Epidemiological aspects of visceral leishmaniasis in the State of Bahia, Brazil
DOI:
https://doi.org/10.33448/rsd-v10i14.22122Keywords:
Visceral leishmaniasis; Neglected diseases; Epidemiology.Abstract
The northeast of Brazil stands out for having a high prevalence of visceral leishmaniasis (VL), being indicated as the main endemic region of Brazil. This fact makes epidemiological studies in the region of great value, as they help to design more assertive public health policies for the control of VL. In this context, this research aims to outline the epidemiological profile of VL between 2007 and 2019 and outline a profile of vulnerability to the disease in the state of Bahia. This is a sectional, exploratory, descriptive, quantitative and retrospective study. The data used related to VL cases in the state of Bahia come from the SINAN database (Information System and Notifiable Diseases). Data analysis was performed using the GraphPad Prism program. Bahia represents the third state with the highest number of notified VL cases in northeastern Brazil between 2007 and 2019, with a total of 4,156 notified cases. A spatial analysis of this distribution demonstrates that Juazeiro (146 cases) and Guanambi (125 cases) are the municipalities in Bahia with the highest number of reported cases in the period evaluated. Through a stratified analysis of the data, we observed a greater vulnerability among males, browns, with a low level of education and aged 1-4 years. With this work, we reinforce the endemic character of visceral leishmaniasis in the state of Bahia and the need to adopt public health policies aimed at combating VL.
References
Adegboye, M. A., Olumoh, J., Saffary, T., Elfaki, F., & Adegboye, O. (2019). Effects of time-lagged meteorological variables on attributable risk of leishmaniasis in central region of Afghanistan. Rev. Science of The Total Environment, 685, 533-541.
Alebie, G., Worku, A., Yohanmes, S., Urga, B., Hailu, A., & Tadesse D. (2019) Epidemiology of visceral leishmaniasis in Shebelle Zone of Somali Region, eastern Ethiopia. Parasit Vectors, 12(1), 209.
Almeida C. P., Cavalcante, F. R. A., Moreno, J. O., Florêncio, C. M. G. D., Cavalcante, K. K. S., & Alencar, H. C. (2020). Leishmaniose visceral: distribuição temporal e espacial em Fortaleza, Ceará, 2007-2017. Epidemiol Serv Saúde, 29(5), 1-11.
Alves, E. B., Costa, C. H. N., Carvalho, F. A. A., Cruz, M. S. P., & Werneck, G. L. (2016). Risk Profiles for Leishmania infantum Infection in Brazil. Am J Trop Med Hyg, 94(6), 1276-1281.
Amro, A. (2019) Epidemiology and spatiotemporal analysis of visceral leishmaniasis in Palestine from 1990 to 2017. Int J Infect Dis, 90, 206–212.
Andrade, A. W. F., Souza, C. D. F., & Carmo, R. F. (2020). Analysis of spatial clustering, time trend, social vulnerability and risk of human visceral leishmaniasis in an endemic area in Brazil: an ecological study. Trans R Soc Trop Med Hyg, 114 (8), 575-584.
Azevedo, T. S., Lorenz, C., & Chiaravalloti-Neto, F. (2019). Risk mapping of visceral leishmaniasis in Brazil. Rev Soc Bras Med Trop, 52, e20190240.
Bispo, A. J. B., Almeida, M. L. D., Almeida, R. P., Neto, J. B., Brito, A. V. O., & França, C. M. (2020). Pulmonary involvement in human visceral leishmaniasis: Clinical and tomographic evaluation. PLoS One, 15 (1), e0228176.
Brasil. (2014). Manual de Vigilância e Controle da Leishmaniose Visceral. https://bvsms.saude.gov.br/bvs/publicacoes/manual_vigilancia_controle_leishmaniose_visceral_1edicao.pdf. Acesso, 2021-07-21.
Brasil. (2016). Guia de Vigilância em Saúde. https://bvsms.saude.gov.br/bvs/publicacoes/guia_vigilancia_saude_1ed_atual.pdf.
Brasil. (2019). Guia de Vigilância em Saúde. https://bvsms.saude.gov.br/bvs/publicacoes/guia_vigilancia_saude_3ed.pdf.
Brasil. (2021). Boletim Epidemiológico. Doenças tropicais negligenciadas. https://www.gov.br/saude/pt-br/media/pdf/2021/marco/3/boletim_especial_doencas_negligenciadas.pdf.
Bruhn, F. R. P., Morais, M. H. F., Bruhn, N. C. P., Cardoso, D. L., Ferreira, F., & Rocha, C. M. B. M. (2018). Human visceral leishmaniasis: factors associated with deaths in Belo Horizonte, Minas Gerais state, Brazil from 2006 to 2013. Epidemiologia e Infecção, 146(5), 565-570.
Cardim, M. F. M., Rodas, L. A. C., Dibo, M. R., Guirado, M. M., Oliveira, A. M., & Neto, F. C. (2013). Introdução e expansão da Leishmaniose visceral americana em humanos no estado de São Paulo. Rev. Saúde Pública, 47 (4), 691-700.
