Effect of acepromazine as an adjuvant to ketamine, midazolam and methadone in the chemical restraint of cats

Authors

DOI:

https://doi.org/10.33448/rsd-v10i7.17064

Keywords:

Anesthesia; Sedatives; Preanesthetic Medication; Dissociative Anesthesia.

Abstract

This study aimed to evaluate the effectiveness of acepromazine as an adjuvant to ketamine, midazolam and methadone in the chemical restraint and anesthesia of cats undergoing ovariohysterectomy. We allocated 14 cats in two groups: group ketamine (GK), premedicated with ketamine 8 mg/kg, midazolam 0.3 mg/kg and methadone 0.3 mg/kg and group acepromazine (GAK), premedicated with acepromazine 0.05 mg/kg in addition to the above-mentioned drugs. At baseline (T0) and every 5 mins up to 20 mins (T5, T10, T15 and T20) after premedication, the sedation score was evaluated at 0 to 24 points. The sedation score was significantly higher at T5, T10, T15 and T20 in both groups. There were no significant differences in extubation times (3.7 ± 1.3 mins in GK; 5.2 ± 2.6 mins in GAK) and the time to reach a score equal to 0 on the sedation scale (88 ± 63.9 mins in GK; 133 ± 39.7 mins in GAK); however, the time of anesthetic release was significantly higher in the GAK than in GK (19.7 ± 6.5 mins vs 11 ± 5.9 mins) (P = 0.023). Sedation was adequate in both groups. The results indicated that the administration of acepromazine did not contribute to sedation in the protocol and could delay the anesthetic release.

References

Bitti, F. S., Campagnol, D., Rangel, P. P., Nunes, J. S. Jr., Loureiro, B., Monteiro, E. R. (2017). Effects of three methadone doses combined with acepromazine on sedation and some cardiopulmonary variables in dogs. Veterinary Anaesthesia and Analgesia, 1-9.

Bortolami, E., Murrell, J. C., Slingsby, L. S. (2012). Methadone in combination with acepromazine as premedication prior to neutering in cat. Veterinary Anaesthesia and Analgesia, 181–193.

Brodbelt, D. C., Flaherty, D., Pettifer, G. R (2015). Anesthetic risk and informed consent. In Grimm, K. A., Lamont, L. A., Tranquilli, W. J., Greene, A. S., Robertson, S. A. Veterinary Anesthesia and Analgesia (5th. ed., Cap. 2, pp. 11-22). Iowa, EUA: Wiley Blackwell.

Fantoni, D. T., Garofalo, N. A. Fármacos analgésicos opioids. (2012). In Fantoni, D. Tratamento da dor na clínica de pequenos animais (Cap. 11, pp. 109-126). Rio de Janeiro, RJ: Elsevier.

Hart, B. L, Eckstein, R. A. (1997). The role of gonadal hormones in the occurrence of objectionable behaviours in dogs and cats. Applied Animal Behaviour Science, 52, 33l-344.

Hunt, J. R., Grint, N. J., Taylor, P. M., Murrel, J. C. (2014). Sedative and analgesic effects of buprenorphine, combined with either acepromazine or dexmedetomidine, for premedication prior to elective surgery in cats and dogs. Veterinary Anaesthesia and Analgesia, 40, 297–307.

Ingwersen, W., Allen, D. G., Dyson, D. H., Pascoe, P. J., O’Grady, M. R. (1988). Cardiopulmonary effects of a ketamine hydrochloride/acepromazine combination in healthy cats. Canadian Journal Veterinary Research, 52, 1-4.

Killos, M. B., Graham, L. F., Lee, J. (2010). Comparison of two anesthetic protocols for feline blood donation. Veterinary Anaesthesia and Analgesia., 37, 230-239.

Manfrinate, R., Dahroug, M. A. A., Farias, D. C., Vasconcelos, L. P. S., Wayhs, N. N. S., Monzem, S. … Guimarães, L. D. (2009). Efeitos da morfina e da metadona associadas à acepromazina em gatas anestesiadas com propofol e halotano e submetidas à ovariossalpingohisterectomia. Acta Scientiae Veterinary, 37(4), 245-251.

Marjani, M., Akbarinejad, V., Bagheri, M. (2015). Comparison of intranasal and intramuscular ketamine-midazolam combination in cats. Veterinary Anaesthesia and Analgesia., 42, 178–181.

