Antitumor potential of phenolic compounds from oliveira (Olea europaea L.): an integrative literature review

Authors

DOI:

https://doi.org/10.33448/rsd-v10i13.20733

Keywords:

Bioactive compounds; Olive oil; Non-communicable disease.

Abstract

The phenolic compounds from olive tree products (Olea europaea L.) have antitumor potential through their effects in the prevention of tumor genesis and tumor suppression in different cancer models. This article aims to carry out a literature review, through an integrative review, on the antitumor potential of phenolic compounds in olive tree products. This is an integrative literature review, qualitative and exploratory, based on pre-clinical, in vitro and in vivo studies, published in journals indexed in databases that address the subject. The search, without date restriction, was performed in the Web of Science, PUBMED and Scopus databases. Evidence suggests that phenolic compounds from olive products (oleuropein, hydroxytyrosol, tyrosol and oleocanthal) may exert tumor genesis inhibiting effects, such as repair and protection against damage from oxidative stress and chronic inflammation, and thus could help in reducing the risk of cancer, delaying the development, progression or recurrence of various types of tumors. The analysis of the studies demonstrated antitumor potential of the olive tree phenolic compounds as they present anticancer activity through the reduction of cell growth and viability, inhibition of cell proliferation, migration and invasion, modulation in cell cycle phases and induction of apoptosis in different tumor models.

References

Aleksandrova, K., Koelman, L., & Rodrigues, C. E. (2021). Dietary patterns and biomarkers of oxidative stress and inflammation: A systematic review of observational and intervention studies. Redox Biology, xxxx, 101869. https://doi.org/10.1016/j.redox.2021.101869

American Cancer Society. (2021). American Cancer Society: Cancer Facts and Figures 2021. Atlanta, Ga: American Cancer Society, 13–15. https://www.cancer.org/content/dam/cancer-org/research/cancer-facts-and-statistics/annual-cancer-facts-and-figures/2021/cancer-facts-and-figures-2021.pdf

Amiot, M. J. (2014). Olive oil and health effects: From epidemiological studies to the molecular mechanisms of phenolic fraction. OCL - Oilseeds and fats, 21(5). https://doi.org/10.1051/ocl/2014029

Babich, H., & Visioli, F. (2003). In vitro cytotoxicity to human cells in culture of some phenolics from olive oil. Il Farmaco, 58(5), 403-407. https://doi.org/10.1016/S0014-827X(03)00048-X

Baci, D., Gallazzi, M., Cascini, C., Tramacere, M., De Stefano, D., Bruno, A., & Albini, A. (2019). Downregulation of pro-inflammatory and pro-angiogenic pathways in prostate cancer cells by a polyphenol-rich extract from olive mill wastewater. International journal of molecular sciences, 20(2), 307. https://doi.org/10.3390/ijms20020307

Bassani, B., Rossi, T., De Stefano, D., Pizzichini, D., Corradino, P., Macrì, N., & Bruno, A. (2016). Potential chemopreventive activities of a polyphenol rich purified extract from olive mill wastewater on colon cancer cells. Journal of Functional Foods, 27, 236-248. https://doi.org/10.1016/j.jff.2016.09.009

Borja, R., Raposo, F., & Rincón, B. (2006). Treatment technologies of liquid and solid wastes from two-phase olive oil mills. Grasas y Aceites, 57(1), 32–46. https://doi.org/10.3989/gya.2006.v57.i1.20

Boskou, D. (2008). Phenolic Compounds in Olives and Olive Oil. In Olive Oil (p. 11–44). CRC Press. https://doi.org/10.1201/9781420059946.ch3

Boss, A., Bishop, K. S., Marlow, G., Barnett, M. P. G., & Ferguson, L. R. (2016). Evidence to support the anti-cancer effect of olive leaf extract and future directions. Nutrients, 8(8). https://doi.org/10.3390/nu8080513

Briante, R., Patumi, M., Terenziani, S., Bismuto, E., Febbraio, F., & Nucci, R. (2002). Olea europaea L. leaf extract and derivatives: Antioxidant properties. Journal of Agricultural and Food Chemistry, 50(17), 4934–4940. https://doi.org/10.1021/jf025540p

