Overview of oral manifestations resulting from the treatment of childhood cancer: An integrative review
DOI:
https://doi.org/10.33448/rsd-v10i8.17072Keywords:
Oncology; Pediatric dentistry; Oral manifestations.Abstract
Children undergoing cancer treatment have many symptoms and diseases that manifest themselves in an acute and chronic manner. The aim of this study was to carry out an integrative literature review on the following clinical question: Can cancer treatments (chemotherapy and radiotherapy) in children have oral repercussions? A search of scientific articles in the medline database was carried out, without the use of time limits. Publications made available in full and in English were considered. Of the 399 titles identified, 37 articles met the inclusion criteria and were included in the review. Eleven articles that did not meet the outcome or had closed access and no return from the authors were removed, finalizing 26 articles for the final study. There is significant evidence that children and adolescents experience numerous and complex symptoms and problems during and after cancer treatment. Diseases can be manifested during treatment as mucositis, ulcerations, xerostomia, caries and periodontal disease. For these diseases, the use of laser, orientation of fluoridated toothpaste and restorations should be performed to improve nutrition and health recovery and, in the long term, according to the dose, time and medication, the treatment promotes delay in the child's growth, and consequently the time of tooth eruption and tooth anomalies. Therefore, understanding the trajectory of symptoms, based on the experiences of the child and family, is essential for comprehensive and sensitive care for children with cancer and their families, with the professional pediatric dentist being essential to monitor and treat these children until their adulthood.
References
Aielli, F., Giusti, R., Rughetti, A., dell'Orso, L., Ficorella, C., & Porzio, G. (2014). Rapid resolution of refractory chemotherapy-induced oral mucositis with platelet gel-released supernatant in a pediatric cancer patient: a case report. J Pain Symptom Manage, 48(5), e2-4. 10.1016/j.jpainsymman.2014.06.015
Avsar, A., Elli, M., Darka, O., & Pinarli, G. (2007). Long-term effects of chemotherapy on caries formation, dental development, and salivary factors in childhood cancer survivors. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 104(6), 781-789. 10.1016/j.tripleo.2007.02.029
Berkowitz, R. J., Neuman, P., Spalding, P., Novak, L., Strandjord, S., & Coccia, P. F. (1989). Developmental orofacial deficits associated with multimodal cancer therapy: case report. Pediatr Dent, 11(3), 227-231. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/2638010
Carl, W., & Wood, R. (1980). Effects of radiation on the developing dentition and supporting bone. J Am Dent Assoc, 101(4), 646-648. 10.14219/jada.archive.1980.0368
Carvalho, C. G., Medeiros-Filho, J. B., & Ferreira, M. C. (2018). Guide for health professionals addressing oral care for individuals in oncological treatment based on scientific evidence. Support Care Cancer, 26(8), 2651-2661. 10.1007/s00520-018-4111-7
Cheng, C. F., Huang, W. H., Tsai, T. P., Ko, E. W., & Liao, Y. F. (2000). Effects of cancer therapy on dental and maxillofacial development in children: report of case. ASDC J Dent Child, 67(3), 218-222, 161. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/10902084
Cheng, K. K., Chang, A. M., & Yuen, M. P. (2004). Prevention of oral mucositis in paediatric patients treated with chemotherapy; a randomised crossover trial comparing two protocols of oral care. Eur J Cancer, 40(8), 1208-1216. 10.1016/j.ejca.2003.10.023
Chi, D. L. (2017). The Science and Art of Evidence-Based Pediatric Dentistry. Dent Clin North Am, 61(3), xi-xii. 10.1016/j.cden.2017.04.001
Cohen, J., Wakefield, C. E., & Laing, D. G. (2016). Smell and Taste Disorders Resulting from Cancer and Chemotherapy. Curr Pharm Des, 22(15), 2253-2263. 10.2174/1381612822666160216150812
de Oliveira, M. M., DRM, E. S., Ramos, F. R., & Curado, M. P. (2020). Children and adolescents cancer incidence, mortality and survival a population-based study in Midwest of Brazil. Cancer Epidemiol, 68, 101795. 10.1016/j.canep.2020.101795
Doline, S., Needleman, H. L., Petersen, R. A., & Cassady, J. R. (1980). The effect of radiotherapy in the treatment of retinoblastoma upon the developing dentition. J Pediatr Ophthalmol Strabismus, 17(2), 109-113. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/7391897
Effinger, K. E., Migliorati, C. A., Hudson, M. M., McMullen, K. P., Kaste, S. C., Ruble, K., & Castellino, S. M. (2014). Oral and dental late effects in survivors of childhood cancer: a Children's Oncology Group report. Support Care Cancer, 22(7), 2009-2019. 10.1007/s00520-014-2260-x
Estrela, C. Metodologia cientifica: ciênica, ensino, pesquisa. Porto Alegre: Artes Médicas. 3ed. 2018.
