Effect of Cannabidiol (CBD) oil on acne





Cannabidiol (CBD); Skin; Acne; Endocannabinoid system.


O Cannabidiol is a non-psychoactive cannabinoid isolated from Cannabis sativa which, due to its alleged beneficial properties and therapeutic potential, and a topic increasingly discussed as decriminalization and legalization of these products continue to expand, has recently raised considerable interest attention of the scientific community. And with little evidence in the literature, the main objective of this study was to investigate the administration of CBD, with a particular focus on the influence of aspects related to anti-inflammatory, antimicrobial properties on acne. However, the current role of CBD in the treatment of dermatological conditions remains to be defined. We performed a review of the current literature to determine the skin applications of cannabinoids. After performing our analysis, we found that cannabinoid products have the potential to treat a variety of skin conditions, including acne. However, most of the data available on these compounds are preclinical and there is a corresponding lack of high-quality controlled studies evaluating their effects.With the chemistry and pharmacology of CBD, and with various molecular targets, including cannabinoid receptors and the endocannabinoid system with which they eventually interact, have been studied extensively. This article provides an update on advances in CBD research to date and potential areas for future exploration.


Ahmed, W., & Katz, S. (2016). Therapeutic use of cannabis in inflammatory bowel disease. Gastroenterology & Hepatology, 12(11), 668–679.

An, D., Peigneur, S., Hendrickx, L. A., & Tytgat, J. (2020). Targeting cannabinoid receptors: Current status and prospects of natural products. International Journal of Molecular Sciences, 21(14), 5064.

Atalay, S., Jarocka-Karpowicz, I., & Skrzydlewska, E. (2019). Antioxidative and anti-inflammatory properties of cannabidiol. Antioxidants (Basel, Switzerland), 9(1), 21.

Aizpurua-Olaizola, O., Soydaner, U., Öztürk, E., Schibano, D., Simsir, Y., Navarro, P., Etxebarria, N., & Usobiaga, A. (2016). Evolution of the Cannabinoid and Terpene Content during the Growth of Cannabis sativa Plants from Different Chemotypes. Journal of Natural Products, 79(2), 324–331. https://doi.org/10.1021/acs.jnatprod.5b00949

Balant, M., Gras, A., Ruz, M., Vallès, J., Vitales, D., & Garnatje, T. (2021). Traditional uses of Cannabis: An analysis of the CANNUSE database. Journal of Ethnopharmacology, 279(114362), 114362.

Baswan, S. M., Klosner, A. E., Glynn, K., Rajgopal, A., Malik, K., Yim, S., & Stern, N. (2020). Therapeutic potential of cannabidiol (CBD) for skin health and disorders. Clinical, Cosmetic and Investigational Dermatology, 13, 927–942.

Bollag, W. B., Aitkens, L., White, J., & Hyndman, K. A. (2020). Aquaporin-3 in the epidermis: more than skin deep. American Journal of Physiology. Cell Physiology, 318(6), C1144–C1153.

Cannabis medicinal: realidade à espera de regulamentação. (n.d.). Leg.Br. https://www12.senado.leg.br/noticias/infomaterias/2021/07/cannabis-medicinal-realidade-a-espera-de-regulamentacao

Carliner, H., Brown, Q. L., Sarvet, A. L., & Hasin, D. S. (2017). Cannabis use, attitudes, and legal status in the U.S.: A review. Preventive medicine, 104, 13–23. https://doi.org/10.1016/j.ypmed.2017.07.008

Casares, L., García, V., Garrido-Rodríguez, M., Millán, E., Collado, J. A., García-Martín, A., Peñarando, J., Calzado, M. A., de la Vega, L., & Muñoz, E. (2020). Cannabidiol induces antioxidant pathways in keratinocytes by targeting BACH1. Redox Biology, 28(101321), 101321.

Casiraghi, A., Musazzi, U. M., Centin, G., Franzè, S., & Minghetti, P. (2020). Topical administration of cannabidiol: Influence of vehicle-related aspects on skin permeation process. Pharmaceuticals (Basel, Switzerland), 13(11), 337.

Castillo, D. E., Nanda, S., & Keri, J. E. (2019). Propionibacterium (Cutibacterium) acnes bacteriophage therapy in acne: Current evidence and future perspectives. Dermatology and Therapy, 9(1), 19–31.

Caterina, M. J. (2014). TRP channel cannabinoid receptors in skin sensation, homeostasis, and inflammation. ACS Chemical Neuroscience, 5(11), 1107–1116.

Chambers, E. S., & Vukmanovic-Stejic, M. (2020). Skin barrier immunity and ageing. Immunology, 160(2), 116–125.

