Comparative study of the metabolic and anthropometric profile of patients with polycystic ovary syndrome under treatment with oral contraceptives containing drospirenone or cyproterone
DOI:
https://doi.org/10.33448/rsd-v10i10.18983Keywords:
Polycystic ovary syndrome; Metabolic syndrome; Oral contraceptive.Abstract
Polycystic Ovary Syndrome (PCOS) is a heterogeneous endocrine dysfunction characterized by oligoamenorrhea and hyperandrogenism. It is associated with comorbidities such as insulin resistance, hyperlipidemia, cardiovascular diseases, cosmetic problems and infertility. Analyse and compare possible impacts on the anthropometric, metabolic and cardiovascular profiles of patients with PCOS before and after 06 months of treatment with combined oral contraceptives (COC) containing Ethinylestradiol (EE) 0.035mg + Cyproterone 2mg or EE 0.03mg + Drospirenone 3mg. Observational, prospective and analytical study, with quantitative approach, approved by the REC of HU-UFPI (number 2.568.977), accomplished between August 2018-June 2019. Women aged 18 to 40 years with a confirmed diagnosis for PCOS were selected and divided into two homogeneous groups to use the following combinations for 06 months: Group 1 (EE + Cyproterone) and Group 2 (EE + Drospirenone). Statistical t-Student and Mann-Whitney U tests were used for data analysis, with a 5% significance level. Anthropometric and metabolic data of the 16 selected participants were analyzed before and after 6 months of COC therapy. There was a statistically significant reduction in BMI in group 2 and a significant increase in HDL and Total Cholesterol in group 1. After 06 months of using these COCs, it was observed: improvement in Total Cholesterol and HDL with EE + Cyproterone; reduction in BMI with EE + Drospirenone; absence of additional risk in the metabolic, anthropometric and cardiovascular profile; no clinical superiority in the metabolic risk of one hormonal combination over the other in patients with PCOS.
References
Abeso. (2009). Associação Brasileira para o estudo da obesidade e da Síndrome Metabólica. ABESO 3ª ed. São Paulo, 2010.
Brandão, A.P. et al. (2005). I Diretriz brasileira de diagnóstico e tratamento da síndrome metabólica. Arq Bras Cardiol, 84, 1-28
Aydin, K., Cinar, N., Aksoy, D. Y., Bozdag, G., & Yildiz, B. O. (2013). Body composition in lean women with polycystic ovary syndrome: effect of ethinyl estradiol and drospirenone combination. Contraception, 87(3), 358-362.
Brasil. Ministério da Saúde. Consulta Pública nº 33, de 26 de agosto de 2010. Brasília: Secretaria de Atenção à Saúde, 2010.
Disponível em: http://bvsms.saude.gov.br/bvs/saudelegis/sas/2010/cop0033_26_08_2010.html. Acesso em: 17. out. 2015.
Christ, J. P., Willis, A. D., Brooks, E. D., Brink, H. V., Jarrett, B. Y., Pierson, R. A., ... & Lujan, M. E. (2014). Follicle number, not assessments of the ovarian stroma, represents the best ultrasonographic marker of polycystic ovary syndrome. Fertility and sterility, 101(1), 280-287.
Finotti, M. Repercussões não reprodutivas da SOP na saúde da mulher. (20130. O que e como avaliar? In: CONGRESSO DE GINECOLOGIA E OBSTETRÍCIA DO DISTRITO FEDERAL, 46. Brasília: SGOB.
Gallo, M. F., Lopez, L. M., Grimes, D. A., Carayon, F., Schulz, K. F., & Helmerhorst, F. M. (2014). Combination contraceptives: effects on weight. Cochrane Database of Systematic Reviews, (1).
Glintborg, D. (2016). Endocrine and metabolic characteristics in polycystic ovary syndrome. Danish Medical Journal. Apr;63(4):B5232.
Guastella, E., Longo, R. A., & Carmina, E. (2010). Clinical and endocrine characteristics of the main polycystic ovary syndrome phenotypes. Fertility and sterility, 94(6), 2197-2201.
Hong, S. H., Sung, Y. A., Hong, Y. S., Jeong, K., Chung, H., & Lee, H. (2017). Polycystic ovary morphology is associated with insulin resistance in women with polycystic ovary syndrome. Clinical endocrinology, 87(4), 375-380.
Jeanes, Y. M., & Reeves, S. (2017). Metabolic consequences of obesity and insulin resistance in polycystic ovary syndrome: diagnostic and methodological challenges. Nutrition research reviews, 30(1), 97-105.
Lopes, I. M. R. S., Baracat, M. C. P., Simões, M. J., Simões, R. S., Baracat, E. C., & Soares Jr, J. M. (2011). Endométrio na janela de implantação em mulheres com síndrome dos ovários policísticos. Revista da Associação Médica Brasileira, 57(6), 702-709.
Lopez, L. M., Grimes, D. A., & Schulz, K. F. (2014). Steroidal contraceptives: effect on carbohydrate metabolism in women without diabetes mellitus. Cochrane Database of Systematic Reviews, (4).
Medeiros, SF (2017). Riscos, tamanho dos benefícios e implicações clínicas do uso de anticoncepcionais orais combinados em mulheres com síndrome dos ovários policísticos. Reproductive Biology and Endocrinology , 15 (1), 1-17.
Melo, A. S., Dos Reis, R. M., Ferriani, R. A., & Vieira, C. S. (2017). Hormonal contraception in women with polycystic ovary syndrome: choices, challenges, and noncontraceptive benefits. Open access journal of contraception, 8, 13.
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