Bisphosphonates and the jaw repercussions: A narrative review

Authors

DOI:

https://doi.org/10.33448/rsd-v10i9.17923

Keywords:

Bisphosphonates; Osteonecrosis; Jaw.

Abstract

Bisphosphonates are drugs that act by decreasing and inhibiting osteoclastic activity, and inducing cell apoptosis. They block osteoclast differentiation and stimulate osteoblasts, resulting in decreased bone resorption. It may contribute to the exposure of necrotic bone in the maxillofacial region. Thus, this narrative review proposes a brief discussion about the development of osteonecrosis of the maxillary bones resulting from therapy with bisphosphonates. Having as the theme the development of osteonecrosis in the jaws resulting from the use of bisphosphonates, we searched through the MeSH terms and DeCS/MeSH terms, between 2006 and 2021, for articles in English and Portuguese indexed in the MEDLINE/PubMed database, Web of Science, LILACS/bvs as well as through a manual search. After analysis the selected articles, it was observed that the possibility of the development of osteonecrosis in the maxillary bones is multifactorial, thus it is imperative to approach these sites with a preventive way and with a minimally invasive therapy.

References

Allen, M. R., & Burr, D. B. (2008). Mandible matrix necrosis in beagle dogs after 3 years of daily oral bisphosphonate treatment. Journal of oral and maxillofacial surgery: official journal of the American Association of Oral and Maxillofacial Surgeons, 66(5), 987–994. https://doi.org/10.1016/j.joms.2008.01.038

AlRahabi, M. K., & Ghabbani, H. M. (2018). Clinical impact of bisphosphonates in root canal therapy. Saudi medical journal, 39(3), 232–238. https://doi.org/10.15537/smj.2018.3.20923

Aparecida Cariolatto, F., Carelli, J., de Campos Moreira, T., Pietrobon, R., Rodrigues, C., & Bonilauri Ferreira, A. P. (2018). Recommendations for the Prevention of Bisphosphonate-Related Osteonecrosis of the Jaw: A Systematic Review. The journal of evidence-based dental practice, 18(2), 142–152. https://doi.org/10.1016/j.jebdp.2017.11.002

Arce, K., Assael, L. A., Weissman, J. L., & Markiewicz, M. R. (2009). Imaging findings in bisphosphonate-related osteonecrosis of jaws. Journal of oral and maxillofacial surgery: official journal of the American Association of Oral and Maxillofacial Surgeons, 67(5 Suppl), 75–84. https://doi.org/10.1016/j.joms.2008.12.002

Barin, L. M., Pillusky, F. M., Pasini, M. M., Denesi, C. C. (2016) Osteonecrose dos maxilares associada ao uso de bifosfonatos: uma revisão de literatura. Revista de Odontologia da Universidade Cidade de São Paulo, 28(2), 126-134. ISSN 1983-5183

Biasotto, M., Chiandussi, S., Dore, F., Rinaldi, A., Rizzardi, C., Cavalli, F., & Di Lenarda, R. (2006). Clinical aspects and management of bisphosphonates-associated osteonecrosis of the jaws. Acta odontologica Scandinavica, 64(6), 348–354. https://doi.org/10.1080/00016350600844360

Bodem, J. P., Schaal, C., Kargus, S., Saure, D., Mertens, C., Engel, M., Hoffmann, J., & Freudlsperger, C. (2016). Surgical management of bisphosphonate-related osteonecrosis of the jaw stages II and III. Oral surgery, oral medicine, oral pathology and oral radiology, 121(4), 367–372. https://doi.org/10.1016/j.oooo.2015.10.033

Borjaille, B.P., Brandão, L.R., Hasegawa, T.M., Rosa, R. F., Antonio, S.F., Chahade, W. H., (2006). Osteonecrose e Síndrome da Imunodeficiência Adquirida. Rev. Bras. Reumatol, 46, suppl.1,36-44.

Brozoski, M. A., Traina, A. A., Deboni, M. C. Z., Marques, M. M., Naclério-Homem, M. da G. (2012). Osteonecrose maxilar associada ao uso de bifosfonatos. Rev Bras Reumatol 2012;52(2):260-270.

