A., & Puttgen, K. B. (2014). Propranolol vs prednisolone for symptomatic

proliferating infantile hemangiomas: a randomized clinical trial. JAMA Otolaryngology–Head & Neck Surgery, 140(4), 323-330.

Brasil. (2018). Protocolo Clínico e Diretrizes Terapêuticas Hemangioma Infantil. http://conitec.gov.br/images/Relatorios

/2018/PCDT_Hemangioma_Infantil.pdf.

Buckmiller, L. M., Munson, P. D., Dyamenahalli, U., Dai, Y., & Richter, G. T. (2010). Propranolol for infantile hemangiomas: early experience at a tertiary

vascular anomalies center. The Laryngoscope, 120(4), 676-681.

Ehsani, AH, Noormohammadpoor, P., Abdolreza, M., Balighi, K., Arianian, Z., & Daklan, S. (2014). Terapia combinada de hemangioma infantil com laser

corante pulsado com propranolol tópico: um ensaio clínico randomizado. Arquivos da medicina iraniana, 17 (10), 0-0.

Ge, J., Zheng, J., Zhang, L., Yuan, W., & Zhao, H. (2016). Propranolol oral combinado com timolol tópico para hemangiomas infantis compostos: um estudo

retrospectivo. Relatórios científicos, 6 (1), 1-7.

Hogeling, M., Adams, S., & Wargon, O. (2011). Um ensaio clínico randomizado de propranolol para hemangiomas infantis. Pediatrics, 128 (2), e259-e266.

Holmes, W. J. M., Mishra, A., Gorst, C., & Liew, S. H. (2011). Propranolol as first-line treatment for rapidly proliferating infantile haemangiomas. Journal of

plastic, reconstructive & aesthetic surgery, 64(4), 445-451.

Hu, L., Zhou, B., Huang, H., Chang, L., Qiu, Y., Ma, G., ... & Li, W. (2016). Efeitos do tratamento sistêmico com propranolol no crescimento físico de

pacientes com hemangiomas infantis. The Journal of dermatology, 43 (10), 1160-1166.

Janmohamed, S. R., Madern, G. C., Nieuwenhuis, K., de Laat, P. C., & Oranje, A. P. (2012). Evaluation of intra-lesional corticosteroids in the treatment of

peri-ocular haemangioma of infancy: still an alternative besides propranolol. Pediatric surgery international, 28(4), 393-398.

Ji, Y., Chen, S., Xiang, B., Xu, Z., Jiang, X., Liu, X., ... & Yang, L. (2016). Características clínicas e tratamento de hemangiomas hepáticos multifocais em

crianças: um estudo retrospectivo. Relatórios científicos, 6 (1), 1-8.

CAMPOS JÚNIOR, D., Burns, D. A. R., & Lopez, F. A. (2014). Tratado de pediatria.

Kaneko, T., Sasaki, S., Baba, N., Koh, K., Matsui, K., Ohjimi, H., ... & Higuchi, T. (2017). Efficacy and safety of oral propranolol for infantile hemangioma in

Japan. Pediatrics International, 59(8), 869-877.

Kim, K. H., Choi, T. H., Choi, Y., Park, Y. W., Hong, K. Y., Kim, D. Y., ... & Jeong, J. H. (2017). Comparison of efficacy and safety between propranolol and

steroid for infantile hemangioma: a randomized clinical trial. JAMA dermatology, 153(6), 529-536.

Kwon, EKM, Seefeldt, M., & Drolet, BA (2013). Hemangiomas infantis. American Journal of Clinical Dermatology, 14 (2), 111-123.

Léauté-Labrèze, C., Hoeger, P., Mazereeuw-Hautier, J., Guibaud, L., Baselga, E., Posiunas, G., ... & Voisard, JJ (2015). Um ensaio clínico randomizado e

controlado de propranolol oral em hemangioma infantil. N Engl J Med, 372, 735-746.

