Non-pharmacological pain management in neonates admitted to Intensive Care Units: update
DOI:
https://doi.org/10.33448/rsd-v10i15.21069Keywords:
Intensive Care Units; Neonatal; Pain Management; Pediatrics.Abstract
Introduction: Inherent in most procedures performed in the Neonatal Intensive Care Unit, pain is a phenomenon that needs to be correctly and early evaluated and treated so that it does not harm the baby's development in the long term. Its non-pharmacological therapy does not block the transmission of nociceptive stimuli to the thalamus and activates descending inhibitory pathways, being an important and diverse ally in pain control. Methodology: This is an Integrative Literature Review carried out with an initial search of the Latin American and Caribbean Literature in Health Sciences (LILACS), Scientific Electronic Library Online (SciELO) and Medical Literature Analysis and Retrieval System databases (Medline). The search term “Intensive Care Units, Neonatal AND Pain management” was used. Publications from 2017 to 2021 were included and review articles, meta-analyses and case reports were excluded. There were no duplications. Articles whose title or abstract corroborated the purpose of this review were also excluded. The 18 articles filtered by the exclusion criteria were organized and, after reading all of their content, 14 articles that make up the results of this review were retrieved. Results and Discussion: All retrieved articles are randomizations and most of them were published in 2020. It was observed that heel puncture is a painful procedure and evaluated in most clinical trials, including the application of the Premature Infant Pain Profile scale (PIPP), for studies with preterms. Furthermore, it was found that 24% oral sucrose was the intervention most compared to others and that it was inferior or comparable to the kangaroo method and the intake of breast milk for pain control in neonates hospitalized in the ICU. Conclusion: this review pointed out the clinical effectiveness of interventions of different natures evidenced in the rescued studies. Smell, hearing, taste and touch have been potential fields of intervention for analgesic control or pain distraction in neonates undergoing routine painful procedures. It is noteworthy that the kangaroo method, the intake of breast milk and its odor, as well as the sound of the maternal heartbeat have shown positive, safe and reproducible results, even in comparison with the use of oral sucrose at 24%. It is noteworthy that new clinical trials and meta-analyses are essential to strengthen the conclusions of this study.
References
Allegaert, K., & Van Den Anker, J. N. (2016). Neonatal pain management: still in search of the Holy Grail. International Journal of Clinical Pharmacology and Therapeutics, 54(7), 514.
Apaydin Cirik, V., & Efe, E. (2020). The effect of expressed breast milk, swaddling and facilitated tucking methods in reducing the pain caused by orogastric tube insertion in preterm infants: A randomized controlled trial. International Journal of Nursing Studies, 104, 103532. https://doi.org/10.1016/j.ijnurstu.2020.103532
Collados‐Gómez, L., Ferrera‐Camacho, P., Fernandez‐Serrano, E., Camacho‐Vicente, V., Flores‐Herrero, C., García‐Pozo, A. M., & Jiménez‐García, R. (2018). Randomised crossover trial showed that using breast milk or sucrose provided the same analgesic effect in preterm infants of at least 28 weeks. Acta Paediatrica, 107(3), 436-441.