Cardoso, C. L., Barros, C. A., Curra, C., Fernandes, L. M. P. da S. R., Franzolin, S. de O. B., Júnior, J. S. F., Curi, M. M. (2017). Radiographic Findings in Patients with Medication-Related Osteonecrosis of the Jaw. International Journal of Dentistry, 2017, 1–6. doi:10.1155/2017/3190301

Chang, J., Hakam, A. E., & McCauley, L. K. (2018). Current Understanding of the Pathophysiology of Osteonecrosis of the Jaw. Current osteoporosis reports, 16(5), 584–595. https://doi.org/10.1007/s11914-018- 0474-4

Chapurlat, R. D., & Delmas, P. D. (2006). Drug insight: Bisphosphonates for postmenopausal osteoporosis. Nature clinical practice. Endocrinology & metabolism, 2(4), 211–238. https://doi.org/10.1038/ncpendmet0121

Chaves, R. A. da C., Órfão, A. M. A., Júnior, W. B., Queiroz, T. P., & Faloni, A. P. (2018). Bifosfonatos e Denosumabes: mecanismos de ação e algumas implicações para a implantodontia. Revista Brasileira Multidisciplinar, 21(2), 66-80. https://doi.org/10.25061/2527-2675/ReBraM/2018.v21i2.483

Christou, J., Johnson, A. R., & Hodgson, T. A. (2013). Bisphosphonate-related osteonecrosis of the jaws and its relevance to children--a review. International journal of paediatric dentistry, 23(5), 330–337. https://doi.org/10.1111/ipd.12047

Coelho, A. I., Gomes, P. De S., Fernandes, M. H. (2010) Osteonecrose dos maxilares associada ao uso de bifosfonatos. Parte I: etiologia e apresentação clínica. Revista Portuguesa de Estomatologia, Medicina Dentária e Cirurgia Maxilofacial, 51(2), 95-101. https://doi.org/10.1016/S1646-2890(10)70093-5

Costa, L. L. R., Mendes, T. M., Santos, L. S., Mendes, P. H. C. (2019). Análise do conhecimento e da conduta médica acerca da prevenção da osteonecorose dos maxilares pelo uso de bifosfonatos. Revista da Universidade Vale do Rio Verde, 17(1),1-8. http://dx.doi.org/10.5892/ruvrd.v17i1.4981

Crépin, S., Laroche, M. L., Sarry, B., & Merle, L. (2010). Osteonecrosis of the jaw induced by clodronate, an alkylbiphosphonate: case report and literature review. European journal of clinical pharmacology, 66(6), 547–554. https://doi.org/10.1007/s00228-010-0822-5

Cunha, K. S., Lippert, V. F., Baldino, M. E. L., Dreyer, J. W., Cunha, R. M. (2019) Alternativa de tratamento reabilitador para pacientes em uso de bisfosfonato intravenoso: relato de caso clinico. Revista Odontológica de Araçatuba, 40(1), 29-34. ISSN 2357-8378 e 1677-6704

De Moraes, S. L. C., Afonso, A. M. P., Santos, R. G. S., Mattos, R. P., Oliveira, M. T. F., Zanetta-Barbosa, D., Duarte, B. G. (2014) Riscos e complicações para os ossos da face decorrentes do uso de bifosfonatos. Revista Brasileira de Odontologia, 70(2), 114-119. ISSN 1984-3747.

De Oliveira, M. A., Martins, M. F., Asah, D. A., Santos, P. S., Gallotini, M. (2014) Osteonecrose induzida por Bifosfonatos: relato de caso clínico e protocolo de atendimento/Osteonecrosis induced by bisphosphonates: case study and protocol service. Arquivos Médicos dos Hospitais e da Faculdade de Ciências Médicas da Santa Casa de São Paulo, 59(1), 43-48.

De Sousa, A. S., Taitra, V. P. A. J., Saveda, L. F., Rodrigues, I. V., Giro, G. (2018) Protocolo de atendimento odontológico de pacientes em tratamento com bifosfonatos. Revista Saúde-UNG-Ser, 12(1/2,), 54-61. http://dx.doi.org/10.33947/1982-3282-v12n1-2-3278

Devogelaer, J. P., Brown, J. P., Burckhardt, P., Meunier, P. J., Goemaere, S., Lippuner, K., Body, J. J., Samsioe, G., Felsenberg, D., Fashola, T., Sanna, L., Ortmann, C. E., Trechsel, U., Krasnow, J., Eriksen, E. F., & Garnero, P. (2007). Zoledronic acid efficacy and safety over five years in postmenopausal osteoporosis. Osteoporosis international: a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 18(9), 1211–1218. https://doi.org/10.1007/s00198-007-0367-3

Dotto, A. C.& Dotto, A. C. (2011) Osteonecrose dos maxilares induzida por Bifosfonatos–revisão de literatura e relato de caso. Revista da Faculdade de Odontologia-UPF,16(2),229-233.

