Diabetic Mastopathy as a differential diagnosis for breast cancer: integrative literature review
DOI:
https://doi.org/10.33448/rsd-v10i14.21961Keywords:
Diabetes mellitus; Breast carcinoma; Diabetes complications.Abstract
Introduction: Diabetic Mastopathy is a rare and benign disease that affects the breasts, being one of the main differential diagnoses related to breast carcinomas. However, despite presenting imaging and clinical features similar to malignant breast processes, it was evidenced that this pathology is not related to premalignant or malignant evolutions. This pathology seems to be related to an autoimmune response secondary to a prolonged hyperglycemic state, present in diabetic patients. Objective: To search the literature for evidence of diabetic mastopathy as a differential manifestation of neoplastic breast lesions. Methodology: Integrative literature review on the PubMed database of productions from 2008 to 2021. The descriptors used were: "diabetic mastopathy"; "mastopathy"; "diabetes mellitus"; "breast"; "breast pathologies", which were conjugated to delimit the search. Results: The search found 45 studies, from which 13 were selected that contemplated the guiding question. The review revealed that the pathology portrayed presents characteristics that require a careful analysis of the clinical history with physical examination and complementation with imaging exams. Biopsy, especially by thick needle, is the most efficient diagnostic method for histopathological elucidation. Furthermore, due to the increasing presence of risk factors for the development of this disease in the current population, diabetic mastopathy is expected to become more common. Final considerations: Diabetic mastopathy is, therefore, an important differential diagnosis for breast neoplasms whose diagnosis is quite complex and requires, besides clinical aspects, the analysis of radiological and laboratory components.
References
Abdullah, S. S., et al. (2020). Mastopathy in a Patient with High Risk of Breast Carcinoma: A Management Dilemma. Cureus. 12 (2).
Accurso, A., et al. (2014). Unusual breast lesion mimicking cancer: Diabetic mastopathy. International Journal of Surgery. 12 (1).
Agochukwu, N. B., et al. (2017). Diabetic Mastopathy. Annals of Plastic Surgery. 4(78): 471–5.
Aja, M. M., et al. (2016). Is contrast-enhanced spectral mammography (CESM) helpful in differentiating diabetic mastopathy from breast carcinoma? Journal of Medical Imaging and Radiation Oncology. 60 (5): 639-41.
Alkhudairi, S., et al. (2020). Diabetic Mastopathy in a Patient with High Risk of Breast Carcinoma: A Management Dilemma. Cureus. 12 (2).
Bilir, B., et al. (2012). A Metabolic Syndrome Case Presenting with Lymphocytic Mastitis. Breast care. 7: 493–495.
Casarin, S. T., et al. (2020). Tipos de revisão de literatura: considerações das editoras do Journal of Nursing and Health. J. nurs. health. 10 (5).
De Sousa, L. D., et al. (2011). The nursing scientific production about the clinic: an integrative review. Rev Esc Enferm, 45 (2), 494-500.
Dorkhova, O., et al. (2012). Diabetic mastopathy, a clinicopathological correlation of 34 cases. Pathol Int. 62: 660–664.
Francisco, C., et al. (2012). Diabetic mastopathy: a case report. Clinical Imaging. 36: 829–832.
Gupta, S., et al. (2019). Diabetic Masthopaty Masquerading as Breast Cancer. The American Journal of Medicine. 132 (4).
Leroux-Stewart, J., & Rabasa-Lhoret, R. (2014). Diabetic Mastopathy: Case Report and Summary of Literature. Canadian Journal of Diabetes. 38 (5): 305–306.
Loscos, et al. Mastopatía Diabética. (2021). Revisión sistemática con 93 pacientes. Revista de Senología y Patología Mamaria. 34: 163-170.
Machado, M. J. C., & Regalo, G. (2020). Lymphocytic Mastopathy – A Rare Entity and A Diagnostic Challenge. International Journal of Surgical Reports. 2 (1).
Miura, K., et al. (2012). Autoantibody with Cross-Reactivity between Insulin and Ductal Cells May Cause Diabetic Mastopathy: A Case Study. Case Reports in Medicine. 2012.
Moschetta, M., et al. (2015). Diabetic Mastopathy: A Diagnostic Challenge in Breast Sonography. Journal of Clinical Ultrasound. 43: 2.
Nasu, H., et al. (2012). Two cases of diabetic mastopathy: MR imaging and pathological correlation. Breast Cancer. 22 (5).
Neetu, G., Pathmanathan, R., & Weng, N. K. (2010). Diabetic mastopathy: a case report and literature review. Case Rep Oncol. 3: 245–51.
Pereira, M. A., et al. (2010). Fibrous mastopathy: clinical, imaging, and histopathologic findings of 31 cases. J ObstetGynaecol Res. 36: 326–335.
Perret, W., Malara, F. A., Hill, P. A., & Cawson, J. N. (2006). Painful Diabetic Mastopathy as a Reason for Mastectomy. The Breast Journal. 12 (6): 559–562.
Rajasundaram, S., et al. (2020). Diabetic mastopathy-An uncommon presentation of a common disease. The Breast Journal. 2020.
Sankaye, S., & Kachewar, S. (2012). Diabetic mastopathy. Australasian Medical Journal. 6: 296-299.
Seidman., et al. (1994). Mastopathy in insulin-requiring diabetes mellitus. Hum Pathol. 5 (8).
Shrikrishnapalasuriya. ,et al. (2018). Diabetic mastopathy: a diagnostic challenge. Br J Diabetes. 18.
Soler, N. G., & Khardori, R. (1984). Fibrous disease of the breast, thyroiditis, and cheiroarthropathy in type I diabetes mellitus. Lancet. 1 (8370): 193-5.
Tomaszewski, J. E., Brooks, J. S. J., Hicks, D., & Livolsi, V. A. (1992). Diabetic mastopathy: A distinctive clinicopathologic entity. Human Pathology. 23 (7): 780–786.
Zhang, Y., et al. (2011). Diabetic Mastopathy Mimicking Breast Cancer: Two Case Reports. Clinical Breast Cancer. 11(6):409-12
Yamashita, M., et al. (2013). An uncommon case of T1b breast cancer with diabetic mastophaty in type II diabetes mellitus. Breast Cancer. 20: 92-96.
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Copyright (c) 2021 Gabriela Troncoso; Álvaro Alves de Sá Júnior; Letícia Dias Escoura; Rafaela Melo Sisconetto; Douglas Reis Abdalla
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