Prevalence of hemoglobinopatities in pregnant women of the stork project, period from january to june 2019 in the state of Piauí

Authors

DOI:

https://doi.org/10.33448/rsd-v9i2.2224

Keywords:

; Hemoglobinopathies; Piaui; Stork Project; Prevalence; Sickle cell anemia.

Abstract

Hemoglobinopathies are the most prevalent genetic diseases in the world, the most common being: Sickle Cell Diseases (SS, SC, SD, SE, SF), variant hemoglobins, and thalassemia. Studies show that about 300,000 children are born each year with these diseases and thousands are with sickle cell anemia which is one of the most severe forms of the disease. In Brazil, approximately 3,500 people are born with sickle cell disease and their high morbidity and mortality has been considered a public health issue, as people's life expectancy is reduced. The objective of the study was to analyze the prevalence of hemoglobinopathies in pregnant women in the first semester of 2019, from the 65 municipalities of the state of Piauí that send samples for exam analysis, from Projeto Cegonha, at the LACEN / PI Piauí Hemoglobinopathies Laboratory. The work was performed through analysis of the tests performed by the HPLC methodology of Bio-Rad / USA® Variant II and D10 equipment, and the Lacen-PI NETLAB data system. For data compilation, the spreadsheet was used in the Microsoft Excel® program. Of the approximately 30 municipalities that sent samples for analysis it was found that 4.6% of pregnant women have hemoglobinopathies. The municipalities with the largest number of cases were Teresina, Oeiras and Bom Jesus, but in other 19 cities were found cases of hemoglobinopathies. These results do not match the overall reality of the state of Piauí due to non-adherence of all municipalities which may result in higher rates that have not yet been found, generating a more worrying epidemiological condition. Research is important for policy discussion. such as the epidemiological condition of these diseases in the state of Piauí, genetic counseling, health education, collaborative and research studies to know the impacts in the state regions and practical impact on the lives of people with  hemoglobinopathies.

References

Achebe, M. (2018) Anemia: Pathophysiology, Diagnosis, and Management. Sickle Cell Syndromes. p. 66-75. 2017. Cambridge: Cambridge University Press.

Barbara J. Bain, et al. (2010) Stephens and Lorraine A. Phelan Variant haemoglobins: a guide to identification. 1 Ed. New Jersey/USA. Willey-Blackwell.

Balgir, R. S. (2013). A Cross-Sectional Study of Hemoglobin Disorders in Pregnant Women Attending Two Urban Hospitals in Eastern Coast of Odisha, India. Online J Health Allied Scs. 12(4):4.

Baracioli, L. M. S, V; Domingos, C. R. B.; Pagliusi, R. A.; et al. (2001). Prevenção de hemoglobinopatias a partir de estudos em gestantes. Rev. Bras. Hematol. Hemoter. 23(1): p. 31-39.

Baxi, A.; Manila, K.; Kadhi, P.; et al. (2013). Carrier Screening for b Thalassemia in Pregnant Indian Women: Experience at a Single Center in Madhya Pradesh Indian. J Hematol Blood Transfus. 29(2): p. 71–74. abril-jun.

Cançado, R. D.; Jesus, J. A. (2007). Sickle Cell Disease in Brazil. Rev. Bras. Hematol. Hemoter. 29(3). p. 203-206.

Cardoso, P. S. R.; Aguiar, R. A. L. P.; Viana, M. B. (2014). Clinical complications in pregnant women with sickle cell disease: prospective study of factors predicting maternal death or near miss. Revista brasileira de hematologia e hemoterapia. 36(4): p. 256–263.

Cerqueira, F. W. "População do Piauí"; Brasil Escola. Disponível em: https://brasilescola.uol.com.br/brasil/a-populacao-piaui.htm. Acesso em: 23 de nov. de 2019.

Dasgrupta, A; Wahed, A. Clinical Chemistry, Immunology and Laboratory Quality Control. 1 Ed. San Diego:Elsevier.; 2014.