Duarte, N. T., Rech, B. de O., Martins, I. G., Franco, J. B., & Ortega, K. L. (2019). Can children be affected by bisphosphonate-related osteonecrosis of the jaw? A systematic review. International Journal of Oral and Maxillofacial Surgery. doi:10.1016/j.ijom.2019.08.004

Endo, Y., Kumamoto, H., Nakamura, M., Sugawara, S., Takano-Yamamoto, T., Sasaki, K., & Takahashi, T. (2017). Underlying Mechanisms and Therapeutic Strategies for Bisphosphonate-Related Osteonecrosis of the Jaw (BRONJ). Biological & pharmaceutical bulletin, 40(6), 739–750. https://doi.org/10.1248/bpb.b16-01020

Etminan, M., Aminzadeh, K., Matthew, I. R., & Brophy, J. M. (2008). Use of oral bisphosphonates and the risk of aseptic osteonecrosis: a nested case-control study. The Journal of rheumatology, 35(4), 691–695.

Fedele, S., Porter, S. R., D'Aiuto, F., Aljohani, S., Vescovi, P., Manfredi, M., Arduino, P. G., Broccoletti, R., Musciotto, A., Di Fede, O., Lazarovici, T. S., Campisi, G., & Yarom, N. (2010). Nonexposed variant of bisphosphonate-associated osteonecrosis of the jaw: a case series. The American journal of medicine, 123(11), 1060–1064. https://doi.org/10.1016/j.amjmed.2010.04.033

Ferreira Jr, L. H., Jr, Mendonça Jr, K. D., Jr, Chaves de Souza, J., Soares Dos Reis, D. C., do Carmo Faleiros Veloso Guedes, C., de Souza Castro Filice, L., Bruzadelli Macedo, S., & Soares Rocha, F. (2021). Bisphosphonate-associated osteonecrosis of the jaw. Minerva dental and oral science, 70(1), 49–57. https://doi.org/10.23736/S0026-4970.20.04306-X

Fliefel, R., Tröltzsch, M., Kühnisch, J., Ehrenfeld, M., & Otto, S. (2015). Treatment strategies and outcomes of bisphosphonate-related osteonecrosis of the jaw (BRONJ) with characterization of patients: a systematic review. International journal of oral and maxillofacial surgery, 44(5), 568–585. https://doi.org/10.1016/j.ijom.2015.01.026

Frascino, A., & Forte, A. (2016). Interação dos Bifosfonatos na Cirurgia Odontológica. Atas de Ciências da Saúde, 4(1), 12-22. http://revistaseletronicas.fmu.br/index.php/ACIS/article/view/1069

Gavalda, C., & Bagan, J. (2016). Concept, diagnosis and classification of bisphosphonate-associated osteonecrosis of the jaws. A review of the literature. Medicina Oral Patología Oral y Cirugia Bucal, e260– e270. doi:10.4317/medoral.21001

Granate-Marques, A., Polis-Yanes, C., Seminario-Amez, M., Jané-Salas, E., & López-López, J. (2019). Medication-related osteonecrosis of the jaw associated with implant and regenerative treatments: Systematic review. Medicina oral, patologia oral y cirugia bucal, 24(2), e195–e203. https://doi.org/10.4317/medoral.22691

Grbic, J. T., Landesberg, R., Lin, S. Q., Mesenbrink, P., Reid, I. R., Leung, P. C., Casas, N., Recknor, C. P., Hua, Y., Delmas, P. D., Eriksen, E. F., & Health Outcomes and Reduced Incidence with Zoledronic Acid Once Yearly Pivotal Fracture Trial Research Group (2008). Incidence of osteonecrosis of the jaw in women with postmenopausal osteoporosis in the health outcomes and reduced incidence with zoledronic acid once yearly pivotal fracture trial. Journal of the American Dental Association (1939), 139(1), 32–40. https://doi.org/10.14219/jada.archive.2008.0017

Guo, Z., Cui, W., Que, L., Li, C., Tang, X., & Liu, J. (2020). Pharmacogenetics of medication-related osteonecrosis of the jaw: a systematic review and meta-analysis. International journal of oral and maxillofacial surgery, 49(3), 298–309. https://doi.org/10.1016/j.ijom.2019.07.016