Chiurchiù, V., Rapino, C., Talamonti, E., Leuti, A., Lanuti, M., Gueniche, A., Jourdain, R., Breton, L., & Maccarrone, M. (2016). Anandamide suppresses proinflammatory T cell responses in vitro through type-1 cannabinoid receptor-mediated mTOR inhibition in human keratinocytes. The Journal of Immunology, 197(9), 3545–3553.

Comissão aprova proposta para legalizar no Brasil o cultivo de Cannabis sativa para fins medicinais. (n.d.). Leg.Br. Retrieved October 17, 2021, from https://www.camara.leg.br/noticias/769630-comissao-aprova-proposta-para-legalizar-no-brasil-o-cultivo-de-cannabis-sativa-para-fins-medicinais

Dhadwal, G., & Kirchhof, M. G. (2018). The risks and benefits of cannabis in the dermatology clinic. Journal of Cutaneous Medicine and Surgery, 22(2), 194–199.

Du, Y., Ren, P., Wang, Q., Jiang, S.-K., Zhang, M., Li, J.-Y., Wang, L.-L., & Guan, D.-W. (2018). Cannabinoid 2 receptor attenuates inflammation during skin wound healing by inhibiting M1 macrophages rather than activating M2 macrophages. Journal of Inflammation (London, England), 15(1), 25.

Fox, L., Csongradi, C., Aucamp, M., du Plessis, J., & Gerber, M. (2016). Treatment modalities for acne. Molecules (Basel, Switzerland), 21(8), 1063.

Graczyk, M., Lewandowska, A. A., & Dzierżanowski, T. (2021). The therapeutic potential of cannabis in counteracting oxidative stress and inflammation. Molecules (Basel, Switzerland), 26(15), 4551.

Gravitz L. Skin. Nature. 2018 Nov;563(7732):S83. 10.1038/d41586-018-07428-4.

Hargis, A. M., & Myers, S. (2017). The Integument. In Pathologic Basis of Veterinary Disease (pp. 1009-1146.e1). Elsevier.

Hashim, P. W., Cohen, J. L., Pompei, D. T., & Goldenberg, G. (2017). Topical cannabinoids in dermatology. Cutis; Cutaneous Medicine for the Practitioner, 100(1), 50–52.

Heng, A. H. S., & Chew, F. T. (2020). Systematic review of the epidemiology of acne vulgaris. Scientific Reports, 10(1), 5754.

Hoover, E., Aslam, S., & Krishnamurthy, K. (2020). Physiology, Sebaceous Glands. In StatPearls. StatPearls Publishing.

Iffland, K., & Grotenhermen, F. (2017). An update on safety and side effects of cannabidiol: A review of clinical data and relevant animal studies. Cannabis and Cannabinoid Research, 2(1), 139–154.

Imprensa Nacional. (n.d.). Imprensa Nacional. Gov.Br. Retrieved October 17, 2021, from https://www.in.gov.br/en/web/dou/-/resolucao-da-diretoria-colegiada-rdc-n-327-de-9-de-dezembro-de-2019-232669072

Isidore, E., Karim, H., & Ioannou, I. (2021). Extraction of phenolic compounds and terpenes from cannabis sativa L. by-products: From conventional to intensified processes. Antioxidants (Basel, Switzerland), 10(6), 942.

Kupczyk, P., Reich, A., & Szepietowski, J. C. (2009). Cannabinoid system in the skin - a possible target for future therapies in dermatology. Experimental Dermatology, 18(8), 669–679.

Lewis, M. M., Yang, Y., Wasilewski, E., Clarke, H. A., & Kotra, L. P. (2017). Chemical Profiling of Medical Cannabis Extracts. ACS Omega, 2(9), 6091–6103. https://doi.org/10.1021/acsomega.7b00996

Lim, M., & Kirchhof, M. G. (2019). Dermatology-related uses of medical cannabis promoted by dispensaries in Canada, Europe, and the United States. Journal of Cutaneous Medicine and Surgery, 23(2), 178–184.

Lim, X. Y., Tan, T. Y. C., Muhd Rosli, S. H., Sa’at, M. N. F., Sirdar Ali, S., & Syed Mohamed, A. F. (2021). Cannabis sativa subsp. sativa’s pharmacological properties and health effects: A scoping review of current evidence. PloS One, 16(1), e0245471.

Lowe, H., Toyang, N., Steele, B., Bryant, J., & Ngwa, W. (2021). The Endocannabinoid System: A potential target for the treatment of various diseases. International Journal of Molecular Sciences, 22(17), 9472.