Bulotta, S., Oliverio, M., Russo, D., & Procopio, A. (2013). Biological Activity of Oleuropein and its Derivatives. In Natural Products (p. 3605–3638). Berlin, Heidelberg: Springer Berlin Heidelberg. https://doi.org/10.1007/978-3-642-22144-6_156

Busnena, B. A., Foudah, A. I., Melancon, T., & El Sayed, K. A. (2013). Olive secoiridoids and semisynthetic bioisostere analogues for the control of metastatic breast cancer. Bioorganic & medicinal chemistry, 21(7), 2117-2127. https://doi.org/10.1016/j.bmc.2012.12.050

Choudhari, A. S., Mandave, P. C., Deshpande, M., Ranjekar, P., & Prakash, O. (2020). Phytochemicals in cancer treatment: From preclinical studies to clinical practice. Frontiers in Pharmacology, 10(January), 1–17. https://doi.org/10.3389/fphar.2019.01614

Cicerale, S., Conlan, X. A., Sinclair, A. J., & Keast, R. S. J. (2009). Chemistry and health of olive oil phenolics. Critical Reviews in Food Science and Nutrition, 49(3), 218–236. https://doi.org/10.1080/10408390701856223

Cicerale, S., Lucas, L., & Keast, R. (2010). Biological activities of phenolic compounds present in virgin olive oil. International Journal of Molecular Sciences, 11(2), 458–479. https://doi.org/10.3390/ijms11020458

Corona, G., Deiana, M., Incani, A., Vauzour, D., Dessì, M. A., & Spencer, J. P. (2009). Hydroxytyrosol inhibits the proliferation of human colon adenocarcinoma cells through inhibition of ERK1/2 and cyclin D1. Molecular nutrition & food research, 53(7), 897-903. https://doi.org/10.1002/mnfr.200800269

Cusimano, A., Balasus, D., Azzolina, A., Augello, G., Emma, M. R., Di Sano, C., & Cervello, M. (2017). Oleocanthal exerts antitumor effects on human liver and colon cancer cells through ROS generation. International journal of oncology, 51(2), 533-544. https://doi.org/10.3892/ijo.2017.4049

Della Ragione, F., Cucciolla, V., Borriello, A., Della Pietra, V., Pontoni, G., Racioppi, L., & Zappia, V. (2000). Hydroxytyrosol, a natural molecule occurring in olive oil, induces cytochrome c-dependent apoptosis. Biochemical and Biophysical Research Communications, 278(3), 733-739. https://doi.org/10.1006/bbrc.2000.3875

Diez-Bello, R., Jardin, I., Lopez, J. J., El Haouari, M., Ortega-Vidal, J., Altarejos, J., & Rosado, J. A. (2019). (−)‑Oleocanthal inhibits proliferation and migration by modulating Ca2+ entry through TRPC6 in breast cancer cells. Biochimica et Biophysica Acta (BBA)-Molecular Cell Research, 1866(3), 474-485. https://doi.org/10.1016/j.bbamcr.2018.10.010

Di Francesco, A., Falconi, A., Di Germanio, C., Di Bonaventura, M. V. M., Costa, A., Caramuta, S., & D’Addario, C. (2014). Extravirgin olive oil up-regulates CB1 tumor suppressor gene in human colon cancer cells and in rat colon via epigenetic mechanisms. The Journal of nutritional biochemistry, 26(3), 250-258. https://doi.org/10.1016/j.jnutbio.2014.10.013

Elnagar, A. Y., Sylvester, P. W., & El Sayed, K. A. (2011). (−)-Oleocanthal as a c-Met inhibitor for the control of metastatic breast and prostate cancers. Planta medica, 77(10), 1013-1019. https://doi.org/10.1055/s-0030-1270724

Erol, Ö., Arda, N., & Erdem, G. (2012). Phenols of virgin olive oil protects nuclear DNA against oxidative damage in HeLa cells. Food and chemical toxicology, 50(10), 3475-3479. https://doi.org/10.1016/j.fct.2012.07.048

Fabiani, R. (2016). Anti-cancer properties of olive oil secoiridoid phenols: A systematic review of: In vivo studies. Food and Function, 7(10), 4145–4159. https://doi.org/10.1039/c6fo00958a