Jain, p.; Kumar, V.; Sem, R.; et al. (2016) International Journal of Research in Medical Sciences, v. 14. Issue 10. p. 4333. out.

Hochman, B.; Nahas, X.F.; Filho, de O. S.R.; Ferreira, M.L.; (2005) Desenhos de pesquisa. Acta Cirúrgica Brasileira - Vol 20 (Supl. 2).

Liberato, K. M. M.; Oselame, G. B.; Neves, E. B. (2017). Hemoglobinopatias em gestantes submetidas ao teste da mãezinha na rede pública de saúde. Rev. Aten. Saúde, São Caetano do Sul, v. 15, n. 51, p. 46-51, jan./mar.

Lopes, T. R. (2013). Análise do perfil genético da população do estado do Piauí por marcadores informativos de ancestralidade. Dissertação de Mestrado, Universidade Federal do Piauí, Parnaíba, Piauí, Brasil.

Marcondes, R. L.; Falci, M. B. K. (2001). Escravidão e Reprodução no Piauí: Oeiras e Teresina(1875). FEA/USP-Ribeirão Preto-SP.

Modell, B.; Darlison, M. (2008). Global epidemiology of harmoglobin disorders and derived service indicators. Bulletin of the World Health Organization. v. 86. n. 6. p. 417-496.

Oliveira, J. B.; Moraes, K. C. M. Hemoglobinopatias: uma questão de saúde pública, revisão bibliográfica. XIII Encontro Latino Americano de Iniciação Científica e IX Encontro Latino Americano de Pós-Graduação – Universidade do Vale do Paraíba (2012).

Rosenfeld, L. G.; Bacal, N. S.; Cuder, M. A. M.; Silva. A. G; Machado, I. E.; Pereira, C. A.; Souza, M. F. M.; Malta, D. C. (2019). Prevalência de hemoglobinopatias na poulação adulta brasileira: pesquisa Nacional de saúde. Rev Bras Epidemiol; 22 (SUPPL 2); E190007.SUPL.2.

Sakamoto, T. M.; Ivo, M. L.; Brum, M. A. R.; Pontes, E. R. J. C.; Domingos, C. R. B.; Júnior, M. A. F. (2012). Anemia e Hemoglobinopatias em Gestantes Atendidas em Hospital Público. J. Nurs. p (1576-81).

Silva, L. C. M.; Castro, F. S. (2017). Hemoglobinopatias: relato de caso familiar. Rev. Bras. An. Clin. Vol. 49 Nº. 3 set./out.

Silva, N C. H.; Silva, J. C. G.; De Melo, M. G. N. et al. (2017). Principais Técnicas para o Diagnóstico da Anemia Falciforme: uma Revisão de Literatura. Ciências Biológicas e de Saúde Unit. Facipe. v. 3 n. 2 p. 33-46.

Soares, L. F.; Oliveira, E. H.; Iraildo B. Lima, I. B.; et al. (2009). Hemoglobinas variantes em doadores de sangue do Centro de Hematologia e Hemoterapia do Estado do Piauí (Hemopi): Conhecendo o perfil epidemiológico para construir a rede de assistência. Rev. Bras. Hematol. Hemoter. 31(6): p. 471-472.

Verhovsek, M.; Chui, D. (2017). The Thalassemia Syndromes. Anemia: Pathophysiology, Diagnosis, and Management. (p.48-58). Cambridge: Cambridge University Press.

Published

01/01/2020

How to Cite

SALES, E. K. R. B.; JUNIOR, R. N. C. M.; COSTA, R.; DIAS, J. de C. da S. Prevalence of hemoglobinopatities in pregnant women of the stork project, period from january to june 2019 in the state of Piauí. Research, Society and Development, [S. l.], v. 9, n. 2, p. e157922224, 2020. DOI: 10.33448/rsd-v9i2.2224. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/2224. Acesso em: 24 sep. 2021.

Issue

Section

Health Sciences