Scientific and technological prospection of the use of nanoparticles with sodium alendronate in cancer treatment




Nanoparticles; Sodium alendronate; Cancer.


Cancer is the name given to a set of complex diseases characterized by the uncontrolled growth of abnormal cells with a high invasive potential, being considered one of the biggest public health problems in the world. The incidence of cancer has increased every year, showing the relevance of conducting research aimed at treating cancer in its various modalities. Thus, this work aims to carry out a scientific and technological prospection on the application of nanoparticles with sodium alendronate in the treatment of cancer. For this, the following keywords were used, with the Boolean operator AND, in the searches: “Sodium alendronate and nanoparticle”, “Sodium alendronate and cancer”, “Nanoparticle and cancer”. The results demonstrated in scientific prospecting a large amount of work related to cancer when associated with nanoparticles. It was found that in the last 10 years there has been a linear growth in scientific production focused on this topic. The same was observed in the search for patents, where up to 37,100 patent applications were observed with these terms in their structure, in the Espace Net database. with nanotechnology a viable and promising alternative.


A Baudino, T. (2015). Targeted cancer therapy: the next generation of cancer treatment. Current drug discovery technologies, 12(1), 3-20. Abbas, Z., & Rehman, S. (2018). An overview of cancer treatment modalities. Neoplasm, 1, 139-57.

Andreopoulou, E., Kelly, C. M., & McDaid, H. M. (2017). Therapeutic advances and new directions for triple-negative breast cancer. Breast Care, 12(1), 20- 27.

Boni, F. I., Almeida, A., Lechanteur, A., Sarmento, B., Cury, B. S. F., & Gremião, M. P. D. (2018). Mucoadhesive nanostructured polyelectrolytes complexes modulate the intestinal permeability of methotrexate. European Journal of Pharmaceutical Sciences, 111, 73-82.

Buranrat, B., & Bootha, S. (2019). Antiproliferative and antimigratory activities of bisphosphonates in human breast cancer cell line MCF-7. Oncology letters, 18(2), 1246-1258.

Cataliotti, L., Buzdar, A. U., Noguchi, S., Bines, J., Takatsuka, Y., Petrakova, K., ... & Tosello de Oliveira, C. (2006). Comparison of anastrozole versus tamoxifen as preoperative therapy in postmenopausal women with hormone receptor‐positive breast cancer: The Pre‐Operative “Arimidex” Compared to Tamoxifen (PROACT) trial. Cancer, 106(10), 2095-2103.

Chlebowski, R. T., Chen, Z., Cauley, J. A., Anderson, G., Rodabough, R. J., McTiernan, A., ... & Wallace, R. B. (2010). Oral bisphosphonate use and breast cancer incidence in postmenopausal women. Journal of Clinical Oncology, 28(22), 3582.

Coleman, R. E., & McCloskey, E. V. (2011). Bisphosphonates in oncology. Bone, 49(1), 71-76.

DEF.(2004) Dicionário de Especialidades Farmacêuticas 2003/2004. Publicações Científicas. 32.ed. Rio de Janeiro:. p.88.

Dimer, F. A., Friedrich, R. B., Beck, R. C., Guterres, S. S., & Pohlmann, A. R. (2013). Impactos da nanotecnologia na saúde: produção de medicamentos. Química Nova, 36, 1520-1526.

Idrees, H., Zaidi, S. Z. J., Sabir, A., Khan, R. U., Zhang, X., & Hassan, S. U. (2020). A review of biodegradable natural polymer-based nanoparticles for drug delivery applications. Nanomaterials, 10(10), 1970.

Idris, A. I., Rojas, J., Greig, I. R., van’t Hof, R. J., & Ralston, S. H. (2008). Aminobisphosphonates cause osteoblast apoptosis and inhibit bone nodule formation in vitro. Calcified tissue international, 82(3), 191-201.

Iles, B., Ribeiro, I. N. S., Dourado, F. F., Ribeiro, F. D. O. S., de Araújo, A. R., de Oliveira, T. M., ... & Medeiros, J. V. R. (2021). Alendronate sodium- polymeric nanoparticles display low toxicity in gastric mucosal of rats and Ofcol II cells. NanoImpact, 100355.

Instituto Nacional de Câncer José Alencar Gomes da Silva (2019). Estimativa 2020: incidência de câncer no Brasil / Instituto Nacional de Câncer José Alencar Gomes da Silva. – Rio de Janeiro: INCA, 2019.

Kato, T. (2019). Encapsulated drugs in targeted cancer therapy. In Controlled drug delivery (pp. 189-240). CRC Press.

Kwon, S., Yoo, K. H., Sym, S. J., & Khang, D. (2019). Mesenchymal stem cell therapy assisted by nanotechnology: a possible combinational treatment for brain tumor and central nerve regeneration. International journal of nanomedicine, 14, 5925.

