Properties, efficacy and safety of hyaluronic acid use in orofacial harmonization
DOI:
https://doi.org/10.33448/rsd-v10i13.21212Keywords:
Hyaluronic Acid; Hyaluronic Harmonization; Dermal Fillers; Aesthetics.Abstract
Hyaluronic acid is a substance that is becoming increasingly popular in minimally invasive aesthetic procedures on the face. Although the human body itself has endogenous hyaluronic acid, it becomes scarce over the years with the natural aging of the skin, resulting in loss of volume and decay throughout the face. Given this, hyaluronic acid dermal fillers appeared, which have the capacity of volumizing soft tissues and promoting harmony and aesthetics to the face. Therefore, this study aimed to investigate the knowledge of the use of hyaluronic acid in facial filling interventions taking into consideration its properties, the level of effectiveness and possible complications. This study consisted of a basic, qualitative, descriptive integrative review based on the PubMed and Virtual Health Library search platforms, exploring the terms hyaluronic acid, hyaluronan, dermal fillers, and aesthetics. Articles were included in the time range from 2016 to 2021 in the English language and the search yielded 16 articles. The selected articles showed that the use of hyaluronic acid brings great levels of effectiveness and satisfaction to patients, but evidenced the need for retreatment sessions months later for maintenance, it is safe, because the most common complications cease mostly within two weeks and without the need for intervention, besides being a substance with excellent properties and rheological characteristics. It can be concluded that the use of hyaluronic acid is effective, safe and has ideal properties in dermal facial filling.
References
Buhren, B. A., Schrumpf, H., Hoff, N. P., Bölke, E., Hilton, S. & Gerber P. A. (2016). Hyaluronidase: from clinical applications to molecular and cellular mechanisms. Eur J Med Res., 21, 5.
Bukhari, S. N. A., Roswandi, N. L., Waqas, M., Habib, H., Hussain, F., Khan, S., Sohail, M., Ramli, N. A., Thu, H. E. & Hussain, Z. (2018). Hyaluronic acid, a promising skin rejuvenating biomedicine: A review of recent updates and pre-clinical and clinical investigations on cosmetic and nutricosmetic effects. Int J Biol Macromol., 120, 1682-1695.
Cabral, L. R. B., Teixeira, L. N., Gimenez, R. P., Demasi, A. P. D., de Brito Junior, R. B., de Araújo, V. C. & Martinez, E. F. (2020). Effect of Hyaluronic Acid and Poly-L-Lactic Acid Dermal Fillers on Collagen Synthesis: An in vitro and in vivo Study. Clin Cosmet Investig Dermatol., 13, 701-710.
Cannella, V., Altomare, R., Leonardi, V., Russotto, L., Di Bella, S., Mira, F. & Guercio, A. (2020). In Vitro Biocompatibility Evaluation of Nine Dermal Fillers on L929 Cell Line. Biomed Res Int., 21.
Choi, M. S. (2020). Basic rheology of dermal filler. Arch Plast Surg., 47(4), 301-304.
Ciccone, V., Zazzetta, M. & Morbidelli, L. (2019). Comparison of the Effect of Two Hyaluronic Acid Preparations on Fibroblast and Endothelial Cell Functions Related to Angiogenesis. Cells, 8(12), 1479.
Estrela, C. (2018). Metodologia Científica: Ciência, Ensino, Pesquisa. Editora Artes Médicas.
Fagien, S., Bertucci, V., Von Grote, E. & Mashburn, J. H. (2019). Rheologic and Physicochemical Properties Used to Differentiate Injectable Hyaluronic Acid Filler Products. Plast Reconstr Surg., 143(4), 707-720.
Fallacara, A., Baldini, E., Manfredini, S. & Vertuani, S. (2018). Hyaluronic Acid in the Third Millennium. Polymers (Basel), 10(7), 701.