Campbell-Yeo, M., Johnston, C. C., Benoit, B., Disher, T., Caddell, K., Vincer, M., Walker, C. D., Latimer, M., Streiner, D. L., & Inglis, D. (2019). Sustained efficacy of kangaroo care for repeated painful procedures over neonatal intensive care unit hospitalization: a single-blind randomized controlled trial. Pain, 160(11), 2580–2588. https://doi.org/10.1097/j.pain.0000000000001646
Chanville, A. B. De, Brevaut-malaty, V., Garbi, A., Tosello, B., & Baumstarck, K. (2017). Analgesic Effect of Maternal Human Milk Odor on Premature Neonates : A Randomized Controlled Trial. https://doi.org/10.1177/0890334417693225
Kahraman, A., Gümüş, M., Akar, M., Sipahi, M., Bal Yılmaz, H., & Başbakkal, Z. (2020). The effects of auditory interventions on pain and comfort in premature newborns in the neonatal intensive care unit; a randomised controlled trial. Intensive and Critical Care Nursing, 61(xxx). https://doi.org/10.1016/j.iccn.2020.102904
Küçük Alemdar, D., & Güdücü Tüfekcİ, F. (2018). Effects of maternal heart sounds on pain and comfort during aspiration in preterm infants. Japan Journal of Nursing Science, 15(4), 330–339. https://doi.org/10.1111/jjns.12202
Lago, P., Cavicchiolo, M. E., Mion, T., Dal Cengio, V., Allegro, A., Daverio, M., & Frigo, A. C. (2020). Repeating a dose of sucrose for heel prick procedure in preterms is not effective in reducing pain: a randomised controlled trial. European Journal of Pediatrics, 179(2), 293–301. https://doi.org/10.1007/s00431-019-03509-2
McGinnis, K., Murray, E., Cherven, B., McCracken, C., & Travers, C. (2016). Effect of vibration on pain response to Heel Lance. Advances in Neonatal Care, 16(6), 439–448. https://doi.org/10.1097/ANC.0000000000000315
Peng, H. F., Yin, T., Yang, L., Wang, C., Chang, Y. C., Jeng, M. J., & Liaw, J. J. (2018). Non-nutritive sucking, oral breast milk, and facilitated tucking relieve preterm infant pain during heel-stick procedures: A prospective, randomized controlled trial. International Journal of Nursing Studies, 77, 162–170. https://doi.org/10.1016/j.ijnurstu.2017.10.001
Perry, M., Tan, Z., Chen, J., Weidig, T., Xu, W., & Cong, X. S. (2018). Neonatal pain: perceptions and current practice. Critical Care Nursing Clinics, 30(4), 549-561.
Sen, E., & Manav, G. (2020). Effect of Kangaroo Care and Oral Sucrose on Pain in Premature Infants: A Randomized Controlled Trial. Pain Management Nursing, 21(6), 556–564. https://doi.org/10.1016/j.pmn.2020.05.003
Shukla, V., Chapla, A., Uperiya, J., Nimbalkar, A., Phatak, A., & Nimbalkar, S. (2018). Sucrose vs. skin to skin care for preterm neonatal pain control—a randomized control trial. Journal of Perinatology, 38(10), 1365–1369. https://doi.org/10.1038/s41372-018-0193-9
Stevens, Bonnie; Yamada, Janet; Campbell-Yeo, M. S. G., Harrison, Denise; Dionne, Kimberley; Taddio, Anna; McNair, Carol; Willan, A. M. B. K. W. S. S., & Riahi, C. E. A. S. J. S. C. V. S. (2018). The Minimally Effective Dose of Sucrose for Procedural Pain Relief in Neonates: A Randomized Controlled Trial. MCN The American Journal of Maternal/Child Nursing, 43(5), 297. https://doi.org/10.1097/NMC.0000000000000457
Tekgündüz, K. Ş., Polat, S., Gürol, A., & Apay, S. E. (2019). Oral Glucose and Listening to Lullaby to Decrease Pain in Preterm Infants Supported with NCPAP: A Randomized Controlled Trial. Pain Management Nursing, 20(1), 54–61. https://doi.org/10.1016/j.pmn.2018.04.008
Ursi, E. S. (2005). Prevenção de lesões de pele no perioperatório: revisão integrativa da literatura. Revista Latino-Americana de Enfermagem, 14(1), 2–127.
Williams, N., Maclean, K., Guan, L., Collet, J. P., & Holsti, L. (2019). Pilot Testing a Robot for Reducing Pain in Hospitalized Preterm Infants. https://doi.org/10.1177/1539449218825436
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2021 Thyago de Oliveira Afonso; Samuel Lopes dos Santos; Gustavo Baroni Araújo; Layanne Cavalcante de Moura; Guilherme Dantas Borges; Joelma Maria dos Santos da Silva Apolinário; Samara Atanielly Rocha; Ronnyele Cássia Araujo Santos; Caroliny Ferreira Lira; Ilana Marjorie Macedo Borges Miranda; André Lucas Santos Rocha ; Ricardo Pessoa Rocha Melo; Cedric Adam Spíndola de Araújo Viana; Denise Delmonde Medeiros; Winícius de Carvalho Alves
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.