Neoplasms of the canine and feline central nervous system: 20-year study

Authors

DOI:

https://doi.org/10.33448/rsd-v10i11.18987

Keywords:

Neurological metastasis; Meningioma; Mammary Carcinoma; Dogs; Cats.

Abstract

The aim of this study was to evaluate the epidemiological and pathological aspects of neurological neoplasms in canines and felines referred to the Laboratório Regional de Diagnóstico of the Faculdade de Veterinária of the Universidade Federal de Pelotas (LRD/FV/UFPel) over a period of 20 years. The protocols for necropsy of canines and felines sent to the LRD/FV/UFPel from January 2000 to December 2020 were reviewed, and cases with a diagnosis of primary and secondary neurological neoplasia were selected. From these, information regarding age, sex, race, clinical signs, macroscopic and histopathological findings were analyzed. During the study period, 35 cases of neoplasms in the central nervous system of canines and six in felines were diagnosed. In both species, neoplasms were more frequent in females, mixed breed animals over five years of age, with secondary tumors being the most prevalent. The most affected neuroanatomical region in canines was the thalamus-cortical region and in felines the spinal cord. In dogs, the most frequent neurological clinical sign was seizure and in cats there was no higher occurrence of any clinical sign. The absence of neurological signs was observed in 37.5% of canines and 50% of felines. The main neoplasms related to the cause of death of dogs and cats in this study were the secondary ones, with metastasis from mammary carcinoma being the main diagnosis, and in many cases neurological clinical signs may not be observed.

References

Andrade, T. M., Caramalac, S. M., Pupin, R. C., Babo-Terra V. J. & Palumbo, M. I. P. (2019). Ependimoma anaplásico em cão. Acta Scientiae Veterinariae, 47(Suppl 1): 389-342.

Azim, H. A., Abdel-Malek, R. & Kassem, L. (2017). Predicting brain metastasis in breast cancer patients: stage versus biology. Clinical Breast Cancer, 18(2): 187-195.

Belluco, S., Avallone, G., Di Palma, S., Rasotto, R. & Oevermann, A. (2019). Inter- and intraobserver agreement of canine and feline nervous system tumors. Veterinary Pathology, 56(3):342-349.

Besalti, O., Caliskan, M., Can, P., Vural, S. A., Algin, O. & Ahlat, O. (2016). Imaging and surgical outcomes of spinal tumors in 18 dogs and one cat. Journal of Veterinary Science, 17(2):225–234.

Castro, M. R., Gouveia, B. A., Silva, M. C. B., Medeiros-Ronchi, A. A. & Bastos, J. E. D. (2017). Metástase de carcinoma mamário em sistema nervoso central de cadela. Enciclopédia Biosfera, 14(26): 438-445.

Cantile, C. & Youssef, S. (2016). Nervous System. In: Jubb, K. V. F., Kennedy, J. P. & Palmer’s Pathology of Domestic Animals. St. Louis: Elsevier, 250-406.

Chaves, R. O., Feranti, J. P. S., Copat, B., Ripplinger, A., França, R. T., Kommers, G. D., Fighera, R. A. & Mazzanti, A. (2018a). Neoplasias encefálicas em 40 cães: aspectos clínico-epidemiológicos e patológicos. Pesquisa Veterinária Brasileira, 38(4): 734-740.

Chaves, R. O., Togni, M., Copat, B., Feranti, J. P. S., Silva, A. P., França, R. T., Fighera, R. A. & Mazzanti, A. (2018b). Doenças neurológicas em gatos: 155 casos. Pesquisa Veterinária Brasileira, 38(1): 107-112.

Coates, J. R. & Johnson, G. C. (2010). Nervous system neoplasia. In: Henry, C. J., Higginbothan, M. L. (Eds). Cancer management in small animal practice. Missouri: Sauders, p. 186-194.

Frade, M. T. S., Ferreira, J. S., Nascimento, M. J. R., Aquino, V. V. F., Macêdo, I. L., Carneiro, R. S., Souza, A. P. & Dantas, A. F. M. (2018). Doenças do sistema nervoso central em cães. Pesquisa Veterinária Brasileira, 38(5): 935-948.

Fraga, C. A. T., Costa, T. C., Headley, S. A. & Gomes, L. A. (2014). Alterações neurológicas associadas a tumor cerebral. PUBVET, 8(23): 2806-2887.

Frank, L., Burigk, L., Lehmbecker, A., Wohlsein, P., Schütter, A., Meyerhoff, N., Tipold, A. & Nessler, J. (2020) Meningioma and associated cerebral infarction in three dogs. BMC Veterinary Research, 16(1):177.

Heck, L. C., Cony, F. G., Bianchi, M. V., Driemeier, D., Sonne, L. & Pavarini, S. P. (2018). Pathological features of 78 metastatic or multicentric neoplasms involving the central nervous system in dogs. Pesquisa Veterinária Brasileira, 38(10):1989-1998.

Higgins, R. J., Bollen, A. W., Dickinson, P. J. & Sisó-Lionch, S. (2017). Tumors of the nervous system. In: Meuten, D. J. (Ed). Tumors of Domestic Animals. 5ed. Iowa: State Press, 834-891.

Horta, R. S, Martins, B. C., Lavalle, G. E., Costa, M. P. & Araújo, R. B. (2013). Neoplasias intracranianas em pequenos animais – revisão de literatura. Acta Veterinaria Brasilica, 7(4): 272-281.

