Impact of antiretroviral therapy on depression and sleep disorders in HIV patients

Authors

DOI:

https://doi.org/10.33448/rsd-v10i12.19989

Keywords:

Sleep disorders; HIV; Depression; Antiretroviral therapy; Efavirenz; Dolutegravir; Atazanavir.

Abstract

Depression and sleep disorders are frequent in patients with HIV. The aim of this article is to detect sleep disorders and depression related to antiretroviral therapy in the adult population with HIV/AIDS. The following scales were applied: Patient Health Questionnaire-9 (PHQ-9), Epworth Sleepiness Scale, adapted to Brazil (ESS-Br), and the Pittsburgh Sleep Quality Index Questionnaire (PSQI). CEP: 3.319.628. In the sleep assessment (PSQI), use of Dolutegravir (DTG) showed 58.8% poor sleep quality, Efavirenz (EFZ) was 38% indicative of poor sleep and 28.5% of sleep disorder, and Atazanavir-ritonavir (ATV-r) with poor quality sleep was found in 40%. The detection of any type of sleep disorder did not differ statistically between the use of EFZ or DTG (p = 0.79). Regarding the assessment of ESS-Br sleepiness, we detected 4.7%, 17.2% and 20% important alterations in patients using EFZ, DTG and ATV, respectively. The analysis obtained for depression (PHQ-9) was moderately severe (EFZ = 10%, DTG = 20.3%, ATV = 0%) and severe (EFZ = 15%, DTG = 6.2%, ATV = 0%). This study showed that HIV-positive individuals suffer from sleep disturbances independent of the ART regimen, but with greater impact with Efavirenz. Daytime sleepiness was present in one in every 5 individuals using ART. And the greater severity of depression was found to be important for the groups using Efavirenz and Dolutegravir.

Author Biographies

Melissa Soares Medeiros, Hospital São José de Doenças Infecciosas

Infectious physician who works with care for HIV patients on an outpatient basis, doing clinical follow-up and research. She contributed to the article with the main research of data collection and application of the questionnaires.

Liliane Nogueira Granjeiro, Hospital Sao Jose de Doencas Infecciosas

Infectious physician who works with care for HIV patients on an outpatient basis, doing clinical follow-up and research. She contributed to the article with the main research of data collection and application of the questionnaires.

Yandra Mirelle Nogueira Alves, Centro Universitario Unichristus

Medical student at Centro Universitario Unichristus, contributing to research during the student period through data collection and application of questionnaires.

Jose Edvar di Castro Junior, Centro Universitario Unichristus

Medical student at Centro Universitario Unichristus, contributing to research during the student period through data collection and application of questionnaires.

Luan Victor Almeida Lima, Hospital Sao Jose de Doencas Infecciosas

Infectious physician who works with care for HIV patients on an outpatient basis, doing clinical follow-up and research. She contributed to the article with the main research of data collection and application of the questionnaires.

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WHO publishes new Consolidated HIV guidelines for prevention, treatment, service delivery & monitoring - news release, https://www.who.int/publications/i/item/9789240031593

Published

12/09/2021

How to Cite

MEDEIROS, M. S. .; GRANJEIRO, L. N. .; ALVES, Y. M. N. .; CASTRO JUNIOR, J. E. di .; LIMA, L. V. A. . Impact of antiretroviral therapy on depression and sleep disorders in HIV patients. Research, Society and Development, [S. l.], v. 10, n. 12, p. e25101219989, 2021. DOI: 10.33448/rsd-v10i12.19989. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/19989. Acesso em: 4 mar. 2024.

Issue

Section

Health Sciences