Hagelauer, N., Pabst, A. M., Ziebart, T., Ulbrich, H., & Walter, C. (2014). In vitro effects of bisphosphonates on chemotaxis, phagocytosis, and oxidative burst of neutrophil granulocytes. Clinical Oral Investigations, 19(1), 139–148. 10.1007/s00784-014-1219-0

He, L., Sun, X., Liu, Z., Qiu, Y., & Niu, Y. (2020). Pathogenesis and multidisciplinary management of medication-related osteonecrosis of the jaw. International journal of oral science, 12(1), 30. https://doi.org/10.1038/s41368-020-00093-2

Izquierdo, C. M., Oliveira, M. G., Weber, B. B. J. (2011) Terapêutica com Bifosfonatos: implicações no paciente odontológico: revisão de literatura. RFO UPF 16(3),347-352.

Junior, C. D. F., Casado, P. L., Barboza, E. S. P. (2007) Osteonecrose associada aos bifosfonatos na odontologia. Periodontia ; 17(4): 24-30.

Junior, H. H. T., Almeida, J. S., Mourão, C. F., Meira, R., Ribeiro, J. (2016) Avaliação qualitativa do tratamento da osteonecrose dos maxilares associada aos bifosfonatos: aspectos atuais da literatura. Ciência Atual–Revista Científica Multidisciplinar do Centro Universitário São José, 8(2),02-11.

Kalra, S., & Jain, V. (2013). Dental complications and management of patients on bisphosphonate therapy: A review article. Journal of oral biology and craniofacial research, 3(1), 25–30. https://doi.org/10.1016/j.jobcr.2012.11.001

Kates, S. L., & Ackert-Bicknell, C. L. (2016). How do bisphosphonates affect fracture healing?. Injury, 47 Suppl 1(0 1), S65–S68. https://doi.org/10.1016/S0020-1383(16)30015-8

Khan, A. A., Morrison, A., Hanley, D. A., Felsenberg, D., McCauley, L. K., O'Ryan, F., Reid, I. R., Ruggiero, S. L., Taguchi, A., Tetradis, S., Watts, N. B., Brandi, M. L., Peters, E., Guise, T., Eastell, R., Cheung, A. M., Morin, S. N., Masri, B., Cooper, C., Morgan, S. L., International Task Force on Osteonecrosis of the Jaw (2015). Diagnosis and management of osteonecrosis of the jaw: a systematic review and international consensus. Journal of bone and mineral research: the official journal of the American Society for Bone and Mineral Research, 30(1), 3–23. https://doi.org/10.1002/jbmr.2405

Khan, A. A., Rios, L. P., Sándor, G. K., Khan, N., Peters, E., Rahman, M. O., Clokie, C. M., Dore, E., & Dubois, S. (2011). Bisphosphonate-associated osteonecrosis of the jaw in Ontario: a survey of oral and maxillofacial surgeons. The Journal of rheumatology, 38(7), 1396–1402. https://doi.org/10.3899/jrheum.100221

Khan, A. A., Sándor, G. K., Dore, E., Morrison, A. D., Alsahli, M., Amin, F., Peters, E., Hanley, D. A., Chaudry, S. R., Lentle, B., Dempster, D. W., Glorieux, F. H., Neville, A. J., Talwar, R. M., Clokie, C. M., Mardini, M. A., Paul, T., Khosla, S., Josse, R. G., Sutherland, S., … Canadian Taskforce on Osteonecrosis of the Jaw (2009). Bisphosphonate associated osteonecrosis of the jaw. The Journal of rheumatology, 36(3), 478–490. https://doi.org/10.3899/jrheum.080759

Khosla, S., Burr, D., Cauley, J., Dempster, D. W., Ebeling, P. R., Felsenberg, D., Gagel, R. F., Gilsanz, V., Guise, T., Koka, S., McCauley, L. K., McGowan, J., McKee, M. D., Mohla, S., Pendrys, D. G., Raisz, L. G., Ruggiero, S. L., Shafer, D. M., Shum, L., Silverman, S. L., … American Society for Bone and Mineral Research (2007). Bisphosphonate-associated osteonecrosis of the jaw: report of a task force of the American Society for Bone and Mineral Research. Journal of bone and mineral research: the official journal of the American Society for Bone and Mineral Research, 22(10), 1479–1491. https://doi.org/10.1359/jbmr.0707onj

Kim, J. E., Yoo, S., & Choi, S. C. (2020). Several issues regarding the diagnostic imaging of medication-related osteonecrosis of the jaw. Imaging science in dentistry, 50(4), 273–279. https://doi.org/10.5624/isd.2020.50.4.273

Leite, G. B., Louro, R., Vivacqua, C. F. P. P., Motta, S. H. G. (2015) Osteonecrose induzida pelo uso de Bifosfonatos após instalação de implantes dentários–relato de caso. ImplantNews,12(6): 771-778.