Hsu, D. W., Efird, J. T. & Hedley-Whyte, E. T. (1997). Progesterone and estrogen receptors in meningiomas: prognostic considerations. Journal of Neurosurgery, 86(1): 113-120.

Kishimoto, T. E., Uchida, K., Chambers, J. K., Kok, M. K., Filho, N. V., Shiga, T., Hirabayashi, M., Ushio, N. & Nakayama H. (2020). A retrospective survey on canine intracranial tumors between 2007 and 2017. The Journal of Veterinary Medical Science, 82(1):77-83.

Mandara, M. T., Motta, L., & Calò, P. (2016). Distribution of feline lymphoma in the central and peripheral nervous systems. The Veterinary Journal, 216:109–116.

Marcasso, R. A., Moreira, J. R., Valentim, L. G., Arias, M. V. B. & Bracarense, A. P. F. R. L. (2015). Meningiomas em cães: aspectos clínicos, histopatológicos e imuno-histoquímicos. Pesquisa Veterinária Brasileira, 35(10): 844-852.

Marioni-Henry, K., Winkle, T. J. V., Smith, S. H. & Vite, C. H. (2008). Tumors affecting the spinal cord of cats: 85 cases (1980–2005). Journal of the American Veterinary Medical Association, 232(2): 237-243.

Mcentee, M. C. & Dewey, C. W. (2013). Tumors of the nervous system. In: Withrow, S. J., Vail, D. M., Page, R. L. (Eds). Small Animal Clinical Oncology. Philadelphia: Saunders, p. 583-596.

Mello, L. S., Leite-Filho, R. V., Panziera, W., Bandinelli, M. B., Sonne L., Driemeier, D. & Pavarini, S. P. (2019). Feline lymphoma in the nervous system: pathological, immunohistochemical, and etiological aspects in 16 cats. Pesquisa Veterinária Brasileira, 39(6):393-401.

Platt, S. R., Scase, T. J., Adams, V., Wieczorek, L., Miller, J., Adamo, F. & Long, S. (2006).Vascular endothelial growth factor expression in canine intracranial meningiomas and association with patient survival. Journal of Veterinary Internal Medicine, 20(3): 663-668.

Prates, K. S., Bianchi, M. V., Mello, L. S., Matesco, V. C., Lorenzo, C., Driemeier, D. & Pavarini, S. P. (2018). Spinal cord anaplastic meningioma with extra-neural metastasis in a cat. Ciência Rural, 48: e20180063.

Santos, R. P., Fighera, R. A., Beckmann, D. V., Brum, J. S., Ripplinger, A., Neto, D. P., Baumhardt, R. & Mazzanti, A. (2012). Neoplasmas envolvendo o sistema nervoso central de cães: 26 casos (2003-2011). Pesquisa Veterinária Brasileira, 32(2): 153-158.

Sapin, C. F., Fernandes, C. G., Nobre, M. O. & Grecco, F. B. (2019). Neoplasmas encefálicos em cães idosos. Acta Scientiae Veterinariae, 47(1): 384.

Snyder, J. M., Lipitz, L., Skorupski, K. A., Shofer, F. S. & Winkle, T. J. V. (2008). Secondary intracranial neoplasia in the dog: 177 cases (1986–2003). Journal of Veterinary Internal Medicine, 22(1):172-177.

Snyder, J. M., Shofer, F. S., Winkle, T. J. V. & Massicotte, C. (2006). Canine intracranial primary neoplasia: 173 cases (1986–2003). Journal of Veterinary Internal Medicine, 20(3): 669-675.

Song, R. B., Vite, C. H., Bradley, C. W. & Cross, J. R. (2013). Postmortem Evaluation of 435 Cases of intracranial neoplasia in dogs and relationship of neoplasm with breed, age, and body weight. Journal of Veterinary Internal Medicine, 27(5): 1143-1152.

Spitzbarth, I., Heinrich, F., Herder, V., Recker, T., Wohlsein, P. & Baumgärtner, W. (2017). Canine central nervous system neoplasm phenotyping using tissue microarray technique. Veterinary Pathology, 54(3): 369-379.

Tomek, A., Cizinauskas, S., Doherr, M., Gandini, G. & Jaggy, A. (2006). Intracranial neoplasia in 61 cats: localisation, tumour types and seizure patterns. Journal of Feline Medicine and Surgery, 8(4): 243-253.

Troxel, M. T., Vite, C. H., Winkle, T. J. V., Newton, A. L., Tiches, D., Dayrell-Hart, B., Kapatkin, A. S., Shofer, F. S. & Steinberg, S. A. (2003). Feline intracranial neoplasia: retrospective review of 160 cases (1985–2001). Journal of Veterinary Internal Medicine, 17:850–859.

Zamboni, R., Alberti, T. S., Schied, H. V., Bermann, C. S., Brunner, C. B., Venancio, F. R., Arantes, E. M. J., Sallis, E. S. V. & Raffi, M. B. (2020). Meningioma microcístico com metástase pulmonar em canino: relato de caso. Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 72(3): 794-798.

Published

24/08/2021

How to Cite

ALBERTI, T. dos S. .; ZAMBONI, R.; VENANCIO, F. da R. .; SOARES, M. P. .; BONEL, J.; RAFFI, M. B. .; SCHILD , A. L.; SALLIS, E. S. V. . Neoplasms of the canine and feline central nervous system: 20-year study. Research, Society and Development, [S. l.], v. 10, n. 11, p. e102101118987, 2021. DOI: 10.33448/rsd-v10i11.18987. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/18987. Acesso em: 22 nov. 2024.

Issue

Section

Agrarian and Biological Sciences