Prevalence of caries and related factors in patients with cystic fibrosis
DOI:
https://doi.org/10.33448/rsd-v10i9.17927Keywords:
Cystic Fibrosis; Susceptibility to Dental Caries; Saliva elimination.Abstract
Cystic fibrosis (CF) is an autosomal recessive, lethal disease, more common in Caucasians and prevalent in both sexes. More than 1000 mutations are known, the most common being Delta-F508, which is the alteration of RTF protein synthesis (cystic fibrosis transmembrane conductance regulatory protein), affecting cells of various organs, especially those of the respiratory tract, which are related to main deleterious effects, causing death in more than 90% of patients, due to impairment of the functioning of the exocrine glands that produce thicker substances, thus hindering their elimination. Aiming to assess the prevalence of caries and related factors in a group of 20 children with cystic fibrosis, aged from 01 to 14 years of age, and to correlate data from the dental questionnaire with information collected from clinical examinations performed. This work is a descriptive, analytical case-control study with a cross-sectional design. To analyze the data obtained, the Shapiro-Wilks, Student's T, Mann-Whitney, ANOVA and Poisson tests were used. For all tests, a statistical significance level of 5% (p<0.05) was adopted. It was shown that the CF and control groups did not differ in terms of caries prevalence (p=0.838). There was a statistically significant difference for the variable saliva pH (p=0.025), with the CF group presenting lower salivary pH values compared to the control group. However, individuals with cystic fibrosis who participated in the study did not have a higher prevalence of caries than the control group, although they had lower salivary pH.
References
Alkhateeb, A. A., Mancl, L. A., Presland, R. B., Rothen, M. L., & Chi, D. L. (2017). Unstimulated Saliva-Related Caries Risk Factors in Individuals with Cystic Fibrosis: A Cross-Sectional Analysis of Unstimulated Salivary Flow, pH, and Buffering Capacity. Caries research, 51(1), 1–6.
Aps, J. K., & Martens, L. C. (2004). Quel risque pour la santé bucco-dentaire des patients souffrant de mucoviscidose?. Revue belge de medecine dentaire, 59(2), 114–120
Aps, J. K., Van Maele, G. O., Claeys, G., & Martens, L. C. (2001). Mutans streptococci, lactobacilli and caries experience in cystic fibrosis homozygotes, heterozygotes and healthy controls. Caries research, 35(6), 407–411.
Aps, J. K., Van Maele, G. O., & Martens, L. C. (2002). Caries experience and oral cleanliness in cystic fibrosis homozygotes and heterozygotes. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, 93(5), 560–563.
Azarpazhooh, A., & Leake, J. L. (2006). Systematic review of the association between respiratory diseases and oral health. Journal of periodontology, 77(9), 1465–1482.
Azevedo, T. D., Feijó, G. C., & Bezerra, A. C. (2006). Presence of developmental defects of enamel in cystic fibrosis patients. Journal of dentistry for children, 73(3), 159–163.
Castellani, C., & Assael, B. M. (2017). Cystic fibrosis: a clinical view. Cellular and molecular life sciences, 74(1), 129–140.
Ceder, O., Dijken, J., Ericson, T., & Kollberg, H. (1985). Ribonuclease in different types of saliva from cystic fibrosis patients. Acta paediatrica Scandinavica, 74(1), 102–106.
Chapper, A. (2010). Avaliação do estado de saúde bucal de pacientes com fibrose cística (tese doutorado). Acessado no UFRGS Repositório Digital.
Chi D. L. (2013). Dental caries prevalence in children and adolescents with cystic fibrosis: a qualitative systematic review and recommendations for future research. International journal of paediatric dentistry, 23(5), 376–386.
Chi, D. L., Rosenfeld, M., Mancl, L., Chung, W. O., Presland, R. B., Sarvas, E., Rothen, M., Alkhateeb, A., McNamara, S., Genatossio, A., Virella-Lowell, I., Milla, C., & Scott, J. (2018). Age-related heterogeneity in dental caries and associated risk factors in individuals with cystic fibrosis ages 6-20 years: A pilot study. Journal of cystic fibrosis: official journal of the European Cystic Fibrosis Society, 17(6), 747–759.
Cury, J. A., Tenuta, L. M. A., Ribeiro, C. C. C., & Leme, A. F. P. (2004). The importance of fluoride dentifrices to the current dental caries prevalence in Brazil. Brazilian Dental Journal. 15(3), 163–174.
Davis, P. B. (1987). Pathophysiology of cystic fibrosis with emphasis on salivary gland involvement. Journal of dental research, 66(1), 667–671.
Dabrowska, E., Błahuszewska, K., Minarowska, A., Kaczmarski, M., Niedźwiecka-Andrzejewicz, I., & Stokowska, W. (2006). Assessment of dental status and oral hygiene in the study population of cystic fibrosis patients in the Podlasie province. Advances in medical sciences, 51(1), 100–103.
