The influence of the gut microbiota on the development of food allergy in children

Authors

DOI:

https://doi.org/10.33448/rsd-v10i14.22156

Keywords:

Keywords: microbiota; dysbiosis; food hypersensitivity.; Dysbiosis; Food hypersensitivity.

Abstract

The gut microbiota, which is formed mainly early in life, plays a crucial role in the formation of the immune system and in food tolerance. Dysbiosis, which means an overgrowth of pathobiont bacteria, creates imbalance and inflammation of the gut microbiota, affecting its function. Because of this, there was interest in evaluating the influence of the microbiota on the development of food allergies in children, analyzing the interference of dysbiosis on the immune system, by the method of integrative review in the last 10 years, since there is an increase in the prevalence of food allergies in children in the last decade. This research is characterized as an integrative literature review, in which articles published in the last 10 years, selected through the inclusion criteria, were analyzed. It is based on the theme "The influence of the microbiota on the development of food allergy in children". Literature published in English, Portuguese and Spanish was sought as the study priority. The intestinal microbiota is directly related to the immune system, and malfunction of one is followed by imbalance of the other. Thus, the composition of a comprehensive and functional gut microbiota contributes to a more resilient immune system and can lead to a greater tolerance to food allergies. However, we conclude that dysbiosis is more conducive to the onset of allergies. Despite the genetic contribution, it has the contribution of environmental factors and hygienic factors that favor the onset of food allergy.

References

Ashley, S., Dang, T., Koplin, J., Martino, D., Prescott, S. (2015) Food for thought. Current Opinion in Allergy & Clinical Immunology, 15(3), 237–242, 2015. 10.1097/ACI.0000000000000159. https://journals.lww.com/coallergy/Abstract/2015/06000/Food_for_thought_progress_in_understanding _the.9.aspx

Azad, M. B., Konya, T., Guttman, D. S., Field, C. J., Sears, M. R., HayGlass, K. T., Mandhane, P. J., Turvey, S. E., Subbarao, P., Becker, A. B., Scott, J. A., Kozyrskyj, A. L., & CHILD Study Investigators. (2015). Infant gut microbiota and food sensitization: associations in the first year of life. Clin Exp Allergy, 45(3):632-43. 10.1111/cea.12487. https://pubmed.ncbi.nlm.nih.gov/25599982/

Azouz, N. P., & Rothenberg, M. E. (2019). Mechanisms of gastrointestinal allergic disorders. The Journal of clinical investigation, 129(4), 1419–1430. https://doi.org/10.1172/JCI124604

Benedé, S., Blázquez, A. B., Chiang, D., Tordesillas, L., & Berin, M. C. (2016). The rise of food allergy: Environmental factors and emerging treatments. EBioMedicine, 7, 27–34. https://doi.org/10.1016/j.ebiom.2016.04.012

Blázquez, A. B., & Berin, M. C. (2017). Microbiome and food allergy. Translational research: the journal of laboratory and clinical medicine, 179, 199–203. https://doi.org/10.1016/j.trsl.2016.09. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5164970/

Brosseau, C., Selle, A., Palmer, D. J., Prescott, S. L., Barbarot, S., & Bodinier, M. (2019). Prebiotics: Mechanisms and Preventive Effects in Allergy. Nutrients, 2019 Aug 8;11(8):1841. 10.3390/nu11081841. https://pubmed.ncbi.nlm.nih.gov/31398959/

Castellazzi, A. M., Valsecchi, C., Caimmi, S., Licari, A., Marseglia, A., Leoni, M. C., Caimmi, D., Miraglia del Giudice, M., Leonardi, S., La Rosa, M., & Marseglia, G. L. (2013). Probiotics and food allergy. Ital J Pediatr, 2013 Jul 29;39:47. 10.1186/1824-7288-39-47. https://pubmed.ncbi.nlm.nih.gov/23895430/

Chong-Neto, H. J., Pastorino, A. C., Melo, A. C. D. B., Medeiros, D., Kuschnir, F. C., Alonso, M. L. O., Wandalsen, N. F., Rosário, C. S., Solé, D., & Barreto, B. A. P. (2019). A microbiota intestinal e sua interface com o sistema imunológico. Brazilian Journal of Allergy and Immunology (BJAI). http://aaai-asbai.org.br/detalhe_artigo.asp?id=1048

