The association of subepithelial connective tissue graft and enamel-derived matrix in the covering of gingival recessions

Authors

DOI:

https://doi.org/10.33448/rsd-v10i13.21417

Keywords:

Enamel matrix derivates; Gingival retraction; Subepithelial connective tissue graft.

Abstract

Gingival recession (GR) can be defined as a condition in which migration occurs in the apical direction with consequent exposure of the cementoenamel junction and root surface. Periodontal plastic surgical techniques aim to improve the gingival phenotype and correct the morphology, position and dimensions of the gingival tissue. In recent years, in order to improve the results of these treatments, new resources related to the optimization of periodontal regeneration have been associated with gingival grafts. Whether or not it is an adjunct to surgical techniques for root coverage, the enamel-derived matrix (Emdogain â) has been increasingly incorporated into these treatments, as both its clinical applicability and its benefits are already supported. in scientific evidence. The aim of this study is to carry out an integrative literature review on the use of enamel-derived matrix (EMD) in periodontal plastic surgical procedures for the treatment of gingival recession. For the elaboration of the study, the PICO strategy and the search in the PubMed, MedLine and Scielo databases were used, using the following keywords: “enamel matrix derivatives”, “gingival retraction” and “subepithelial connective tissue graft”. From this search, 181 articles published between the years 2016 to 2021 were selected, and of this number, only 12 were used to perform the literature review. With this review, it was possible to conclude that EMD associated with subepithelial connective tissue grafts can increase the predictability of the covering therapy, which may favor a new periodontal insertion.

References

Alexiou, A., Vouros, I., Menexes, G., & Konstantinidis, A. (2017). Comparison of enamel matrix derivative (Emdogain) and subepithelial connective tissue graft for root coverage in patients with multiple gingival recession defects: A randomized controlled clinical study. Quintessence international (Berlin, Germany: 1985), 48(5), 381–389.

Aroca, S., Keglevich, T., Nikolidakis, D., Gera, I., Nagy, K., Azzi, R., & Etienne, D. (2010). Treatment of class III multiple gingival recessions: a randomized-clinical trial. Journal of clinical periodontology, 37(1), 88–97.

Aydinyurt, H. S., Tekin, Y., & Ertugrul, A. S. (2019). The effect of enamel matrix derivatives on root coverage: a 12-month follow-up of a randomized clinical trial. Brazilian oral research, 33, e006.

Baker P. (2020). Gingival Recession - Causes and Management. Primary dental journal, 8(4), 40–47.

Cairo, F., Nieri, M., & Pagliaro, U. (2014). Efficacy of periodontal plastic surgery procedures in the treatment of localized facial gingival recessions. A systematic review. Journal of clinical periodontology, 41, S44-S62, 2014.

Chambrone, L., Salinas Ortega, M. A., Sukekava, F., Rotundo, R., Kalemaj, Z., Buti, J., & Pini Prato, G. P. (2018). Root coverage procedures for treating localised and multiple recession-type defects. The Cochrane database of systematic reviews, 10(10), CD007161.

Cortellini, Pierpaolo; Pini Prato, Giovanpaolo. Cortellini, P., & Pini Prato, G. (2012). Coronally advanced flap and combination therapy for root coverage. Clinical strategies based on scientific evidence and clinical experience. Periodontology 2000, 59(1), 158-184.

De Sanctis, Massimo; Zucchelli, G. de Sanctis, M., & Zucchelli, G. (2007). Coronally advanced flap: a modified surgical approach for isolated recession-type defects: three-year results. Journal of clinical periodontology, 34(3), 262-268, 2007.

Discepoli, N., Mirra, R., & Ferrari, M. (2019). Efficacy of Enamel Derivatives to Improve Keratinized Tissue as Adjunct to Coverage of Gingival Recessions: A Systematic Review and Meta-Analysis. Materials (Basel, Switzerland), 12(17), 2790.

Estrela, C. (2018). Metodologia Científica: Ciência, Ensino, Pesquisa. Editora Artes Médicas.

Gibson CW (2008) A amelogenina “proteínas do esmalte” e células do periodonto. Crit Rev Eukaryot Gene Expr 18 (4): 345-360.

