Oral mucositis in children with cancer: difficulties of evaluation and effective therapy
DOI:
https://doi.org/10.33448/rsd-v10i11.20018Keywords:
Neoplasm; Chemotherapy; Mucositis; Protocol.; protocolAbstract
Cancer is a public health problem in the world and, in children, the incidence of increase is around 1% per year. Despite its effectiveness, antineoplastic therapy causes effects of significant toxicity, often causing the patient to be hospitalized, difficult to continue with oncotherapy or not readjusted to the treatment for the non-progression of the disease. Oral mucositis is one of the most common deleterious effects; it causes pain, affects speech and nutrition, and makes the patient susceptible to sepsis. In children, the frequency of oral mucositis is around 65%. Its manifestations are evaluated using different scales and treated with different protocols. The objective of this work is to verify, in a systematic literature review, the state of the art in the evaluation of oral mucositis in children undergoing cancer treatment. Studies have shown that assessment is essential to establish treatment strategies, that protocols and scales used are inconsistent, and that there is no viable and valid system to score childhood mucositis caused by cancer, preventing a more effective therapeutic intervention. It was concluded that the Children's International Mucositis Evaluation Scale has been the scale with the greatest acceptability and validity according to its criteria.
References
Aggarwal R., Bansal D., Naru J., Salaria M., Rana A., Minz RW., Trehan A. & Marwaha K. (2014). HSV-1 as well as HSV-2 is frequent in oral mucosal lesions of children on chemotherapy. Support Care Cancer, 22, 1773–1779.
Allen G., Logan R .& Gue S. (2020). Oral manifestations of cancer treatment in children: a review of the literature. Clinical Journal of Oncology Nursing, 14 (4), 481-490.
Argelagós A.P., Cárdenas A.B.C. & Blanco J.R., (2014). Protocolos de atención odontológica a pacientes pediátricos oncológicos. Odontol Pediátr, 22 (2),153-161.
Botelho, L. L. R., de Almeida Cunha, C. C., & Macedo, M. (2011). O método da revisão integrativa nos estudos organizacionais. Gestão e sociedade, 5(11), 121-136
Bourdelin M., Daguindau E., Larosa F., Legrand F., Nerich V. & Deconinck E., Limat S. (2015). La mucite post-allogreffe de cellules souches he´matopoı¨e´tiques: facteurs de risque, conse´quences cliniques et pre´vention. Pathologie Biologie, 63, 106–110.
Bulut H.K.& Tüfekci F.G. (2016). Honey prevents oral mocositis in children undergoing chemotherapy: A quasi-experimental study with a control group. Complementary Therapies in Medicine, 29, 132–140.
Castro J.F.L., Abreu E.G.F., Correia A.V.L., Brasil C.M.V., Perez D.E.C. & Pedroso F.P.R. (2013). Low-level laser in prevention and treatment of oral mucositis in pediatric patients with acute lymphoblastic leukemia. Photomedicine and Laser Surgery, 31 (12), 613–618.
Devi K.S. & Allenidekaniab A. (2019). The relationship of oral care practice at home with mucositis incidence in children with acute lymphoblastic leukemia. Comprehensive Child and Adolescent Nursing, 42 (S1), 56–64.
Figliolia S.L.C., Oliveira D.T., Pereira M.C., Lauris J.R.P, Maurício A.R., Oliveira D.T. & Mello de Andrea M.L.(2008). Oral mucositis in acute lymphoblastic leukaemia: analysis of 169 paediatric patients. Oral Diseases, 14, 761–766.
Garrocho-Rangel J.A., Herrera-Moncada M., Márquez-Preciado R., Tejeda-Nava F., Ortiz-Zamudio J.J. & Pozos-Guillén A. (2018). Oral mucositis in paediatric acute lymphoblastic leukemia patients receiving methotrexate-based chemotherapy: case series. European Journal of Paediatric Dentistry, 9/3.
Hashemi A., Bahrololoumi Z., Khaksar Y., Saffarzadeh N., Neamatzade H. & Foroughi E. (2015). Mouth-rinses for the prevention of chemotherapy induced oral mucositis in children: a systematic review. Iranian Journal of Pediatric Hematology Oncology, 15 (2).
Jacobs S., Baggott C., Agarwal R., Hesser T., Schechter T., Judd P., Tomlinson D., Beyene J. & Sung L. (2013). Validation of the Children’s International Mucositis Evaluation Scale (ChIMES) in paediatric cancer and SCT. British Journal of Cancer, 109, 2515–2522.
