Disparities related to risk factors and mortality between men and women with STEMI - VICTIM Register





Myocardial infarction; Indicators of morbidity and mortality; Men; Women; Health status disparities.


Objective: Analyze the burden of cardiovascular risk factors and mortality among men and women diagnosed with STEMI in the state of Sergipe. Method: Cross-sectional, quantitative study, developed between December/2014 and March/2017. Data were collected at hospitals in Sergipe, using their own instrument, information from medical records and interviews. The analysis performed using the Person test and the Student t test. Ethics and Research Committee of UFS number 483.749. Results: Of the total number of patients analyzed in the study (707), it was identified that women were older (p = 0.035). Systemic arterial hypertension (p = 0.001) and dyslipidemia (p<0.001) were more frequent in women and smoking in men (p = 0.592). Mortality was higher in females than males (p = 0.027). Conclusion: Knowing the clinical-epidemiological profile and risk factors enables early intervention and encourages the effectiveness of treatment in both sexes.

Author Biography

Laís Costa Souza Oliveira, Hospital Primavera




Almeida, M., Montenegro, C. E., Sarteschi, C., Montenegro, G. L., Montenegro, P. B., Livera, J. R., Montenegro, S. M., Montenegro, S., Silva, O. B., & Carvalho, E. M. (2014). Comparison of clinical and epidemiological profiles among men and women with acute coronary syndrome. Int. J. Cardiovasc. Sci., 27, 423-429.

Berger, J. S., Elliott, L., Gallup, D., Roe, M., Granger, C. B., Armstrong, P. W., Simes, R. J., White, H. D., Van de Werf, F., Topol, E. J., Hochman, J. S., Newby, L. K., Harrington, R. A., Califf, R. M., Becker, R. C., & Douglas, P. S. (2009). Sex Differences in Mortality Following Acute Coronary Syndromes. JAMA, 302(8), 874-882. 10.1001/jama.2009.1227.

Cenko, E., van der Schaar, M., Yoon, J., Kedev, S., Valvukis, M., Vasiljevic, Z., Ašanin, M., Miličić, D., Manfrini, O., Badimon, L., & Bugiardini, R. (2019). Sex-specific treatment effects after primary percutaneous intervention: a study on coronary blood flow and delay to hospital presentation. J Am Heart Assoc, 8(4), e011190. 10.1161/JAHA.118.011190.

Cho, K. I., Shin, E. S., Ann, S. H., Garg, S., Her, A. Y., Kim, J. S., Han, J. H., Jeong, M. H., & KAMIR Registry. (2016). Gender differences in risk factors and clinical outcomes in young patients with acute myocardial infarction. J Epidemiol Community Health, 70(11), 1057-1064. 10.1136/jech-2015-207023

Choi, J., Daskalopoulou, S.S., Thanassoulis, G., Karp, I., Pelletier, R., Behlouli, H., & Pilote, L. (2014). Sex- and gender-related risk factor burden in patients with premature acute coronary syndrome. Can J Cardiol, 30(1), 109-117. 10.1016/j.cjca.2013.07.674

Dreyer, R. P., Smolderen, K. G., Strait, K. M., Beltrame, J. F., Lichtman, J. H., Lorenze, N. P., D'Onofrio, G., Bueno, H., Krumholz, H. M., & Spertus, J. A (2016). Gender differences in pre-event health status of young patients with acute myocardial infarction: A VIRGO study analysis. Eur Heart J Acute Cardiovasc Care, 5(1), 43-54. 10.1177/2048872615568967

Dreyer, R. P., Wang, Y., Strait, K. M., Lorenze, N. P., D'Onofrio, G., Bueno, H., Lichtman, J. H., Spertus, J. A., & Krumholz, H. M. (2015). Gender differences in the trajectory of recovery in health status among young patients with acute myocardial infarction: results from the virgo study. Circulation, 131(22), 1971-1980. 10.1161/CIRCULATIONAHA.114.014503

