Clinical aspects of the incident of dermatophytoses in the State of Sergipe, Brazil

Authors

DOI:

https://doi.org/10.33448/rsd-v10i10.19136

Keywords:

Dermatophytoses; Descriptive epidemiology; Infections; Mycoses.

Abstract

Dermatophytosis demonstrates a worlwide prevalence, especially in children and adults from tropical and subtropical areas. Epidemiological studies have highlighted three main genera as the most common for affecting approximately 20% of the world population: Trichophyton, Microsporum and Epidermophyton. This study aimed to evaluate the number of cases of dermatophytosis in the state of Sergipe from 2014 to 2017. Therefore, a documentary, cross-sectional and prospective study was performed to detect dermatophyte cases in Sergipe, taking into account the following aspects: mycological diagnoses by municipality of residence, sex and anatomical sites. Data was acquired from Central Public Health Laboratory of Sergipe (LACEN) in the same period. The results of the analyzes showed that among the 1386 mycological exams, the number of female patients was significantly higher compared to males, however male cases positive for dermatophytosis were higher, 51.4%. Another aspect that exhibited greater results was the age group between 0-5 and 6-10 years (18.04% and 17.07%, respectively). As for the municipalities of residence of the studied patients, Aracaju demonstrated the majority of the cases. Concerning the infection sites, there was a predominance of the scalp (20.73%), followed by the lower limbs (23.90%) and nails (15.60%). Moreover, it is noted that such results were relevant, as the panorama of this non-compulsory notification disease in the municipalities of the state of Sergipe was elevated. Finally, these results encourage the need for interventions that provide improvements in public health as well as in the social field through the adoption of preventive measures and sanitary actions.

References

AL-Khikani, F. H., & Ayit, A. S. (2021). Major challenges in dermatophytosis treatment: current options and future visions. Egyptian Journal of Dermatology and Venerology, 41(1), 1.

Aneke, C. I., Otranto, D., & Cafarchia, C. (2018). Therapy and antifungal susceptibility profile of Microsporum canis. Journal of Fungi, 4(3), 107.

Bernardi, A. C. A., Silva, J. L. M., Souto, A. P. G., & Almeida, C. C. (2009). Estudo de Fungos Queratinofílicos Geofílicos em Praças Públicas de Jaboticabal-SP. Revista Brasileira Multidisciplinar, 12(2), 79-88.

Bhat, Y. J., Keen, A., Hassan, I., Latif, I., & Bashir, S. (2019). Can dermoscopy serve as a diagnostic tool in dermatophytosis? A pilot study. Indian dermatology online journal, 10(5), 530.

Brasil. Instituto Brasileiro de Geografia e Estatística. 2020. Disponível em: <https://cidades.ibge.gov.br/brasil/se/panorama >. Acesso em: 15 abr. 2021.

Begum, J., Mir, N. A., Lingaraju, M. C., Buyamayum, B., & Dev, K. (2020). Recent advances in the diagnosis of dermatophytosis. Journal of basic microbiology, 60(4), 293-303.

Cock, I. E., & Van Vuuren, S. F. (2020). A review of the traditional use of southern African medicinal plants for the treatment of fungal skin infections. Journal of ethnopharmacology, 251, 112539.

Coelho, J. L. G., Saraiva, E. M. S., Mendes, R. C., & de Santana, W. J. (2020). Dermatófito: resistência a antifúngicos. Brazilian Journal of Development, 6(10), 74675-74686.

Cordeiro, L. V. (2015). Perfil epidemiológico de dermatofitoses superficiais em pacientes atendidos em um laboratório da rede privada de João Pessoa-PB.

Costa-de-Oliveira, S., & Rodrigues, A. G. (2020). Candida albicans antifungal resistance and tolerance in bloodstream infections: The triad yeast-host-antifungal. Microorganisms, 8(2), 154.

Fajardo, A. D., Silva, R. R., Costa, A. P. M., Rossetto, A. L., & Cruz, R. C. B. (2017). Estudo epidemiológico das infecções fúngicas superficiais em Itajaí, Santa Catarina. RBAC, 49(4), 396-400.

Ferro, L. O., Souza, A. K. P., Rodrigues, D. K. B., Silva, J. R. M., K. W. L. S., Freitas, L. W. S., & dos Santos Araújo, M. A. (2020). Trichophyton rubrum como principal agente etiológico de dermatofitoses em um laboratório de Maceió–Al. Brazilian Journal of Health Review, 3(5), 13198-13207.

