Hypertrophic cardiomyopathy, an important cause of sudden death in young: integrative review

Authors

DOI:

https://doi.org/10.33448/rsd-v10i13.21498

Keywords:

Hypertrophic cardiomyopathy; Sudden death; Clinical manifestations.

Abstract

The Hypertrophic Cardiomyopathy (HCM) is a cardiac disease from genetic bases and most common hereditary transmission, has been identified numerous mutations in the genes of the cardiac sarcomere. The major characteristic of the disease is left ventricular hypertrophy (LVH) of diferente morphologies, without other causes that explain the condition. Its clinical manifestations vary according to the mutations of each individual and/or family; the patient may present in the asymptomatic form, or evolve with outcomes such as arrhythmias, subvalvular aortic stenosis, heart failure and even sudden death. Thus, the objective of this work is to approach the main clinical manifestations of HCM. An Integrative Literature Review was carried out, searching the Scielo, LILACS, UpToDate and MEDLINE databases. Articles published from 2015 to 2021, in full and available electronically in English, Spanish or Portuguese, were included. Articles that were repeated themselves, made available only in summary or unrelated to the purpose of the study, were excluded. Has been found 17.796 publications summing all platforms, after using the inclusion and exclusion criteria and using the descriptors 3187 articles remained; then, after reading the titles and/or abstracts, 25 articles were selected and analyzed. Therefore, it was understood that HCM is a silent disease in many cases, making screening essential to detect the disease early and allow precocious medical intervention, improving the prognosis and quality of life of patients; in addition, there is great difficulty in determining the risk of developing clinical manifestations, such as sudden cardiac death (SCD).

References

Arias, A. M., Arenaza, P. R., Marenchino, R. G., Garagoli, F., Rivello, H. G. & Belziti, C. (2018). Cardiomiopatia Hipertrófica, Todos os Fenótipos em um. International Journal of Cardiovascular Sciences. 31(3)312-315. https://pesquisa.bvsalud.org/portal/resource/pt/biblio-909037

Baron, Émilie., Karam, N., Donal, E., Puscas, T., Mirabel, M., Bacher, A., Wahbi, K., Mazzella, JM., Jeunemaitre, X., Reant, P., Hagège, A. (2021). Gestion et résultats de la cardiomyopathie hypertrophique chez les jeunes adultes. Archives of Cardiovascular Diseases, 114(6-7): 465-473. https://sfcardio.fr/sites/default/files/2021-06/2021_06-article_ACVD.pdf

Bazan, S. G. Z., Oliveira, G. O., Silveira, C. F. S. M. P. , Reis, F. M., Malagutte, K. N. D. S., Tinasi, L. S. N., Bazan, R., Hueb, J. C., & Okoshi, K. (2020). Cardiomiopatia Hipertrófica – Revisão. Arq. Bras. Cardiol., 115(5), 927-935. https://doi.org/10.36660/abc.20190802

Bittencourt, M. I., Cader, S. A., Araúlo, D. V., Salles, A. l. F., Albuquerque, F. N., Spineti, P. P. M., Albuquerque, D. C. & Rocha, R. M. (2016). Morte Súbita na Cardiomiopatia Hipertrófica. International Journal of Cardiovascular Sciences, 29(6):504-511. https://pesquisa.bvsalud.org/portal/resource/pt/biblio-832441

Braunwald, E. (2013). Braunwald: Tratado de Doenças Cardiovasculares: Cardiomiopatia Hipertrófica. In: Cardiomiopatia Hipertrófica. [S. l.: s. n.], 2013. cap. 69, p. 1620.

Braunwald, E. (2013). Braunwald: Tratado de Doenças Cardiovasculares: Causas Hereditárias da Doença Cardiovascular. In: Causas Genéticas da Cardiomiopatia. [S. l.: s. n.], 2013. Cap. 8, p. 72.

Braunwald, E. (2013). Braunwald: Tratado de Doenças Cardiovasculares: Causas Hereditárias da Doença Cardiovascular. In: Mutações de genes da proteína do sarcômero. [S. l.: s. n.], 2013. cap. 8, p. 72.

Brown & Co (1994). O Comitê de Critérios da New York Heart Association. Nomenclatura e critérios para o diagnóstico de doenças do coração e grandes vasos, 9 ª ed, Little, Boston 1994. p.253

Cardim, N., Brito, D., Lopes, L.R., Freitas, A., Araújo, C., Belo, A., Gonçalves, L., Mimoso, J., Olivotto, I., Elliott, P., Madeira, H. (2018). The Portuguese Registry of Hypertrophic Cardiomyopathy: Overall results. Revista Portuguesa de Cardiologia, 37(1): 1-10. https://www.sciencedirect.com/science/article/pii/S0870255117305425?via%3Dihub