Fino, P., Maruccia, M., Ciotti, M., Amorosi, V & Scuderi, N. (2016). Patient satisfaction as an excellent track record in nonsurgical rejuvenation procedures. Eur Rev Med Pharmacol Sci., 20(10), 1911-1917.
Goodman, G. J., Liew, S., Callan, P. & Hart, S. (2020). Facial aesthetic injections in clinical practice: Pretreatment and posttreatment consensus recommendations to minimise adverse outcomes. Australas J Dermatol., 61(3), 217-225.
Heitmiller, K., Ring, C. & Saedi, N. (2021). Rheologic properties of soft tissue fillers and implications for clinical use. J Cosmet Dermatol., 20(1), 28-34.
Herrmann, J. L., Hoffmann, R. K., Ward, C. E., Schulman, J. M. & Grekin, R. C. (2018). Biochemistry, Physiology, and Tissue Interactions of Contemporary Biodegradable Injectable Dermal Fillers. Dermatol Surg., 44, 19-31.
Jung, J. M., Lee, W. S., Yoon, J., Paik, S. H., Han, H. S., Lee, W. J., Chang, S. E., Won, C. H. & Kim, B. J. (2021). A multicenter, randomized, double-blind comparison of two hyaluronic acid fillers in mid-face volume restoration in Asians: A 2-year extension study. Dermatol Ther., 34(2), 14787.
Kruk, D., Rochowski, P., Masiewicz, E., Wilczynski, S., Wojciechowski M., Broche, L. M. & Lurie, D. J. (2019). Mechanism of Water Dynamics in Hyaluronic Dermal Fillers Revealed by Nuclear Magnetic Resonance Relaxometry. Chemphyschem., 20(21), 2816-2822.
La Gatta, A., Salzillo, R., Catalano, C., D’Agostino, A., Pirozzi, A. V. A., De Rosa, M. & Schiraldi, C. (2019). Hyaluronan-based hydrogels as dermal fillers: The biophysical properties that translate into a "volumetric" effect. PLoS One, 14(6).
La Gatta, A., Schiraldi, C., Zaccaria, G. & Cassuto, D. (2020). Hyaluronan Dermal Fillers: Efforts Towards a Wider Biophysical Characterization and the Correlation of the Biophysical Parameters to the Clinical Outcome. Clin Cosmet Investig Dermatol., 13, 87-97.
Lee, W., Hwang, S-G., Oh, W., Kim, C-Y., Lee, J-L. & Yang, E-J. (2020). Practical Guidelines for Hyaluronic Acid Soft-Tissue Filler Use in Facial Rejuvenation. Dermatol Surg., 46(1), 41-49.
Lipko-Godlewska, S., Bolanča, Ž., Kalinová, L., Kermen, I., Onisak, B., Papp, I., Rebrov, M. & Valančienė, G. (2021). Whole-Face Approach with Hyaluronic Acid Fillers. Clin Cosmet Investig Dermatol., 14, 169-178.
Maia, I. E. F. & Salvi, J. de O. (2018). O Uso do Ácido Hialurônico na Harmonização Facial: Uma Breve Revisão. Brazilian Journal of Surgery and Clinical Research, 23(2), 135-139.
Maytin, E. V. (2016). Hyaluronan: More than just a wrinkle filler. Glycobiology, 26 (6), 553-559.
McKeown, D. J. (2021). Impact of Minimally Invasive Aesthetic Procedures on the Psychological and Social Dimensions of Health. Plast Reconstr Surg Glob Open., 9(4), 3578.
Michaud, T. (2016). Rheology of hyaluronic acid and dynamic facial rejuvenation: Topographical specificities. J Cosmet Dermatol., 17(5), 736-743.
Nakab, L., Hee, C. K. & Guetta, O. (2020). Improvements in Skin Quality Biological Markers in Skin Explants Using Hyaluronic Acid Filler VYC-12L. Plast Reconstr Surg Glob Open., 8(3), 2723.
