Calcium hydroxyapatite: a review for efficacy, safety and imaging when used as a filler and as a biostimulator
DOI:
https://doi.org/10.33448/rsd-v10i14.21689Keywords:
Calcium hydroxylapatite; Esthetics; Dermal fillers.Abstract
The purpose of this article was to present, through a literature review, the effectiveness, safety and satisfaction of patients with the use of calcium hydroxyapatite as a filler and as a collagen biostimulator. This is a literature review carried out through an active search for scientific articles in the database: U.S. National Library of Medicine (PubMed), using the search term: calcium hydroxylapatite cosmetic. Sixty nine publications were selected, from 2016 to 2021, however, based on the inclusion and exclusion criteria, 20 articles were selected. Based on the literature review carried out in this study, calcium hydroxyapatite was effective as a biostimulator of collagen and elastin; as a filler it presented a better lift effect (except in the case of eyebrow lift) because of its high modulus of elasticity, which can be used as a support for other fillers and support threads; had a high level of patient satisfaction; it is considered a material with a good safety profile, as long as the technique and indications are respected; and can be viewed on radiographs, tomographies and high resolution ultrasounds.
References
Bass, L. S., et al (2009). Calcium Hydroxylapatite (Radiesse) for Treatment of Nasolabial Folds: Long-Term Safety and Efficacy Results. Aesthetic Surg J. 30(2).235-238.
Casabona, G., & Marchese P (2007). Calcium Hydroxylapatite Combined with Microneedling and Ascorbic Acid is Effective for Treating Stretch Marks. PRS Global Open. 5(9).1-9.
Courderot-Masuyer, C., et al (2016). Evaluation of lifting and antiwrinkle effects of calcium hydroylapatite filler. In vitro quantification of contractile forces of human wrinkle and normal aged fibroblastos treated with calcium hydroxylapatite. J Cosmetic Dermatol.15(3). 260-268.
Danysz, W., Nowag, B., Hengl, T., Kreymerman, P., Furne, C., Madeuf, E., & Robinson, D. M. (2020). Can sodium thiosulfate act as a reversal agent for calcium hydroxylapatite filler? Results of a preclinical study. Clinical, Cosmetic and Investigational Dermatology. 13, 1059.
De Almeida, A. T., et al (2019). Consensus Recommendations for the Use of Hyperdiluted Calcium Hydroxyapatite (Radiesse) as a Face and Body Biostimulatory Agent. PRS Global Open.7(3).1-9.
Fabi, S., et al (2017). Combined aesthetic interventions for prevention of facial ageing, and restoration and beutification of face and body. Clin Cosmetic Inves Dermatol.10:423-429.
Fakih-Gomez, N., & Kadouch, J. (2021). Combining calcium hydroxylapatite and hyaluronic acid fillers for aesthetic indications: efficacy of an innovative hybrid filler. Aesthetic plastic surgery. 1-9.
Goldberg, D. J. et al (2018). Expanding Treatment Options for Injectable Agents. Aesthetic Surg J. 38(S1): S1-S7.
Guida, S., Longhitano, S., Shaniko, K., Galadari, H., Chester, J., Ciardo, S., & Farnetani, F. (2020). Hyperdiluted calcium hydroxylapatite for skin laxity and cellulite of the skin above the knee: A pilot study. Dermatologic Therapy. 33(6).e14076.
Guida, S., Longhitano, S., Spadafora, M., Lazzarotto, A., Farnetani, F., Zerbinati, N., & Galadari, H. (2021). Hyperdiluted calcium hydroxylapatite for the treatment of skin laxity of the neck. Dermatologic Therap. e15090.
Kadouch, J. A., (2017). Calcium hydroxylapatite: A review on safety and complications. J Cosmetic Dermatol.16(2).152-161.
Koka, S., et al (2017). Derma Filler Presenting as Lobular Radiopacities in na Edentulous Patient: A Clinical Report. J Prosthodontics.26(8).670-671.
Lee, J. C., & Lorenc, Z. P (2016). Synthetic Fillers for Facial Rejuvenation. Clin Plastic Surg.43(3).497-503.
Liu, R., et al (2018). Alopecia with foreign body granulomas induced by Radiesse injection: A case report. J Cosmetic Laser Therapy. 20 (7-8).462-464
Lorenc, Z. P., et al (2018). Physiochemical Characteristics of Calcium Hydroxylapatite (CaHA).201 Aesthetic Surg J. 38(S1). S8-S12.
Rullan, P. P., Olson, R., & Lee, K. C. (2020). The use of intralesional sodium thiosulfate to dissolve facial nodules from calcium hydroxylapatite. Dermatologic Surgery. 46(10).1366-1368.
van Loghem, J., Funt, D., Pavicic, T., Goldie, K., Yutskovskaya, Y., Fabi, S., & Saeed, P. (2020). Managing intravascular complications following treatment with calcium hydroxylapatite: an expert consensus. Journal of cosmetic dermatology. 19(11). 2845-2858.
Van Loghem, J., Yutskovskaya, Y. A., & Werschler, W. P. (2015). Calcium hydroxylapatite: over a decade of clinical experience. The Journal of clinical and aesthetic dermatology. 8(1). 38.
Wollina, U., & Goldman, A. (2020). Long lasting facial rejuvenation by repeated placement of calcium hydroxylapatite in elderly women. Dermatologic Therapy. 33(6). e14183.
Zerbinati, N. & Calligaro, A., (2018). Calcium hydroxylapatite treatment of human skin: evidence of collagen turnover through picrosirius red staining and circulary polarized microscopy. Clin Cosmetic Inves Dermatol.11.29-35.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2021 Cristiani Sandrelli Ferreira Pacheco de Oliveira; Tereza Jacy da Silva Almeida; Luciene de Oliveira Martins; Lara Andréa Torelli Marques Sorpreso; Nathalia Silveira Finck
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.