Antitumoral effect of green tea on oral squamous cell carcinoma: Integrative review
DOI:
https://doi.org/10.33448/rsd-v10i8.17039Keywords:
Green tea; Camellia sinensis; Oral cancer; Squamous cell carcinoma; Animals.Abstract
Objective: To evaluate the antitumor effect of green tea and its natural compounds on oral squamous cell carcinoma (OSCC). Methodology: This is an integrative literature review based on the guiding question “Does green tea have an anti-tumor effect on the development of OSCC?”. The search was carried out with the descriptors "Camellia sinensis", "Green tea"; "Oral cancer"; “Squamous cell carcinoma”; “Animals” and “anticarcinogenic agents” in the PubMed, Science Direct, Scielo and Google Scholar databases. The inclusion criteria were scientific articles on the effect of green tea, in the form of extract or isolated compounds, in the OSCC, in vivo studies, in any language. Results: A total of 1,245 articles were obtained, of which 11 were selected. Most studies (90.9%) were carried out by eastern countries. Epigallocatechin gallate, hamsters and DMBA were the most used compounds, animal model and carcinogen, respectively. There were several mechanisms of action (oxidative stress, apoptosis, inhibition of cell proliferation and differentiation) and molecular effects (alteration in the expression of glycoconjugates, amyloid precursor proteins, metalloproteinases and the formation of invadopodia) in green tea. Final considerations: Green tea has an anti-tumor effect on oral squamous cell carcinoma, exerting both chemopreventive and therapeutic action, by different routes. As it is a natural, biocompatible, safe and easily accessible/low cost product, its use should be explored in order to contribute to the treatment / prevention of OSCC, the most frequent type of oral cancer.
References
Chandra Mohan, K. V. P., Hara, Y., Abraham, S. K., & Nagini, S. (2005). Comparative evaluation of the chemopreventive efficacy of green and black tea polyphenols in the hamster buccal pouch carcinogenesis model. Clinical biochemistry, 38(10), 879–886.
Chandra Mohan, K. V. P., Subapriya, R., Hara, Y., & Nagini, S. (2006). Enhancement of erythrocyte antioxidants by green and black tea polyphenols during 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis. Journal of medicinal food, 9(3), 373–377.
Cheng, Z., Zhang, Z., Han, Y., Wang, J., Wang, Y., Chen, X., Shao, Y., Cheng, Y., Zhou, W., Lu, X., & Wu, Z. (2020). A review on anti-cancer effect of green tea catechins. Journal of Functional Foods, 74, 104-172.
Chimenos-Küstner, E., Marques-Soares, M. S., & Schemel-Suárez, M. (2019). Consideraciones sobre etiopatogenia y prevención del cáncer orofaríngeo [Aetiopathology and prevention of oropharyngeal cancer]. Semergen, 45(7), 497–503.
Chowdhury, A., Sarkar, J., Chakraborti, T., Pramanik, P. K., & Chakraborti, S. (2016). Protective role of epigallocatechin-3-gallate in health and disease: A perspective. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 78, 50–59.
Filippini, T., Malavolti, M., Borrelli, F., Izzo, A. A., Fairweather-Tait, S. J., Horneber, M., & Vinceti, M. (2020). Green tea (Camellia sinensis) for the prevention of cancer. The Cochrane database of systematic reviews, 3(3), CD005004.
Herrera-Serna, B. Y., Lara-Carrillo, E., Toral-Rizo, V. H. Amaral, R. C. (2019). Efecto de las políticas de control de factores de riesgo sobre la mortalidad por cáncer oral en América Latina. Revista espanola de salud publica, 93, e201907050.
Hwang, Y. S., Park, K. K., & Chung, W. Y. (2013). Epigallocatechin-3 gallate inhibits cancer invasion by repressing functional invadopodia formation in oral squamous cell carcinoma. European journal of pharmacology, 715(1-3), 286–295.
INCA. (2021). Câncer de boca. https://www.inca.gov.br/tipos-de-cancer/cancer-de-boca
Ishida, K., Tomita, H., Nakashima, T., Hirata, A., Tanaka, T., Shibata, T., & Hara, A. (2017). Current mouse models of oral squamous cell carcinoma: Genetic and chemically induced models. Oral oncology, 73, 16–20.