Niforos, F., Acquilla, R., Ogilvie, P., Safa, M., Signorini, M., Creutz, L., Kerson. G. & Silberberg, M. (2017). A Prospective, Open-Label Study of Hyaluronic Acid-Based Filler With Lidocaine (VYC-15L) Treatment for the Correction of Infraorbital Skin Depressions. Dermatol Surg., 43(10), 1271-1280.
Ogilvie, P., Benouaiche, L., Philipp-Dormston, W. G., Belhaouari, L., Gaymans, F., Sattler, G., Harvey, C & Schumacher, A. (2020). VYC-25L Hyaluronic Acid Injectable Gel Is Safe and Effective for Long-Term Restoration and Creation of Volume of the Lower Face. Aesthet Surg J., 40(9), 499-510.
Rohrich, R. J., Bartlett, E. L. & Dayan, E. (2019). Practical Approach and Safety of Hyaluronic Acid Fillers. Plast Reconstr Surg Glob Open., 7(6), 2172.
Rzany, B., Bayerl, C., Bodokh, I., Boineau, D., Dirschka, T., Queille-Roussel, C., Sebastian, M., Sommer, B. Edwartz, C. & Podda, M. (2017). An 18-Month Follow-up, Randomized Comparison of Effectiveness and Safety of Two Hyaluronic Acid Fillers for Treatment of Moderate Nasolabial Folds. Dermatol Surg., 43(1), 58-65.
Shin, J-W., Kwon, S-H., Choi, J-Y., Na, J-I., Huh, C-H., Choi, H-R & Park, K-C. (2019). Molecular Mechanisms of Dermal Aging and Antiaging Approaches. Int J Mol Sci., 20(9), 2126.
Singh, K. & Nooreyezdan, S. (2020). Nonvascular Complications of Injectable Fillers-Prevention and Management. Indian J Plast Surg., 53(3), 335-343.
Sito, G., Manzoni, V. & Sommariva, R. (2019). Vascular Complications after Facial Filler Injection: A Literature Review and Meta-analysis. J Clin Aesthet Dermatol., 12(6), 65-72.
Stojanovič, L. & Majdič, N. (2019). Effectiveness and safety of hyaluronic acid fillers used to enhance overall lip fullness: A systematic review of clinical studies. J Cosmet Dermatol., 18(2), 436-443.
Vandeputte, J. (2018). Real-world Experience with Volume Augmentation using Cohesive Polydensified Matrix Hyaluronic Acid Gel: A Retrospective Single-center Analysis of 110 Consecutive Patients with Medium- to Long-term Follow-up. J Clin Aesthet Dermatol., 11(12), 30-39.
Vasconcelos, S. C. B., Nascente, F. M., De Souza, C. M. D. & Sobrinho, H. M. da R. (2020). O uso do ácido hialurônico no rejuvenescimento facial. Revista Brasileira Militar De Ciências, 6(14), 8-15.
Wang, C., Luan, S., Panayi, A. C., Xin, M., Mi, B. & Luan, J. (2018). Effectiveness and Safety of Hyaluronic Acid Gel with Lidocaine for the Treatment of Nasolabial Folds: A Systematic Review and Meta-analysis. Aesthetic Plast Surg., 42(4), 1104-1110.
Wollina U & Goldman A. (2020). Facial vascular danger zones for filler injections. Dermatol Ther., 33(6), 14285.
Wu, Y., Sun, N., Xu, Y., Liu, H., Zhong, S., Chen, L. & Li, D. (2016). Clinical comparison between two hyaluronic acid-derived fillers in the treatment of nasolabial folds in Chinese subjects: BioHyalux versus Restylane. Arch Dermatol Res., 308(3), 145-151.
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Copyright (c) 2021 Matheus Rangel Alves Ribeiro; Antônio Afonso Sommer; Rodrigo Soares de Andrade; Thiago de Amorim Carvalho; Maria Teresa Borges Araujo; Patrícia Cristine de Oliveira Afonso Pereira
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