Establishing a cohort in Central Brazil: Strategies and challenges.
DOI:
https://doi.org/10.33448/rsd-v10i8.16975Keywords:
Dengue; Cohort studies; Universities; Public health services; Intersectoral collaboration.Abstract
Dengue is considered the most important acute febrile arbovirus in the world due to its burden on morbidity and mortality of countries. Cohort studies are appropriate for understanding dengue transmission dynamics and establishing baselines prior to the adoption of new control strategies. However, these studies pose major operational challenges that tend to hinder their execution, especially in developing countries. The strategies used in implanting and conducting a cohort in Central Brazil (city of Goiania) are presented, including the approaches adopted to overcome the challenges observed. The following steps are described and discussed: defining the field work team, establishing partnerships and the recruitment of participants; the initial serosurvey; technology in field research; and monitoring and evaluation of febrile episodes. A partnership between academia and public health services was the adopted approach and participation of the Municipal Health Secretariat and the Family Health Teams was essential for the proper implementation and conduction of the study. In return, the researchers' performance favored the Health Service through surveillance and health care activities of the population. This interinstitutional experience was successful with benefits for both institutions.
References
Alera, M. T., Srikiatkhachorn, A., Velasco, J. M., Tac-Na, I. A., Lago, C. B., Clapham, H. E., & et al (2016). Incidence of dengue virus infection in adults and children in a prospective longitudinal cohort in the Philippines. PLoS Negl Trop Dis, 10(2), 1–14. doi: 10.1371/journal.pntd.0004337
Araújo, H., Carvalho, D., Ioshino, R., Costa-da-Silva, A., & Capurro, M. (2015). Aedes aegypti control strategies in Brazil: incorporation of new technologies to overcome the persistence of dengue epidemics. Insects, 6(2), 576–594. doi: 10.3390/insects6020576
Baldacchino, F., Caputo, B., Chandre, F., Drago, A., della Torre, A., Montarsi, F., & et al (2015). Control methods against invasive Aedes mosquitoes in Europe: a review. Pest Manag Sci, 71(11), 1471–1485. doi: 10.1002/ps.4044
Brasil. Ministério da Saúde (2012). https://bvsms.saude.gov.br/bvs/saudelegis/cns/2013/res0466_12_12_2012.html
Brasil. Ministério da Saúde (2015). https://portalarquivos.saude.gov.br/images/PDF/2015/julho/29/Dengue-at---2014.pdf.
Brasil. Ministério da Saúde (2017). https://bvsms.saude.gov.br/bvs/saudelegis/gm/2017/prt2436_22_09_2017.html
Dayan, G., Arredondo, J. L., Carrasquilla, G., Deseda, C. C., Dietze, R., Luz, K., & et al (2015). Prospective cohort study with active surveillance for fever in four dengue endemic countries in Latin America. Am J Trop Med Hyg, 93(1), 18–23.
Eldredge, J. (2002). Cohort studies in health sciences librarianship. J Med Libr Assoc, 90(4), 380–392.
Goiânia (2019). https://saude.goiania.go.gov.br/wp-uploads/sites/3/2020/05/Informe_Semanal_Den_Chik_Zika_16_07_19_SE_28.pdf
Grollmus, N. S., & Tarrès, J. P. (2015). Relatos metodológicos: difractando experiências narrativas de investigación. Fórum Qualitative Social Research, 16(2), 1-24.
Guzman, M. G., & Harris E. (2015). Dengue. Lancet, 385(9966). 453–465. doi: 10.1016/S0140-6736(14)60572-9
IBGE (2015). https://cidades.ibge.gov.br/brasil/go/goiania/panorama.
Jaenisch, T., Tam, D. T. H., Kieu, N. T. T., Van-Ngoc, T., Nam, N. T., Van-Kinh, N., & et al (2016). Clinical evaluation of dengue and identification of risk factors for severe disease: protocol for a multicentre study in 8 countries. BMC Infect Dis, 16(1), 120. doi: 10.1186/s12879-016-1440-3
Kuan, G., Gordon, A., Aviles, W., Ortega, O., Hammond, S. N., Elizondo, D., & et al (2009). The Nicaraguan pediatric dengue cohort study: study design, methods, use of information technology, and extension to other infectious diseases. Am J Epidemiol, 170(1), 120–129. doi: 10.1093/aje/kwp092
Luz, P. M., Codeço, C. T., Massad, E., & Struchiner, C. J. (2003). Uncertainties regarding dengue modeling in Rio de Janeiro, Brazil. Mem Inst Oswaldo Cruz, 98(7), 871–878. doi: https://doi.org/10.1590/S0074-02762003000700002
Mandacarú, P. M. P. (2012). Timeliness of the dengue, exanthematic diseases, meningitis and tuberculosis surveillance systems in Brazil. Dissertação (Mestrado). 106 f. Instituto de Patologia Tropical e Saúde Pública. Universidade Federal de Goias. Goiania.