Górski, B., Górska, R., Szerszeń, M., & Kaczyński, T. (2021). Modified coronally advanced tunnel technique with enamel matrix derivative in addition to subepithelial connective tissue graft compared with connective tissue graft alone for the treatment of multiple gingival recessions: prognostic parameters for clinical treatment outcomes. Clinical oral investigations.

Górski, B., Górska, R., Wysokińska-Miszczuk, J., & Kaczyński, T. (2020). Tunnel technique with enamel matrix derivative in addition to subepithelial connective tissue graft compared with connective tissue graft alone for the treatment of multiple gingival recessions: a randomized clinical trial. Clinical oral investigations, 24(12), 4475–4486.

Graziani, F., Gennai, S., Roldán, S., Discepoli, N., Buti, J., Madianos, P., & Herrera, D. (2014). Efficacy of periodontal plastic procedures in the treatment of multiple gingival recessions. Journal of clinical periodontology, 41, S63-S76, 2014.

Haase HR, Bartold PM (2001) O derivado da matriz do esmalte induz a síntese da matriz por células de fibroblastos periodontais humanos em cultura. J Periodontol 72 (3): 341–348.

Hagewald S, Spahr A, Rompola E, et al. Hägewald, S., Spahr, A., Rompola, E., Haller, B., Heijl, L., & Bernimoulin, J. P. (2002). Comparative study of Emdogain and coronally advanced flap technique in the treatment of human gingival recessions. A prospective controlled clinical study. Journal of clinical periodontology, 29: 35-41.

Lyngstadaas, S. P., Wohlfahrt, J. C., Brookes, S. J., Paine, M. L., Snead, M. L., & Reseland, J. E. (2009). Enamel matrix proteins; old molecules for new applications. Orthodontics & craniofacial research, 12(3), 243-253, 2009.

McGuire, M. K., Scheyer, E. T., & Schupbach, P. (2016). A Prospective, Case-Controlled Study Evaluating the Use of Enamel Matrix Derivative on Human Buccal Recession Defects: A Human Histologic Examination. Journal of periodontology, 87: 645-653

Mercado, F., Hamlet, S., & Ivanovski, S. (2020). A 3-year prospective clinical and patient-centered trial on subepithelial connective tissue graft with or without enamel matrix derivative in Class I-II Miller recessions. Journal of periodontal research, 55(2), 296–306.

Mercado, F., Hamlet, S., & Ivanovski, S. (2020). Subepithelial connective tissue graft with or without enamel matrix derivative for the treatment of multiple Class III-IV recessions in lower anterior teeth: A 3-year randomized clinical trial. Journal of periodontology, 91(4), 473–483.

Miron RJ, Sculean A, Cochran DL, Froum S, Zucchelli G, Nemcovsky C, Donos N, Lyngstadaas SP, Deschner J, Dard M, Stavropoulos A, Zhang Y, Trombelli L, Kasaj A, Shirakata Y, Cortellini P, Tonetti M, Rasperini G, Jepsen S, Bosshardt DD (2016) Vinte anos de derivada da matriz do esmalte: o passado, o presente e o futuro. J Clin Periodontol 43 (8): 668–683.

Meza Mauricio, J., Furquim, C. P., Bustillos-Torrez, W., Soto-Peñaloza, D., Peñarrocha-Oltra, D., Retamal-Valdes, B., & Faveri, M. (2021). Does enamel matrix derivative application provide additional clinical benefits in the treatment of maxillary Miller class I and II gingival recession? A systematic review and meta-analysis. Clinical oral investigations, 25(4), 1613–1626.

Salhi, L., Lecloux, G., Seidel, L., Rompen, E., & Lambert, F. (2014). Coronally advanced flap versus the pouch technique combined with a connective tissue graft to treat Miller's class I gingival recession: a randomized controlled trial. Journal of clinical periodontology, 41(4), 387-395.

Sarfati, A., Bourgeois, D., Katsahian, S., Mora, F., & Bouchard, P. (2010). Risk assessment for buccal gingival recession defects in an adult population. Journal of periodontology, 81: 1419-1425.