Elborn J. S. (2016). Cystic fibrosis. Lancet (London, England), 388(10059), 2519–2531.
Ferrazzano, G. F., Orlando, S., Sangianantoni, G., Cantile, T., & Ingenito, A. (2009). Dental and periodontal health status in children affected by cystic fibrosis in a southern Italian region. European journal of paediatric dentistry, 10(2), 65–68.
Gruebbel, A. O. (1944). A measuremente of dental caries prevalence and treatment service for deciduous teeth. Journal of Dental Research, 23(3), 163–168.
Kamieńska, T. P., Lewicka, M. B., & Gabryel, H. B. (2019). Salivary Biomarkers and Oral Microbial Load in Relation to the Dental Status of Adults with Cystic Fibrosis. Microorganisms, 7(12), 692.
Kinirons, M. J. (1992). The effect of antibiotic therapy on the oral health of cystic fibrosis children. International Journal of Paediatric Dentistry. 2(3), 139–143.
Klein, H. & Palmer, C. E. (1937). Dental caries in American indian children. Public Health Bull. 239(1), 1–54.
Livnat, G., Bentur, L., Kuzmisnsky, E., & Nagler, R. M. (2010). Salivary profile and oxidative stress in children and adolescents with cystic fibrosis. Journal of oral pathology & medicine, 39(1), 16–21.
Mantovani, R. P., Sandri, A., Boaretti, M., Grilli, A., Volpi, S., Melotti, P., Burlacchini, G., Lleò, M. M., & Signoretto, C. (2019). Toothbrushes may convey bacteria to the cystic fibrosis lower airways. Journal of oral microbiology, 11(1), 1–8.
Minayo, M. C. S. (2007). Trabalho de campo: contexto de observação, interação e descoberta. Editora Vozes.
Mérelle, M. E., Schouten, J. P., Gerritsen, J., & Dankert-Roelse, J. E. (2001). Influence of neonatal screening and centralized treatment on long-term clinical outcome and survival of CF patients. The European respiratory journal, 18(2), 306–315.
Narang, A., Maguire, A., Nunn, J. H., & Bush, A. (2003). Oral health and related factors in cystic fibrosis and other chronic respiratory disorders. Archives of disease in childhood, 88(8), 702–707.
Nauntofte, B., Tenovuo, O. J., & Lagerlof, F. (2005). Secreção e composição da saliva. São Paulo: Santos.
O'Leary, T. (1967). The periodontal screening examination. Journal of periodontology, 38(6), 617–624.
Paju, S., & Scannapieco, F. A. (2007). Oral biofilms, periodontitis, and pulmonary infections. Oral diseases, 13(6), 508–512.
Paranjape, S. M., & Mogayzel, P. J., Jr (2014). Cystic fibrosis. Pediatrics in review, 35(5), 194–205.
Peker, S., Kargul, B., Tanboga, I., Tunali-Akbay, T., Yarat, A., Karakoc, F., Ersu, R., & Dagli, E. (2015). Oral health and related factors in a group of children with cystic fibrosis in Istanbul, Turkey. Nigerian journal of clinical practice, 18(1), 56–60.
Ratjen, F., Bell, S. C., Rowe, S. M., Goss, C. H., Quittner, A. L., & Bush, A. (2015). Cystic fibrosis. Nature reviews. Disease primers, 1(15010), 1-19.
Sanders, D. B., & Fink, A. K. (2016). Background and Epidemiology. Pediatric clinics of North America, 63(4), 567–584.
Serratine, A. C. P., & Silva, M. R. M. (2009). Validação de um método simplificado de avaliação do pH salivar em crianças. Pesquisa Brasileira Odontopediatria e Clínica Integrada. 9(2), 217–221.
Silva, A. C. S.; Veiga, J. B.; Veiga, B. B.; Caioni, C. & Oliveira, A. S. (2014). Avaliação do software bioestat para o ensino de estatística nos cursos de graduação. Revista da Universidade Vale do Rio Verde. 12(2), 375-385.
Sosnay, P. R., Raraigh, K. S., & Gibson, R. L. (2016). Molecular Genetics of Cystic Fibrosis Transmembrane Conductance Regulator: Genotype and Phenotype. Pediatric clinics of North America, 63(4), 585–598.
Storhaug, K., & Holst, D. (1987). Caries experience of disabled school-age children. Community dentistry and oral epidemiology, 15(3), 144–149.
Timbó, F. (2014). ABC de bioestatística. (2 ed.). Edufal.
Walsh, T., Worthington, H. V., Glenny, A. M., Appelbe, P., Marinho, V. C., & Shi, X. (2010). Fluoride toothpastesof different concentrations for preventing dental caries in children and adolescents. Cochrane Database Syst Rev, 20(1), 102–118.
Minayo, M. C. S. (2007). Trabalho de campo: contexto de observação, interação e descoberta. Editora Vozes.
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