Martins, J., Fantoni, D. T. (2010). Recuperação pós-anestésica. In Fantoni, D. T. Anestesia de cães e gatos (2nd. ed., Cap. 12, pp. 217-227). São Paulo, SP: Roca.

Mocholi, D. R., Belda, E., Bosmans, T., Laredo, F. G. (2016). Clinical efficacy and cardiorespiratory effects of intramuscular administration of alfaxalone alone or in combination with dexmedetomidine in cats. Veterinary Anaesthesia and Analgesia., 43, 291–300.

Monteiro, E. R., Rabello, T.A., Rangel, J. P. P. (2019). Effects of 3 morphine doses, in combination with acepromazine, on sedation and some physiological parameters in dogs. The Canadian Journal of Veterinary Research, 83, 235-240.

Moreno, J. C. D. (2012). Antagonistas de receptores N-metil-D-Aspartato (NMDA). In Fantoni D. Tratamento da dor na clínica de pequenos animais (Cap. 16, pp. 171-201). Rio de Janeiro, RJ: Elsevier.

Pawson, P., Forsyth, S. (2010). Agentes anestésicos. In Maddison, J. E., Page, S. W., Church, D. B. Farmacologia clínica de pequenos animais (Cap. 5, pp. 83-112). Rio de Janeiro, RJ: Elsevier.

Rankin, D. C. (2015) Sedatives and tranquilizers. In Grimm, K. A., Lamont, L. A., Tranquilli, W. J. Veterinary Anesthesia and Analgesia (5th. ed., Cap. 10, pp. 196-206). Iowa, EUA: Wiley Blackwell.

Schwarz, A., Kalchofner, K., Palm, J., Picek, S., Hartnack, S., Wolfensberger, R. B. (2014). Minimum infusion rate of alfaxalone for total intravenous anesthesia after sedation with acepromazine or medetomidine in cats undergoing ovariohysterectomy. Veterinary Anaesthesia and Analgesia., 41, 480-490.

Shah, M. A., Yates, D., Hunt J., Murrell, J. (2018). Comparison between methadone and buprenorphine within the QUAD protocol for perioperative analgesia in cats undergoing ovariohysterectomy. Journal Feline Medicine. Surgery, 21(8), 723-731.

Robertson, S. A., Gogoiski, S. M., Pascoe, P., Shafford, H. L., Sager, J., Griffernhargen, G. M. (2018). AAFP feline anesthesia guidelines. Journal Feline Medicine Surgery, 20, 602-634.

Slingsby, L. S., Bortolami, E., Murrell, J. C. (2018). Methadone in combination with medetomidine as premedication prior to ovariohysterectomy and castration in the cat. Journal Feline Medicine. Surgery. 17(10), 864-872.

Steagall, P. V., Taylor, P. M., Rodrigues, L. C. C., Ferreira, T. H., Minto, B. W., Aguiar, A. J. A. (2009). Analgesia for cats after ovariohysterectomy with either buprenorphine or carprofen alone or in combination. Veterinary Record, 164, 359-363.

Steagall, P. V. M., Taylor, P. M., Brondoni, J. T., Luna, S. P. L., Dixon, M. J. (2008). Antinociceptive effects of tramadol and acepromazine in cats. Journal Feline Medicine. Surgery, 10, 24-31.

Volpato, J., Mattoso, C. R. S., Beier, S. L., Coelho, M. M., Tochedo, R., Kirsten, C. E., Yonezawa, L. A., Saito, M. E. (2014). Sedative, hematologic and hemostatic effects of dexmedetomidine–butorphanol alone or in combination with ketamine in cats. Journal Feline Medicine Surgery, 17(6), 500-506.

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Published

20/06/2021

How to Cite

MACARINI, B. M. N.; BOFF, G. A.; MARCO, C. J. de; ANDRADES, J. de L.; MENDES, C. B. de M.; AZAMBUJA, S. A.; PIRES, B.; CAYE, P.; GUIM, T. N.; GEHRCKE, M. I. Effect of acepromazine as an adjuvant to ketamine, midazolam and methadone in the chemical restraint of cats. Research, Society and Development, [S. l.], v. 10, n. 7, p. e52410717064, 2021. DOI: 10.33448/rsd-v10i7.17064. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/17064. Acesso em: 12 nov. 2024.

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Section

Agrarian and Biological Sciences