Schlueter, S. R., Carnes, D. L., & Cochran, D. L. (2007). In vitro effects of enamel matrix derivative on microvascular cells. Journal of periodontology, v. 78, n. 1, p. 141-151, 2007.

Sculean, A., Chiantella, G. C., Windisch, P., & Donos, N. (2000). Clinical and histologic evaluation of human intrabony defects treated with an enamel matrix protein derivative (Emdogain). The International journal of periodontics & restorative dentistry, 20: 374-381.

Sculean, A., & Allen, E. P. (2018). The Laterally Closed Tunnel for the Treatment of Deep Isolated Mandibular Recessions: Surgical Technique and a Report of 24 Cases. The International journal of periodontics & restorative dentistry, 38(4), 479–487.

Sculean, A., Cosgarea, R., Stähli, A., Katsaros, C., Arweiler, N. B., Miron, R. J., & Deppe, H. (2016). Treatment of multiple adjacent maxillary Miller Class I, II, and III gingival recessions with the modified coronally advanced tunnel, enamel matrix derivative, and subepithelial connective tissue graft: A report of 12 cases. Quintessence international (Berlin, Germany: 1985), 47(8), 653–659.

Seong, J., Bartlett, D., Newcombe, R. G., Claydon, N., Hellin, N., & West, N. X. (2018). Prevalence of gingival recession and study of associated related factors in young UK adults. Journal of dentistry, 76, 58–67.

Spahr, A., Haegewald, S., Tsoulfidou, F., Rompola, E., Heijl, L., Bernimoulin, J. P., Ring, C., Sander, S., & Haller, B. (2005). Coverage of Miller class I and II recession defects using enamel matrix proteins versus coronally advanced flap technique: a 2-year report. Journal of periodontology, 76(11), 1871–1880.

Stähli, A., Imber, J. C., Raptis, E., Salvi, G. E., Eick, S., & Sculean, A. (2020). Effect of enamel matrix derivative on wound healing following gingival recession coverage using the modified coronally advanced tunnel and subepithelial connective tissue graft: a randomised, controlled, clinical study. Clinical oral investigations, 24(2), 1043–1051.

Suárez-López Del Amo, F., Monje, A., Padial-Molina, M., Tang, Z., & Wang, H. L. (2015). Biologic Agents for Periodontal Regeneration and Implant Site Development. BioMed research international, 2015, 957518.

Tabassum, S., Adnan, S., & Khan, F. R. (2017). Gingival Retraction Methods: A Systematic Review. Journal of prosthodontics: official journal of the American College of Prosthodontists, 26(8), 637–643.

Wyganowska-Swiatkowska, M., Urbaniak, P., Lipinski, D., Szalata, M., Borysiak, K., Jakun, J., & Kotwicka, M. (2017). Effects of enamel matrix proteins on adherence, proliferation and migration of epithelial cells: A real-time in vitro study. Experimental and therapeutic medicine, 13(1), 160–168.

Zucchelli, G., & De Sanctis, M. (2005). Long-term outcome following treatment of multiple Miller class I and II recession defects in esthetic areas of the mouth. Journal of periodontology, 76(12), 2286–2292.

Zuhr, O., Akakpo, D., Eickholz, P., Vach, K., Hürzeler, M. B., Petsos, H., & Research Group for Oral Soft Tissue Biology & Wound Healing (2021). Tunnel technique with connective tissue graft versus coronally advanced flap with enamel matrix derivate for root coverage: 5-year results of an RCT using 3D digital measurement technology for volumetric comparison of soft tissue changes. Journal of clinical periodontology, 48(7), 949–961.

Published

18/10/2021

How to Cite

BIZZARIA, V. D.; LIMA, G. P. de .; PEREIRA, L. B. .; TEIXEIRA, D. N. R. .; MENDONÇA, M. B. de .; ANDRADE, R. S. de .; BORGES, D. C. . The association of subepithelial connective tissue graft and enamel-derived matrix in the covering of gingival recessions. Research, Society and Development, [S. l.], v. 10, n. 13, 2021. DOI: 10.33448/rsd-v10i13.21417. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/21417. Acesso em: 13 nov. 2024.

Issue

Section

Health Sciences