The role of adipocyte in the inflammation and metabolism of the obese

Authors

DOI:

https://doi.org/10.33448/rsd-v10i9.18191

Keywords:

Inflammation; Metabolism; Adipocytes; Obesity.

Abstract

Objective: To investigate the role of adipocytes in inflammation caused by obesity. Methodology: This is an integrative review, carried out in the LILACS, SCIELO and MEDLINE / PUBMED databases, in the period from September 2020 to May 2021, in English, Spanish and Portuguese language, published between 2015 and May 2021. The following descriptors were used: inflammation, metabolism, adipocytes and obesity, as well as their English versions. Results: The inflammatory state produced by metabolic stress due to obesity is different from classical inflammation, the triggering factor is the excess of nutrients resulting from growth and increase in the number of adipocytes, making it a dysfunctional tissue. Metabolic complications in a state of obesity can be aggravated by an abnormal inflammatory response and it is known to be associated with the formation of toxic reactive oxygen species. Conclusion: It is concluded that adipocytes play an important role in the inflammation and metabolism of the obese, because through adipocytes the main pro-inflammatory cytokines are produced, which can lead to insulin resistance, hypertension, among other metabolic problems.

References

Cozzolino, S. M. F., & Cominetti, C. (2016). Bases bioquímicas e fisiológicas da nutrição. Manole.

Dludla, P, D., Nkambule, B, B., Jack, B., Mkandla, Z., Mutize, T., Silvestri, S., Orlando, P., Tiano, L., Louw, J., & Mazibuko-Mbeje, S. (2018). Inflammation and Oxidative Stress in an Obese State and the Protective Effects of Gallic Acid. Nutrients, 11(1), 23. https://doi.org/10.3390/nu11010023

Francisqueti, F. V., Nascimento, A. F., & Corrêa, C. R. (2015). Obesidade, inflamação e complicações metabólicas. Nutrire, 40 (1), 81-89. http://sban.cloudpainel.com.br/files/revistas_publicacoes/452.pdf

Han, M. S., White, A., Perry, R. J., Camporez, J.-P., Hidalgo, J., Shulman, G. I., & Davis, R. J. (2020). Regulation of adipose tissue inflammation by interleukin 6. Proceedings of the National Academy of Sciences, 117(6), 2751–2760. https://doi.org/10.1073/pnas.1920004117

Júnior, A. J. S. (2017). Adipocinas: a relação endócrina entre obesidade e diabetes tipo II. RBONE - Revista Brasileira de Obesidade, Nutrição e Emagrecimento, 11(63), 135-144. http://www.rbone.com.br/index.php/rbone/article/view/504

Lacerda, M. S., Malheiros, G. C., & Abreu, A. O. W. (2016). Tecido adiposo, uma nova visão: as adipocinas e seu papel endócrino / adiposo tissue, a newvision: adipocines and its endocrine paper. Revista Científica da Faculdade de Medicina de Campos, 11(2), 25-31. https://www.fmc.br/ojs/index.php/RCFMC/article/view/6

Liechocki, S. (2018). Avaliação do perfil inflamatório de diferentes depósitos de tecido adiposo na obesidade. Fiocruz.br, 1-128. https://www.arca.fiocruz.br/handle/icict/26991

Longo, M., Zatterale, F., Naderi, J., Parrillo, L., Formisano, P., Raciti, G. A., Beguinot, F., & Miele, C. (2019). Adipose Tissue Dysfunction as Determinant of Obesity-Associated Metabolic Complications. International Journal of Molecular Sciences, 20(9), 2358. https://doi.org/10.3390/ijms20092358

Magdalon, J., & Festuccia, W. T. (2017). Regulation of adiposity by mTORC1. Einstein (São Paulo), 15(4), 507–511. https://doi.org/10.1590/s1679-45082017rb4106

Magnuson, A. M., Fouts, J. K., Regan, D. P., Booth, A. D., Dow, S. W., & Foster, M. T. (2018). Adipose tissue extrinsic factor: Obesity-induced inflammation and the role of the visceral lymph node. Physiology & Behavior, 190, 71–81. https://doi.org/10.1016/j.physbeh.2018.02.044

Mendes, K. S, Silveira, R. C. C. P., & Galvão, C. M. (2008). Revisão integrativa: método de pesquisa para a incorporação de evidências na saúde e na enfermagem. Texto contexto - enferm.,17, (4), 758-764. https://doi.org/10.1590/S0104-07072008000400018

Ministério da Saúde. (2019). Brasileiros atingem maior índice de obesidade dos últimos treze anos, de acordo com pesquisa Vigitel. Instituto nacional do câncer.

Nascimento, S. S. C., Queiroz, J. L. C., Medeiros, A. F., Nunes, A. C. F., Piuvezam, G. Maciel, B. L. L., Passos, T. S., & Morais, A. H. A. (2021). What are the mechanisms of action of anti-inflammatory agentes in adipose tissue? Medicine, 100 (8), 24677. https://doi.org/10.1097/md.0000000000024677

Russo, L., & Lumeng, C. N. (2018). Propriedades e funções dos macrófagos do tecido adiposo na obesidade. Immunology, 155 (4), 407–417. https://doi.org/10.1111/imm.13002

Santos, C. M. C., Pimenta, C. A. M., & Nobre, M. R. C. (2007) A estratégia PICO para a construção da pergunta de pesquisa e busca de evidências. Rev. Latino-Am. Enfermagem, 15 (3), 508-511. https://doi.org/10.1590/S0104-11692007000300023

Santos, F. M. M. (2017). Obesidade e estado inflamatório: principais adipocinas envolvidas. Universidade Federal do Rio Grande do Sul- LUME- Repositório Digital, 1-28.

Silva, N. I., Rocha Sobrinho, H. M., Blanch, G. T., Cruvinel, W. M., & Gomes, M. G. (2019). Adipocinas e sua relação com a obesidade. Revista EVS - Revista de Ciências Ambientais e Saúde, 46 (1), 53-64. https://doi.org/10.18224/evs.v46i1.7179

Soares, P. E. M., Ferreira, E. T. de O., Mafra, G. C. S., Silva, J. G. Santos, R. L. dos, Farias, J. V. C., & Farias, I. C. C. (2020). O Papel das adipocinas na imunologia da obesidade. Research, Society and Development, 9 (7), e935975095. https://doi.org/10.33448/rsd-v9i7.5095

Suárez-Carmona, W., Sánchez-Oliver, A. J. & González-Jurado, J. A. (2017) Fisiopatologia da obesidade: Perspectiva atual. Revista chilena de nutrição, 44 (3), 226–233. https://dx.doi.org/10.4067/s0717-75182017000300226

Veronese, A., Carmona, E. V., Silva, J. B., Carvalho, S. D., Trevisa, D. D., & Beck, A. N. M. (2015). Revisão Sistemática ou Integrativa. REME - Revista Mineira de Enfermagem, 19 (3), 768-773. https://doi.org/10.5935/1415-2762.20150058

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Published

31/07/2021

How to Cite

SOUSA, E. F. G. de .; REIS , B. G. S. .; NUNES MENDES DE BRITO, A. . The role of adipocyte in the inflammation and metabolism of the obese. Research, Society and Development, [S. l.], v. 10, n. 9, p. e45810918191, 2021. DOI: 10.33448/rsd-v10i9.18191. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/18191. Acesso em: 22 nov. 2024.

Issue

Vol. 10 No. 9

Section

Review Article

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Copyright (c) 2021 Erica Fernanda Gomes de Sousa; Bruno Gabriel Santos Reis ; Andrea Nunes Mendes de Brito

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