Du, X., Spatz, E. S., Dreyer, R. P., Hu, S., Wu, C., Li, X., Li, J., Wang, S., Masoudi, F. A., Spertus, J. A., Nasir, K., Krumholz, H. M., & Jiang, L. (2016). Sex differences in clinical profiles and quality of care among patients with st-segment elevation myocardial infarction from 2001 to 2011: insights from the China Patient-Centered Evalueted Assessment os Cardiac Events (PEACE): Retrospective study. J Am Heart Assoc, 5(2), e.002157. 10.1161/JAHA.115.002157

Grosmaitre, P., Le Vavasseur, O., Yachouh, E., Courtial, Y., Jacob, X., Meyran, S., & Lantelme, P. (2013). Significance of atypical symptoms for the diagnosis and management of myocardial infarction in elderly patients admitted to emergency departments. Arch Cardiovasc Dis, 106(11), 586–92. 10.1016/j.acvd.2013.04.010.

Lam, C. S. P., McEntegart, M., Claggett, B., Liu, J., Skali, H., Lewis, E., Køber, L., Rouleau, J., Velazquez, E., Califf, R., McMurray, J. J., Pfeffer, M., & Solomon, S. (2015). Sex differences in clinical characteristics and outcomes after myocardial infarction: insights from the Valsartan in Acute Myocardial Infarction Trial (VALIANT). Eur J Heart Fail, 17(3), 301–312. 10.1002/ejhf.238.

Lawesson, S. S, Isaksson, R. M., Ericsson M., Ängerud, K., & Thylén, I. (2018). Gender disparities in first medical contact and delay in ST-elevation myocardial infarction: a prospective multicentre Swedish survey study. BMJ Open, 8(5), e020211. 10.1136/bmjopen-2017-020211.

Mackenbach, J. P., Stirbu, I., Roskam, A. J., Schaap, M. M., Menvielle, G., Leinsalu, M., & Kunst, A. E. (2008). Socioeconomic inequalities in health in 22 european countries. N Engl J Med, 358(23), 2468-2481. 10.1056/NEJMsa0707519.

Oliveira, J. C., Barros, M. P. S., Barreto, I. D. C., Silva Filho, R. C., Andrade, V. A., Oliveira, A. M., & Barreto Filho, J. A. S. (2021). Acesso à Terapia de Reperfusão e Mortalidade em Mulheres com Infarto Agudo do Miocárdio com Supradesnivelamento do Segmento ST: Registro VICTIM. Arq Bras Cardiol., 116(4), 695-703. 10.36660/abc.20190468.

Pereira A. S., Shitsuka, D. M., Parreira, F. J., & Shitsuka, R. (2018). Metodologia da pesquisa científica (1ª ed). Universidade Federal de Santa Maria. https://repositorio.ufsm.br/bitstream/handle/1/15824/Lic_Computacao_Metodologia-Pesquisa-Cientifica.pdf?sequence=1

Perk, J., De Backer, G., Gohlke, H., Graham, I., Reiner, Z., Verschuren, M., & Zannad, F. (2012). European guidelines on cardiovascular disease prevention in clinical practice (version 2012). The fifth joint task force of the European society of cardiology and other societies on cardiovascular disease prevention in clinical practice (constituted by representatives of nine societies and by invited experts). Eur Heart J, 33(13), 635-701. 10.1093/eurheartj/ehs092.

Piegas, L. S., Avezum, A., Guimarães, H. P., Muniz, A. J., Reis, H. J. L., Santos, E. S., Knobel, M., & Souza, R. (2013). Comportamento da síndrome coronariana aguda: resultados de um registro brasileiro. Arq Bras Cardiol, 100(6), 502-510. 10.5935/abc.20130101.