Cardim, M. F. M., Guirado, M. M., Dibo, M. R., & Chiaravalloti, F. (2016). Leishmaniose visceral no estado de São Paulo, Brasil: análise espacial e espaço-temporal. Rev. Saúde Pública, 50, (48), 1-11.
Cavalcante, I. J. M., & Vale, M. R. (2014). Epidemiological aspects of visceral leishmaniasis (kala-azar) in Ceará in the period 2007 to 2011. Rev bras epidemiol, 17(4), 911-924.
Cavalcante, F. R. A., Cavalcante, K.K. S., Florêncio, C. M. G. D., Moreno, J. O., Correia, F. G. S., & Alencar, C. H. (2020). Human visceral leishmaniasis: epidemiological, temporal and spacial aspects in Northeast Brazil, 2003-2017. Rev Inst Med Trop São Paulo, 62, 1-10 .
Cloots K., Burza, S., Maiaviya, P., Hasker, E., Kansal, S., Mollett, G., Chakravarty, J., Roy, N., Lai, B. K., Rijal, S., Sundar, S., & Boelaert, M. (2020). Male predominance in reported Visceral Leishmaniasis cases: Nature or nurture? A comparison of population-based with health facility-reported data. PLOS Negl Trop Dis, 14(1), e0007995.
Daher, E. F., Soares, D. S., Filho, S. L. A. P., Meneses, G. C., Freitas, T. V. S., Leite, T. T., & Junior, G. B. S. (2017). Hyponatremia and risk factors for death in human visceral leishmaniasis: new insights from a cross-sectional study in Brazil. BMC Infect Dis, 17(1), 168.
De Oliveira, M. L., Nascimento, L. S., Carvalho, E. A., & Machado, F. A. (2019). Análise epidemiológica da leishmaniose visceral no Estado do Tocantins no período de 2007 a 2017. Rev Epidemiol Controle Infecç, 9(4), 316-322.
Del Carro, K. B., Leite, G. R., Filho, A. G. O., Santos, C. B., Pinto, I. S., Fux, B., & Falqueto, A. (2020). Assessing geographic and climatic variables to predict the potential distribution of the visceral leishmaniasis vector Lutzomyia longipalpis in the state of Espírito Santo, Brazil. PLoS One, 15(9), e0238198.
DNDI (2021). Leishmanioses. https://www.dndial.org/doencas/leishmanioses/.
Dos Reis, L. L., Bailieiro, A. A. S., Fonseca, F. R., & Gonçalves, M. J. F. (2017) Changes in the epidemiology of visceral leishmaniasis in Brazil from 2001 to 2014. Rev Soc Bras Med Trop, 50 (5), 638-645.
Farias, H. M. T., Gusmão, J. D., Aguiar, R. V., & Barbosa, S. F. A. (2019). Perfil Epidemiológico da Leishmaniose Visceral Humana nas Regiões de Saúde do Norte de Minas Gerais. Enferm foco, 10 (2), 90-96.
FIOCRUZ. (2021). Leishmaniose. https://portal.fiocruz.br/taxonomia-geral-7-doencas-relacionadas/leishmaniose-0#:~:text =A%20transmiss%C3%A3o%20acontece%20quando%20uma,c%C3%A3o%2C%20ca valo%20etc.
Góes, M. A. O., Jeraldo, V. L. S., & Oliveira, A. S. (2014). Urbanização da leishmaniose visceral: aspectos clínicos e epidemiológicos em Aracaju, Sergipe, Brasil. Rev Bras Med Fam Comunidade, 9(31), 119-126.
Gomila, H. A., Vanzo, C., Garnero, A., Peruzzo, L., & Badalotti, M. (2017). Visceral leishmaniasis. Pediatric case report. Arch Argent Pediatr, 115(4), 251-254.
Kahime, K., Boussaa, S., Nhammi, H., & Boumezzough, A. (2017). Urbanization of human visceral leishmaniasis in Morocco. Parasite Epidemiol Control, 2(4), 1-6.
Luz, J. G. G., Naves, D. B., Carvalho, A. G., Meira, G. A., Dias, J. V. L., & Fontes, C. J. F. (2018). Visceral leishmaniasis in a Brazilian endemic area: an overview of occurrence, HIV coinfection and lethality. Rev Inst Med trop S. Paulo, 60. 1-9.
Luz, J. G. G., Carvalho, A. G., Naves, D. B., Dias, J. V. L., & Fontes, C. J. F. (2019). Where, when, and how the diagnosis of human visceral leishmaniasis is defined: answers from the Brazilian control program. Mem Inst Oswaldo Cruz, 114, e190253.
Oliveira, D. M., Saraiva, E., Ishikawa, E., Sousa, A. A. A., Silva. E., & Silva, I. M. (2011). Distribution of phlebotomine fauna (Diptera: Psychodidae) across an urban-rural gradient in an area of endemic visceral leishmaniasis in northern Brazil. Mem Inst Oswaldo Cruz, 106(8), 1039-1044.