Constanzo, M., Paparo, L., Cosenza, L., Carmen, Scala, C., Nocerino, R., & Aitoro, R. (2016). Food Allergies: Novel Mechanisms and Therapeutic Perspectives. Methods in Molecular Biology, 215–221, 2016. https://link.springer.com/protocol/10.1007%2F978-1-4939-3139-2_14

Cukrowska B. (2018). Microbial and Nutritional Programming-The Importance of the Microbiome and Early Exposure to Potential Food Allergens in the Development of Allergies. Nutrients, 10(10), 1541. https://doi.org/10.3390/nu10101541

Di Costanzo, M., Carucci, L., Berni Canani, R., & Biasucci, G. (2020). Gut Microbiome Modulation for Preventing and Treating Pediatric Food Allergies. International journal of molecular sciences, 21(15), 5275.https://doi.org/10.3390/ijms21155275.

Di Costanzo, M., De Paulis, N., & Biasucci, G. (2021). Butirato: uma ligação entre a nutrição na primeira infância e o microbioma intestinal no desenvolvimento da alergia alimentar. Life (Basel, Suíça), 11 (5), 384. https://doi.org/10.3390/life11050384

Giudice, M. M., Leonardi, S., Maiello, N., & Brunese, F. P. (2010). Food Allergy and Probiotics in Childhood. Journal of Clinical Gastroenterology, 2010 44: S22–5.https://pubmed.ncbi.nlm.nih.gov/20562632/

Gourbeyre, P, Denery, S. & Bodinier, M. (2011). Probiotics, prebiotics, and synbiotics: impact on the gut immune system and allergic reactions. (Journal of Leukocyte Biology), 89(5):685–95.https://jlb.onlinelibrary.wiley.com/doi/full/10.1189/jlb.1109753

Harumi, J. (2012). Non-IgE Mediated Food Allergy – Update of Recent Progress in Mucosal Immunity. Inflammation & Allergy - Drug Targets (Discontinued), 11(5), 382–396. https://www.eurekaselect.com/103206/article

Inoue, R., Sawai, T., Sawai, C., Nakatani, M., Romero-Pérez, G. A., Ozeki, M., Nonomura, K., Tsukahara, T. (2017). A preliminary study of gut dysbiosis in children with food allergy. Bioscience, Biotechnology, and Biochemistry, 81(12), 2396–2399. https://doi.org/10.1080/09168451.2017.1383849

Isolauri, E., Rautava, S., & Salminen, S. (2012). Probiotics in the development and treatment of allergic disease. Gastroenterol Clin North Am, 41(4):747-62. 10.1016/j.gtc.2012.08.007. https://pubmed.ncbi.nlm.nih.gov/23101685/

Järvinen, K. M., Martin, H., & Oyoshi, M. K. (2019). Immunomodulatory effects of breast milk on food allergy. Annals of allergy, asthma & immunology: official publication of the American College of Allergy, Asthma, & Immunology, 123(2), 133–143. https://doi.org/10.1016/j.anai.2019.04.022

Jungles, K. N., Jungles, K. M., Greenfield, L., Mahdavinia, M. (2021) The Infant Microbiome and Its Impact on Development of Food Allergy. Immunology and Allergy Clinics of North America, 41(2), 285–299, 2021. https://doi.org/10.1016/j.iac.2021.01.004.

Lee, H. L., Shen, H., Hwang, I. Y., Ling, H., Yew, W. S., Lee, Y. S., & Chang, M. W. (2018). Targeted Approaches for In Situ Gut Microbiome Manipulation. Genes, 9(7), 351. https://doi.org/10.3390/genes9070351. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071227/

Lee, K. H., Guo, J., Song, Y., Ariff, A., O'Sullivan, M., Hales, B., Mullins, B. J., & Zhang, G. (2021). Dysfunctional Gut Microbiome Networks in Childhood IgE-Mediated Food Allergy. International journal of molecular sciences, 22(4), 2079. https://doi.org/10.3390/ijms22042079

McCoy, K. D., & Köller, Y. (2015). New developments providing mechanistic insight into the impact of the microbiota on allergic disease. Clinical immunology (Orlando, Fla.), 159(2), 170–176. https://doi.org/10.1016/j.clim.2015.05.007. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4553911/

Marrs, T., & Sim, K. (2018). Demystifying Dysbiosis: Can the Gut Microbiome Promote Oral Tolerance Over IgE-mediated Food Allergy? Curr Pediatr, Rev. 2018,14(3):156-163. 10.2174/1573396314666180507120424. https://pubmed.ncbi.nlm.nih.gov/29732975/

Morhardt, T. L., Hayashi, A., Kao, J. Y., & Kamada, N. (2018). Regional control of regulatory immune cells in the intestine. Current pathobiology reports, 6(1), 29–34. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943041/

Mennini, M., Fierro, V., Di Nardo, G., Pecora, V., & Fiocchi, A. (2020) Microbiota in non-IgE-mediated food allergy. Curr Opin Allergy Clin Immunol. 2020 20(3):323-328. 10.1097/ACI.0000000000000644.

