Metabolic profile of obese and non-obese patients with Polycystic Ovary Syndrome

Authors

DOI:

https://doi.org/10.33448/rsd-v10i12.20482

Keywords:

Polycystic Ovary Syndrome; Insulin Resistance; Metabolic Syndrome X; Obesity.

Abstract

To evaluate the clinical and metabolic characteristics of women with Polycystic Ovary Syndrome (PCOS) of different phenotypes. Controlled and analytical cross-sectional design. Sampling was non-probabilistic and composed of 120 participants, forming four groups: 1A (without PCOS and normal weight); 1B (without PCOS and with abnormal weight); 2A (PCOS and normal weight) and 2B (PCOS and abnormal weight). Structured form and electronic medical record were used for data collection. Uni and bivariate statistics were performed using IBM® SPSS® 21.0 software. Metabolic syndrome predominated in groups 2A (7.1%) and 2B (37.5%) compared to the respective controls 1A (0%) and 1B (19.2%). Similarly, the insulin was higher in groups 2A (15.7±8.2) and 2B (19.8±6.7) compared to 1A (6.5±4) and 1B (6.5±4,8). The 2-hour oral glucose tolerance test (OGTT) was superior in group 2B (132.1±31.3) compared to group 1B (115.2±20.8) and in group 2A (111.9±24.7) in relation to 1A (105.4±12.1). Total and free testosterone levels were higher in groups 2A (4.4±6.7 and 1.4±1.5, respectively) and 2B (2±2.4 and 1±0.9) in relation to 1A (1,2±3.8 and 0.2±0.3) and 1B (0.5±0.4 and 0.2±0.4). The systolic blood pressure was higher in 2B (125.8±11.7) than 1B (123.3±11.7) and in 2A (122.1±10) compared to 1A (113.7±8,7). PCOS is associated with an unfavorable metabolic profile, with significance for insulin resistance, hyperandrogenism and metabolic syndrome, making essential the broad and multidisciplinary clinical follow-up.

References

Abeso. Associação Brasileira para o Estudo da Obesidade e da Síndrome Metabólica. (2016). Diretrizes brasileiras de obesidade. (4), 1-188.

Bortoletto, M. S. S., Souza, R. K. T. D., Cabrera, M. A. S., & González, A. D. (2014). Síndrome metabólica em estudos com adultos brasileiros: uma revisão sistemática. Espaç Saúde, 15(4), 86-98.

De Leo, V., Musacchio, M. C., Cappelli, V., Massaro, M. G., Morgante, G., & Petraglia, F. J. R. B. (2016). Genetic, hormonal and metabolic aspects of PCOS: an update. Reproductive Biology and Endocrinology, 14(1), 1-17.

Delitala, A. P., Capobianco, G., Delitala, G., Cherchi, P. L., & Dessole, S. (2017). Polycystic ovary syndrome, adipose tissue and metabolic syndrome. Archives of gynecology and obstetrics, 296(3), 405-419.

Escobar-Morreale, H. F. (2017). The role of androgen excess in metabolic dysfunction in women. Sex and Gender Factors Affecting Metabolic Homeostasis, Diabetes and Obesity, 597-608.

Flores, C. B., Flores, L., & Comim, F. V. (2013). Hirsutismo: avaliação e princípios do tratamento. Revista da AMRIGS, 57(3), 232-9

Jeanes, Y. M., & Reeves, S. (2017). Metabolic consequences of obesity and insulin resistance in polycystic ovary syndrome: diagnostic and methodological challenges. Nutrition research reviews, 30(1), 97-105.

Küçük, U., Küçük, H. O., Cüce, F., & Balta, S. (2016). Relationship between neck circumference and epicardial fat thickness in a healthy male population. Arquivos brasileiros de cardiologia, 107, 266-270.

Pontes, A., & Almeida Filho, B. S. (2016). Síndrome dos ovários policísticos: diagnóstico, tratamento e repercussões ao longo da vida. FMB–UNESP 2016, 978-85.

Sociedade Brasileira de Cardiologia. (2016); VII Diretriz Brasileira de Hipertensão Arterial. Arquivos Brasileiros de Cardiologia, 107, 7-13.

Stabe, C., Vasques, A. C. J., Lima, M. M. O., Tambascia, M. A., Pareja, J. C., Yamanaka, A., & Geloneze, B. (2013). Neck circumference as a simple tool for identifying the metabolic syndrome and insulin resistance: results from the Brazilian Metabolic Syndrome Study. Clinical endocrinology, 78(6), 874-881.

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Published

27/09/2021

How to Cite

LOPES, I. M. R. S. .; SILVA, A. N. de C. e . Metabolic profile of obese and non-obese patients with Polycystic Ovary Syndrome. Research, Society and Development, [S. l.], v. 10, n. 12, 2021. DOI: 10.33448/rsd-v10i12.20482. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/20482. Acesso em: 26 nov. 2024.

Issue

Vol. 10 No. 12

Section

Health Sciences

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Copyright (c) 2021 Ione Maria Ribeiro Soares Lopes; Amanda Nogueira de Castro e Silva

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