Cardiomiopatia hipertrófica: abordagem clínica e opções de tratamento. (2020). Uruguai Journal of Cardiology , 35 (1), 290-348. Epub 01 de abril de 2020. https://dx.doi.org/10.29277/cardio.35.1.15

Ciarambino, T., Menna, G., Sansone, G., Giordano, M. (2021). "Cardiomyopathies: An Overview". International Journal of Molecular Sciences, 22(14): 7722. https://www.mdpi.com/1422-0067/22/14/7722/htm

Conde, M. D., Miranda, D. B., Villegas, F. G. M. & Pliego, R. R. H. (2017). Parada cardíaca súbita atribuída a cardiomiopatia hipertrófica devido ao uso de esteróides anabolizantes. Relato de caso. Critical Medicine (Mexican College of Critical Medicine), 31 (2), 101-105. http://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S2448-89092017000200101&lng=es&tlng=es

Cooper, R.M., Raphael,C.E., Liebregts, M., Anavekar, N.S., Veselka, J. (2017). New Developments in Hypertrophic Cardiomyopathy. Canadian Journaul of Cardiology, 33(10): 1254-1265. https://www.onlinecjc.ca/article/S0828-282X(17)30371-9/fulltext

Duarte, K. M., Duarte, V. S., Bezerra, A. L. D., Feitosa, A. A. N., Assis, E. V. & Sousa, M. N. A. (2014). Dificuldades encontradas para a implantação da educação popular na realização da promoção de saúde. Revista Interdisciplinar em Saúde, Cajazeiras, v. 1, n. 1, p.33-51.

Fernandes, F. V., Bello, J. H. S. M., Shiozaki, A. A. & Roberto, C. (2018). Papel Atual da Ressonância Magnética Cardíaca na Cardiomiopatia Hipertrófica. Arq Bras Cardiol: Imagem cardiovasc, 31(4):277-283. https://pesquisa.bvsalud.org/portal/resource/pt/biblio-964042

Gil, T. C. P, Castier, M. C., Gondar, A. F. P., Sales, A. F., Santos, M. O., Lima, F. C. S. & Rocha, R. M. (2019). Análise de Strain da Função Ventricular Esquerda na Associação de Cardiomiopatia Hipertrófica e Hipertensão Arterial Sistêmica. Arquivos Brasileiros de Cardiologia, v. 113, n. 4. https://doi.org/10.5935/abc.20190176

Jefferies, J. L., Ryan, T. D. & Maron, M. S. (2020). Hypertrophic cardiomyopathy in children: Clinical manifestations and diagnosis. In Triedman J K, ed. UpToDate. Waltham, Mass.:UpToDate. https://www.uptodate.com/contents/hypertrophic-cardiomyopathy-in-children-clinical-manifestations-and-diagnosis?search=manifesta%C3%A7%C3%B5es%20clinicas%20na%20cardiomiopatia%20hipertrofica&source=search_result&selectedTitle=2~150&usage_type=default&display_rank=2

Kumar, V. (2020). Robbins & Cotran Patologia: Bases Patológicas das Doenças: O Coração. In: CARDIOMIOPATIA Hipertrófica. 9ª. ed. [S. l.: s. n.], 2020. cap. 12, p. 1026.

Kumar, V. (2020). Robbins & Cotran: Patologia: Bases Patológicas das Doenças: O Coração. In: CARDIOMIOPATIA Hipertrófica. 9ª. ed. [S. l.: s. n.], 2020. cap. 12, p. 1025.

Licarião, E. G. D. (2018). Síncope na cardiomiopatia hipertrófica obstrutiva. JBAC, 31(3):121-5. https://pesquisa.bvsalud.org/portal/resource/pt/biblio-967814

Loss, F. S., Ueda, L. S. I. & Luiz, A. A. (2019). Cardiomiopatia hipertrófica. Relato de caso. Uruguai Journal of Cardiology , 34 (3), 184-196. Epub 01 de dezembro de 2019. https://dx.doi.org/10.29277/cardio.34.3.16

Ludke, M. & Andre, M. E. D. A. (2013). Pesquisas em educação: uma abordagem qualitativa. São Paulo: E.P.U

Maron, M. S. (2019). Hypertrophic cardiomyopathy: Medical therapy for heart failure. In McKenna W J, ed. UpToDate. Waltham, Mass.:UpToDate, 2019. https://www.uptodate.com/contents/hypertrophic-cardiomyopathy-medical-therapy-for-heart-failure?search=Hypertrophic%20cardiomyopathy:%20Medical%20therapy%20for%20heart%20failure&source=search_result&selectedTitle=1~150&usage_type=default&display_rank=1

Maron, M. S. (2020). Hypertrophic cardiomyopathy: Clinical manifestations, diagnosis, and evaluation. In McKenna W J, ed. UpToDate. Waltham, Mass.:UpToDate. https://www.uptodate.com/contents/hypertrophic-cardiomyopathy-clinical-manifestations-diagnosis-and-evaluation?source=history_widget