Fabiani, R., & Morozzi, G. (2010). Anticarcinogenic properties of olive oil phenols: effects on proliferation, apoptosis and differentiation. In Olives and olive oil in health and disease prevention (pp. 981-988). Academic Press. https://doi.org/10.1016/B978-0-12-374420-3.00105-4

Fabiani, R., Fuccelli, R., Pieravanti, F., De Bartolomeo, A., & Morozzi, G. (2009a). Production of hydrogen peroxide is responsible for the induction of apoptosis by hydroxytyrosol on HL60 cells. Molecular nutrition & food research, 53(7), 887-896. https://doi.org/10.1002/mnfr.200800376

Fabiani, R., Rosignoli, P., De Bartolomeo, A., Fuccelli, R., & Morozzi, G. (2008a). Inhibition of cell cycle progression by hydroxytyrosol is associated with upregulation of cyclin-dependent protein kinase inhibitors p21WAF1/Cip1 and p27Kip1 and with induction of differentiation in HL60 cells. The Journal of nutrition, 138(1), 42-48. https://doi.org/10.1093/jn/138.1.42

Fabiani, R., Rosignoli, P., De Bartolomeo, A., Fuccelli, R., Servili, M., Montedoro, G. F., & Morozzi, G. (2008b). Oxidative DNA damage is prevented by extracts of olive oil, hydroxytyrosol, and other olive phenolic compounds in human blood mononuclear cells and HL60 cells. The Journal of Nutrition, 138(8), 1411-1416. https://doi.org/10.1093/jn/138.8.1411

Fabiani, R., Rosignoli, P., Fuccelli, R., Pieravanti, F., De Bartolomeo, A., & Morozzi, G. (2009b). Involvement of hydrogen peroxide formation on apoptosis induction by olive oil phenolic compounds. Czech J. Food Sci, 27, S197-S199. https://www.agriculturejournals.cz/publicFiles/07747.pdf

Femia, A. P., Dolara, P., Servili, M., Esposto, S., Taticchi, A., Urbani, S., & Caderni, G. (2008). No effects of olive oils with different phenolic content compared to corn oil on 1, 2-dimethylhydrazine-induced colon carcinogenesis in rats. European journal of nutrition, 47(6), 329. https://doi.org/10.1007/s00394-008-0731-x

Fernandes, J., Fialho, M., Santos, R., Peixoto-Plácido, C., Madeira, T., Sousa-Santos, N., Virgolino, A., Santos, O., & Vaz Carneiro, A. (2020). Is olive oil good for you? A systematic review and meta-analysis on anti-inflammatory benefits from regular dietary intake. Nutrition, 69. https://doi.org/10.1016/j.nut.2019.110559

Flamminii, F., Di Mattia, C. D., Difonzo, G., Neri, L., Faieta, M., Caponio, F., & Pittia, P. (2019). From by-product to food ingredient: evaluation of compositional and technological properties of olive-leaf phenolic extracts. Journal of the Science of Food and Agriculture, 99(14), 6620–6627. https://doi.org/10.1002/jsfa.9949

Francisco, V., Ruiz-Fernández, C., Lahera, V., Lago, F., Pino, J., Skaltsounis, L., Gualillo, O. (2019). Natural Molecules for Healthy Lifestyles: Oleocanthal from Extra Virgin Olive Oil. Journal of Agricultural and Food Chemistry, 67(14), 3845–3853. https://doi.org/10.1021/acs.jafc.8b06723

Galanakis, C. M. (2012). Recovery of high added-value components from food wastes: Conventional, emerging technologies and commercialized applications. Trends in Food Science and Technology, 26(2), 68–87. https://doi.org/10.1016/j.tifs.2012.03.003

García-Villalba, R., Carrasco-Pancorbo, A., Oliveras-Ferraros, C., Vázquez-Martín, A., Menéndez, J. A., Segura-Carretero, A., & Fernández-Gutiérrez, A. (2010). Characterization and quantification of phenolic compounds of extra-virgin olive oils with anticancer properties by a rapid and resolutive LC-ESI-TOF MS method. Journal of Pharmaceutical and Biomedical Analysis, 51(2), 416-429. https://doi.org/10.1016/j.jpba.2009.06.021