Molloy, J., Allen, K., Collier, F., Tang, M. L., Ward, A. C., & Vuillermin, P. (2013). The potential link between gut microbiota and IgE-mediated food allergy in early life. International journal of environmental research and public health, 10(12), 7235–7256. https://doi.org/10.3390/ijerph10127235

Muir, A. B., Benitez, A. J., Dods, K., Spergel, J. M., & Fillon, S. A. (2016). Microbiome and its impact on gastrointestinal atopy. Allergy, 71(9), 1256–1263.

https://doi.org/10.1111/all.12943

Nance, C. L., Deniskin, R., Diaz, V. C., Paul, M., Anvari, S., & Anagnostou, A. (2020). The Role of the Microbiome in Food Allergy: A Review. Children (Basel, Switzerland), 7(6), 50. https://doi.org/10.3390/children7060050

Noval Rivas, M., Burton, O. T., Wise, P., Zhang, Y. Q., Hobson, S. A., Garcia Lloret, M., Chehoud, C., Kuczynski, J., DeSantis, T., Warrington, J., Hyde, E. R., Petrosino, J. F., Gerber, G. K., Bry, L., Oettgen, H. C., Mazmanian, S. K., & Chatila, T. A. (2013). A microbiota signature associated with experimental food allergy promotes allergic sensitization and anaphylaxis. The Journal of allergy and clinical immunology, 131(1), 201–212. https://doi.org/10.1016/j.jaci.2012.10.026. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3860814/

Nowak-Wegrzyn, A., Szajewska, H. & Lack, G. (2017). Food allergy and the gut. Nat Rev Gastroenterol Hepatol 14, 241–257 (2017). https://doi.org/10.1038/nrgastro.2016.187

Pannaraj, P. S., Li, F., Cerini, C., Bender, J. M., Yang, S., Rollie, A., Adisetiyo, H., Zabih, S., Lincez, P.J., Bittinger, K., Bailey, A., Bushman, F. D., Sleasman, J. W., & Aldrovandi, G. M. (2017). Association Between Breast Milk Bacterial Communities and Establishment and Development of the Infant Gut Microbiome. JAMA Pediatr, 1;171(7):647-654. 10.1001/jamapediatrics.2017.0378. https://pubmed.ncbi.nlm.nih.gov/28492938/

Prince, B. T., Mandel, M. J., Nadeau, K., & Singh, A. M. (2015). Gut Microbiome and the Development of Food Allergy and Allergic Disease. Pediatric clinics of North America, 62(6), 1479–1492. https://doi.org/10.1016/j.pcl.2015.07.007 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4721650/

Peroni, D. G., Nuzzi, G., Trambusti, I., Di Cicco, M. E., & Comberiati, P. (2020). Microbiome Composition and Its Impact on the Development of Allergic Diseases. Frontiers in immunology, 11, 700. https://doi.org/10.3389/fimmu.2020.00700

Rachid, R., & Chatila, T.A. (2016). The role of the gut microbiota in food allergy. Curr Opin Pediatr, 28(6):748-753. 10.1097/MOP.0000000000000427. https://pubmed.ncbi.nlm.nih.gov/27749359/

Sardecka, I., Krogulska, A., & Toporowska-Kowalska, E. (2017). The influence of dietary immunomodulatory factors on development of food allergy in children. Postepy dermatologii i alergologii, 34(2), 89–96. https://doi.org/10.5114/pdia.2016.63955