Li, S. B., Xu, G. Q., Gao, F., & Huo, R. (2015). Treatment with propranolol for infantile hemangiomas: A case series of 106 infants. Experimental and

therapeutic medicine, 10(1), 51-54.

Malik, M. A., Menon, P., Rao, K. L. N., & Samujh, R. (2013). Effect of propranolol vs prednisolone vs propranolol with prednisolone in the management of

infantile hemangioma: a randomized controlled study. Journal of pediatric surgery, 48(12), 2453-2459.

Perkins, J. A., Chen, B. S., Saltzman, B., Manning, S. C., & Parikh, S. R. (2014). Propranolol therapy for reducing the number of nasal infantile hemangioma

invasive procedures. JAMA Otolaryngology–Head & Neck Surgery, 140(3), 220-227.

Sondhi, V., & Patnaik, SK (2013). Propranolol para hemangioma infantil (PINCH): um estudo aberto para avaliar a eficácia do propranolol no tratamento de

hemangiomas infantis e para determinar o declínio da frequência cardíaca para prever a resposta ao propranolol. Journal of pediatric hematology /

oncology, 35 (7), 493-499.

Souza, M. T. D., Silva, M. D. D., & Carvalho, R. D. (2010). Revisão integrativa: o que é e como fazer. Einstein, 8(1), 102-106.

Szychta, P., Stewart, K., & Anderson, W. (2014). Tratamento de hemangiomas infantis com propranolol: diretrizes clínicas. Cirurgia plástica e

reconstrutiva, 133 (4), 852-862.

Tan, S. T, Itinteang, T., & Leadbitter, P. (2011). Propranolol em baixa dosagem para hemangioma infantil. Journal of Plastic, Reconstructive & Aesthetic

Surgery, 64 (3), 292-299.

Wedgeworth, E., Glover, M., Irvine, A. D, Neri, I., Baselga, E., Clayton, T. H, ... & Flohr, C. (2016). Propranolol no tratamento de hemangiomas infantis:

lições da pesquisa do Grupo de Trabalho Europeu Propranolol no Tratamento de Haemangiomas Complicados (PITCH). British Journal of

Dermatology, 174 (3), 594-601.

Yun, Y. J, Gyon, Y. H, Yang, S., Lee, Y. K, Park, J., & Park, M. (2015). Um estudo prospectivo para avaliar a eficácia e segurança do propranolol oral como

tratamento de primeira linha para hemangioma superficial infantil. Jornal coreano de pediatria, 58 (12), 484

Downloads

Published

07/07/2021

How to Cite

BOMFIM, . V. V. B. da S. .; BEZERRA, M. E. L. de M. .; MACEDO, M. C. T. C. .; LIMA, M. M. G. .; CARNEIRO, H. P. .; EBERHARDT, E. da S. .; VIEIRA, M. F. .; SILVA, M. B. de C. .; PAULA, L. E. P. de .; ALBUQUERQUE , V. O. .; PAZ, A. C. da .; SILVA, L. P. T. da .; LIMA, E. W. de M. .; SILVA, M. A. G. da . The use of propranolol in child hemangioma therapy. Research, Society and Development, [S. l.], v. 10, n. 8, p. e10010816968, 2021. DOI: 10.33448/rsd-v10i8.16968. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/16968. Acesso em: 25 may. 2025.

Issue

Vol. 10 No. 8

Section

Health Sciences

License

Copyright (c) 2021 Vitoria Vilas Boas da Silva Bomfim; Maria Eduarda Lopes de Macedo Bezerra; Maria Clara Teles Cabanelas Macedo; Mikaele Montalvão Galliza Lima; Hanah Passos Carneiro; Emily da Silva Eberhardt; Mirella Figueirôa Vieira; Monalisa Batatinha de Castro Silva; Lorenna Evellyn Pereira de Paula; Vyttória Oliveira Albuquerque ; Ayana Cavalcante da Paz; Lúcio Petterson Tôrres da Silva; Erica Williams de Moreira Lima; Maria Aparecida Guimarães da Silva

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors who publish with this journal agree to the following terms:

1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.