Gnat, S., Łagowski, D., & Nowakiewicz, A. (2020). Major challenges and perspectives in the diagnostics and treatment of dermatophyte infections. Journal of applied microbiology, 129(2), 212-232.

Gupta, A. K., Renaud, H. J., Quinlan, E. M., Shear, N. H., & Piguet, V. (2021). The growing problem of antifungal resistance in onychomycosis and other superficial mycoses. American journal of clinical dermatology, 22(2), 149-157.

Heinen, M. P., Cambier, L., Antoine, N., Gabriel, A., Gillet, L., Bureau, F., & Mignon, B. (2019). Th1 and Th17 immune responses act complementarily to optimally control superficial dermatophytosis. Journal of Investigative Dermatology, 139(3), 626-637.

Jesus, M. J. S., & Sousa, Z. L. (2020). Pesquisa de fungos dermatófitos em amostras de solo de parques recreácionais da cidade de Ilhéus, Bahia. Revista Cereus, 12(1), 77-90.

Kaul, S., Yadav, S., & Dogra, S. (2017). Treatment of dermatophytosis in elderly, children, and pregnant women. Indian dermatology online journal, 8(5), 310.

Khurana, A., Sardana, K., & Chowdhary, A. (2019). Antifungal resistance in dermatophytes: Recent trends and therapeutic implications. Fungal Genetics and Biology, 132, 103255.

Lana, D. F.D., Batista, B. G., Alves, S. H., & Fuentefria, A. M. (2016). Dermatofitoses: agentes etiológicos, formas clínicas, terapêutica e novas perspectivas de tratamento. Clinical and biomedical research. Vol. 36, n. 4 (2016), p. 230-241.

Lin, B. B., Pattle, N., Kelley, P., & Jaksic, A. S. (2021). Multiplex RT-PCR provides improved diagnosis of skin and nail dermatophyte infections compared to microscopy and culture: a laboratory study and review of the literature. Diagnostic Microbiology and Infectious Disease, 115413.

Mahboubi, M., & Kazempour, N. (2015). The antifungal activity of Artemisia sieberi essential oil from different localities of Iran against dermatophyte fungi. Journal de mycologie medicale, 25(2), e65-e71.

Maranhão, F. C. A., Oliveira-Júnior, J. B., Araújo, M. A. S, & Silva, D. M. W. (2019). Mycoses in northeastern Brazil: epidemiology and prevalence of fungal species in 8 years of retrospective analysis in Alagoas. Brazilian Journal of Microbiology, 50(4), 969-978.

Mercer, D. K., & Stewart, C. S. (2019). Keratin hydrolysis by dermatophytes. Medical mycology, 57(1), 13-22.

Mezzari, A., Hernandes, K. M., Fogaça, R. F. H., & Calil, L. N. (2017). Prevalência de micoses superficiais e cutâneas em pacientes atendidos numa atividade de extensão universitária. Revista Brasileira de Ciências da Saúde, 21(2), 151-156.

Motamedi, M., Mirhendi, H., Zomorodian, K., Khodadadi, H., Kharazi, M., Ghasemi, Z., ... & Makimura, K. (2017). Clinical evaluation of β‐tubulin real‐time PCR for rapid diagnosis of dermatophytosis, a comparison with mycological methods. Mycoses, 60(10), 692-696.

Morais, T. G., Pereira, J. M., & Cunha, R. (2018). Morfologia de fungos isolados de um ambiente hospitalar e avaliação do conhecimento dos visitantes/acompanhantes sobre infecção hospitalar. In Anais do Congresso de Ensino, Pesquisa e Extensão da UEG (CEPE)(ISSN 2447-8687) (Vol. 4).

Morris, A. J., Arthur, I. H., Kidd, S. E., Halliday, C. L., Meyer, W., Robson, J. M., ... & Haremza, E. (2016). Mycological testing of clinical samples in Australasian pathology laboratories: wide diversity and room for improvement. Pathology, 48(6), 531-534.

Oliveira, A. R., Cintra, J., Pereira, L., Pires, R. H., & Dias, F. (2015). Incidência de dermatófitos em felinos atendidos no hospital veterinário da universidade de franca (UNIFRAN-SP). Enciclopédia biosfera, 11(22).