Lyles, K. W., Colón-Emeric, C. S., Magaziner, J. S., Adachi, J. D., Pieper, C. F., Mautalen, C., Hyldstrup, L., Recknor, C., Nordsletten, L., Moore, K. A., Lavecchia, C., Zhang, J., Mesenbrink, P., Hodgson, P. K., Abrams, K., Orloff, J. J., Horowitz, Z., Eriksen, E. F., Boonen, S., & HORIZON Recurrent Fracture Trial (2007). Zoledronic acid and clinical fractures and mortality after hip fracture. The New England journal of medicine, 357(18), 1799–1809. https://doi.org/10.1056/NEJMoa074941

Mariotti A. (2008). Bisphosphonates and osteonecrosis of the jaws. Journal of dental education, 72(8), 919–929.

Matsuura, T., Tokutomi, K., Sasaki, M., Katafuchi, M., Mizumachi, E., & Sato, H. (2014). Distinct characteristics of mandibular bone collagen relative to long bone collagen: relevance to clinical dentistry. BioMed research international, 2014, 769414. https://doi.org/10.1155/2014/769414

Moinzadeh, A. T., Shemesh, H., Neirynck, N. A., Aubert, C., & Wesselink, P. R. (2013). Bisphosphonates and their clinical implications in endodontic therapy. International endodontic journal, 46(5), 391–398. https://doi.org/10.1111/iej.12018

Moreno-Rabié, C., Gaêta-Araujo, H., Oliveira-Santos, C., Politis, C., & Jacobs, R. (2020). Early imaging signs of the use of antiresorptive medication and MRONJ: a systematic review. Clinical oral investigations, 24(9), 2973–2989. https://doi.org/10.1007/s00784-020-03423-0

Mourão, C. F. A. B., Moura, A. P., Manso, J. E. F. (2013) Tratamento da osteonecrose dos maxilares associada aos bifosfonatos: revisão da literatura. Rev Bras Cir Cabeça Pescoço, 42(2), 113-117. https://www.researchgate.net/publication/284717613

Ogura I, Minami Y, Ono J, Kanri Y, Okada Y, Igarashi K, Haga-Tsujimura M, Nakahara K, Kobayashi E. CBCT imaging and histopathological characteristics of osteoradionecrosis and medicationrelated osteonecrosis of the jaw. Imaging Sci Dent. 51(1):73- 80. https://doi.org/10.5624/isd.20200230

Ogura I, Minami Y, Ono J, Kanri Y, Okada Y, Igarashi K, Haga-Tsujimura M, Nakahara K, Kobayashi E. CBCT imaging and histopathological characteristics of osteoradionecrosis and medicationrelated osteonecrosis of the jaw. Imaging Sci Dent. 51(1):73-80. https://doi.org/10.5624/isd.20200230

Otto, S., Hafner, S., & Grötz, K. A. (2009). The role of inferior alveolar nerve involvement in bisphosphonate-related osteonecrosis of the jaw. Journal of oral and maxillofacial surgery: official journal of the American Association of Oral and Maxillofacial Surgeons, 67(3), 589–592. https://doi.org/10.1016/j.joms.2008.09.028

Otto, S., Pautke, C., Hafner, S., Hesse, R., Reichardt, L. F., Mast, G., Ehrenfeld, M., & Cornelius, C. P. (2013). Pathologic fractures in bisphosphonate-related osteonecrosis of the jaw-review of the literature and review of our own cases. Craniomaxillofacial trauma & reconstruction, 6(3), 147–154. https://doi.org/10.1055/s-0033-1343776

Papadakis, I., Spanou, A., & Kalyvas, D. (2021). Success Rate and Safety of Dental Implantology in Patients Treated With Antiresorptive Medication: A Systematic Review. The Journal of oral implantology, 47(2), 169–180. https://doi.org/10.1563/aaid-joi-D-19-00088

