Androgenic alopecia: The use of minoxidil and it’s adverse effects
Keywords:Androgenetic alopecia; Minoxidil; Adverse reactions.
Objective: to analyze the adverse effects of using Minoxidil in patients with androgenic Alopecia. Methods: An integrative literature review was carried out, a method that allows a synthesis of the knowledge obtained in a certain number of studies and its incorporation in the form of applicability of the results obtained from significant studies in the practice of evidence-based research. The research question “What are the adverse effects of using Minoxidil in androgenetic alopecia?” Was used. Then, a search was conducted in the international database Medical Publisher (PUBMED) and in the Virtual Health Library (VHL) with the keywords “Minoxidil” AND “Alopecia” AND “Adverse effects”. Results: the most common adverse effects with the use of topical Minoxidil are Hypertrichosis, itchy scalp, contact dermatitis and erythema. Dry skin, increased sensitivity, dandruff production have also been reported. Some less frequent symptoms were systemic cardiovascular signs, such as hypotension and syncope. Conclusion: Treatment with Minoxidil in both it’s topical and systemic conformation for Androgenetic Alopecia is an effective and safe measure for hair growth, with adverse effects that can be well controlled and tolerated.
Adil, A., & Godwin, M. (2017). The effectiveness of treatments for androgenetic alopecia: A systematic review and meta-analysis. Journal of the American Academy of Dermatology, 77(1), 136–141.e5. https://doi.org/10.1016/j.jaad.2017.02.054
Barat, T., Abdollahimajd, F., Dadkhahfar, S., & Moravvej, H. (2020). Evaluation of the efficacy and safety of cow placenta extract lotion versus minoxidil 2% in the treatment of female pattern androgenetic alopecia. International journal of women's dermatology, 6(4), 318–321. https://doi.org/10.1016/j.ijwd.2020.04.012
Beach R. A. (2018). Case series of oral minoxidil for androgenetic and traction alopecia: Tolerability & the five C's of oral therapy. Dermatologic therapy, 31(6), e12707. https://doi.org/10.1111/dth.12707
Cranwell, W. & Sinclair R. (2016). Male Androgenetic Alopecia. Endotext [Internet]. https://www.ncbi.nlm.nih.gov/books/NBK278957/
Dubrey, S. W., VanGriethuysen, J., & Edwards, C. M. (2015). A hairy fall: syncope resulting from topical application of minoxidil. BMJ case reports, bcr2015210945. https://doi.org/10.1136/bcr-2015-210945
Galvão, T F. (2015). Principais itens para relatar Revisões sistemáticas e Meta-análises: a recomendação prisma. Epidemiologia e Serviços de Saúde, 24(2), 335-342. http://dx.doi.org/10.5123/s1679-49742015000200017.
Gargallo, V., Gutierrez, C., Vanaclocha, F., & Guerra-Tapia, A. (2015). Hipertricosis generalizada secundaria a minoxidil tópico. Actas Dermo-Sifiliográficas, 106(7), 599-600. http://dx.doi.org/10.1016/j.ad.2014.12.016.
Gong, L., Bao, L., Tian, T., & Li, Y. (2018). The clinical effect of JetpPeel-assisted topical minoxidil in the treatment of androgenetic alopecia: A randomized pilot study. Journal of cosmetic and laser therapy: official publication of the European Society for Laser Dermatology, 20(1), 58–63. https://doi.org/10.1080/14764172.2017.1341046.
Hu, R., Xu, F., Sheng, Y., Qi, S., Han, Y., Miao, Y., Rui, W., & Yang, Q. (2015). Combined treatment with oral finasteride and topical minoxidil in male androgenetic alopecia: a randomized and comparative study in Chinese patients. Dermatologic therapy, 28(5), 303–308. https://doi.org/10.1111/dth.12246.