Martina, B. E. E., Koraka, P., & Osterhaus A. D. M. E. (2009). Dengue virus pathogenesis: an integrated view. Clin Microbiol Ver, 22(4), 564–581. doi: 10.1128/CMR.00035-09
Martínez-Vega, R. A., Rodriguez-Morales, A. J., Bracho-Churio, Y. T., Castro-Salas, M. E., Galvis-Ovallos, F., Díaz-Quijano, R. G., & et al (2016). A prospective cohort study to assess seroprevalence, incidence, knowledge, attitudes and practices, willingness to pay for vaccine and related risk factors in dengue in a high incidence setting. BMC Infect Dis, 16(1), 705. doi: 10.1186/s12879-016-2055-4
Medronho, R. A., Macrini, L., Novellino, D. M., Lagrotta, M. T. F., Câmara, V. M., & Pedreira, C. E. (2009). Aedes aegypti immature forms distribution according to type of breeding site. Am J Trop Med Hyg, 80(3), 401–404. doi: https://doi.org/10.4269/ajtmh.2009.80.401
Pedro, R. S., Carvalho, M. S., Girianelli, V. R., Damasceno, L. S., Leal, I., Cunha, D. C., & et al (2019). A populational-based birth cohort study in a low-income urban area in Rio de Janeiro, Brazil: implementation and description of the characteristics of the study. Cad. Saúde Pública, 35(5), 1-14. e00023918. doi: https://doi.org/10.1590/0102-311X00023918
Simmons, C. P., Farrar, J. J., Nguyen-van, V. C., & Wills, B. Dengue (2012). N Engl J Med, 366(15), 1423–1432. doi: 10.1056/NEJMra1110265
Siqueira, J. B., Martelli, C. M. T., Maciel, I. J., Oliveira, R. M., Ribeiro, M. G., Amorim, F. P., & et al (2004). Household survey of dengue infection in central Brazil: spatial point pattern analysis and risk factors assessment. Am J Trop Med Hyg, 71(5), 646–651.
Sirivichayakul, C., Limkittikul, K.., Chanthavanich, P., Jiwariyavej, V., Chokejindachai, W., Pengsaa, K., & et al (2012). Dengue infection in children in Ratchaburi, Thailand: a cohort study. ii. clinical manifestations. PLoS Negl Trop Dis, 6(2), 1-10. e1520. doi: 10.1371/journal.pntd.0001520
Tissera, H., Amarasinghe, A., Silva, A. D., Kariyawasam, P., Corbett, K. S., Katzelnick, L., & et al (2014). Burden of dengue infection and disease in a pediatric cohort in urban Sri Lanka. Am J Trop Med Hyg, 91(1), 132–137. doi: 10.4269/ajtmh.13-0540
WHO (2009). https://www.who.int/tdr/publications/documents/dengue-diagnosis.pdf
WHO (2012). https://apps.who.int/iris/bitstream/handle/10665/75303/9789241504034_eng.pdf?sequence=1&isAllowed=y
Yoksan, S., Tubthong, K., Kanitwithayanun, W., & Jirakanjanakit, N. (2009). Laboratory assays and field dengue vaccine evaluation at Ratchaburi Province, Thailand: a preliminary result. J Clin Virol, 46 (Supl.2), S13-15. doi: 10.1016/S1386-6532(09)70289-6
Yoon, I. K., Alera, M. T., Lago, C. B., Tac-An, I. A., Villa, D., Fernandez, S., & et al (2015). High rate of subclinical chikungunya virus infection and association of neutralizing antibody with protection in a prospective cohort in the Philippines. PLoS Negl Trop Dis, 9(5), 1–14. doi: 10.1371/journal.pntd.0003764
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2021 Claudio Morais Siqueira; Valéria Christina Rezende Feres ; Livia Aires Coutinho; João Bosco Siqueira Júnior
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
