Articaine: molecular aspects and applicability in the dental clinic

Authors

DOI:

https://doi.org/10.33448/rsd-v10i10.18954

Keywords:

Local anesthesia; Articaine; Epinephrine; Toxicity.

Abstract

Local anesthesia is commonly used in dentistry to perform procedures that involve pain. Currently available local anesthetics belong to the amide group and act by temporarily blocking the passage of nerve impulses. Articaine, despite being a relatively new anesthetic compared to others, has been widely used, showing several clinical benefits; however, it is a drug commonly associated with episodes of non-surgical paresthesia. The aim of this study was to review the literature on the use of articaine in dentistry, highlighting its clinical and molecular characteristics and possible complications arising from its use. The present work was carried out through a bibliographical research of scientific articles and books on the subject, seeking to know the supposed advantages and disadvantages of the use of articaine in dental procedures. Regarding the advantages, it has a high capacity to diffuse into the nerve cell, which allows for high success rates and short latency, in addition to a short half-life and longer duration of action, compared to the others local anesthetics. With regard to the supposed disadvantages, articaine has been commonly associated with an increased risk of non-surgical paresthesia, probably due to the higher concentration in which it is marketed, at 4%. However, there is not enough evidence to confirm this relationship nor to refute it. It was possible to conclude that articaine is an effective and safe local anesthetic for use in the dental clinic, with some advantages over other commonly used local anesthetics.

References

Abu-Mostafa, N., Al-Showaikhat, F., Al-Shubbar, F., Al-Zawad, K., & Al-Banawi, F. (2015). Hemodynamic changes following injection of local anesthetics with different concentrations of epinephrine during simple tooth extraction: A prospective randomized clinical trial. Journal of Clinical and Experimental Dentistry, 7(4), e471–e476. https://doi.org/10.4317/jced.52321

Bartlett, G., & Mansoor, J. (2016). Articaine buccal infiltration vs lidocaine inferior dental block - A review of the literature. British Dental Journal, 220(3), 117–120. https://doi.org/10.1038/sj.bdj.2016.93

Becker, D. E., & Reed, K. L. (2012). Local Anesthetics: Review of Pharmacological Considerations. Anesthesia Progress, 59(2), 90–102. https://doi.org/10.2344/0003-3006-59.2.90

Britto, A. C. S., Oliveira, A. C. A. DE, Lima, C. A. A., Souza, L. M. de A., Paixão, M. S., & Groppo, F. C. (2014). Comparação da latência anestésica de Articaína, Lidocaína, Levobupivacaína e Ropivacaína através de “Pulp Tester.” Revista de Odontologia Da UNESP, 43(1), 8–14. https://doi.org/10.1590/s1807-25772014000100002

De Morais, H. H. A., Holanda Vasconcellos, R. J., De Santana Santos, T., Rocha, N. S., Da Costa Araújo, F. A., & De Carvalho, R. W. F. (2013). Clinical study of hemodynamic changes comparing 4% articaine hydrochloride with 1:100,000 and 1:200,000 epinephrine. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 116(1), e14–e22. https://doi.org/10.1016/j.oooo.2011.10.043

Dhimar, A. A., Sangada, B. R., Upadhyay, M. R., & Patel, S. H. (2018). I-Gel versus laryngeal mask airway ( LMA ) classic as a conduit for tracheal intubation using ventilating bougie. 34(1), 467–472. https://doi.org/10.4103/joacp.JOACP

Gaffen, A. S., & Haas, D. A. (2009). Retrospective Review of Voluntary Reports of. Journal (Canadian Dental Association), 75(8).

Garisto, G. A., Gaffen, A. S., Lawrence, H. P., Tenenbaum, H. C., & Haas, D. A. (2010). Occurrence of paresthesia after dental local anesthetic administration in the United States. The Journal of the American Dental Association, 141(7), 836–844. https://doi.org/10.14219/jada.archive.2010.0281

Kakroudi, S. H. A., Mehta, S., & Millar, B. J. (2015). Articaine hydrochloride: is it the solution? Dental Update, 42(1), 88–93. https://doi.org/10.12968/denu.2015.42.5.493

Lasemi, E., Sezavar, M., Habibi, L., Hemmat, S., Sarkarat, F., & Nematollahi, Z. (2015). Articaine (4%) with epinephrine (1:100.000 or 1:200.000 ) in inferior alveolar nerve block: Effects on the vital signs and onset, and duration of anesthesia. J Dent Anesth Pain Med, 15(4), 201–205.