Jimenez-Cauhe, J., Saceda-Corralo, D., Rodrigues-Barata, R., Hermosa-Gelbard, A., Moreno-Arrones, O. M., Fernandez-Nieto, D., & Vaño-Galvan, S. (2019). Effectiveness and safety of low-dose oral minoxidil in male androgenetic alopecia. Journal of the American Academy of Dermatology, 81(2), 648–649. https://doi.org/10.1016/j.jaad.2019.04.054
Macedo, C. L. A. de., Santana, T. S., Ferreira, A. F. P., Jucá, N. B. H., Crispim, K. S. L, Banhos, M. E. H., Amorim, L. C. P., Rabelo, K. P. S., Brasil, D. R. M., Basso, S., Araújo, R. C. de., Rios, M. S., Costa, A. J. A. da., & Castro Júnior, J. E. di. (2020). Androgenetic alopecia (New capillary protocol in androgenic alopecia). Research, Society and Development, 9(9), e989997457. https://doi.org/10.33448/rsd-v9i9.7457
Macedo, J. L., Oliveira, A. S. da S. S., Pereira, I. C., Assunção, F. D., Reis, E. R., & Assunção, M. de J. S. M. (2019). Efficacy of phytotherapy in the treatment of androgenetic alopecia. Research, Society and Development, 8(5), e285868. https://doi.org/10.33448/rsd-v8i5.868
Maitra, M., Goyal, A. K., & Rath, G. (2017). A novel approach for follicular delivery of minoxidil for treatment of alopecia. Journal Of Drug Delivery Science And Technology, 41(17) 113-123. http://dx.doi.org/10.1016/j.jddst.2017.07.002.
Panchaprateep, R., & Lueangarun, S. (2020). Efficacy and Safety of Oral Minoxidil 5 mg Once Daily in the Treatment of Male Patients with Androgenetic Alopecia: An Open-Label and Global Photographic Assessment. Dermatology and therapy, 10(6), 1345–1357. https://doi.org/10.1007/s13555-020-00448-x
Ramos, P. M., Sinclair, R. D., Kasprzak, M., & Miot, H. A. (2020). Minoxidil 1 mg oral versus minoxidil 5% topical solution for the treatment of female-pattern hair loss: A randomized clinical trial. Journal of the American Academy of Dermatology, 82(1), 252–253. https://doi.org/10.1016/j.jaad.2019.08.060
Rampon, G., Henkin, C., de Souza, P. R., & Almeida, H. L., Jr (2016). Infantile generalized hypertrichosis caused by topical minoxidil. Anais brasileiros de dermatologia, 91(1), 87–88. https://doi.org/10.1590/abd1806-4841.20164010
Randolph, M., & Tosti, A. (2021). Oral minoxidil treatment for hair loss: A review of efficacy and safety. Journal of the American Academy of Dermatology, 84(3), 737–746. https://doi.org/10.1016/j.jaad.2020.06.1009
Rossi, A., Anzalone, A., Fortuna, M. C., Caro, G., Garelli, V., Pranteda, G., & Carlesimo, M. (2016). Multi-therapies in androgenetic alopecia: review and clinical experiences. Dermatologic therapy, 29(6), 424–432. https://doi.org/10.1111/dth.12390
Souza, M. T. de, Silva, M. D. da, Carvalho, R. de (2010). Integrative review: what is it? how to do it? Einstein (São Paulo), 8(1), 102-106. http://dx.doi.org/10.1590/s1679-45082010rw1134.
Stoehr, J. R., Choi, J. N., Colavincenzo, M., & Vanderweil, S. (2019). Off-Label Use of Topical Minoxidil in Alopecia: A Review. American journal of clinical dermatology, 20(2), 237–250. https://doi.org/10.1007/s40257-018-0409-y
Suchonwanit, P., Rojhirunsakool, S., & Khunkhet, S. (2019). A randomized, investigator-blinded, controlled, split-scalp study of the efficacy and safety of a 1550-nm fractional erbium-glass laser, used in combination with topical 5% minoxidil versus 5% minoxidil alone, for the treatment of androgenetic alopecia. Lasers in medical science, 34(9), 1857–1864. https://doi.org/10.1007/s10103-019-02783-8
Suchonwanit, P., Thammarucha, S., & Leerunyakul, K. (2019). Minoxidil and its use in hair disorders: a review. Drug design, development and therapy, 13, 2777–2786. https://doi.org/10.2147/DDDT.S214907
Tai, T., & Kochhar, A. (2020). Physiology and Medical Treatments for Alopecia. Facial plastic surgery clinics of North America, 28(2), 149–159. https://doi.org/10.1016/j.fsc.2020.01.004
Van Zuuren, E. J., Fedorowicz, Z., & Schoones, J. (2016). Interventions for female pattern hair loss. The Cochrane database of systematic reviews, 2016(5), CD007628. https://doi.org/10.1002/14651858.CD007628.pub4
Wu, M., Yu, Q., & Li, Q. (2016). Differences in reproductive toxicology between alopecia drugs: an analysis on adverse events among female and male cases. Oncotarget, 7(50), 82074–82084. https://doi.org/10.18632/oncotarget.12617
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