Papapoulos, S. E. (2008). Bisphosphonates: how do they work?. Best practice & research. Clinical endocrinology & metabolism, 22(5), 831–847. https://doi.org/10.1016/j.beem.2008.07.001

Passeri, L. A., Bértolo, M. B., Abuabara, A. (2011) Osteonecrose dos maxilares associada ao uso de Bifosfonatos. Revista Brasileira de Reumatologia, 51(4), 404-407. SSN: 1809-4570

Pazianas, M., Blumentals, W. A., & Miller, P. D. (2008). Lack of association between oral bisphosphonates and osteonecrosis using jaw surgery as a surrogate marker. Osteoporosis international: a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 19(6), 773–779. https://doi.org/10.1007/s00198-007-0547-1

Poubel, V. L. N., Cruz, D. S. M., Gil, L. F., Júnior, N. L. Claus, J. D. P., Gil, J. N. (2012) Osteonecrose maxilo-mandibular induzida por bisfosfonato: revisão bibliográfica. Revista de Cirurgia e Traumatologia Buco-maxilo-facial, 12(1),33-42. ISSN 1808-5210.

Powell, D., Bowler, C., Roberts, T., Garton, M., Matthews, C., McCall, I., & Davie, M. (2012). Incidence of serious side effects with intravenous bisphosphonate: a clinical audit. QJM: monthly journal of the Association of Physicians, 105(10), 965–971. https://doi.org/10.1093/qjmed/hcs112

Querrer, R., Ferrare, N., Melo, N., Stefani, C. M., Dos Reis, P., Mesquita, C., Borges, G. A., Leite, A. F., & Figueiredo, P. T. (2021). Differences between bisphosphonate-related and denosumab-related osteonecrosis of the jaws: a systematic review. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 29(6), 2811–2820. https://doi.org/10.1007/s00520-020-05855-6

Rasmusson, L., & Abtahi, J. (2014). Bisphosphonate associated osteonecrosis of the jaw: an update on pathophysiology, risk factors, and treatment. International journal of dentistry, 2014, 471035. https://doi.org/10.1155/2014/471035

Reich, W., Bilkenroth, U., Schubert, J., Wickenhauser, C., & Eckert, A. W. (2015). Surgical treatment of bisphosphonate-associated osteonecrosis: Prognostic score and long-term results. Journal of cranio-maxillo-facial surger: official publication of the European Association for Cranio-Maxillo-Facial Surgery, 43(9), 1809–1822. https://doi.org/10.1016/j.jcms.2015.07.035

Rigo, R. F., Gomes, F. V., Mayer, L. (2017) Osteonecrose perimplantar relacionada ao uso de bifosfonatos: revisão de literatura. Revista da AcBO, 6(1), 31-37.

Rother, E. . Revisão sistemática X revisão narrativa. Acta paul. enferm., 20(2), v-vi, https://doi.org/10.1590/S0103-21002007000200001

Ruggiero, S. L., & Woo, S. B. (2008). Biophosphonate-related osteonecrosis of the jaws. Dental clinics of North America, 52(1), 111–ix. https://doi.org/10.1016/j.cden.2007.09.002

Ruggiero, S. L., Dodson, T. B., Assael, L. A., Landesberg, R., Marx, R. E., Mehrotra, B., & American Association of Oral and Maxillofacial Surgeons (2009). American Association of Oral and Maxillofacial Surgeons position paper on bisphosphonate-related osteonecrosis of the jaws--2009 update. Journal of oral and maxillofacial surgery: official journal of the American Association of Oral and Maxillofacial Surgeons, 67(5 Suppl), 2–12. https://doi.org/10.1016/j.joms.2009.01.009

Ruggiero, S. L., Dodson, T. B., Fantasia, J., Goodday, R., Aghaloo, T., Mehrotra, B., O'Ryan, F., & American Association of Oral and Maxillofacial Surgeons (2014). American Association of Oral and Maxillofacial Surgeons position paper on medication-related osteonecrosis of the jaw--2014 update. Journal of oral and maxillofacial surgery:fficial journal of the American Association of Oral and Maxillofacial Surgeons, 72(10),1938–1956. https://doi.org/10.1016/j.joms.2014.04.031

Sacco, R., Woolley, J., Yates, J., Calasans-Maia, M. D., Akintola, O., & Patel, V. (2021). A systematic review of metastatic cancer presenting in osteonecrosis of the jaws (MC-ONJ) in patients undergoing antiresorptive and/or antiangiogenic therapy for skeletal-related adverse events. Oral surgery, oral medicine, oral pathology and oral radiology, 131(6), 650–659. https://doi.org/10.1016/j.oooo.2021.01.001