Jang, J. Y., Lee, J. K., Jeon, Y. K., & Kim, C. W. (2013). Exosome derived from epigallocatechin gallate treated breast cancer cells suppresses tumor growth by inhibiting tumor-associated macrophage infiltration and M2 polarization. BMC cancer, 13, 421.
Kanojia, D., & Vaidya, M. M. (2006). 4-nitroquinoline-1-oxide induced experimental oral carcinogenesis. Oral oncology, 42(7), 655–667.
Katiyar, S., & Mukhtar, H. (1996). Tea in chemoprevention of cancer. International journal of oncology, 8(2), 221–238.
Ko, S. Y., Chang, K. W., Lin, S. C., Hsu, H. C., & Liu, T. Y. (2007). The repressive effect of green tea ingredients on amyloid precursor protein (APP) expression in oral carcinoma cells in vitro and in vivo. Cancer letters, 245(1-2), 81–89.
Koh, Y. W., Choi, E. C., Kang, S. U., Hwang, H. S., Lee, M. H., Pyun, J., Park, R., Lee, Y., & Kim, C. H. (2011). Green tea (-)-epigallocatechin-3-gallate inhibits HGF-induced progression in oral cavity cancer through suppression of HGF/c-Met. The Journal of nutritional biochemistry, 22(11), 1074–1083.
Lee, U. L., & Choi, S. W. (2011). The chemopreventive properties and therapeutic modulation of green tea polyphenols in oral squamous cell carcinoma. ISRN oncology, 2011, 403707.
Li, N., Chen, X., Liao, J., Yang, G., Wang, S., Josephson, Y., Han, C., Chen, J., Huang, M. T., & Yang, C. S. (2002). Inhibition of 7, 12-dimethylbenz[a]anthracene (DMBA)-induced oral carcinogenesis in hamsters by tea and curcumin. Carcinogenesis, 23(8), 1307–1313.
Li, N., Han, C., & Chen, J. (1999). Tea preparations protect against DMBA-induced oral carcinogenesis in hamsters. Nutrition and cancer, 35(1), 73–79.
Liao, S., Tang, Y., Chu, C., Lu, W., Baligen, B., Man, Y., & Qu, Y. (2020). Application of green tea extracts epigallocatechin-3-gallate in dental materials: Recent progress and perspectives. Journal of biomedical materials research. Part A, 108(12), 2395–2408.
Maciel, J. A. C., Castro-Silva, I. I. (2021). Mortalidade por câncer de boca frente às desigualdades sociais e o desenvolvimento humano no brasil: um estudo ecológico. Hygeia - Revista Brasileira de Geografia Médica e Da Saúde, 17, 45–54.
Maggioni, D., Biffi, L., Nicolini, G., & Garavello, W. (2015). Flavonoids in oral cancer prevention and therapy. European journal of cancer prevention: the official journal of the European Cancer Prevention Organisation (ECP), 24(6), 517–528.
Moghadamtousi, S. Z., Fadaeinasab, M., Nikzad, S., Mohan, G., Ali, H. M., & Kadir, H. A. (2015). Annona muricata (Annonaceae): A Review of Its Traditional Uses, Isolated Acetogenins and Biological Activities. International journal of molecular sciences, 16(7), 15625–15658.
Montero, P. H., & Patel, S. G. (2015). Cancer of the oral cavity. Surgical oncology clinics of North America, 24(3), 491–508.
Nagle, D. G., Ferreira, D., & Zhou, Y. D. (2006). Epigallocatechin-3-gallate (EGCG): chemical and biomedical perspectives. Phytochemistry, 67(17), 1849–1855.
Peter, B., Bosze, S., & Horvath, R. (2017). Biophysical characteristics of proteins and living cells exposed to the green tea polyphenol epigallocatechin-3-gallate (EGCg): review of recent advances from molecular mechanisms to nanomedicine and clinical trials. European biophysics journal: EBJ, 46(1), 1–24.
Rady, I., Mohamed, H., Rady, M., Siddiqui, I. A., Mukhtar, H. (2018). Cancer preventive and therapeutic effects of EGCG, the major polyphenol in green tea. Egyptian Journal Of Basic And Applied Sciences, 5(1), 1-23.