Oliveira, A.M., López, R. V. M., Dibo, M. R., Rodas, L. A. C., Guirado, M. M., & Chiaravalloti-Neto, F. (2018). Dispersion of Lutzomyia longipalpis and expansion of visceral leishmaniasis in São Paulo State, Brazil: identification of associated factors through survival analysis. Parasit Vectors, 11(1), 503.
Paho. (2018). Leishmanioses. Informe Epidemiológico das Américas. https://iris.paho.org/bitstream/handle/10665.2/34857/LeishReport6_por.pdf?sequence=5#:~:text=Em%202016%2C%20foram%20registrados%20um,popula%C3%A7%C3%A3o%20total%20do%20pa%C3%ADs%2C%20respectivamente.
Paho (2020a). Leishmaniases. Epidemiological Report of the Americas, December 2020. https://www.paho.org/en/documents/leishmaniases-epidemiological-report-americas-december-2020.
Paho (2020b). Leishmanioses. Informe Epidemiológico das Américas. https://iris.paho.org/handle/10665.2/53091.
Pereira, A. S., Shitsuka, D. M., Parreira, F. J., & Shitsuka, R (2018). Metodologia da pesquisa científica. free e-book]. Santa Maria/RS. Ed. UAB/NTE/UFSM.
Pérez-Cabezas, B., Cécilio, P., Gaspar, T. B., Gartner, F., Vasconcellos, R., & Cordeiro-da-Silva, A. (2019). Understanding Resistance vs. Susceptibility in Visceral Leishmaniasis Using Mouse Models of Leishmania infantum Infection. Front Cell Infect Microbiol, 9:30.
Ribeiro, C. J. N., Santos, A. D., Lima, S. V. M. A., Silva, E. R., Ribeiro, B. V. S., Duque, A. M., Peixoto, M. V. S., Santos, P. L., Oliveira, I. M., Lispcomb, M. W., Araújo, K. C. G. M., & Moura, T. R. (2021). Space-time risk cluster of visceral leishmaniasis in Brazilian endemic region with high social vulnerability: An ecological time series study. PLoS Negl. Trop. Dis, 15(1), e0009006.
Rocha, M. A. N., Matos-Rocha, T. J., Ribeiro, C. M. B., & Abreu, S. R. O. (2018). Epidemiological aspects of human and canine visceral leishmaniasis in State of Alagoas, Northeast, Brazil. Braz J Biol, 78 (4), 609-614.
Sampaio, C. K. R. P., Cunha, I. P., Bulgareli, J. V., Guerra, L. M., Gondinho, B. V. C., & Cortellazzi, K. L. (2021). Leishmaniose visceral na região de Sobral-CE: perfil epidemiológico dos casos notificados entre os anos de 2015 a 2018. Sanare, 20 (1), 7-16.
Secretaria da Saúde. (2020). Boletim Epidemiológico da Leishmaniose Visceral no Estado da Bahia. http://www.saude.ba.gov.br/wp-content/uploads/2017/11/boletimEpidimiologicoLeishmanioseVisceral2020.pdf.
Shrestha, M. (2019). Molecular evidence supports the expansion of visceral leishmaniasis towards non-program districts of Nepal. BMC Infect, 19(1), 444.
Silva, D.A., Madeira, M. F., & Figueiredo F. B. (2015). Geographical expansion of canine visceral leishmaniasis in Rio de Janeiro state, Brazil. Rev Inst Med Trop S. Paulo, 57(5), 435- 438.
Silva, T. L., Telleria E. L., & Csekö Y. M. T. (2021). The gene expression of Leishmania infantum chagasi inside Lutzomyia longipalpis, the main vector of visceral leishmaniasis in Brazil. Mem Inst Oswaldo Cruz, 116, e200571.
SINAN (2021). Leishmaniose Visceral. Brasília: Ministério da Saúde. http://www.portalsinan.saude.gov.br/leishmaniose-visceral.
Sousa, J. M. D. S., Ramalho, W. M., & De Melo, M. A. (2018). Demographic and clinical characterization of human visceral leishmaniasis in the State of Pernambuco, Brazil between 2006 and 2015. Rev Soc Bras Med Trop, 51 (5), 622-630.
Souza H. P., Oliveira, W. T. G. H., Santos, J. P. C., Toledo, J. P., Ferreira, I. P. S., Esashika, S. N. G. S., & Lima, T. (2020). Doenças infecciosas e parasitárias no Brasil de 2010 a 2017: aspectos para vigilância em saúde. Rev Panam Salud Publica, 44, e10, 1-7.
WHO (2021a). Control of Neglected Tropical. https://www.who.int/teams/control-of-neglected-tropical-diseases (who.int).
WHO (2021b). Leishmaniasis. https://www.who.int/news-room/fact-sheets/detail/leishmaniasis.
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Copyright (c) 2021 Isabela Santos Cezar; Jéssica Santos Dias de Abreu; Dahara Keyse Carvalho Silva; Cássio Santana Meira
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