García-Villalba, R., Carrasco-Pancorbo, A., Oliveras-Ferraros, C., Menéndez, J. A., Segura-Carretero, A., & Fernández-Gutiérrez, A. (2012). Uptake and metabolism of olive oil polyphenols in human breast cancer cells using nano-liquid chromatography coupled to electrospray ionization–time of flight-mass spectrometry. Journal of Chromatography B, 898, 69-77. https://doi.org/10.1016/j.jchromb.2012.04.021

Giovannini, C., Straface, E., Modesti, D., Coni, E., Cantafora, A., De Vincenzi, M., & Masella, R. (1999). Tyrosol, the major olive oil biophenol, protects against oxidized-LDL-induced injury in Caco-2 cells. The Journal of nutrition, 129(7), 1269-1277. https://doi.org/10.1093/jn/129.7.1269

Goldsmith, C. D., Vuong, Q. V., Sadeqzadeh, E., Stathopoulos, C. E., Roach, P. D., & Scarlett, C. J. (2015). Phytochemical properties and anti-proliferative activity of Olea europaea L. leaf extracts against pancreatic cancer cells. Molecules, 20(7), 12992–13004. https://doi.org/10.3390/molecules200712992

Goya, L., Mateos, R., & Bravo, L. (2007). Effect of the olive oil phenol hydroxytyrosol on human hepatoma HepG2 cells. European Journal of Nutrition, 46(2), 70-78. https://doi.org/10.1007/s00394-006-0633-8

Goya, L., Mateos, R., Ramos, S., & Bravo, L. (2010). Uptake, Metabolism and Biological Effect of the Olive Oil Phenol Hydroxytyrosol in Human HepG2 Cells. In Olives and Olive Oil in Health and Disease Prevention (pp. 1157-1165). Academic Press. https://doi.org/10.1016/B978-0-12-374420-3.00127-3

Granados‐Principal, S., Quiles, J. L., Ramirez‐Tortosa, C., Camacho‐Corencia, P., Sanchez‐Rovira, P., Vera‐Ramirez, L., & Ramirez‐Tortosa, M. (2011). Hydroxytyrosol inhibits growth and cell proliferation and promotes high expression of sfrp4 in rat mammary tumours. Molecular nutrition & food research, 55(S1), S117-S126. https://doi.org/10.1002/mnfr.201000220

Han, J., Talorete, T. P., Yamada, P., & Isoda, H. (2009). Anti-proliferative and apoptotic effects of oleuropein and hydroxytyrosol on human breast cancer MCF-7 cells. Cytotechnology, 59(1), 45-53. https://doi.org/10.1007/s10616-009-9191-2

Hashim, Y. Z. Y., Rowland, I. R., McGlynn, H., Servili, M., Selvaggini, R., Taticchi, A., & Gill, C. I. (2008). Inhibitory effects of olive oil phenolics on invasion in human colon adenocarcinoma cells in vitro. International journal of cancer, 122(3), 495-500. https://doi.org/10.1002/ijc.23148

Hassan, Z. K., Elamin, M. H., Omer, S. A., Daghestani, M. H., Al-Olayan, E. S., Elobeid, M. A., & Virk, P. (2013). Oleuropein induces apoptosis via the p53 pathway in breast cancer cells. Asian Pacific Journal of Cancer Prevention, 14(11), 6739-6742. http://doi.org/10.7314/APJCP.2013.14.11.6739

Instituto Nacional de Câncer José Alencar Gomes da Silva. (2020). ABC do câncer: abordagens básicas para o controle do câncer. 6ª edição revista e atualizada. Rio de Janeiro, Brasil: INCA. https://www.inca.gov.br/publicacoes/livros/abc-do-cancer-abordagens-basicas-para-o-controle-do-cancer

International Olive Council – IOC (2021). Designations and definitions of olive oils. https://www.internationaloliveoil.org/olive-world/olive-oil/

Jimenez-Lopez, C., Carpena, M., Lourenço-Lopes, C., Gallardo-Gomez, M., Lorenzo, J. M., Barba, F. J., & Simal-Gandara, J. (2020). Bioactive Compounds and Quality of Extra Virgin Olive Oil. Foods, 9(8), 1014. https://doi.org/10.3390/foods9081014