Relat, J., Blancafort, A., Oliveras, G., Cufí, S., Haro, D., Marrero, P. F., & Puig, T. (2012). Different fatty acid metabolism effects of (−)-Epigallocatechin-3-Gallate and C75 in Adenocarcinoma lung cancer. BMC Cancer, 12(1).
Rivera C. (2015). Essentials of oral cancer. International journal of clinical and experimental pathology, 8(9), 11884–11894.
Somers-Edgar, T. J., Scandlyn, M. J., Stuart, E. C., Le Nedelec, M. J., Valentine, S. P., & Rosengren, R. J. (2007). The combination of epigallocatechin gallate and curcumin suppresses ERα-breast cancer cell growth in vitro and in vivo. International Journal of Cancer, 122(9), 1966–1971.
Srinivasan, P., Sabitha, K. E., Shyamaladevi, C. S. (2004). Therapeutic efficacy of green tea polyphenols on cellular thiols in 4-Nitroquinoline 1-oxide-induced oral carcinogenesis. Chemico-biological interactions, 149(2-3), 81–87.
Srinivasan, P., Sabitha, K. E., Shyamaladevi, C. S. (2006). Modulatory efficacy of green tea polyphenols on glycoconjugates and immunological markers in 4-Nitroquinoline 1-oxide-induced oral carcinogenesis-A therapeutic approach. Chemico-biological interactions, 162(2), 149–156.
Srinivasan, P., Suchalatha, S., Babu, P. V., Devi, R. S., Narayan, S., Sabitha, K. E., & Shyamala Devi, C. S. (2008). Chemopreventive and therapeutic modulation of green tea polyphenols on drug metabolizing enzymes in 4-Nitroquinoline 1-oxide induced oral cancer. Chemico-biological interactions, 172(3), 224–234.
Tandon, P., Dadhich, A., Saluja, H., Bawane, S., & Sachdeva, S. (2017). The prevalence of squamous cell carcinoma in different sites of oral cavity at our Rural Health Care Centre in Loni, Maharashtra - a retrospective 10-year study. Contemporary oncology (Poznan, Poland), 21(2), 178–183.
Telles, O. S. (1996). Carcinogênese biomolecular em cancerologia. J Biomolec med Free Rad., 5 (2), 49-52.
Torres-Pereira, C. C., Angelim-Dias, A. Melo, N. S., Junior, C. A. L., Oliveira, E. M. F. (2012) Abordagem do câncer da boca: uma estratégia para os níveis primário e secundário de atenção em saúde. Cadernos de Saúde Pública, 28, 30-39.
Wang, P., Heber, D., & Henning, S. M. (2012). Quercetin increased the antiproliferative activity of green tea polyphenol (-)-epigallocatechin gallate in prostate cancer cells. Nutrition and cancer, 64(4), 580–587.
Yang, C. S., Ju, J., Lu, G., Xiao, H., Hao, X., Sang, S., & Lambert, J. D. (2008). Cancer prevention by tea and tea polyphenols. Asia Pacific journal of clinical nutrition, 17 Suppl 1(Suppl 1), 245–248.
Yasueda, A., Urushima, H., & Ito, T. (2016). Efficacy and Interaction of Antioxidant Supplements as Adjuvant Therapy in Cancer Treatment: A Systematic Review. Integrative cancer therapies, 15(1), 17–39.
Yoshimura, H., Yoshida, H., Matsuda, S., Ryoke, T., Ohta, K., Ohmori, M., Yamamoto, S., Kiyoshima, T., Kobayashi, M., & Sano, K. (2019). The therapeutic potential of epigallocatechin 3 gallate against human oral squamous cell carcinoma through inhibition of cell proliferation and induction of apoptosis: In vitro and in vivo murine xenograft study. Molecular medicine reports, 20(2), 1139–1148.
Ziech, D., Franco, R., Georgakilas, A. G., Georgakila, S., Malamou-Mitsi, V., Schoneveld, O., Pappa, A., & Panayiotidis, M. I. (2010). The role of reactive oxygen species and oxidative stress in environmental carcinogenesis and biomarker development. Chemico-biological interactions, 188(2), 334-339.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2021 William José e Silva Filho; Divyashree Singh; Shalini Singh; Rosilene Calazans Soares; Débora dos Santos Tavares
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