Piegas, L. S., Timerman, A., Feitosa, G. S., Nicolau, J. C., Mattos, L. A. P., Andrade, M. D., & Mathias Junior, W. (2015). V Diretriz da sociedade brasileira de cardiologia sobre tratamento do infarto agudo do miocárdio com supradesnível do segmento st. Arq. Bras. Cardiol., 105(2), 1-105. http://observatorio.fm.usp.br/handle/OPI/12652

Schmidt, K., Lima, A. S., Schmitt, K. R., Moraes, M. A., & Schmidt, M. M. (2020). Stress in women with acute myocardial infarction: a closer look. Arq bras cardiol, 115(4), 649-57. 10.36660/abc.20190282.

Shehab, A., AlHabib, K. F., Bhagavathula, A. S., Hersi, A., Alfaleh, H., Alshamiri, M. Q., & Salam, A. M. (2019). Clinical Presentation, Quality of Care, Risk Factors and Outcomes in Women with Acute ST-Elevation Myocardial Infarction (STEMI): An Observational Report from Six Middle Eastern Countries. Curr Vasc Pharmacol, 17(4), 388-395. 10.2174/1570161116666180315104820.

Vaccarino, V., Krumholz, H. M., Berkman, L. F., & Horwitz, R. I. (1995). Sex differences in mortality after myocardial infarction: is there evidence for an increased risk for women?. Circulation, 91(6), 61-71. 10.1161/01.cir.91.6.1861.

Vaccarino, V., Parsons, L., Every, N. R., Barron, H. V., & Krumholz, H. M. (1999). Sex-based differences in early mortality after myocardial infarction. N Engl J Med, 341(4), 217-25. 10.1056/NEJM199907223410401.

Venetsanos, D., Sederholm Lawesson, S., Alfredsson, J., Janzon, M., Cequier, A., Chettibi, M., Goodman, S. G., Van't Hof, A. W., Montalescot, G., & Swahn, E. (2017). Association between gender and short-term outcome in patients with ST elevation myocardial infraction participating in the international, prospective, randomised Administration of Ticagrelor in the catheterisation Laboratory or in the Ambulance for New ST elevation myocardial Infarction to open the Coronary artery (ATLANTIC) trial: a prespecified analysis. BMJ Open., 7(9), e015241. 10.1136/bmjopen-2016-015241.

Wein, B., Bashkireva, A., Au-Yeung, A., Yoculan, A., Vinereanu, D., Deleanu, D., Pereira, H., Pereira, E., de Mello, S., Rumoroso, J. R., Ganyukov, V., Wijns, W., & Naber, C. K. (2020). Systematic investment in the delivery of guideline-coherent therapy reduces mortality and overall costs in patients with ST-elevation myocardial infarction: results from the stent for life economic model for Romania, Portugal, Basque Country and Kemerovo region. Eur Heart J Acute Cardiovasc Care., 9(8), 902–910. 10.1177/2048872619853959.

Worrall-Carter, L., McEvedy, S., Wilson, A., & Rahman, M. A. (2016). Gender differences in presentation, coronary intervention, and outcomes of 28.985 acute coronary syndrome patients in victoria, australia. Womens Health Issues, 26(1), 14-20. 10.1016/j.whi.2015.09.002.

Yusuf, S., Rangarajan, S., Teo, K., Islam, S., Li, W., Liu, L., & Orlandini, A. (2014). Cardiovascular Risk and Events in 17 Low-, Middle-, and High-Income Countries. N Engl J Med, 371, 818-827. 10.1056/NEJMoa1311890.



How to Cite

OLIVEIRA, J. C. .; OLIVEIRA, A. de M. .; OLIVEIRA, J. C. .; LIMA, T. R. M. .; BARRETO, Íkaro Daniel de C. .; ARCELINO, L. A. M. .; SANTOS, I. .; OLIVEIRA, L. C. S. .; RAMOS, M. J. .; BARRETO-FILHO, J. A. Disparities related to risk factors and mortality between men and women with STEMI - VICTIM Register. Research, Society and Development, [S. l.], v. 10, n. 14, p. e259101421959, 2021. DOI: 10.33448/rsd-v10i14.21959. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/21959. Acesso em: 17 jun. 2024.



Health Sciences