Kuhn A., Porto F.A., Miraglia P. & Brunetto A.L. (2009) Low-level infrared laser therapy in chemotherapy-induced oral mucositis. A randomized placebo-controlled trial in children. J Pediatr Hematol Oncol, 31 (1), 33-8.
Mendonça R.M.H., Araujo M., Levy C.E., Morari J., Silva R.A. & Yunes JA, Brandalise SR. (2015). Oral mucositis in pediatric acute lymphoblastic leukemia patients: evaluation of microbiological and hematological factors. Pediatric Hematology and Oncology, 1(9).
Otmani N., Raouf A., Hessissen L.L., Mokhtari A., Soulaymani A. & Khattab M. (2011). Determinants of severe oral mucositis in paediatric cancer patients: a prospective study. International Journal of Paediatric Dentistry, 21, 210– 216.
Paiva B.S.R., Barroso E.M., Cadamuro S.A., Paula L.A.B., Pirola W.E, Serrano C.V.M.P. & Paiva CE. (2018).The Children’s International Mucositis Evaluation Scale is valid and reliable for the assessment of mucositis among brazilian children with cancer. Journal of Pain and Sympton Management, 56(5),774-783.
Schubert M.M., Williams B.E., Lloid M.E., Donaldson G. & Chapko M.K. (1992). Clinical assessment scale for the rating of oral mucosal changes associated with bone marrow transplantation: development of an oral mucositis index. Cancer, 69, 2469-77. Recuperado em 1 fevereiro 2021, de https://acsjournals.online library.wiley.com/doi/pdfdirect/10.1002/1097-0142(19920515)69.
Singh R., Sharma S., Kaur S., Medhi B., Trehan A. & Bijarania SK. (2019) Effectiveness of topical application of honey on oral mucosa of children for the management of oral mucositis associated with chemotherapy. The Indian Journal of Pediatrics, 86(3), 224–228.
Sonis S. T., Eilers J.P., Epstein J.B., Le Veque F.G., Liggett Jr W.H .& Mulagha MT.(1999) Validation of a new scoring system for the assessment of clinical trial research of oral mucositis induced by radiation or chemotherapy. Am Cancer Soc. 85, 2103-13.
Stiff P.J., Erder H., Bensinger W.I., Emmanouilides C., Gentile T., Isitt J., Lu Z.J. & Spielberger R. (2006) Reliability and validity of a patient self-administered daily questionnaire to assess impact of oral mucositis (OM) on pain and daily functioning in patients undergoing autologous hematopoietic stem cell transplantation (HSCT). Bone Marrow Transplantation, 37(4),393–401.
Sung L., Robinson P., Treister N., Baggott T., Gibson P., Tissing W., Wiernikowski J. & Brinklow J, Dupuis LL.(2017) Guideline for the prevention of oral and oropharyngeal mucositis in children receiving treatment for cancer or undergoing haematopoietic stem cell transplantation. Supportive & Palliative Care, 7, 7–16.
Tomlinson D., Gibson F., Treister N., Baggott C., Judd J.P., Hendershot E., Maloney A.M., Doyle J., Feldman B., Kwong K. & Sung L. (2009a) Understandability, content validity, and overall acceptability of the Children’s International Mucositis Evaluation Scale (ChIMES) Child and parent reporting. J Pediatr Hematol Oncol, 31 (6), 416-24.
Tomlinson D., Gibson F., Treister F., Baggott C., Judd P., Hendershot E., Maloney A.M., Doyle J., Feldman B., Kwong K. & Sung L. (2010a) Refinement of the Children’s International Mucositis Evaluation Scale (ChIMES): child and parent perspectives on understandability, content validity and acceptability. European Journal of Oncology Nursing, 14, 29-41.
Tomlinson D., von Baeyer C.L., Stinso J.N. & Sung L. (2010b) A systematic review of faces scales for the self-report of pain intensity in children. Pediatrics, 126(5), 1168-98. Recuperado em 2 fevereiro 2021, de https:// pubmed.ncbi.nlm.nih.gov/20921070/
WHO World Health Organization. (1979) WHO handbook for reporting results of cancer treatment. Recuperado em 1 de fevereiro de 2021, de https://apps.who.int/iris/handle/10665/37200.
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Copyright (c) 2021 Ana Bessa Muniz; Maria Aparecida Rodrigues de Holanda ; Kleyton Nolasco de Abreu; Samuel Barbosa Macedo; Ellen Roberta Lima Bessa; Lady Daiane Pereira Leite; Mariana Raquel da Cruz Vegian; Rivaldave Rodrigues de Holanda Cavalcante; Rodrigo Asfury Rodrigues
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