Duodenal gastrointestinal stromal tumor: case report and importance of ecoendoscopy

Authors

DOI:

https://doi.org/10.33448/rsd-v10i11.19407

Keywords:

Gastrointestinal Stromal Tumor; C-KIT Protein; Gastrointestinal Tract; Endoscopy ultrasound.

Abstract

Gastrointestinal stromal tumors (GISTs) are generally quite rare, but the same are the mesenchymal neoplasms that are most frequently identified in the gastrointestinal tract (GIT) and represent 0.1 to 3% of all gastrointestinal tumors. The diagnosis of this pathology is made according to the clinical picture, in the morphological characteristics, and fundamentally in the consideration of the presence of the protein c-KIT (CD117) detected by immunohistochemical method. In most cases, these tumors present in the individual asymptomatically, so they are discovered incidentally by imaging exams. The prognostic factors of great importance are the size of the tumor and the mitotic index. Surgical resection is the therapy of choice and imatinib mesylate chemotherapy, which is indicated in cases of unresectability or metastatic disease. We present a case of Duodenal GIST diagnoses by echoendoscopy after an incidental finding during an upper gastrointestinal endoscopy exam.

References

Beham, A., Schaefer, I. M., Cameron, S., von Hammerstein, K., Füzesi, L., Ramadori, G., & Ghadimi, M. B. (2013). Duodenal GIST: a single center experience. International journal of colorectal disease, 28(4), 581-590.

Casali, P. G., et al. (2009). Gastrointestinal stromal tumors: ESMO clinical recommendations for diagnosis, treatment and follow-up. Annals of Oncology, Oxford 20(1), 64-67.

Castro-Poças, F. M., Araújo, T. P., Silva, J. D., Lopes, C. A., & Saraiva, M. M. (2015). Duodenal gastrointestinal stromal tumor and endoscopic ultrasound. Revista española de enfermedades digestivas, 107(12), 759-760.

Chandrasekhara, V., Khashab, M. A., Muthusamy, V. R., Acosta, R. D., Agrawal, D., Bruining, D. H., & DeWitt, J. M. (2017). Adverse events associated with ERCP. Gastrointestinal endoscopy, 85(1), 32-47.

Consolo, F. D. S., Cardoso, A. A. P., Branco, O. M., Lamego, H., & Arruda, L. (2007). Hemorragia digestiva por tumor estromal gástrico. Revista do Colégio Brasileiro de Cirurgiões, 34, 64-66.

D'amato, G., Steinert, D. M., McAuliffe, J. C., & Trent, J. C. (2005). Update on the biology and therapy of gastrointestinal stromal tumors. Cancer control, 12(1), 44-56.

DeMatteo, R. P., Lewis, J. J., Leung, D., Mudan, S. S., Woodruff, J. M., & Brennan, M. F. (2000). Two hundred gastrointestinal stromal tumors: recurrence patterns and prognostic factors for survival. Annals of surgery, 231(1), 51.

Garcia, A. Z. G., & Blanco, A. P. (2009). Tumores del estroma gastrointestinal: tratamiento endoscópico. GH Continuada, Barcelona, 8(2). 76-81.

Harris, P. S., Romano, J., Russ, K. B., Shoreibah, M. G., & Baig, K. R. K. K. (2020). Gastrointestinal Stromal Tumor: GIST Another Duodenal Ulcer. Ochsner Journal, 20(2), 236-238.

Hirota, S., Isozaki, K., Moriyama, Y., Hashimoto, K., Nishida, T., Ishiguro, S., & Kitamura, Y. (1998). Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors. Science, 279(5350), 577-580.

Hompes, D., Topal, B., Ectors, N., Aerts, R., & Penninckx, F. (2004). Gastro-intestinal stromal tumour of the duodenum: extreme presentation in two cases. Acta Chirurgica Belgica, 104(1), 110-113.

Levy, A. D., Remotti, H. E., Thompson, W. M., Sobin, L. H., & Miettinen, M. (2003). Gastrointestinal stromal tumors: radiologic features with pathologic correlation. Radiographics: a review publication of the Radiological Society of North America, Inc, 23(2), 283-304.

Lopasso, F. P. (2008). Neoplasias de estômago. In: Moraesfilho, J. P. P. Tratado das enfermidades gastrintestinais e pancreáticas. Roca, 722-724.

Meesters, B., Pauwels, P. A. A., Pijnenburg, A. M., Vlasveld, L. T., & van Driel, O. R. (1998). Metastasis in a ‘benign’duodenal stromal tumour. European Journal of Surgical Oncology (EJSO), 24(4), 334-335.

Mennigen, R., Wolters, H. H., Schulte, B., & Pelster, F. W. (2008). Segmental resection of the duodenum for gastrointestinal stromal tumor (GIST). World Journal of Surgical Oncology, 6(1), 1-6.

Mugayar, J. et al. (2008). Tumor estromal gastrointestinal. Conduta Médica, 9(36),10-15.

Muñoz, C., Sabah, S., Navarro, A., Planzer, M., Silva, C., & Santander, R. (2006). Tumores del estroma gastrointestinal (GIST): Revisión de la literatura. Gastr Latinoam, 17(1), 43-51.

Rossini, L. G. B, Averbach, M.(2008). Endoscopia. In: MoraesFilho, Joaquim Prado Pinto. Tratado das enfermidades gastrintestinais e pancreáticas. 344.

Uchida, H., Sasaki, A., Iwaki, K., Tominaga, M., Yada, K., Iwashita, Y., & Kitano, S. (2005). An extramural gastrointestinal stromal tumor of the duodenum mimicking a pancreatic head tumor. Journal of hepato-biliary-pancreatic surgery, 12(4), 324-327.

Yokoyama, R. M. et al. Tumor estromal gastrointestinal. Revista Brasileira de Videocirurgia, 5(2), 65-71.

Published

25/08/2021

How to Cite

SANTOS, B. F. dos .; LEMOS JUNIOR, V. de .; LINO, J. R. da C. .; LEITE, C. Q. . Duodenal gastrointestinal stromal tumor: case report and importance of ecoendoscopy . Research, Society and Development, [S. l.], v. 10, n. 11, p. e124101119407, 2021. DOI: 10.33448/rsd-v10i11.19407. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/19407. Acesso em: 19 apr. 2024.

Issue

Section

Health Sciences