Maron, M. S. (2020). Hypertrophic cardiomyopathy: Management of ventricular arrhythmias and sudden cardiac death risk. In Lévy S, McKenna W J, ed. UpToDate. Waltham, Mass.:UpToDate. https://www.uptodate.com/contents/hypertrophic-cardiomyopathy-management-of-ventricular-arrhythmias-and-sudden-cardiac-death-risk?search=manifesta%C3%A7%C3%B5es%20clinicas%20na%20cardiomiopatia%20hipertrofica&topicRef=4951&source=see_link

Maron, M. S. (2020). Hypertrophic cardiomyopathy: Morphologic variants and the pathophysiology of left ventricular outflow tract obstruction. In McKenna W J, ed. UpToDate. Waltham, Mass.:UpToDate. https://www.uptodate.com/contents/hypertrophic-cardiomyopathy-morphologic-variants-and-the-pathophysiology-of-left-ventricular-outflow-tract-obstruction?search=manifesta%C3%A7%C3%B5es%20clinicas%20na%20cardiomiopatia%20hipertrofica&topicRef=119625&source=see_link

Maron, M. S. (2020). Hypertrophic cardiomyopathy: Risk stratification for sudden cardiac death. In Lévy S, McKenna W J, ed. UpToDate. Waltham, Mass.:UpToDate. https://www.uptodate.com/contents/hypertrophic-cardiomyopathy-risk-stratification-for-sudden-cardiac-death?topicRef=4948&source=see_link

Marston, N. A., Han, L., Olivotto, I., Day, S. M., Ashley, E. A., Michels, M., Pereira, A. C., Ingles, J., Semsarian, C., Jacoby, D., Colan, S. D., Rossano, J. W., Wittekind, S.G., Ware, J. S., Saberi, S., Helms, A. S., Ho, C.Y. (2021). Clinical characteristics and outcomes in childhood-onset hypertrophic cardiomyopathy. European Heart Journal, 42(20): 1988-1996. https://academic.oup.com/eurheartj/article/42/20/1988/6189026

Mattos, B. P. (2001). Bases Genéticas da Cardiomiopatia Hipertrófica. Arq Bras Cardiol, Porto Alegre, v. 78, ed. 3, p. 323, 26 mar.

Mattos, B. P., Scolari, F. L. & Garbin, H. I. (2020). Discordância entre Diretrizes Internacionais sobre Critérios de Prevenção Primária de Morte Súbita na Cardiomiopatia Hipertrófica. Arq Bras Cardiol., 115(2):197-204. https://pesquisa.bvsalud.org/portal/resource/pt/biblio-1131297

Pujades-Rodriguez, M., Guttmann, O.P., Gonzalez-Izquierdo, A., Duyx, B., O´Mahony, C., Elliott, P., Hemingway, H. (2018). Identifying unmet clinical need in hypertrophic cardiomyopathy using national electronic health records. PloS ONE, 13(1): e0191214. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0191214

Repetti, G.G., Kim, Y., Pereira, A.C., Ingles, J., Russell, M.W., Lakdawala, N.K., Ho, C.Y., Day, S., Semsarian, C., McDonough, B., DePalma, S.R., Quiat, D., Green, E.M., Seidman, C.E., Seidman, JG. (2021). Discordant clinical features of identical hypertrophic cardiomyopathy twins. PNAS, 118(10): e2021717118. https://www.pnas.org/content/118/10/e2021717118

Sarli, I. V. & Benvenuti, L. A. (2019). Case 3/2019 - Jovem macho com Dispneia Intensa, Infiltrado Pulmonar, Área Cardíaca Normal e Obliteração da Porção Apical do Ventrículo Esquerdo. Arquivos Brasileiros de Cardiologia [online]. 2019, v. 112, n. 6. https://doi.org/10.5935/abc.20190105

Vrancic, J. M., Costabel, J. P., Espinola, J. C., Piccinini, F., Camporrotondo, M., Pedernera, G. O., Avegliano, G., Diez, M., Dorsa, A. & Navia, D. (2018). Miectomía septal ampliada en la miocardiopatía hipertrófica obstructiva, resultados clínicos y evolución ecocardiográfica a mediano plazo. Rev ARgent CARdiol, 86:96-102. https://pesquisa.bvsalud.org/portal/resource/pt/biblio-1003184

Published

16/10/2021

How to Cite

SOUSA, T. do N. .; LUSTOSA, H. C. P. .; TÁVORA, H. C. .; GODINHO, M. A. de S. .; SENA, M. A. de . Hypertrophic cardiomyopathy, an important cause of sudden death in young: integrative review. Research, Society and Development, [S. l.], v. 10, n. 13, p. e336101321498, 2021. DOI: 10.33448/rsd-v10i13.21498. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/21498. Acesso em: 7 dec. 2021.

Issue

Section

Review Article