Lima, J. L., Dias-Ribeiro, E., Ferreira-Rocha, J., Soares, R., Costa, F. W. G., Fan, S., & Sant’ana, E. (2013). Comparison of buccal infiltration of 4% articaine with 1 : 100,000 and 1 : 200,000 epinephrine for extraction of maxillary third molars with pericoronitis: a pilot study. Anesthesia Progress, 60(2), 42–45. https://doi.org/10.2344/0003-3006-60.2.42

Malamed, S. F. (2005). Manual de Anestesia Local (5a ed.). Elsevier Editora Ltda.

MALAMED, S. F. (2013). Manual de anestesia local (6a ed.)Elsevier.

Mcentire, M., Nusstein, J., Drum, M., Reader, A., & Beck, M. (2011). as a Primary Buccal Infiltration in the Mandibular First Molar. Journal of Endodontics, 37(4), 450–454. https://doi.org/10.1016/j.joen.2010.12.007

Moore, P. A., Boynes, S. C., Hersh, E. V., DeRossi, S. S., Sollecito, T. P., Goodson, J. M., & Hutcheson, M. (2006). The anesthetic efficacy of 4 percent articaine 1:200,000 epinephrine: Two controlled clinical trials. Journal of the American Dental Association, 137(11), 1572–1581. https://doi.org/10.14219/jada.archive.2006.0093

Moore, P. A., & Hersh, E. V. (2010). Local Anesthetics: Pharmacology and Toxicity. Dental Clinics of North America, 54(4), 587–599. https://doi.org/10.1016/j.cden.2010.06.015

Pereira, L. A. P., Groppo, F. C., Bergamaschi, C. D. C., Meechan, J. G., Ramacciato, J. C., Motta, R. H. L., & Ranali, J. (2013). Articaine (4%) with epinephrine (1:100,000 or 1:200,000) in intraosseous injections in symptomatic irreversible pulpitis of mandibular molars: Anesthetic efficacy and cardiovascular effects. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 116(2), e85–e91. https://doi.org/10.1016/j.oooo.2011.10.045

Snoeck, M. (2013). Articaine: A review of its use for localand regional anesthesia. Local and Regional Anesthesia, 5(1), 23–33. https://doi.org/10.2147/LRA.S16682

Thakare, A., Bhate, K., & Kathariya, R. (2014). Comparison of 4% articaine and 0.5% bupivacaine anesthetic efficacy in orthodontic extractions: Prospective, randomized crossover study. Acta Anaesthesiologica Taiwanica, 52(2), 59–63. https://doi.org/10.1016/j.aat.2014.04.006

Victorino, F. R., Daniel, A. N., Iwaki Filho, L., Camarini, E. T., Mazucheli, J., & Pavan, Â. J. (2004). Análise comparativa entre os anestésicos locais Articaína 4% e Prilocaína 3% na extração de terceiros molares retidos em humanos. Acta Scientiarum - Health Sciences, 26(2), 351–356. https://doi.org/10.4025/actascihealthsci.v26i2.1588

Yapp, K. E., Hopcraft, M. S., & Parashos, P. (2011). Articaine: a review of the literature. British Dental Journal, 210(7), 323–329. https://doi.org/10.1038/sj.bdj.2011.240

Published

11/08/2021

How to Cite

GONÇALVES, C. M. .; SIMÕES, I. B. .; RODRIGUES, L. D. .; TAVARES, L. F. .; TOTOLA, P. H. B. .; BOTASSI, R. dos S. .; CALENZANI, A. L. Z. .; MELLO ASSIS, P. S. de. Articaine: molecular aspects and applicability in the dental clinic. Research, Society and Development, [S. l.], v. 10, n. 10, p. e299101018954, 2021. DOI: 10.33448/rsd-v10i10.18954. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/18954. Acesso em: 27 oct. 2021.

Issue

Section

Review Article