Technological prospection: the genus Mikania in therapeutic use
DOI:
https://doi.org/10.33448/rsd-v10i14.22076Keywords:
Mikania; Innovation; Intellectual property.Abstract
The genus Mikania (Asteraceae) comprises about 450 species of these, 203 are found in Brazil and present several chemical and biological activities. Considering the variety of species and their therapeutic properties, the present study aimed to perform technological prospecting of this genus, since this approach aims to contribute to technological, scientific and innovation research. For this purpose, the patent documents were analyzed, regarding the applicant countries, year of filing and the international classification of patents of the genus Mikania. The search was conducted in the databases World Intellectual Property Organization (WIPO), European Patent Office (EPO) and the National Institute of Industrial Property (INPI) in October 2020, using the descriptor “Mikania”; present in the title and/or abstract in addition, documents that included medicinal approaches were selected. Thus, taking into consideration the filing countries, Japan, Brazil and the United States led the patent deposits, with the first document filed in 1991 and the largest number of applications in the years 2000 and 2010. The data concerning the international patent classification are concentrated in subclass A61K, which deals with preparations for medical, dental or hygienic purposes. These results demonstrated the therapeutic and technological potential of the Mikania species and thus which can be evidenced the potential of this study.
References
Bittencourt, C. B., Nascimento, M. G. P., Araújo, J. C. M., Costa, D. N., Santos, J. O., & Andrade, I. M. (2020). Scientic and Technological Prospection of the Pilocarpus Vahl Genus. Cadernos de Prospecção, 13(4), 1205–1219.
Brazil. Ministry of Health. Secretariat for Science, Technology, I. and S. H. I. D. of P. A. and S. I. (2020). National List of Essential Medicines 2020.
Brazil. Ministry of Health. Secretariat of Science, T. and S. I. D. of P. A. and S. I. (2018). Medicinal Plants of interest to SUS: Mikania glomerata Spreng., Asteraceae - Guaco.
Brazil, & Environment, M. of. (2021). Fauna e Flora.
Correia, R., Júnior, R. A., Spósito, R., & Pungartnik, C. (2020). Technological Prospection of the Species Cyperus esculentus L.: a panorama about the scientific and technological production. Cadernos de Prospecção, 13(3), 721–732. Retrieved from http://dx.doi.org/10.9771/cp.v13i3.30769
Coutinho, L. A., Gonçalves, C. P., & Marcucci, M. C. (2020). Chemical composition, biological activity and safety of use of plants from genus Mikania. Revista Fitos, 14(01), 118–144. https://doi.org/10.32712/2446-4775.2020.822
Dey, P., Chandra, S., Chatterjee, P., & Bhattacharya, S. (2011). Neuropharmacological properties of Mikania scandens (L.) Willd. (Asteraceae). Journal of Advanced Pharmaceutical Technology and Research, 2(4), 255–259. https://doi.org/10.4103/2231-4040.90883
Dong, L. M., Jia, X. C., Luo, Q. W., Zhang, Q., Luo, B., Liu, W. Bin, … Tan, J. W. (2017). Phenolics from Mikania micrantha and Their Antioxidant Activity. Molecules (Basel, Switzerland), 22(7), 1–10. https://doi.org/10.3390/molecules22071140
Dou, X., Zhang, Y., Sun, N., Wu, Y., & Li, L. (2014). The anti-tumor activity of Mikania micrantha aqueous extract in vitro and in vivo. Cytotechnology, 66(1), 107–117. https://doi.org/10.1007/s10616-013-9543-9
Dutta, S., Lanvin, B., & Wunsch-Vincent, S. (2019). Global Innovation Index 2019: Creating Healthy Lives - The Future of Medical Innovation. Retrieved from https://www.wipo.int/edocs/pubdocs/pt/wipo_pub_gii_2019.pdf
Honório, A. C., Quaresma, A. S., Oliveira, C. T., & Loiola, M. I. B. (2019). Flora of Ceará, Brazil: Mikania (Asteraceae: Eupatorieae). Rodriguesia, 70, 1–15. https://doi.org/10.1590/2175-7860201970003
Liu, B., Yan, J., Li, W., Yin, L., Li, P., Yu, H., … Wan, F. (2020). Mikania micrantha genome provides insights into the molecular mechanism of rapid growth. Nature Communications, 11(1), 1–13. https://doi.org/10.1038/s41467-019-13926-4
Moreira, M. R., Souza, A. B., Soares, S., Bianchi, T. C., De Souza Eugênio, D., Lemes, D. C., … Veneziani, R. C. S. (2016). Ent-Kaurenoic acid-rich extract from Mikania glomerata: In vitro activity against bacteria responsible for dental caries. Fitoterapia, 112, 211–216. https://doi.org/10.1016/j.fitote.2016.06.007
Moreti, D. L. C., Leandro, L. F., da Silva Moraes, T., Moreira, M. R., Sola Veneziani, R. C., Ambrosio, S. R., … Martins, C. H. G. (2017). Mikania glomerata Sprengel extract and its major compound ent-kaurenoic acid display activity against bacteria present in endodontic infections. Anaerobe, 47, 201–208. https://doi.org/10.1016/j.anaerobe.2017.06.008
Perucchi, V., & Mueller, S. P. M. (2014). Study about the produced patents and the profile of the inventors of the federal institutions of education, science and technology. RDBCI: Revista Digital de Biblioteconomia e Ciência Da Informação, 12(1), 191–213. https://doi.org/10.20396/rdbci.v12i1.1624
Pires, E. A., Ribeiro, N. M., & Quintella, C. M. (2020). Patent Search Systems: Comparative Analysis Between Espacenet, Patentscope, Google Patents, Lens, Derwent Innovation Index and Orbit Intelligence. Cadernos de Prospecção, 13(1), 13–29. Retrieved from http://dx.doi.org/10.9771/cp.v13i1.35147
Piyasena, K. G. N. P., & Dharmaratne, H. R. W. (2013). Allelopathic activity studies of Mikania scandens. Natural Product Research, 27(1), 76–79. https://doi.org/10.1080/14786419.2012.656110
Pojo, S. da R. (2014). Proteção e licenciamento de patentes da universidade: a experiência da UFRGS.