Khanal, P., Oh, W. K., Yun, H. J., Namgoong, G. M., Ahn, S. G., Kwon, S. M., & Choi, H. S. (2011). p-HPEA-EDA, a phenolic compound of virgin olive oil, activates AMP-activated protein kinase to inhibit carcinogenesis. Carcinogenesis, 32(4), 545-553. https://doi.org/10.1093/carcin/bgr001

Kouka, P., Tsakiri, G., Tzortzi, D., Dimopoulou, S., Sarikaki, G., Stathopoulos, P., Kouretas, D. (2019). The polyphenolic composition of extracts derived from different Greek extra virgin olive oils is correlated with their antioxidant potency. Oxidative Medicine and Cellular Longevity. https://doi.org/10.1155/2019/1870965

LeGendre, O., Breslin, P. A., & Foster, D. A. (2015). (-)-Oleocanthal rapidly and selectively induces cancer cell death via lysosomal membrane permeabilization. Molecular & cellular oncology, 2(4), e1006077. https://doi.org/10.1080/23723556.2015.1006077

Liguori, I., Russo, G., Curcio, F., Bulli, G., Aran, L., Della-Morte, D., Gargiulo, G., Testa, G., Cacciatore, F., Bonaduce, D., & Abete, P. (2018). Oxidative stress, aging, and diseases. Clinical Interventions in Aging, 13, 757–772. https://doi.org/10.2147/CIA.S158513

Liu, L., Ahn, K. S., Shanmugam, M. K., Wang, H., Shen, H., Arfuso, F., & Tang, F. R. (2019). Oleuropein induces apoptosis via abrogating NF‐κB activation cascade in estrogen receptor–negative breast cancer cells. Journal of cellular biochemistry, 120(3), 4504-4513. https://doi.org/10.1002/jcb.27738

Lopez de las Hazas, M. C., Pinol, C., Macià, A., & Motilva, M. J. (2017). Hydroxytyrosol and the colonic metabolites derived from virgin olive oil intake induce cell cycle arrest and apoptosis in colon cancer cells. Journal of agricultural and food chemistry, 65(31), 6467-6476. https://doi.org/10.1021/acs.jafc.6b04933

Lozano-Sanchez, J., Segura-Carretero, A., Menendez, J. A., Oliveras-Ferraros, C., Cerretani, L., & Fernandez-Gutierrez, A. (2010). Prediction of extra virgin olive oil varieties through their phenolic profile. Potential cytotoxic activity against human breast cancer cells. Journal of agricultural and food chemistry, 58(18), 9942-9955. https://doi.org/10.1021/jf101502q

Macaluso, M., Bianchi, A., Sanmartin, C., Taglieri, I., Venturi, F., Testai, L. & Zinnai, A. (2020). By-Products from Winemaking and Olive Mill Value Chains for the Enrichment of Refined Olive Oil: Technological Challenges and Nutraceutical Features. Foods, 9(10), 1390. https://doi.org/10.3390/foods9101390

Mahmoud, A. E., Fathy, S. A., Ali, M. M., Ezz, M. K., & Mohammed, A. T. (2018). Antioxidant and anticancer efficacy of therapeutic bioactive compounds from fermented olive waste. Grasas y Aceites, 69(3), 266. https://doi.org/10.3989/gya.0230181

Manna, C., Galletti, P., Cucciolla, V., Moltedo, O., Leone, A., & Zappia, V. (1997). The protective effect of the olive oil polyphenol (3, 4-Dihydroxyphenyl)-ethanol counteracts reactive oxygen metabolite–induced cytotoxicity in Caco-2 cells. The Journal of nutrition, 127(2), 286-292. https://doi.org/10.1093/jn/127.2.286

Marković, A. K., Torić, J., Barbarić, M., & Brala, C. J. (2019). Hydroxytyrosol, tyrosol and derivatives and their potential effects on human health. Molecules, 24(10). https://doi.org/10.3390/molecules24102001

Martín, M. A., Ramos, S., Granado‐Serrano, A. B., Rodríguez‐Ramiro, I., Trujillo, M., Bravo, L., & Goya, L. (2010). Hydroxytyrosol induces antioxidant/detoxificant enzymes and Nrf2 translocation via extracellular regulated kinases and phosphatidylinositol‐3‐kinase/protein kinase B pathways in HepG2 cells. Molecular nutrition & food research, 54(7), 956-966. https://doi.org/10.1002/mnfr.200900159