Pereira A.S. et al. (2018). Metodologia da pesquisa científica. [e-book]. Santa Maria. Ed. UAB/NTE/UFSM. https://repositorio.ufsm.br/bitstream/handle/1/15824/Lic_Computacao_Metodologia-Pesquisa-Cientifica.pdf?sequence=1.

Pereira, L. F. S., Neves, A. D. C., Fontes, M. L. A., Brabo, G. L. C., Lino, R. M., Trindade, E. L., & Bezerra, N. V. (2019). Avaliação da presença de fungos no ar, água e areia de duas praias de Outeiro, Pará, Brasil. Brazilian Journal of Health Review, 2(5), 4174-4187.

Pereira, R. S., Santos, H. D. H., Moraes, O. S., Júnior, D. P. L., & Hahn, R. C. (2020). Children’s public health: Danger of exposure to pathogenic fungi in recreational places in the middle-west region of Brazil. Journal of infection and public health, 13(1), 51-57.

Rezaei-Matehkolaei, A., Khodavaisy, S., Alshahni, M. M., Tamura, T., Satoh, K., Abastabar, M., ... & Badali, H. (2018). In vitro antifungal activity of novel triazole efinaconazole and five comparators against dermatophyte isolates. Antimicrobial agents and chemotherapy, 62(5).

Ribeiro, C. S. D. C., Zaitz, C., Framil, V. M. D. S., Ottoboni, T. S. D. C., Tonoli, M. S. D. C., & Ribeiro, R. P. (2015). Descriptive study of onychomycosis in a hospital in São Paulo. Brazilian Journal of Microbiology, 46(2), 485-492.

Rodrigues, D. A., Tomimori, J., Floriano, M. C., & Mendonça, S. (2010). Atlas de dermatologia em povos indígenas. SciELO-Editora Fap-Unifesp.

Sidrim, J. J., Rocha, M. F. G. (2012). Micologia à Luz dos Autores Contemporâneos. Ed. Guanabara Koogan. Guanabara Koogan, 157-167.

Silva-Rocha, W. P., Azevedo, M. F., & Chaves, G. M. (2017). Epidemiology and fungal species distribution of superficial mycoses in Northeast Brazil. Journal de mycologie medicale, 27(1), 57-64.

Silva, C. S. (2019). Etiologia e epidemiologia da tinea capitis: relato de série de casos e revisão da literatura. RBAC, 51(1), 9-16.

Silva, K. A. D., Gomes, B. S., Magalhães, O. M. C., & Lacerda Filho, A. M. (2018). Etiologia das dermatofitoses diagnosticadas em pacientes atendidos no Laboratório de Micologia Médica no Centro de Biociências da Universidade Federal de Pernambuco, entre 2014-2017. Rev Bras Analises Clin, 50(1), 33-7.

Song, X., Wei, Y. X., Lai, K. M., He, Z. D., & Zhang, H. J. (2018). In vivo antifungal activity of dipyrithione against Trichophyton rubrum on guinea pig dermatophytosis models. Biomedicine & Pharmacotherapy, 108, 558-564.

Xiao, Y., Hu, Q., Jiao, L., Cui, X., Wu, P., He, P., & Zhao, S. (2019). Production of anti-Trichophyton rubrum egg yolk immunoglobulin and its therapeutic potential for treating dermatophytosis. Microbial pathogenesis, 137, 103741.

Published

21/08/2021

How to Cite

SILVA, E. S. .; PINTO, D. S. .; SANTOS-NETO, A. G. dos .; ALMEIDA-JUNIOR, E. C. de .; SANTOS, T. B. dos; ROCHA, F. S. .; SANTOS, A. de F.; ARAÚJO, E. dos S. .; SANTANA, T. S. .; SANTOS, J. V. R. dos .; BOMFIM, A. C. S.; ALVES, L. L. .; DROPPA-ALMEIDA, D.; GASPAR, L. M. do A. C. .; OLIVEIRA, I. D. . Clinical aspects of the incident of dermatophytoses in the State of Sergipe, Brazil. Research, Society and Development, [S. l.], v. 10, n. 10, 2021. DOI: 10.33448/rsd-v10i10.19136. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/19136. Acesso em: 21 oct. 2021.

Issue

Section

Health Sciences