Martinelli, G., Magnavacca, A., Fumagalli, M., DellʼAgli, M., Piazza, S., & Sangiovanni, E. (2021). Cannabis sativa and Skin Health: Dissecting the Role of Phytocannabinoids. Planta Medica. https://doi.org/10.1055/a-1420-5780

Millar, S. A., Maguire, R. F., Yates, A. S., & O’Sullivan, S. E. (2020). Towards better delivery of cannabidiol (CBD). Pharmaceuticals (Basel, Switzerland), 13(9), 219.

Nam, G., Jeong, S. K., Park, B. M., Lee, S. H., Kim, H. J., Hong, S.-P., Kim, B., & Kim, B.-W. (2016). Selective cannabinoid receptor-1 agonists regulate mast cell activation in an oxazolone-induced atopic dermatitis model. Annals of Dermatology, 28(1), 22–29.

Oláh, A., Markovics, A., Szabó-Papp, J., Szabó, P. T., Stott, C., Zouboulis, C. C., & Bíró, T. (2016). Differential effectiveness of selected non-psychotropic phytocannabinoids on human sebocyte functions implicates their introduction in dry/seborrhoeic skin and acne treatment. Experimental Dermatology, 25(9), 701–707.

Oláh, A., Tóth, B. I., Borbíró, I., Sugawara, K., Szöllõsi, A. G., Czifra, G., Pál, B., Ambrus, L., Kloepper, J., Camera, E., Ludovici, M., Picardo, M., Voets, T., Zouboulis, C. C., Paus, R., & Bíró, T. (2014). Cannabidiol exerts sebostatic and antiinflammatory effects on human sebocytes. The Journal of Clinical Investigation, 124(9), 3713–3724.

Osseiran, S., Cruz, J. D., Jeong, S., Wang, H., Fthenakis, C., & Evans, C. L. (2018). Characterizing stratum corneum structure, barrier function, and chemical content of human skin with coherent Raman scattering imaging. Biomedical Optics Express, 9(12), 6425–6443.

Rippa, A. L., Kalabusheva, E. P., & Vorotelyak, E. A. (2019). Regeneration of dermis: Scarring and cells involved. Cells (Basel, Switzerland), 8(6), 607.

Scheau, C., Badarau, I. A., Mihai, L.-G., Scheau, A.-E., Costache, D. O., Constantin, C., Calina, D., Caruntu, C., Costache, R. S., & Caruntu, A. (2020). Cannabinoids in the pathophysiology of skin inflammation. Molecules (Basel, Switzerland), 25(3), 652.

Souza, A. A. F. de, Silva, A. F. M. da, Abreu, L. R. de, Silva, T. F. da, Greco, G., Santos, S. da S., & Gonzaga, R. V. (2021). Medicinal uses of Cannabis sp. Research, Society and Development, 10(7), e58010716930.

Souza, M. T. D., Silva, M. D. D., & Carvalho, R. D. (2010). Revisão integrativa: o que é e como fazer. Einstein, 8, 102-106.

Spindle, T. R., Bonn-Miller, M. O., & Vandrey, R. (2019). Changing landscape of cannabis: novel products, formulations, and methods of administration. Current opinion in psychology, 30, 98–102. https://doi.org/10.1016/j.copsyc.2019.04.002

Tallima, H., & El Ridi, R. (2018). Arachidonic acid: Physiological roles and potential health benefits – A review. Journal of Advanced Research, 11, 33–41.

Turcotte, C., Blanchet, M.-R., Laviolette, M., & Flamand, N. (2016). The CB2 receptor and its role as a regulator of inflammation. Cellular and Molecular Life Sciences: CMLS, 73(23), 4449–4470.

Veniaminova, N. A., Grachtchouk, M., Doane, O. J., Peterson, J. K., Quigley, D. A., Lull, M. V., Pyrozhenko, D. V., Nair, R. R., Patrick, M. T., Balmain, A., Dlugosz, A. A., Tsoi, L. C., & Wong, S. Y. (2019). Niche-specific factors dynamically regulate sebaceous gland stem cells in the skin. Developmental Cell, 51(3), 326-340.e4.

Yousef, H., Alhajj, M., & Sharma, S. (2021). Anatomy, skin (integument), epidermis. In StatPearls. StatPearls Publishing.



How to Cite

VIANA, L. S.; AIRES SILVA, T.; ANTUNES, V. M. de S. .; GONZAGA, R. V. Effect of Cannabidiol (CBD) oil on acne. Research, Society and Development, [S. l.], v. 10, n. 14, p. e306101422075, 2021. DOI: 10.33448/rsd-v10i14.22075. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/22075. Acesso em: 28 sep. 2022.



Health Sciences