Póvoa, L. M. C. (2010). Should Universities Patent their Inventions? Revista Brasileira de Inovação, 9(2), 231–256. https://doi.org/10.20396/rbi.v9i2.8649001
Ricardo, L. M., Paula-Souza, J., Andrade, A., & Brandão, M. G. L. (2017). Plants from the Brazilian traditional medicine: Species from the books of the Polish physician piotr czerniewicz (Pedro Luiz Napoleão Chernoviz, 1812–1881). Revista Brasileira de Farmacognosia, 27(3), 388–400. https://doi.org/10.1016/j.bjp.2017.01.002
Ritter, M. R., Gandara, A., Simão-Bianchini, R., Souza-Buturi, F. O., & Abreu, V. H. R. (2020). Mikania Willd.
Rufatto, L. C., Gower, A., Schwambach, J., & Moura, S. (2012). Genus Mikania: Chemical composition and phytotherapeutical activity. Revista Brasileira de Farmacognosia, 22(6), 1384–1403. https://doi.org/10.1590/S0102-695X2012005000099
Rüngeler, P., Brecht, V., Tamayo-Castillo, G., & Merfort, I. (2001). Germacranolides from Mikania guaco. Phytochemistry, 56(5), 475–489. https://doi.org/10.1016/S0031-9422(00)00394-0
Sampaio, P. A., Filho, J. M. T. A., Souza, N. A. C., Teixeira, H. A. P., Araújo, T. C. L., Neto, P. J. R., … Rolim, L. A. (2018). Technological prospection of Morus nigra L. Revista GEINTEC, 8(2), 4381–4391.
Siddiqui, S. A., Islam, R., Islam, R., Jamal, A. H. M., Parvin, T., & Rahman, A. (2017). Chemical composition and antifungal properties of the essential oil and various extracts of Mikania scandens (L.) Willd. Arabian Journal of Chemistry, 10, S2170–S2174. https://doi.org/10.1016/j.arabjc.2013.07.050
Siddiqui, S. A., Rahman, A., Oliur Rahman, M., Akbar, M. A., Shamsur Rouf, A. S., Ali, M. A., … Farah, M. A. (2018). Evaluation of anti-nociceptive, anti-inflammatory and antipyretic potential of Mikania cordata (Burm. f.) Robinson in experimental animal model. Saudi Journal of Biological Sciences, 25, 1049–1055. https://doi.org/10.1016/j.sjbs.2018.01.009
Siddiqui, S. A., Rahman, A., Rahman, M. O., Akbar, M. A., Ali, M. A., Al-Hemaid, F. M. A., … Farah, M. A. (2019). A novel triterpenoid 16-hydroxy betulinic acid isolated from Mikania cordata attributes multi-faced pharmacological activities. Saudi Journal of Biological Sciences, 26, 554–562. https://doi.org/10.1016/j.sjbs.2018.03.002
Silva, A. S. B., Owiti, A. O., & Barbosa, W. L. R. (2018). Pharmacology of Mikania genus: A systematic review. Pharmacognosy Reviews, 12(24), 230–237. https://doi.org/10.4103/phrev.phrev
Silva, J. C., Oliveira-Júnior, R. G., Ribeiro, F. P. R. A., Santos, M. R. M. C., Quintans-Júnior, L. J., Almeida, J. R. G. S. P. (2015). Technological prospection of alkaloids used in the treatment of pain. Revista GEINTEC, 5(3), 2284-2295.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2021 Nathália Andrezza Carvalho de Souza; Victória Laysna dos Anjos Santos; Tarcísio Cícero de Lima Araújo; Pedrita Alves Sampaio; Renata Rivelli Menezes de Souza; Pedro José Rolim Neto; Rodolfo Hideki Vicente Nishimura; Larissa Araújo Rolim
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