Medeiros, R. M. L., Villa, F., Silva, D. F., & Júlio, L. R. C. (2016). Destinação e Reaproveitamento de Subprodutos da Extração Olivícola. Scientia Agraria Paranaensis, 15(2), 100–108. https://doi.org/10.18188/1983-1471/sap.v15n2p100-108

Menendez, J. A., Vazquez-Martin, A., Colomer, R., Brunet, J., Carrasco-Pancorbo, A., Garcia-Villalba, R., & Segura-Carretero, A. (2007). Olive oil's bitter principle reverses acquired autoresistance to trastuzumab (Herceptin™) in HER2-overexpressing breast cancer cells. BMC cancer, 7(1), 1-19. https://doi.org/10.1186/1471-2407-7-80

Menendez, J. A., Vazquez-Martin, A., Garcia-Villalba, R., Carrasco-Pancorbo, A., Oliveras-Ferraros, C., Fernandez-Gutierrez, A., & Segura-Carretero, A. (2008b). tabAnti-HER2 (erb B-2) oncogene effects of phenolic compounds directly isolated from commercial Extra-Virgin Olive Oil (EVOO). Bmc Cancer, 8(1), 1-23. https://doi.org/10.1186/1471-2407-8-377

Menendez, J. A., Vazquez-Martin, A., Oliveras-Ferraros, C., Garcia-Villalba, R., Carrasco-Pancorbo, A., Fernandez-Gutierrez, A., & Segura-Carretero, A. (2008a). Analyzing effects of extra-virgin olive oil polyphenols on breast cancer-associated fatty acid synthase protein expression using reverse-phase protein microarrays. International journal of molecular medicine, 22(4), 433-439. https://doi.org/10.3892/ijmm_00000039

Menendez, J. A., Vazquez-Martin, A., Oliveras-Ferraros, C., Garcia-Villalba, R., Carrasco-Pancorbo, A., Fernandez-Gutierrez, A., & Segura-Carretero, A. (2009). Extra-virgin olive oil polyphenols inhibit HER2 (erbB-2)-induced malignant transformation in human breast epithelial cells: relationship between the chemical structures of extra-virgin olive oil secoiridoids and lignans and their inhibitory activities on the tyrosine kinase activity of HER2. International journal of oncology, 34(1), 43-51. https://doi.org/10.3892/ijo_00000127

Nunes, M. A., Pimentel, F. B., Costa, A. S. G., Alves, R. C., & Oliveira, M. B. P. P. (2016). Olive by-products for functional and food applications: Challenging opportunities to face environmental constraints. Innovative Food Science and Emerging Technologies, 35, 139–148. https://doi.org/10.1016/j.ifset.2016.04.016

Pampaloni, B., Mavilia, C., Fabbri, S., Romani, A., Ieri, F., Tanini, A., & Brandi, M. L. (2014). In vitro effects of extracts of extra virgin olive oil on human colon cancer cells. Nutrition and cancer, 66(7), 1228-1236. https://doi.org/10.1080/01635581.2014.951727

Pasban-Aliabadi, H., Esmaeili-Mahani, S., Sheibani, V., Abbasnejad, M., Mehdizadeh, A., & Yaghoobi, M. M. (2013). Inhibition of 6-hydroxydopamine-induced PC12 cell apoptosis by olive (Olea europaea L.) leaf extract is performed by its main component oleuropein. Rejuvenation research, 16(2), 134-142. https://doi.org/10.1089/rej.2012.1384

Pereira, P. C., Vicente, A. F., Cabrita, A. S., & Mesquita, M. F. (2009). The influence of olive oil on Sprague Dawley rats DMBA-induced mammary tumors. International Journal of Cancer Research (USA), 5(4), 144-152. https://doi.org/10.3923/ijcr.2009.144.152

Quiles, J. L., Farquharson, A. J., Simpson, D. K., Grant, I., & Wahle, K. W. (2002). Olive oil phenolics: effects on DNA oxidation and redox enzyme mRNA in prostate cells. British Journal of Nutrition, 88(3), 225-234. https://doi.org/10.1079/BJN2002620