Solé, D., Rodrigues, L., Cocco, R. R., Ferreira, C. T., Sarni, R. O., Oliveira, L. C., Pastorino, A. C., Weffort, V., Morais, M. B., Barreto, B. P., Oliveira, J. C., Castro, A. P. M., Franco, J. M., Neto, H. J. C., Rosário, N. A., Alonso, M. L. O., Sarinho, E. C., Yang, A., Maranhão, H., Toporovski, M. S., Epifânio, M., Wandalsen, N. F., & Rubini, N. M. (2018). Consenso Brasileiro sobre Alergia Alimentar: 2018 - Parte 1 - Etiopatogenia, clínica e diagnóstico. Documento conjunto elaborado pela Sociedade Brasileira de Pediatria e Associação Brasileira de Alergia e Imunologia. Arquivos de Asma, Alergia e Imunologia. http://aaai-asbai.org.br/detalhe_artigo.asp?id=851

Souza, M. T. de, Silva, M. D. da, & Carvalho, R. de. (2010). Integrative review: what is it? How to do it? Einstein, 8(1), 102–106. https://doi.org/10.1590/s1679-45082010rw1134

Silva, C. V., Mello, E. V. S. L., & Schneider, L. C. L. (2019). O Papel da Microbiota como Aliada no Sistema Imunológico. Arquivos do Mudi, 23(3), 345-358, https://doi.org/10.4025/arqmudi.v23i3.51557. http://www.periodicos.uem.br/ojs/index.php/ArqMudi/article/view/51557

Stephen-Victor, E., Crestani, E., & Chatila, T. A. (2020). Dietary and Microbial Determinants in Food Allergy. Immunity, 53(2), 277–289. https://doi.org/10.1016/j.immuni.2020.07.025

Savage, J. H., Lee-Sarwar, K. A., Sordillo, J., Bunyavanich, S., Zhou, Y., O'Connor, G., Sandel, M., Bacharier, L. B., Zeiger, R., Sodergren, E., Weinstock, G. M., Gold, D. R., Weiss, S. T., & Litonjua, A. A. (2018). A prospective microbiome-wide association study of food sensitization and food allergy in early childhood. Allergy, 73(1), 145–152. https://doi.org/10.1111/all.13232

Savage, J. H., Lee-Sarwar, K. A., Sordillo, J. E., Lange, N. E., Zhou, Y., O'Connor, G. T., Sandel, M., Bacharier, L. B., Zeiger, R., Sodergren, E., Weinstock, G. M., Gold, D. R., Weiss, S. T., & Litonjua, A. A. (2018). Diet during Pregnancy and Infancy and the Infant Intestinal Microbiome. The Journal of pediatrics, 203, 47–54.e4. https://doi.org/10.1016/j.jpeds.2018.07.066

Suther, C., Moore, M. D., Beigelman, A., & Zhou, Y. (2020). The Gut Microbiome and the Big Eight. Nutrients, 12(12), 3728. https://doi.org/10.3390/nu12123728

Stephen-Victor, E., & Chatila, T. A. (2019). Regulation of oral immune tolerance by the microbiome in food allergy. Current opinion in immunology, 60, 141–147. https://doi.org/10.1016/j.coi.2019.06.001

Tsabouri, S., Priftis, K. N., Chaliasos, N., & Siamopoulou, A. (2013). Modulation of gut microbiota downregulates the development of food allergy in infancy. Allergol Immunopathol (Madr), 42(1):69-77. 10.1016/j.aller.2013.03.010. https://pubmed.ncbi.nlm.nih.gov/23827644/

Vandenplas, Y., Huys, G., & Daube, G. (2014). Probiotics: an update. J Pediatr (Rio J), 2015 Jan-Feb;91(1):6-21. 10.1016/j.jped.2014.08.005. https://pubmed.ncbi.nlm.nih.gov/25458874/

Vernocchi, P., Del Chierico, Fiocchi, A. G., Hachem, M. E., Dallapiccola, B., Rossi, P., & Putignani, L. (2015). Understanding probiotics’ role in allergic children. Current Opinion in Allergy and Clinical Immunology, 15(5), 495-503. 10.1097/ACI.0000000000000203

Published

02/11/2021

How to Cite

SOUSA, S. M. dos S.; BANDEIRA, D. R.; QUINTANILHA , L. F. da C.; BALDAÇARA, R. P. de C.; CAVALCANTE, C. P. A.; SILVA, J. B. N. F. The influence of the gut microbiota on the development of food allergy in children . Research, Society and Development, [S. l.], v. 10, n. 14, p. e293101422156, 2021. DOI: 10.33448/rsd-v10i14.22156. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/22156. Acesso em: 3 dec. 2024.

Issue

Section

Health Sciences