Sales, K. O., Conceição, L. S. (2020) A atuação do cirurgião-dentista frente à osteonecrose dos maxilares associada ao uso de bifosfonatos: uma revisão de literatura. Original Article. J Business Techn, 14(2),99-110. ISSN 2526-4281

Santos de Souza, E., de Jesus Santos, J., & Botelho de Santana, L. L. (2019). Impactos associados ao uso prolongado de bifosfonatos no tratamento da osteoporose em idosos. Revista Textura, 12(20),151-161. https://doi.org/10.22479/desenreg2018v12n20p151-161

Santos, L. C. S., Pereira, R. P., Gusmão, J. M. R., Almeida, O. D. S. (2016). Influência do uso de Bifosfonatos em pacientes submetidos a implantes dentários: revisão de literatura. Revista Bahiana de Odontologia, Salvador, 7(1), 22-30. http://2238-2720revbahianaodonto.v7i1.706

Santos, P. S. S., Oliveira, M. A., Felix, V. B. (2011) Osteonecrose maxilofacial induzida por Bifosfonatos em indivíduos com osteoporose. Revista Brasileira de Ortopedia,46(5), 495-499, https://doi.org/10.1590/S0102-36162011000500003

Sarasquete, M. E., González, M., San Miguel, J. F., & García-Sanz, R. (2009). Bisphosphonate-related osteonecrosis: genetic and acquired risk factors. Oral diseases, 15(6), 382–387. https://doi.org/10.1111/j.1601-0825.2009.01568.x

Sawatari, Y., & Marx, R. E. (2007). Bisphosphonates and bisphosphonate induced osteonecrosis. Oral and maxillofacial surgery clinics of North America, 19(4), 487–vi. https://doi.org/10.1016/j.coms.2007.07.003

Sérgio Perri de Carvalho, P., Fernandes Santos, H., Gomes Duarte, B., Astolphi Carvalho, F., Dias-Ribeiro, E., & Ferreira Rocha, J. (2010). Principais aspectos da cirurgia bucomaxilofacial no paciente sob terapia com bifosfonatos. Revista Da Faculdade De Odontologia - UPF, 15(2). https://doi.org/10.5335/rfo.v15i2.1351

Sharma, D., Ivanovski, S., Slevin, M., Hamlet, S., Pop, T. S., Brinzaniuc, K., Petcu, E. B., & Miroiu, R. I. (2013). Bisphosphonate-related osteonecrosis of jaw (BRONJ): diagnostic criteria and possible pathogenic mechanisms of an unexpected anti-angiogenic side effect. Vascular cell, 5(1), 1. https://doi.org/10.1186/2045-824X-5-1

Srinivasan, D., Shetty, S., Ashworth, D., Grew, N., & Millar, B. (2007). Orofacial pain - a presenting symptom of bisphosphonate associated osteonecrosis of the jaws. British dental journal, 203(2), 91–92. https://doi.org/10.1038/bdj.2007.635

Srivastava, A., Nogueras Gonzalez, G. M., Geng, Y., Won, A. M., Cabanillas, M. E., Naing, A., Myers, J. N., Li, Y., & Chambers, M. S. (2021). Prevalence of medication related osteonecrosis of the jaw in patients treated with sequential antiresorptive drugs: systematic review and meta-analysis. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 29(5), 2305–2317. https://doi.org/10.1007/s00520-020-05882-3

Stockmann, P., Ebker, T., Bergauer, J., & Wehrhan, F. (2020). Saliva diagnostics in patients suffering from bisphosphonate-associated osteonecrosis of the jaw: Results of an observational study. Journal of craniomaxillo-facial surgery: official publication of the European Association for Cranio-Maxillo-Facial Surgery, 48(2), 176–180. https://doi.org/10.1016/j.jcms.2020.01.005

Stramandinoli-Zanicotti, R. T., Deliberador, T. M., Schussel, J., Torres-Pereira, C., Sassi, L. M. (2018) Implantes dentários em pacientes usuários de bifosfonatos: o risco de osteonecrose e perda dos implantes é real? Relato de três casos clínicos. RSBO, 15(1),50-9. https://www.researchgate.net/publication/328137190

Tavares Junior, H. H., Almeida, J. S., Mourão, C. F., Meira, R., Ribeiro, J. (2016) Avaliação qualitativa do tratamento da osteonecrose dos maxilares associada aos bifosfonatos: aspectos atuais da literatura. Ciênc Atual, 8(2),02-11.