Farsi, D. J. (2016). Children Undergoing Chemotherapy: Is It Too Late for Dental Rehabilitation? J Clin Pediatr Dent, 40(6), 503-505. 10.17796/1053-4628-40.6.503
Fleming, P. (1991). Dental management of the pediatric oncology patient. Curr Opin Dent, 1(5), 577-582. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/1839663
Gandhi, K., Datta, G., Ahuja, S., Saxena, T., & A, G. D. (2017). Prevalence of Oral Complications occurring in a Population of Pediatric Cancer Patients receiving Chemotherapy. Int J Clin Pediatr Dent, 10(2), 166-171. 10.5005/iD-iournals-10005-1428
Hwang, S. Y., & Yoon, R. K. (2011). Developmental dental defects linked with chemoradiotherapy: a case report. J Clin Pediatr Dent, 35(3), 309-313. 10.17796/jcpd.35.3.t127p755m568x023
Jalali, G., Unkel, J. H., & Reed, J. A. (2012). Management of dental complications in a child with rhabdomyosarcoma. Pediatr Dent, 34(7), 506-509. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/23265172
Juarez-Lopez, M. L. A., Solano-Silva, M. N., Fragoso-Rios, R., & Murrieta-Pruneda, F. (2018). Oral diseases in children with acute lymphoblastic leukemia with chemotherapy treatment. Rev Med Inst Mex Seguro Soc, 56(2), 132-135. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/29901909
Kapoor, G., Goswami, M., Sharma, S., Mehta, A., & Dhillon, J. K. (2019). Assessment of oral health status of children with Leukemia: A cross-sectional study. Spec Care Dentist, 39(6), 564-571. 10.1111/scd.12419
Kaste, S. C., & Hopkins, K. P. (1994). Micrognathia after radiation therapy for childhood facial tumors. Report of two cases with long-term follow-up. Oral Surg Oral Med Oral Pathol, 77(1), 95-99. 10.1016/s0030-4220(06)80115-5
Katalin, G., Mihaly, O., & Arpad, C. (1995). [Dental complications of radiotherapy of tumors of the nasal cavity in childhood]. Fogorv Sz, 88(12), 387-391. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/8713940
Kowlessar, A., Naidu, R., Ramroop, V., Nurse, J., Dookie, K., Bodkyn, C., & Lalchandani, S. (2019). Oral health among children attending an oncology clinic in Trinidad. Clin Exp Dent Res, 5(6), 665-669. 10.1002/cre2.232
Lalla, R. V., Sonis, S. T., & Peterson, D. E. (2008). Management of oral mucositis in patients who have cancer. Dent Clin North Am, 52(1), 61-77, viii. 10.1016/j.cden.2007.10.002
Laudenbach, P., Boudiere, J. P., & Heubes, J. (1979). [Disturbances in development of the maxilla following interstitial radium therapy for a facial rhabdomyosarcoma at the age of 3 years (author's transl)]. Rev Stomatol Chir Maxillofac, 80(3), 174-177. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/288161
Lucena, N. N. N., Damascena, L. C. L., Ribeiro, I. L. A., Lima-Filho, L. M. A., & Valenca, A. M. G. (2019). The Contribution of Motor Changes to Oral Mucositis in Pediatric Cancer Patients: A Cross-Sectional Study. Int J Environ Res Public Health, 16(18). 10.3390/ijerph16183395
Ludke, M. & Andre, M. E. D. A. (2013). Pesquisas em educação: uma abordagem qualitativa. São Paulo: E.P.U.
Peretz, B., Sarnat, H., & Kharouba, J. (2014). Chemotherapy induced dental changes in a child with medulloblastoma: a case report. J Clin Pediatr Dent, 38(3), 251-254. 10.17796/jcpd.38.3.c707838527x3155q
Ponce-Torres, E., Ruiz-Rodriguez Mdel, S., Alejo-Gonzalez, F., Hernandez-Sierra, J. F., & Pozos-Guillen Ade, J. (2010). Oral manifestations in pediatric patients receiving chemotherapy for acute lymphoblastic leukemia. J Clin Pediatr Dent, 34(3), 275-279. 10.17796/jcpd.34.3.y060151580h301t7
Rimulo, A. L., Ferreira, M. C., Abreu, M. H., Aguirre-Neto, J. C., & Paiva, S. M. (2011). Chemotherapy-induced oral mucositis in a patient with acute lymphoblastic leukaemia. Eur Arch Paediatr Dent, 12(2), 124-127. 10.1007/BF03262792
Ritwik, P., & Chrisentery-Singleton, T. E. (2020). Oral and dental considerations in pediatric cancers. Cancer Metastasis Rev, 39(1), 43-53. 10.1007/s10555-020-09842-5
Svoboda, W. E., Aaron, G. R., & Albano, E. A. (1991). North American Burkitt's lymphoma presenting with intraoral symptoms. Pediatr Dent, 13(1), 52-58. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/1945986
Velten, D. B., Zandonade, E., & Monteiro de Barros Miotto, M. H. (2017). Prevalence of oral manifestations in children and adolescents with cancer submitted to chemotherapy. BMC Oral Health, 17(1), 49. 10.1186/s12903-016-0331-8
Venkataraghavan, K., Patil, S., Guvva, S., Karthik, S., & Bhandi, S. (2013). Abnormal odontogenesis following management of childhood cancer (retinoblastoma): review and a new variant. J Contemp Dent Pract, 14(2), 360-364. 10.5005/jp-journals-10024-1328
Zarina, R. S., & Nik-Hussein, N. N. (2005). Dental abnormalities of a long-term survivor of a childhood hematological malignancy: literature review and report of a case. J Clin Pediatr Dent, 29(2), 167-174. 10.17796/jcpd.29.2.hq7307703428nt3v
Zubowska, M., Wyka, K., Fendler, W., Mlynarski, W., & Zalewska-Szewczyk, B. (2013). Interleukin 18 as a marker of chronic nephropathy in children after anticancer treatment. Dis Markers, 35(6), 811-818. 10.1155/2013/369784
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2021 Larissa Silva Costa; Maria Salete Nahás Pires Côrrea; José Carlos P. Imparato; Karla Mayra Rezende
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.