Lipton, A. (2008). Emerging role of bisphosphonates in the clinic—antitumor activity and prevention of metastasis to bone. Cancer treatment reviews, 34, S25-S30.

Massey, A. S., Pentlavalli, S., Cunningham, R., McCrudden, C. M., McErlean, E. M., Redpath, P., ... & McCarthy, H. O. (2016). Potentiating the anticancer properties of bisphosphonates by nanocomplexation with the cationic amphipathic peptide, RALA. Molecular pharmaceutics, 13(4), 1217-1228.

MN Iqbal, H., MV Rodriguez, A., Khandia, R., Munjal, A., & Dhama, K. (2016). Recent trends in nanotechnology-based drugs and formulations for targeted therapeutic delivery. Recent patents on inflammation & allergy drug discovery, 10(2), 86-93.

Neville-Webbe, H. L., Gnant, M., & Coleman, R. E. (2010, June). Potential anticancer properties of bisphosphonates. In Seminars in oncology (Vol. 37, pp. S53-S65). WB Saunders.

Oliveira, V. M. D., Aldrighi, J. M., & Bagnoli, F. (2011). Evidências da ação dos bisfosfonatos na prevenção do câncer de mama. Revista da Associação Médica Brasileira, 57(1), 7-8.

Papamitsou, T., Sotiriou, S., Papakoulas, A., Toskas, A., Kamperis, D., Karachrysafi, S., ... & Sioga, A. (2019). Alendronate effect in esophagus, stomach and liver: an animal based pathological study. Histology and histopathology, 35(4), 417-422.

Pinto-Alphandary, H., Andremont, A., & Couvreur, P. (2000). Targeted delivery of antibiotics using liposomes and nanoparticles: research and applications. International journal of antimicrobial agents, 13(3), 155-168.

Rai, R., Alwani, S., & Badea, I. (2019). Polymeric nanoparticles in gene therapy: New avenues of design and optimization for delivery applications. Polymers, 11(4), 745.

Rosado, C., Silva, C., & Reis, C. P. (2013). Hydrocortisone-loaded poly (ε-caprolactone) nanoparticles for atopic dermatitis treatment. Pharmaceutical development and technology, 18(3), 710-718.

Russell, R. G. G. (2011). Bisphosphonates: the first 40 years. Bone, 49(1), 2-19.

Russell, R. G. G., & Rogers, M. J. (1999). Bisphosphonates: from the laboratory to the clinic and back again. Bone, 25(1), 97-106.

Scarpa, L. C., de Mello Leite, L. C., de Lacerda, J. C. T., & Arantes, D. C. B. (2010). Osteonecrose nos ossos da maxila e mandíbula associada ao uso do bifosfonato de sódio. Revista Brasileira de Pesquisa em Saúde/Brazilian Journal of Health Research.

Schaffazick, S. R., Guterres, S. S., Freitas, L. D. L., & Pohlmann, A. R. (2003). Caracterização e estabilidade físico-química de sistemas poliméricos nanoparticulados para administração de fármacos. Química nova, 26, 726-737.

Sousa, P. S. A., Nogueira, S. S., Ayala, K. N. R., Silva, P. C., Santos, E. S., Sa, R. E., Lima Neto, F. E. M., Lima, J. R. C., Rodrigues, K. A. F., Rocha, J. A., Veras, L. M. C. (2021). Prospecção científica e tecnológica de Pilocarpus microphyllus e do alcaloide epiisopiloturina com ênfase na atividade antileishmania. Research, Society And Development, v. 10, p. 1-17.

Steenbruggen, T. G., van Ramshorst, M. S., Kok, M., Linn, S. C., Smorenburg, C. H., & Sonke, G. S. (2017). Neoadjuvant therapy for breast cancer: established concepts and emerging strategies. Drugs, 77(12), 1313-1336.

Van den Wyngaert, T., Claeys, T., Huizing, M. T., Vermorken, J. B., & Fossion, E. (2009). Initial experience with conservative treatment in cancer patients with osteonecrosis of the jaw (ONJ) and predictors of outcome. Annals of Oncology, 20(2), 331-336.

Ye, F., Zhao, Y., El-Sayed, R., Muhammed, M., & Hassan, M. (2018). Advances in nanotechnology for cancer biomarkers. Nano Today, 18, 103-123.



How to Cite

MACHADO, F. dos S. .; ILES, B. .; SÁ, R. E. de .; ARAÚJO, D. D.; ANDRADE, G. L. de .; ARANTES, A. R. .; SOUSA, G. C. .; MONTEIRO, L. D. .; OLIVEIRA, A. C. P. de .; SANTOS, L. B. P. dos .; FRANCO, M. S. C. R. . Scientific and technological prospection of the use of nanoparticles with sodium alendronate in cancer treatment. Research, Society and Development, [S. l.], v. 10, n. 12, p. e317101220491, 2021. DOI: 10.33448/rsd-v10i12.20491. Disponível em: Acesso em: 26 may. 2024.



Health Sciences