Ramos, P., Santos, S. A., Guerra, Â. R., Guerreiro, O., Felício, L., Jerónimo, E., & Duarte, M. (2013). Valorization of olive mill residues: Antioxidant and breast cancer antiproliferative activities of hydroxytyrosol-rich extracts derived from olive oil by-products. Industrial Crops and Products, 46, 359-368. https://doi.org/10.1016/j.indcrop.2013.02.020

Reboredo-Rodríguez, P., González-Barreiro, C., Cancho-Grande, B., Forbes-Hernández, T. Y., Gasparrini, M., Afrin, S., & Battino, M. (2018). Characterization of phenolic extracts from Brava extra virgin olive oils and their cytotoxic effects on MCF-7 breast cancer cells. Food and Chemical Toxicology, 119, 73-85. https://doi.org/10.1016/j.fct.2018.05.026

Romani, A., Ieri, F., Urciuoli, S., Noce, A., Marrone, G., Nediani, C., & Bernini, R. (2019). Health effects of phenolic compounds found in extra-virgin olive oil, by-products, and leaf of Olea europaea L. Nutrients, 11(8), 1776. https://doi.org/10.3390/nu11081776

Ruzzolini, J., Peppicelli, S., Andreucci, E., Bianchini, F., Scardigli, A., Romani, A., la Marca, G., Nediani, C., & Calorini, L. (2018). Oleuropein, the Main Polyphenol of Olea europaea Leaf Extract, Has an Anti-Cancer Effect on Human BRAF Melanoma Cells and Potentiates the Cytotoxicity of Current Chemotherapies. Nutrients, 10(12), 1950. https://doi.org/10.3390/nu10121950

Seyedsadjadi N, Grant R. (2020). The Potential Benefit of Monitoring Oxidative Stress and Inflammation in the Prevention of Non-Communicable Diseases (NCDs). Antioxidants (Basel), 10(1):15. 10.3390/antiox10010015. PMID: 33375428.

Tsimidou, M. Z., & Papoti, V. T. (2010). Bioactive Ingredients in Olive Leaves. Olives and Olive Oil in Health and Disease Prevention. Elsevier Inc. https://doi.org/10.1016/B978-0-12-374420-3.00039-5

Uylaşer, V., & Yildiz, G. (2014). The Historical Development and Nutritional Importance of Olive and Olive Oil Constituted an Important Part of the Mediterranean Diet. Critical Reviews in Food Science and Nutrition, 54(8), 1092–1101. https://doi.org/10.1080/10408398.2011.626874

Virruso, C., Accardi, G., Colonna-Romano, G., Candore, G., Vasto, S., & Caruso, C. (2014). Nutraceutical properties of extra-virgin olive oil: A natural remedy for age-related disease? Rejuvenation Research, 17(2), 217–220. https://doi.org/10.1089/rej.2013.1532

Visioli, F., & Bernardini, E. (2012). Extra-Virgin Olive Oil-Healthful Properties of its Phenolic Constituents. Recent Advances in Polyphenol Research, Volume 3, 3, 223–248. https://doi.org/10.1002/9781118299753.ch10

Wrege, M. S., Coutinho, E. F., Pantano, A. P., & Jorge, R. O. (2015). Distribuição potencial de oliveiras no Brasil e no mundo. Revista Brasileira de Fruticultura, 37(3), 656-666. https://doi.org/10.1590/0100-2945-174/14

Zeb, A., & Murkovic, M. (2011). Olive (Olea europaea L.) Seeds, From Chemistry to Health Benefits. Nuts and Seeds in Health and Disease Prevention, 847–853. https://doi.org/10.1016/B978-0-12-375688-6.10100-8

Published

03/10/2021

How to Cite

FERREIRA, W. A. .; AGUIAR, G. S. .; PESSOA, H. R. .; COSTA, D. C. F. da .; ZAGO, L. Antitumor potential of phenolic compounds from oliveira (Olea europaea L.): an integrative literature review. Research, Society and Development, [S. l.], v. 10, n. 13, p. e22101320733, 2021. DOI: 10.33448/rsd-v10i13.20733. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/20733. Acesso em: 6 dec. 2021.

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Section

Health Sciences