Tennis, P., Rothman, K. J., Bohn, R. L., Tan, H., Zavras, A., Laskarides, C., Calingaert, B., & Anthony, M. S. (2012). Incidence of osteonecrosis of the jaw among users of bisphosphonates with selected cancers or osteoporosis. Pharmacoepidemiology and drug safety, 21(8), 810–817. https://doi.org/10.1002/pds.3292

Thumbigere-Math, V., Michalowicz, B. S., Hodges, J. S., Tsai, M. L., Swenson, K. K., Rockwell, L., & Gopalakrishnan, R. (2014). Periodontal Disease as a Risk Factor for Bisphosphonate-Related Osteonecrosis of the Jaw. Journal of Periodontology, 85(2), 226–233. doi:10.1902/jop.2013.130017

Tsao, C., Darby, I., Ebeling, P. R., Walsh, K., O’Brien-Simpson, N., Reynolds, E., & Borromeo, G. (2013). Oral Health Risk Factors for Bisphosphonate-Associated Jaw Osteonecrosis. Journal of Oral and Maxillofacial Surgery, 71(8), 1360–1366. doi:10.1016/j.joms.2013.02.016

Ulmner, M., Jarnbring, F., & Törring, O. (2014). Osteonecrosis of the jaw in Sweden associated with the oral use of bisphosphonate. Journal of oral and maxillofacial surgery: official journal of the American Association of Oral and Maxillofacial Surgeons, 72(1), 76–82. https://doi.org/10.1016/j.joms.2013.06.221

Vilela-Carvalho, L. N., Tuany-Duarte., N., Andrade-Figueiredo, M., López-Ortega, K. Osteonecrosis de los maxilares relacionados con el uso de medicamentos: Diagnóstico, tratamiento y prevención. Rev. CES Odont 2018; 31(2), 48-63. http://dx.doi.org/10.21615/cesodon.31.2.5

Walter, C., Laux, C., & Sagheb, K. (2013). Radiologic bone loss in patients with bisphosphonate-associated osteonecrosis of the jaws: a case–control study. Clinical Oral Investigations, 18(2), 385– 390. doi:10.1007/s00784-013-0974-7

Wan, J. T., Sheeley, D. M., Somerman, M. J., & Lee, J. S. (2020). Mitigating osteonecrosis of the jaw (ONJ) through preventive dental care and understanding of risk factors. Bone research, 8(1), 14. https://doi.org/10.1038/s41413-020-0088-1

Wasserzug, O., Kaffe, I., Lazarovici, T. S., Weissman, T., Yahalom, R., Fliss, D. M., & Yarom, N. (2017). Involvement of the maxillary sinus in bisphosphonate-related osteonecrosis of the jaw: Radiologic aspects. American journal of rhinology & allergy, 31(1), 36–39. https://doi.org/10.2500/ajra.2017.31.4395

Zadik, Y., Benoliel, R., Fleissig, Y., & Casap, N. (2012). Painful trigeminal neuropathy induced by oral bisphosphonate-related osteonecrosis of the jaw: a new etiology for the numb-chin syndrome. Quintessence international (Berlin, Germany : 1985), 43(2), 97–104. PMID: 22257870

Zhang, X., Hamadeh, I. S., Song, S., Katz, J., Moreb, J. S., Langaee, T. Y., Lesko, L. J., & Gong, Y. (2016). Osteonecrosis of the Jaw in the United States Food and Drug Administration's Adverse Event Reporting System (FAERS). Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 31(2), 336–340. https://doi.org/10.1002/jbmr.2693

Published

26/07/2021

How to Cite

GATIS, M. C. de Q. .; SILVA, A. dos S. .; RIBEIRO, M. L. A. .; BARBIRATO, D. .; PONZI, E. C. de A. .; CAVALCANTI FILHO, J. B. H. .; LAGO, C. A. P. do .; VASCONCELOS, B. C. do E. . Bisphosphonates and the jaw repercussions: A narrative review. Research, Society and Development, [S. l.], v. 10, n. 9, p. e28410917923, 2021. DOI: 10.33448/rsd-v10i9.17923. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/17923. Acesso em: 18 sep. 2021.

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Health Sciences